Gene: Dmel\beat-Ia
beat, beaten path, l(2)35Eb, triclops, beat Ia
Please see the JBrowse view of Dmel\beat-Ia for information on other features
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Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
3.0 (northern blot)
None of the polypeptides share 100% sequence identity.
427 (aa); 43 (kD observed); 48, 44 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\beat-Ia using the Feature Mapper tool.
beat expression is first observed in a subset of CNS neurons. It is thought to be expressed by all motor neurons and exclusively by motor neurons. Expression peaks at stage 13, drops to a lower level after stage 14 and continues through stage 17. beat is expressed at higher levels in some motor neurons than others. For example, expression is stronger in RP1 and RP3 than in aCC.
beat protein localizes to motor neurons in embryos. It is found around axons and growth cones, especially in choice point regions during the period of branch formation. It may be secreted at choice point regions where motor neurons diverge.
GBrowse - Visual display of RNA-Seq signals
View Dmel\beat-Ia in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: beat CG4846
Source for merge of: beat tric
Identification: Ethyl methanesulfonate screen for mutations that disrupt the larval visual system: enumeration or adhesion of the larval photoreceptor cells.
beat-Ia is required for the selective defasciculation of motor neurons at choice points along the major motor nerves. Mutant phenotype can be suppressed by mutations in Fas2 and Con suggesting beat-Ia provides an antiadhesive function. Rescue and ectopic expression experiments support the model that beat-Ia protein is secreted by motor axons where it functions to regulate their selective defasciculation at specific choice points.
Identification: Screen for mutations affecting neuromuscular connectivity, using an antibody to Fas2.
