Bar, BH1
transcription factor - homeodomain - neural selector genes involved in the development of the external sensilli - part of a transcription factor network that patterns the developing olfactory tissue - transcriptional repression of atonal by Bar prevents ectopic retinal neurogenesis
Please see the JBrowse view of Dmel\B-H1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
Gene model reviewed during 5.51
3.1, 0.8 (northern blot)
None of the polypeptides share 100% sequence identity.
543 (aa)
The B-H1 protein may represent a unique subclass of homeodomain based on the presence of a tyrosine residue in the homeodomain where a phenylalanine is found in all other homeodomains.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\B-H1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as gnathal lobes anlage
Comment: reported as dorsal/lateral sensory complexes
B-H1 is expressed in H-cells at embryonic stage 11 and the expression remains on through the end of embyrogenesis.
When it is first expressed in the prospective tarsus, B-H1 abuts the dac expression domain distally. Just before the central fold forms, a gap region devoid of either apears. By the prepupal stage, B-H1 is expressed strongly in presumptive tarsal segment 5 and moderately in presumptive tarsal segment 4.
The B-H1 and B-H2 proteins are detected in the R1/R6 prephotoreceptor pair from late third larval instar to early pupal stages. Anterior and posterior primary pigment cells of the developing ommatidium are labeled starting at 20 hours of pupariation and continuing until at least 80 hours of pupariation.
JBrowse - Visual display of RNA-Seq signals
View Dmel\B-H1 in JBrowse
1-57
1-57.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus Engrailed binding site.
B-H1 and B-H2 are expressed only in embryogenesis and metamorphosis. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 prephotoreceptor cells and anterior and posterior primary pigment cells for normal eye development. B-H1 gene function is required for the formation of primary, secondary and tertiary pigment cells.
B-H1 and B-H2 are paired homeotic genes required for the fate determination of es organs. Immunostaining demonstrated that B-H1 and B-H2 proteins are coexpressed in embryonic CNS and PNS cells. Deletion of the entire bar region causes morphological changes in the complex es organs and partial conversion of the simple es organs from campaniform-like sensilla to trichoid sensilla.
Polypeptides from B-H1 of D.melanogaster and Om(1D) of D.ananassae have homeodomains identical in sequence except for one amino acid replacement: the conserved Phe in helix 3 is replaced by Tyr.
Reported by Kojima et al. as being the gene responsible for the phenotype of B mutants; this was revised by Norris et al. who state that the BarA transcription unit is responsible.
Dp(1;3)DC329 (which encompasses B-H1) causes a Bar eye phenotype in males and females.
Dp(1;3)DC328 (which encompasses B-H2 but not B-H1) does not exhibit a Bar phenotype.
