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Important message

Updated sequence information for this Drosophila species is no longer provided by FlyBase. Gene model annotations for this species are now updated and maintained at NCBI, using the gnomon automated annotation pipeline. See the NCBI page ‘Eukaryotic genomes annotated at NCBI’.

The FlyBase BLAST tool will continue to support queries against the reference genome of this species, but not queries against annotated transcripts or proteins. For the current release, there is no JBrowse or GBrowse view of the gene model annotations for this species.

The FlyBase archived release FB2017_05 includes the last NCBI annotation update for this species that was imported into FlyBase. That sequence data can be accessed from archived gene reports, via the archived GBrowse tool, and via archived bulk-data downloads.

General Information
D. yakuba
Alcohol dehydrogenase
Annotation Symbol
Feature Type
FlyBase ID
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As


GO Summary Ribbons
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
inferred from electronic annotation with InterPro:IPR002424, InterPro:IPR002425
(assigned by InterPro )
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
inferred from electronic annotation with InterPro:IPR002425
(assigned by InterPro )
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the short-chain dehydrogenases/reductases (SDR) family. (P26719)
Gene Model and Products
Number of Transcripts
Number of Unique Polypeptides
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
External Data
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dyak\Adh using the Feature Mapper tool.

    External Data
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
    Subcellular Localization
    CV Term
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dyak\Adh in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 0 )
    For All Classical and Insertion Alleles Show
    Other relevant insertions
    Transgenic Constructs ( 0 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Dyak\Adh
    Transgenic constructs containing regulatory region of Dyak\Adh
    Aberrations (Deficiencies and Duplications) ( 0 )
    Inferred from experimentation ( 0 )
    Inferred from location ( 0 )
      For more details about a specific phenotype click on the relevant allele symbol.
      Phenotype manifest in
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Ortholog(s) in Drosophila melanogaster (via OrthoDB v9.1) ( EOG09190EAD )
      Common Name
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila melanogaster
      fruit fly
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Modifiers Based on Experimental Evidence ( 0 )
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        OMIM Phenotype
        DO term
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        External Data
        Subunit Structure (UniProtKB)
        (UniProt, P26719 )
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Experimentally Determined Recombination Data
        Left of (cM)
        Right of (cM)
        Stocks and Reagents
        Stocks (0)
        Genomic Clones (0)
          cDNA Clones (0)

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Antibody Information
                    Laboratory Generated Antibodies
                    Commercially Available Antibodies
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments
                    Other Comments

                    Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

                    The phylogenetic relationships and divergence times of 39 drosophilid species have been studied by using the coding region of the Adh gene.

                    Isolated from a D.yakuba genomic library using a D.melanogaster Adh fragment as a probe.

                    Dyak\Adh has been cloned and sequenced, and compared with the Adh sequences of the other members of the melanogaster species subgroup.

                    Adh activity in 71 Drosophila species is assayed to determine if the protein plays a key role in the adaptation of species to substrates undergoing alcoholic fermentation.

                    A comparison of the number of amino acid replacements to synonymous substitutions between Adh, Dsim\Adh and Dyak\Adh locus was performed to test the neutral theory of protein evolution hypothesis. An excess of replacement substitutions was found suggesting adaptive fixation of selectively advantageous mutations.

                    McDonald and Kreitman (Nature 351: 652--654) claim adaptive mutations are responsible for the evolution of the Adh locus. In a general test of the hypothesis designed to evaluate the average nucleotide substitutions for all pairwise combinations of sequences within and between species, results do not support the conclusion that there is a significant excess of nonsynonymous substitutions resulting from adaptive fixation of mutants.

                    Origin and Etymology
                    External Crossreferences and Linkouts ( 30 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    Other crossreferences
                    • Dyak_gnomon_100_gene.10420685
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    Synonyms and Secondary IDs (6)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project Type
                    References (55)