Gene model reviewed during 5.47
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
Gene model reviewed during 5.51
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\B-H1 using the Feature Mapper tool.
Comment: reported as dorsal/lateral sensory complexes
When it is first expressed in the prospective tarsus, B-H1 abuts the dac expression domain distally. Just before the central fold forms, a gap region devoid of either apears. By the prepupal stage, B-H1 is expressed strongly in presumptive tarsal segment 5 and moderately in presumptive tarsal segment 4.
The B-H1 and B-H2 proteins are detected in the R1/R6 prephotoreceptor pair from late third larval instar to early pupal stages. Anterior and posterior primary pigment cells of the developing ommatidium are labeled starting at 20 hours of pupariation and continuing until at least 80 hours of pupariation.
GBrowse - Visual display of RNA-Seq signalsView Dmel\B-H1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
B-H1 and B-H2 regulate the formation of microchaetae via activation of ac and sc. B-H1 and B-H2 is limited dorsally and posteriorly by dpp and ventrally by wg which is in turn regulated by dpp. In direction of increasing cytology: f? Fim? B-H2+ B-H1+ anon-X2?
B-H1 and B-H2 may belong to a different class of prepattern genes expressed latitudinally, giving a different coordinate to the prepattern in the developing notum. They are required for the formation of notal microchaetae and presutural macrochaetae.
One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus Engrailed binding site.
B-H1 and B-H2 are expressed only in embryogenesis and metamorphosis. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 prephotoreceptor cells and anterior and posterior primary pigment cells for normal eye development. B-H1 gene function is required for the formation of primary, secondary and tertiary pigment cells.
B-H1 and B-H2 are paired homeotic genes required for the fate determination of es organs. Immunostaining demonstrated that B-H1 and B-H2 proteins are coexpressed in embryonic CNS and PNS cells. Deletion of the entire bar region causes morphological changes in the complex es organs and partial conversion of the simple es organs from campaniform-like sensilla to trichoid sensilla.
Reported by Kojima et al. as being the gene responsible for the phenotype of B mutants; this was revised by Norris et al. who state that the BarA transcription unit is responsible.