neuropeptide that regulates ecdysone production that in turn developmental timing cue involved in promoting larval development and eclosion - signals through Torso/RAS/Erk pathway - modulates larval light avoidance independently of ecdysone
Please see the JBrowse view of Dmel\Ptth for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.57
Gene model reviewed during 5.42
Gene model reviewed during 5.46
Gene model reviewed during 5.55
Gene model reviewed during 6.02
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptth using the Feature Mapper tool.
Comment: 44h-120h AEL
A marked increase in Ptth expression is detected before the start of wandering third instar larval stage. It co-localizes with Scer\GAL4NP0423 and Scer\GAL4NP0394 in the same pair of prothoracic gland innervating neurons in the third instar larval brain.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ptth in GBrowse 22-1.5
2-0.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Ptth CG13687
Ptth is isolated and characterised from whole larval extracts. Ptth encodes a monomeric 66kD glycoprotein containing N-linked carbohydrate chains and intradisulfide bonds. Deglycosylated Ptth exists as a single 45kD peptide that is cleaved at a minimum of 3 different sites. The deglycosylated form shows heterogeneity, presumably as a result of varying degrees of deglycosylation at the N-terminus. Purified 45kD peptide can stimulate ecdysone synthesis and secretion by ring glands in vitro.
Ptth peptide has been purified and characterised.