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FB2021_03, released June 15, 2021

Gene: Dmel\repo

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General Information
Symbol
Dmel\repo
Species
D. melanogaster
Name
reversed polarity
Annotation Symbol
CG31240
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011701
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
reversed polarity (repo) encodes a homeodomain transcription factor specifically expressed in glial cells. It is is a direct target of the pan-glial fate determinant encoded by gcm and is required for acquisition of glial fate and subsequent terminal glial differentiation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

RK2, reverse polarity

Key Links
Genomic Location
Cytogenetic map
90F9-90F10
Sequence location
3R:18,236,192..18,239,602 [+]
Recombination map
3-62
RefSeq locus
NT_033777 REGION:18236192..18239602
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Yuasa et al., 2003)
enables DNA-binding transcription repressor activity, RNA polymerase II-specific
inferred from direct assay
(Trébuchet et al., 2019)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Halter et al., 1995)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004692309
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004692309
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in glial cell development
inferred from mutant phenotype
(Yuasa et al., 2003)
involved_in negative regulation of hemocyte differentiation
inferred from mutant phenotype
(Trébuchet et al., 2019)
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Trébuchet et al., 2019)
involved_in nervous system development
inferred from mutant phenotype
(Halter et al., 1995)
involved_in peripheral nervous system development
inferred from mutant phenotype
(Wright et al., 2010)
involved_in positive regulation of gene expression
inferred from direct assay
(Mandalaywala et al., 2008)
involved_in positive regulation of glial cell differentiation
inferred from mutant phenotype
(Trébuchet et al., 2019)
involved_in regulation of phagocytosis
inferred from mutant phenotype
(Shklyar et al., 2014)
inferred from genetic interaction with FLYBASE:drpr; FB:FBgn0027594
(Shklyar et al., 2014)
inferred from genetic interaction with FLYBASE:NimC4; FB:FBgn0260011
(Shklyar et al., 2014)
involved_in synapse organization
inferred from mutant phenotype
(Kerr et al., 2014)
involved_in synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Kerr et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in glial cell differentiation
non-traceable author statement
(Hidalgo, 2002)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004692309
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Schreader et al., 2010)
located_in nucleus
inferred from direct assay
(Schreader et al., 2010, Sharma and Nirenberg, 2007, Halter et al., 1995)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
reversed polarity (repo) encodes a homeodomain transcription factor specifically expressed in glial cells. It is is a direct target of the pan-glial fate determinant encoded by gcm and is required for acquisition of glial fate and subsequent terminal glial differentiation. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS -
Paired-like (PRD-like) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. PRD-like transcription factors lack a paired domain but possess a homeodomain characteristic of the paired homeobox transcription factors. Some members also possess an Engrailed Homology 1 (EH1) and/or an OAR motif near the C-terminus. (Adapted from FBrf0232555 and FBrf0106517).
Summary (Interactive Fly)

transcription factor - homeodomain - required for aspects of glial differentiation - a direct target of the pan-glial fate determinant

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\repo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.54

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
repo-RA
FBtr0083564
NM_057678
2996
612
Additional Transcript Data and Comments
Reported size (kB)

3.4 (northern blot)

(Campbell et al., 1994)

3.5 (northern blot)

(Xiong et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
repo-PA
FBpp0082986
65.6
612
6.73
NP_477026
AAF55517
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

612 (aa)

(Campbell et al., 1994)

612 (aa); 66 (kD predicted)

(Xiong et al., 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\repo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
interface glial cell
(Xiong et al., 1994)
glial cell
(Xiong et al., 1994)
embryonic stage 9
glioblast
(Xiong et al., 1994)
embryonic stage 11 -- 12
dorsal sensory complex primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic glioblast of ventral nerve cord primordium

Comment: reported as glioblasts of ventral nervous system

(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic glioblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain
(Fisher et al., 2012)
embryonic central brain surface glia
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
channel glial cell
(Kearney et al., 2004)
Additional Descriptive Data

repo is first expressed in embryonic stage 9 in glioblasts located in the lateral-most row of neuroblasts and at the anterior margin of each segment. The repo-expressing cell divides symmetrically to produce progeny. A third repo-positive cell is seen medial to the first pair in stage 11. In stage 12, two clusters of stained cells flank each segment border. By germ band retraction, numerous longitudinal glia are stained in every hemisegment. On northern blots, the highest levels of repo transcripts are observed in embryos and adult heads.

(Xiong et al., 1994)
Marker for
 
embryonic/larval lateral glial cell
(Mondal et al., 2007)
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
intersegmental nerve root glial cell
(Halter et al., 1995)
presumptive embryonic/larval peripheral nervous system
(Campbell et al., 1994)
B-subperineurial glial cell of abdomen
(Halter et al., 1995)
A-subperineurial glial cell
(Halter et al., 1995)
peripheral glial cell
(Halter et al., 1995)
lateral intersegmental nerve root glial cell
(Halter et al., 1995)
medial intersegmental nerve root glial cell
(Halter et al., 1995)
exit glial cell
(Halter et al., 1995, Campbell et al., 1994)
interface glial cell
(Halter et al., 1995, Campbell et al., 1994)
glial cell of central nervous system
(Campbell et al., 1994)
scolopidial ligament cell
(Halter et al., 1995, Campbell et al., 1994)
bipolar dendrite neuron
(Halter et al., 1995)
channel glial cell
(Halter et al., 1995)
support cell of the dorsal bipolar dendritic cell
(Halter et al., 1995)
embryonic peripheral glial cell 4 -- embryonic peripheral glial cell 10
(Campbell et al., 1994)
medial-most cell body glial cell
(Halter et al., 1995)
embryonic stage 9 -- 11
tritocerebral neuroblast | subset
(Urbach and Technau, 2003)
embryonic stage 10 -- 11
protocerebrum & CNS glial cell | subset
(Urbach et al., 2003)
tritocerebrum & CNS glial cell | subset
(Urbach et al., 2003)
embryonic stage 11 -- 17
embryonic glioblast
• nucleus
(Campbell et al., 1994)
embryonic/larval glial cell
• nucleus

Comment: NOT midline glial cell

(Campbell et al., 1994)
PNS glial cell
• nucleus
(Campbell et al., 1994)
embryonic stage 12 -- 17
exit glial cell
• nucleus
(Campbell et al., 1994)
intermediate peripheral glial cell of ISN
• nucleus
(Campbell et al., 1994)
scolopidial ligament cell
• nucleus
(Campbell et al., 1994)
embryonic stage 12 -- third instar larval stage
glial cell of the perineurium
• nucleus
(Campbell et al., 1994)
embryonic stage 14
glial cell
(Mellerick and Modica, 2002)
embryonic stage 16 -- 17
glial cell
• nucleus
(Jones, 2001)
larval stage
glial cell
• nucleus
(Campbell et al., 1994)
larval stage -- prepupal stage
glial cell of supraesophageal ganglion
• nucleus
(Watts et al., 2004)
third instar larval stage
embryonic/larval optic stalk
(Campbell et al., 1994)
glial cell of wing disc
(Campbell et al., 1994)
glial cell of eye-antennal disc
(Campbell et al., 1994)
glial cell of ventral thoracic disc
(Campbell et al., 1994)
lamina anlage glial cell
(Tayler et al., 2004)
prepupal stage
glial cell
• nucleus
(Campbell et al., 1994)
pupal stage
glial cell of brain
(Jhaveri et al., 2004)
Additional Descriptive Data

pupal expression assayed at 12 hr APF

(Watts et al., 2004)

Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d7

(Urbach and Technau, 2003)

At late stage 10 and into stage 11 repo protein is detected in approximately 20 glial cells or glioblasts in the proto and trito cerebral hemispheres.

(Urbach et al., 2003)

In the embryonic CNS, all known glial cells express repo protein, with the exception of the midline glia and two of three segmental nerve root glial cells. In the CNS of a stage 16 embryo, 27-29 cells per hemimere are stained. In the PNS, all known peripheral glia express repo protein except for the glia associated with the transverse nerve. In addition, some ligament cells, and the lateral bipolar dendrite neuron express repo protein. repo expression appear to be glial specific in the brain as well.

(Halter et al., 1995)

repo protein is expressed throughout development. It is expressed in all glia of the developing PNS and CNS, excluding the midline glia. It is first detected in embryonic stage 11 in a single cell per hemisegment, which corresponds to the lateral glioblast. These cells divide to form two repo-positive cells.These cells subsequently divide and migrate to form the longitudinal glial array. Many other repo-positive cells (presumably of neuroblast origin) appear and will ultimately contribute to the perineurium surrounding the CNS. By stage 12, most of the repo-expressing cells are evident. They include exit glia, three peripheral glial cells per hemisegment (ps1,2,3) and ligament cells of the chordotonal organs. Double staining for repo and elav shows that the repo-postivie cells are glial. repo is also expressed in glial cells in the imaginal discs. In the eye disc, repo is expressed in the glial cells from the optic lobes which populate the optic stalk and subretinal region. repo is also found associated with axon tracts in the leg and wing imaginal discs.

(Campbell et al., 1994)
Marker for
 
CNS glial cell
(Watts et al., 2004)
embryonic/larval glial cell
(Soshnev et al., 2013)
glial cell
(Jhaveri et al., 2004, Garrity et al., 1999)
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Schreader et al., 2010)
located_in nucleus
inferred from direct assay
(Schreader et al., 2010, Sharma and Nirenberg, 2007, Halter et al., 1995)
Expression Deduced from Reporters
Reporter: M{repo-StingerGFP}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval glial cell
(Otto et al., 2018)
Reporter: P{GAL4}repo
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
glial cell
(Kester and Nambu, 2011)
embryonic stage 12 -- 17
CNS glial cell | subset
(Sepp et al., 2001)
glial cell | subset
(Sepp and Auld, 2003)
PNS glial cell | subset
(Sepp et al., 2001)
embryonic stage 13 -- 17
glial cell | subset
(Fradkin et al., 2004)
larval stage
glial cell
(Kester and Nambu, 2011, Awasaki and Ito, 2004)
adult stage
glial cell | subset
(Comas et al., 2004)
adult stage
glial cell of lamina
(Chaturvedi et al., 2014)
Reporter: P{PZ}repo00692
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
interface glial cell
(Xiong et al., 1994)
exit glial cell
(Xiong et al., 1994)
peripheral glial cell
(Xiong et al., 1994)
presumptive embryonic/larval peripheral nervous system
(Xiong et al., 1994)
neuropil associated CNS glial cell
(Xiong et al., 1994)
glial cell of central nervous system
(Xiong et al., 1994)
third instar larval stage
adult optic lobe
(Xiong et al., 1994)
glial cell of eye-antennal disc
(Xiong et al., 1994)
adult stage
lamina
(Xiong et al., 1994)
medulla
(Xiong et al., 1994)
Reporter: P{PZ}repo02138
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
interface glial cell
(Xiong et al., 1994)
exit glial cell
(Xiong et al., 1994)
peripheral glial cell
(Xiong et al., 1994)
presumptive embryonic/larval peripheral nervous system
(Xiong et al., 1994)
neuropil associated CNS glial cell
(Xiong et al., 1994)
glial cell of central nervous system
(Xiong et al., 1994)
third instar larval stage
adult optic lobe
(Xiong et al., 1994)
glial cell of eye-antennal disc
(Xiong et al., 1994)
adult stage
lamina
(Xiong et al., 1994)
medulla
(Xiong et al., 1994)
Reporter: P{PZ}repo03702
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
interface glial cell
(Xiong et al., 1994)
exit glial cell
(Xiong et al., 1994)
peripheral glial cell
(Xiong et al., 1994)
neuropil associated CNS glial cell
(Xiong et al., 1994)
glial cell of central nervous system
(Xiong et al., 1994)
presumptive embryonic/larval peripheral nervous system
(Xiong et al., 1994)
third instar larval stage
glial cell of eye-antennal disc
(Xiong et al., 1994)
adult optic lobe
(Xiong et al., 1994)
wandering third instar larval stage
eye disc
(Harvie et al., 1998)
embryonic/larval brain
(Meister and Braun, 1995.10)
embryonic/larval optic lobe
(Harvie et al., 1998)
larval ventral nerve cord
(Harvie et al., 1998)
ring gland
(Harvie et al., 1998)
adult stage
third segment of antenna
(Vosshall, 1998.8.10)
medulla
(Xiong et al., 1994)
adult optic lobe
(Vosshall, 1998.8.10)
lamina
(Xiong et al., 1994)
adult central complex
(Vosshall, 1998.8.10)
adult brain | restricted
(Vosshall, 1998.8.10)
Reporter: P{repo-GAL4.8.5}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult glial cell
(Awasaki et al., 2008)
adult CNS glial cell
(Lai and Lee, 2006)
Reporter: P{repo-Gal4.L}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16 -- 17
embryonic/larval glial cell
(Lee and Jones, 2005)
larval stage
embryonic/larval glial cell
(Schmidt et al., 2012)
third instar larval stage
embryonic/larval glial cell
(Kerr et al., 2014)
pupal stage
glial cell
(Hilu-Dadia et al., 2018)
adult stage
adult glial cell
(Tanenhaus et al., 2012)
Reporter: P{repo-GAL4.U}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval glial cell
(Avet-Rochex et al., 2010)
adult stage
glial cell
(Boerner and Duch, 2010)
adult glial cell
(Soares et al., 2014)
Reporter: P{repo-LexA-GAD}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult glial cell
(Awasaki et al., 2008)
adult CNS glial cell
(Lai and Lee, 2006)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\repo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of repo
Transgenic constructs containing regulatory region of repo
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal - all die during embryonic stage | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
abnormal memory | adult stage, with Scer\GAL4NP1243
abnormal memory | adult stage | dominant
abnormal memory | adult stage | heat sensitive, with Scer\GAL4hs.PB
abnormal memory | adult stage | RU486 conditional, with Scer\GAL4Atpα-GSG3285-1
abnormal neuroanatomy
abnormal neuroanatomy | embryonic stage
abnormal neuroanatomy | recessive
abnormal neurophysiology (with repo1)
abnormal neurophysiology (with repo03702)
some die during embryonic stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
central nervous system
embryonic/larval glial cell
glial cell
interface glial cell
lamina & glial cell
lamina & neuron
lamina anlage
larval intersegmental nerve branch ISNb of A1-7
larval longitudinal connective
larval longitudinal connective | embryonic stage
larval ventral nerve cord
larval ventral nerve cord | embryonic stage
lateral cord glial cell
macrophage
medial-most cell body glial cell
mesothoracic tergum, with Scer\GAL4pnr-MD237
phagocytic vesicle
PNS glial cell
retina
retina & axon
trichogen cell, with Scer\GAL4pnr-MD237
VUM1 neuron & axon
VUM2 neuron & axon
VUM3 neuron & axon
VUM4 neuron & axon
VUM5 neuron & axon
VUM6 neuron & axon
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ALX1
2 of 15
Yes
No
Hsap\ALX3
2 of 15
Yes
No
Hsap\ALX4
2 of 15
Yes
No
Hsap\ARX
2 of 15
Yes
No
Hsap\ISX
2 of 15
Yes
Yes
Hsap\LHX8
2 of 15
Yes
No
Hsap\DMBX1
1 of 15
No
Yes
Hsap\DRGX
1 of 15
No
No
Hsap\DUX4L5
1 of 15
No
Yes
Hsap\DUX4L6
1 of 15
No
Yes
Hsap\DUX4L7
1 of 15
No
Yes
Hsap\ESX1
1 of 15
No
No
Hsap\GSC2
1 of 15
No
No
Hsap\GSC
1 of 15
No
No
Hsap\HOXB8
1 of 15
No
No
Hsap\LDB3
1 of 15
No
No
Hsap\LHX2
1 of 15
No
No
1  
Hsap\LHX6
1 of 15
No
No
1  
Hsap\LPXN
1 of 15
No
No
1  
Hsap\PAX3
1 of 15
No
No
1  
Hsap\PAX4
1 of 15
No
No
Hsap\PAX6
1 of 15
No
No
2  
Hsap\PDLIM1
1 of 15
No
No
Hsap\PDLIM3
1 of 15
No
No
Hsap\PDLIM7
1 of 15
No
No
Hsap\PHOX2A
1 of 15
No
No
Hsap\PHOX2B
1 of 15
No
No
Hsap\PITX1
1 of 15
No
No
2  
Hsap\PITX3
1 of 15
No
No
Hsap\RHOXF1
1 of 15
No
Yes
Hsap\RHOXF2B
1 of 15
No
No
Hsap\RHOXF2
1 of 15
No
No
Hsap\SHOX2
1 of 15
No
No
Hsap\SHOX
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (30)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Alx3
2 of 15
Yes
No
Mmus\Alx4
2 of 15
Yes
Yes
Mmus\Arx
2 of 15
Yes
No
Mmus\Isx
2 of 15
Yes
Yes
Mmus\Alx1
1 of 15
No
No
Mmus\Dmbx1
1 of 15
No
Yes
Mmus\Esx1
1 of 15
No
No
Mmus\Gsc2
1 of 15
No
No
Mmus\Gsc
1 of 15
No
No
Mmus\Ldb3
1 of 15
No
No
Mmus\Lhx2
1 of 15
No
No
Mmus\Lhx6
1 of 15
No
No
Mmus\Lhx8
1 of 15
No
No
Mmus\Pax3
1 of 15
No
No
1  
Mmus\Pax6
1 of 15
No
No
3  
Mmus\Pdlim1
1 of 15
No
No
Mmus\Pdlim3
1 of 15
No
No
Mmus\Pdlim5
1 of 15
No
No
Mmus\Pdlim7
1 of 15
No
No
Mmus\Phox2a
1 of 15
No
No
Mmus\Phox2b
1 of 15
No
No
Mmus\Pitx1
1 of 15
No
No
Mmus\Pitx3
1 of 15
No
No
Mmus\Prrxl1
1 of 15
No
No
Mmus\Rhox5
1 of 15
No
Yes
Mmus\Rhox10
1 of 15
No
Yes
Mmus\Rhox11
1 of 15
No
Yes
Mmus\Rhox12
1 of 15
No
Yes
Mmus\Rhox13
1 of 15
No
Yes
Mmus\Shox2
1 of 15
No
No
Rattus norvegicus (Norway rat) (14)
Rnor\Alx1
2 of 13
Yes
No
Rnor\Alx4
2 of 13
Yes
No
Rnor\Alx3
1 of 13
No
No
Rnor\Arx
1 of 13
No
No
Rnor\Drgx
1 of 13
No
No
Rnor\Esx1
1 of 13
No
Yes
Rnor\Isx
1 of 13
No
Yes
Rnor\Lhx2
1 of 13
No
No
Rnor\Phox2a
1 of 13
No
No
Rnor\Phox2b
1 of 13
No
No
Rnor\Rhox10
1 of 13
No
Yes
Rnor\Rhox11
1 of 13
No
No
Rnor\Rhox12
1 of 13
No
Yes
Rnor\Rhox13
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (13)
Xtro\alx1
2 of 12
Yes
No
Xtro\arx
2 of 12
Yes
No
Xtro\alx4
1 of 12
No
No
Xtro\drgx
1 of 12
No
No
Xtro\gsc
1 of 12
No
No
Xtro\hoxb8
1 of 12
No
No
Xtro\lhx8
1 of 12
No
No
Xtro\pax3
1 of 12
No
No
Xtro\pdlim5
1 of 12
No
No
Xtro\pitx1
1 of 12
No
No
Xtro\pitx3
1 of 12
No
No
Xtro\sebox
1 of 12
No
Yes
Xtro\shox2
1 of 12
No
No
Danio rerio (Zebrafish) (33)
Drer\alx1
2 of 15
Yes
No
Drer\alx3
2 of 15
Yes
No
Drer\alx4a
2 of 15
Yes
No
Drer\arxa
2 of 15
Yes
No
Drer\pax6a
2 of 15
Yes
No
Drer\phox2a
2 of 15
Yes
No
Drer\si:dkey-43p13.5
2 of 15
Yes
Yes
Drer\alx4b
1 of 15
No
No
Drer\arxb
1 of 15
No
No
Drer\dharma
1 of 15
No
No
Drer\dmbx1a
1 of 15
No
Yes
Drer\dmbx1b
1 of 15
No
Yes
Drer\drgx
1 of 15
No
No
Drer\gsc
1 of 15
No
No
Drer\hoxb8a
1 of 15
No
No
Drer\ldb3a
1 of 15
No
No
Drer\lhx6
1 of 15
No
No
Drer\lhx8a
1 of 15
No
No
Drer\mxtx2
1 of 15
No
No
Drer\otx5
1 of 15
No
No
Drer\pax6b
1 of 15
No
No
Drer\pdlim3b
1 of 15
No
No
Drer\pdlim7
1 of 15
No
No
Drer\phox2ba
1 of 15
No
No
Drer\phox2bb
1 of 15
No
No
Drer\pitx1
1 of 15
No
No
Drer\pitx3
1 of 15
No
No
Drer\prop1
1 of 15
No
Yes
Drer\rx1
1 of 15
No
No
Drer\rx2
1 of 15
No
No
Drer\sebox
1 of 15
No
Yes
Drer\shox2
1 of 15
No
No
Drer\shox
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\ceh-45
2 of 15
Yes
No
Cele\alp-1
1 of 15
No
No
Cele\alr-1
1 of 15
No
No
Cele\ceh-8
1 of 15
No
No
Cele\ceh-10
1 of 15
No
No
Cele\ceh-17
1 of 15
No
No
Cele\ceh-51
1 of 15
No
No
Cele\ceh-53
1 of 15
No
No
Cele\ceh-54
1 of 15
No
No
Cele\lim-4
1 of 15
No
No
Cele\unc-42
1 of 15
No
No
Cele\vab-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (4)
Atha\AT4G03250
1 of 9
Yes
Yes
Atha\AT4G12750
1 of 9
Yes
No
Atha\HB-1
1 of 9
Yes
Yes
Atha\RLT2
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PHO2
1 of 15
Yes
No
Scer\PXL1
1 of 15
Yes
No
Scer\YHP1
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\phx1
1 of 12
Yes
No
Spom\pxl1
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AQD )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009791
Drosophila simulans
Dsim\GD19218
Drosophila sechellia
Dsec\GM15291
Drosophila erecta
Dere\GG22770
Drosophila yakuba
Dyak\GE25524
Drosophila ananassae
Dana\GF23072
Drosophila pseudoobscura pseudoobscura
Dpse\GA16115
Drosophila persimilis
Dper\GL12006
Drosophila willistoni
Dwil\GK22387
Drosophila virilis
Dvir\GJ22545
Drosophila mojavensis
Dmoj\GI24758
Drosophila grimshawi
Dgri\GH18559
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506UA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004877
Glossina morsitans
Tsetse fly
Gmor\GMOY011655
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13564
Mayetiola destructor
Hessian fly
Mdes\Mdes001764
Anopheles gambiae
Malaria mosquito
Agam\AGAP003574
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010424
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W070K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007802
Danaus plexippus
Monarch butterfly
Dple\DPOGS204459-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006244
Apis florea
Little honeybee
Aflo\2204441764
Apis mellifera
Western honey bee
Amel\repo
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21472
Bombus terrestris
Buff-tailed bumblebee
Bter\15211128
Linepithema humile
Argentine ant
Lhum\LH13006
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002076
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013310
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00526
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05070
Tribolium castaneum
Red flour beetle
Tcas\repo
Pediculus humanus
Human body louse
Phum\PHUM165720
Rhodnius prolixus
Kissing bug
Rpro\RPRC005801
Cimex lectularius
Bed bug
Clec\CLEC009854
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI34506
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ERD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009839
Strigamia maritima
European centipede
Smar\SMAR006320
Strigamia maritima
European centipede
Smar\SMAR006755
Strigamia maritima
European centipede
Smar\SMAR002877
Strigamia maritima
European centipede
Smar\SMAR006775
Ixodes scapularis
Black-legged tick
Isca\ISCW015819
Ixodes scapularis
Black-legged tick
Isca\ISCW021525
Ixodes scapularis
Black-legged tick
Isca\ISCW017712
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61913.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60030.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60468.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g01030
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g06020
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347554
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_29123
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_95717
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_36325
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_8649
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (31)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Gsc
3 of 10
al
2 of 10
CG9876
2 of 10
CG11294
2 of 10
CG32532
2 of 10
ey
2 of 10
Pph13
2 of 10
Awh
1 of 10
CG34367
1 of 10
Drgx
1 of 10
eve
1 of 10
eyg
1 of 10
gsb
1 of 10
gsb-n
1 of 10
hbn
1 of 10
oc
1 of 10
otp
1 of 10
PHDP
1 of 10
Poxm
1 of 10
Poxn
1 of 10
prd
1 of 10
Ptx1
1 of 10
Rx
1 of 10
sv
1 of 10
toe
1 of 10
toy
1 of 10
unc-4
1 of 10
Vsx1
1 of 10
Vsx2
1 of 10
Zasp52
1 of 10
Zasp66
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    RNA-RNA
    Physical Interaction
    Assay
    References
    repo - mir-1
    luminiscence technology
    (Trébuchet et al., 2019)
    repo - mir-124
    luminiscence technology
    (Sun et al., 2012)
    protein-protein
    Physical Interaction
    Assay
    References
    repo - CG18262
    two hybrid array
    (Shokri et al., 2019)
    repo - gcm
    anti bait coimmunoprecipitation, anti tag western blot
    (Flici et al., 2014)
    repo - nej
    anti bait coimmunoprecipitation, western blot
    (Flici et al., 2014)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    repo
    suppressible
    NimC4
    (Shklyar et al., 2014)
    repo
    suppressible
    NimC4|drpr
    (Shklyar et al., 2014)
    repo
    enhanceable
    Tre1
    (Yoshiura et al., 2012)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    gcm
    enhanceable
    repo
    (Popkova et al., 2012)
    gcm
    suppressible
    repo
    (Yuasa et al., 2003)
    GlcAT-P
    enhanceable
    repo
    (Pandey et al., 2011)
    klg
    suppressible
    repo
    (Matsuno et al., 2015)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-62
    Cytogenetic map
    90F9-90F10
    Sequence location
    3R:18,236,192..18,239,602 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    90F9-90F10
    Limits computationally determined from genome sequence between P{EP}cpoEP3679 and P{EP}Dlc90FEP3634
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    90F1-90F2
    (BDGP Project Members, 1994-1999, Montell, 1994.3.18)
    90F1-90F2
    (determined by in situ hybridisation)
    (Spradling et al., 1999, Halter et al., 1995, Xiong et al., 1994)
    90F-90F
    (determined by in situ hybridisation)
    (Campbell et al., 1994)
    Experimentally Determined Recombination Data
    Location

    3-62

    (FlyBase, 2016)

    3-61.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (22)
    cDNA Clones (19)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Sieglitz et al., 2013, von Hilchen et al., 2013, Halter et al., 1995, Campbell et al., 1994)

    polyclonal antibody

    (Jhaveri et al., 2004)
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

    (Harvie et al., 1998)

    Eleven gcm binding sequences are found in the upstream region of the repo gene.

    (Akiyama et al., 1996)

    repo is required for the differentiation and maintenance of glia function in the embryonic nervous system, but not for the determination of the glial cells.

    (Halter et al., 1995)

    repo gene product is not required for the initial determination of glial cells but it is essential for their further differentiation and for the maintenance of glial function.

    (Urban et al., 1995)

    Neurons in the laminar region of the repo optic lobe undergo cell death, indicating that laminar glia express one or more factors essential for neuronal survival. Also repo photoreceptor cells degenerate following cell death of the laminar cells. This retinal degeneration in repo appears to be due to retrograde degeneration.

    (Xiong and Montell, 1995)

    repo encodes a glial specific homeodomain protein. repo is not required for early glial determination, but for aspects of glial differentiation or function that are required for embryonic viability.

    (Campbell et al., 1994)

    Encodes the glial specific epitope for the antibody RK2 of A. Tomlinson.

    (Giangrande, 1994)

    repo is required for proper differentiation of glia in the visual system and in the embryonic nervous system.

    (Xiong et al., 1994)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 41 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    DRscDB
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (16)
    Reported As
    Symbol Synonym
    3702
    (Harvie et al., 1998)
    AbRK2
    CG31240
    (Ni et al., 2010.12.1, Perkins et al., 2009)
    CG8045(CT24072)
    (Coulier et al., 2000)
    CT24072
    (Bayraktaroglu, 2000.4.13)
    REPO
    (Kremer et al., 2017, Jepson et al., 2013, Schauer et al., 2013, Bolkan et al., 2012, Fuentes-Medel et al., 2012, Kallijärvi et al., 2012, Damulewicz and Pyza, 2011, Keller et al., 2011, Chu-Lagraff et al., 2010, Kim et al., 2010, Robinett et al., 2010, Ruiz et al., 2010, Górska-Andrzejak et al., 2009, Kato et al., 2009, Albornoz et al., 2008, Erclik et al., 2008, Kurant et al., 2008, Lee et al., 2008, O'Farrell and Kylsten, 2008, Venkatachalam et al., 2008, Beaucher et al., 2007, Grillenzoni et al., 2007, Wang et al., 2007, Yuasa and Hiromi, 2007, Sprecher et al., 2006, Shandala et al., 2002, Sanchez et al., 2000, Montell, 1994.3.18)
    RK2
    (Clements et al., 2003, Panganiban and Rubenstein, 2002, Kammermeier et al., 2001, Certel et al., 2000, Rao et al., 2000, Bossing et al., 1996, Okabe et al., 1996, Salzberg et al., 1996, Xiong et al., 1994)
    Repo
    (Nagai et al., 2021, Tavares et al., 2021, Dalui et al., 2020, Kessissoglou et al., 2020, Kozlov et al., 2020, Lai et al., 2020, Li and Hidalgo, 2020, Neal et al., 2020, Tindell et al., 2020, Enriquez et al., 2018, Hakes et al., 2018, Altenhein et al., 2016, Kwon et al., 2016, Yasugi and Nishimura, 2016, Romano et al., 2015, Amaral et al., 2014, Fidler et al., 2014, Jeibmann et al., 2014, Lai and Doe, 2014, Stork et al., 2014, Carney et al., 2013, Diaper et al., 2013, Górska-Andrzejak, 2013, Hasegawa et al., 2013, Hopkins, 2013, Laneve et al., 2013, Li et al., 2013, Nahm et al., 2013, Read et al., 2013, Ruan et al., 2013, Sone et al., 2013, Unhavaithaya et al., 2013, Berger et al., 2012, Dahlgaard et al., 2012, Fujioka and Jaynes, 2012, Gurudatta et al., 2012, Kapfhamer et al., 2012, Moraru et al., 2012, Mukherjee et al., 2012, Oyallon et al., 2012, Petersen et al., 2012, Rodrigues et al., 2012, Schmidt et al., 2012, Sun et al., 2012, Tomlinson, 2012, Belacortu et al., 2011, Besson et al., 2011, Biersmith et al., 2011, Ghosh et al., 2011, Gontang et al., 2011, Leiserson et al., 2011, Mast et al., 2011, Miles et al., 2011, Quijano et al., 2011, Sprecher et al., 2011, Viktorin et al., 2011, Xie and Auld, 2011, Yuva-Aydemir et al., 2011, Berger et al., 2010, Boto et al., 2010, Colodner and Feany, 2010, Kannan et al., 2010, Kosmidis et al., 2010, Monastirioti et al., 2010, Mosca and Schwarz, 2010, Pérez et al., 2010, Repnikova et al., 2010, Schreader et al., 2010, Siegrist et al., 2010, Silies and Klämbt, 2010, von Hilchen et al., 2010, Wu et al., 2010, Al-Anzi and Wyman, 2009, Edwards and Meinertzhagen, 2009, Ho et al., 2009, Izergina et al., 2009, Jansen et al., 2009, Leal et al., 2009, Lüer and Technau, 2009, Meyer et al., 2009, Ohayon et al., 2009, Park et al., 2009, Rand et al., 2009, Read et al., 2009, Zhang et al., 2009, Chen and Hing, 2008, Kaplow et al., 2008, Lin et al., 2008, Ly et al., 2008, Miller et al., 2008, Moyer and Jacobs, 2008, Nicholson et al., 2008, Remaud et al., 2008, Soustelle et al., 2008, Stork et al., 2008, von Hilchen et al., 2008, Watson et al., 2008, Wouda et al., 2008, Zhu et al., 2008, Ziegenfuss et al., 2008, Bazigou et al., 2007, Belay et al., 2007, Firth and Baker, 2007, Griffiths et al., 2007, Guenin et al., 2007, Kuraishi et al., 2007, Lee et al., 2007, Mondal et al., 2007, Murakami et al., 2007, Nishimura et al., 2007, Pereanu et al., 2007, Roy et al., 2007, Sharma and Nirenberg, 2007, Silies et al., 2007, Soustelle and Giangrande, 2007, Altenhein et al., 2006, Buescher et al., 2006, Edenfeld et al., 2006, Lai and Lee, 2006, Layden et al., 2006, Long et al., 2006, Parker et al., 2006, Strigini et al., 2006, Urbach et al., 2006, Zimmermann et al., 2006, Babu et al., 2005, Davis et al., 2005, Dornan et al., 2005, Merianda et al., 2005, Sen et al., 2005, Mellerick and Liu, 2004, Page, 2004, Kuniyoshi et al., 2003, Song and Taylor, 2003, Kaminker et al., 2002)
    l(3)03702
    repo
    (Armitage et al., 2020, Mahmud et al., 2020, Ogienko et al., 2020, Portela et al., 2020, Tsao et al., 2020, Brunet Avalos et al., 2019, Matsuno et al., 2019, Mazaud et al., 2019, Shah et al., 2019, Shokri et al., 2019, Ariss et al., 2018, Bischof et al., 2018, Croset et al., 2018, Davie et al., 2018, Górska-Andrzejak et al., 2018, Losada-Perez, 2018, Aw et al., 2017, Charlton-Perkins et al., 2017, Transgenic RNAi Project members, 2017-, Xi et al., 2017, Bürglin and Affolter, 2016, Gupta et al., 2016, Losada-Perez et al., 2016, Huang et al., 2015, Kim et al., 2015, Lee and Sun, 2015, Romano et al., 2015, Schertel et al., 2015, Stratoulias and Heino, 2015, Ugrankar et al., 2015, Ciglar et al., 2014, Flici et al., 2014, Jeibmann et al., 2014, Kerr et al., 2014, Lawton et al., 2014, Ma and Weake, 2014, Shklyar et al., 2014, Tasdemir-Yilmaz and Freeman, 2014, Victorsen and White, 2014.5.13, Xie et al., 2014, Coutinho-Budd and Freeman, 2013, Dai et al., 2013, Fang et al., 2013, Fernández-Hernández et al., 2013, Haussmann et al., 2013, Hopkins, 2013, Naval-Sánchez et al., 2013, Park et al., 2013, Risse et al., 2013, Sieglitz et al., 2013, von Hilchen et al., 2013, Yang et al., 2013, Callan et al., 2012, Carney et al., 2012, Chen et al., 2012, Dani et al., 2012, Gistelinck et al., 2012, Johnson et al., 2012, Kapfhamer et al., 2012, Popkova et al., 2012, Stork et al., 2012, Volders et al., 2012, Weng and Cohen, 2012, Yoshiura et al., 2012, Zhou et al., 2012, Benchabane et al., 2011, Besson et al., 2011, Fulkerson and Estes, 2011, Hartenstein, 2011, Hasegawa et al., 2011, Hidalgo et al., 2011, Jepson et al., 2011, Kuzina et al., 2011, Miller et al., 2011, Pandey et al., 2011, Pérez et al., 2011, Reddy and Irvine, 2011, Sousa-Nunes et al., 2011, Berger et al., 2010, Forero et al., 2010, Hebbar and Fernandes, 2010, Kannan et al., 2010, Kim et al., 2010, Klein et al., 2010, Lorbeck et al., 2010, Malartre et al., 2010, Rendic et al., 2010, Rhiner et al., 2010, Wright et al., 2010, Doherty et al., 2009, Franzdóttir et al., 2009, Kuraishi et al., 2009, Leal et al., 2009, Lüer and Technau, 2009, Mazzi et al., 2009, Miller et al., 2009, Read et al., 2009, Reuveny et al., 2009, Spokony and Restifo, 2009, Tamura et al., 2009, von Trotha et al., 2009, Witte et al., 2009, Zhou et al., 2009, Aigouy et al., 2008, Awasaki et al., 2008, Beckervordersandforth et al., 2008, Bloomington Drosophila Stock Center, 2008.7.16, Christensen et al., 2008.12.28, Christensen et al., 2008.12.28, Estes et al., 2008, Hofmeyer et al., 2008, Johnson et al., 2008, Mandalaywala et al., 2008, Oland et al., 2008, Ostrowski et al., 2008, Pantazis et al., 2008, Soustelle et al., 2008, Wang et al., 2008, Weake et al., 2008, Jones and Lamberton, 2007, Kim et al., 2007, Minidorff et al., 2007, Ratnaparkhi and Zinn, 2007, Rogulja-Ortmann et al., 2007, Sevrioukov et al., 2007, Shcherbata et al., 2007, Thomas and van Meyel, 2007, Awasaki et al., 2006, Choe et al., 2006, Garces and Thor, 2006, Girard et al., 2006, MacDonald et al., 2006, Meier et al., 2006, Sprecher and Hirth, 2006, Sun et al., 2006, Bainton et al., 2005, Chotard et al., 2005, Muhlig-Versen et al., 2005, Stark et al., 2005, Urbach and Technau, 2003, Sepp et al., 2000)
    rk2
    (Campbell, 1995.10.28, Campbell et al., 1994)
    Name Synonyms
    Antibody RK2
    Repo
    (Baccino-Calace et al., 2020, Spindler et al., 2009, Martinek et al., 2008)
    Reversed Polarity
    (Keller et al., 2011, Kim et al., 2010, Ho et al., 2009, Tamura et al., 2009, O'Farrell and Kylsten, 2008)
    Reversed polarity
    (Hakes et al., 2018, Moraru et al., 2012, Oyallon et al., 2012, Park et al., 2009)
    reverse polarity
    (Lee and Sun, 2015, Fulkerson and Estes, 2011, Jones and Lamberton, 2007, Kim et al., 2007, Roy et al., 2007, Yussa and Jones, 2002)
    reversed polarity
    (Losada-Perez, 2018, Kerr et al., 2014, Johnson et al., 2012, Hidalgo et al., 2011, Miles et al., 2011, Reddy and Irvine, 2011, Wright et al., 2010, Mazzi et al., 2009, Spokony and Restifo, 2009, von Trotha et al., 2009, Witte et al., 2009, Estes et al., 2008, Johnson et al., 2008, Mandalaywala et al., 2008, Muhlig-Versen et al., 2005, Song and Taylor, 2003)
    Secondary FlyBase IDs
    • FBgn0010814
    • FBgn0013744
    • FBgn0051240
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (593)