FlyBase Gene Report: Dmel\beat-Ia

General Information

Symbol

Dmel\beat-Ia

Species

D. melanogaster

Name

beaten path Ia

Annotation Symbol

CG4846

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013433

Gene Model Status

Stock Availability

12 publicly available

Gene Snapshot

beaten path Ia (beat-Ia) encodes a transmembrane protein and the founding member of the beat family of proteins, which is part of the immunoglobulin superfamily. It is required for the selective defasciculation of motor axons. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

beat, beaten path, tric, beat Ia, BG:DS00913.3

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:16,049,965..16,081,684 [+]

Recombination map

2-51

RefSeq locus

NT_033779 REGION:16049965..16081684

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2013-02-14 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from genetic interaction with FLYBASE:SoxN; FB:FBgn0029123

(Girard et al., 2006)

involved_in Bolwig's organ morphogenesis

inferred from mutant phenotype

(Holmes and Heilig, 1999)

involved_in defasciculation of motor neuron axon

inferred from mutant phenotype

(Fambrough and Goodman, 1996)

inferred from genetic interaction with FLYBASE:beat-Ic; FB:FBgn0028644

(Pipes et al., 2001)

involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

inferred from genetic interaction with FLYBASE:beat-Ic; FB:FBgn0028644

(Pipes et al., 2001)

involved_in motor neuron axon guidance

inferred from mutant phenotype

(Zarin et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in axon choice point recognition

traceable author statement

(Chiba, 1999)

involved_in motor neuron axon guidance

inferred from biological aspect of ancestor with PANTHER:PTN000479519

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from sequence or structural similarity

(Fambrough and Goodman, 1996)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

BEAT FAMILY -: BEAT is a multigene family encoding immunoglobulin superfamily proteins. They can interact with SIDE family members. Interactions between beat-Ia and side have been shown to play a role in the control of motor axon guidance. (Adapted from FBrf0141485, FBrf0207934 and FBrf0222007).

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\beat-Ia for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0080806

2840

427

FBtr0343728

2870

437

Additional Transcript Data and Comments

Reported size (kB)

3.0 (northern blot)

(Fambrough and Goodman, 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0080364

47.9

427

9.88

FBpp0310300

49.2

437

9.78

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

427 (aa); 43 (kD observed); 48, 44 (kD predicted)

(Fambrough and Goodman, 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\beat-Ia using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

beat-Ia_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

presumptive embryonic/larval central nervous system | presumptive

(Fambrough and Goodman, 1996)

(Fambrough and Goodman, 1996)

embryonic stage

RP1 motor neuron

(Fambrough and Goodman, 1996)

(Fambrough and Goodman, 1996)

RP3 motor neuron

(Fambrough and Goodman, 1996)

embryonic stage 15

(Zarin et al., 2014)

RP2 motor neuron

(Zarin et al., 2014)

Additional Descriptive Data

beat expression is first observed in a subset of CNS neurons. It is thought to be expressed by all motor neurons and exclusively by motor neurons. Expression peaks at stage 13, drops to a lower level after stage 14 and continues through stage 17. beat is expressed at higher levels in some motor neurons than others. For example, expression is stronger in RP1 and RP3 than in aCC.

(Fambrough and Goodman, 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Fambrough and Goodman, 1996)

Additional Descriptive Data

beat protein localizes to motor neurons in embryos. It is found around axons and growth cones, especially in choice point regions during the period of branch formation. It may be secreted at choice point regions where motor neurons diverge.

(Fambrough and Goodman, 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\beat-Ia in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\beat-Ia

View exonic expression by tissue for Dmel\beat-Ia

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013433

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0013433

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4846-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4846

Flygut - An atlas of the Drosophila adult midgut

FBgn0013433

Images

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of beat-Ia

Transgenic constructs containing regulatory region of beat-Ia

Deletions and Duplications ( 11 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)BSC278)

beat-Ia^C163

lethal | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

beat-Ia^f06843

Other Phenotypes

Allele

neuroanatomy defective, with Df(2R)eve, Scer\GAL4^eve.RN2

beat-Ia^UAS.cFa

Phenotype manifest in

Allele

A1-7 dorsal acute muscle 1, with Scer\GAL4^Mef2.PR

beat-Ia^UAS.cFa

A1-7 dorsal acute muscle 1 (with beat-Ia³)

beat-Ia^C163

A1-7 dorsal acute muscle 1 (with beat-Ia^C163)

beat-Ia³

A1-7 dorsal acute muscle 2, with Scer\GAL4^Mef2.PR

beat-Ia^UAS.cFa

A1-7 dorsal acute muscle 2 (with beat-Ia³)

beat-Ia^C163

A1-7 dorsal acute muscle 2 (with beat-Ia^C163)

beat-Ia³

A1-7 dorsal oblique muscle 1, with Scer\GAL4^Mef2.PR

beat-Ia^UAS.cFa

A1-7 dorsal oblique muscle 1 (with beat-Ia³)

beat-Ia^C163

A1-7 dorsal oblique muscle 1 (with beat-Ia^C163)

beat-Ia³

A1-7 dorsal oblique muscle 2, with Scer\GAL4^Mef2.PR

beat-Ia^UAS.cFa

A1-7 dorsal oblique muscle 2 (with beat-Ia³)

beat-Ia^C163

A1-7 dorsal oblique muscle 2 (with beat-Ia^C163)

beat-Ia³

A1-7 ventral longitudinal muscle 1 (with beat-Ia³)

beat-Ia^C163

A1-7 ventral longitudinal muscle 1 (with beat-Ia^C163)

beat-Ia³

A1-7 ventral longitudinal muscle 2 (with beat-Ia³)

beat-Ia^C163

A1-7 ventral longitudinal muscle 2 (with beat-Ia^C163)

beat-Ia³

A1-7 ventral longitudinal muscle 3 (with beat-Ia³)

beat-Ia^C163

A1-7 ventral longitudinal muscle 3 (with beat-Ia^C163)

beat-Ia³

A1-7 ventral longitudinal muscle 4 (with beat-Ia³)

beat-Ia^C163

A1-7 ventral longitudinal muscle 4 (with beat-Ia^C163)

beat-Ia³

abdominal intersegmental nerve

abdominal segmental nerve

abdominal segmental nerve, with Scer\GAL4^how-24B

beat-Ia^UAS.cFa

intersegmental nerve

intersegmental nerve, with Df(2R)eve, Scer\GAL4^eve.RN2

beat-Ia^UAS.cFa

intersegmental nerve | distal, with Scer\GAL4^how-24B

beat-Ia^UAS.cFa

segmental nerve

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

1 of 15

Yes

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (0)

No records found.

Rattus norvegicus (Norway rat) (0)

No records found.

Xenopus tropicalis (Western clawed frog) (0)

No records found.

Danio rerio (Zebrafish) (2)

1 of 15

Yes

Yes

1 of 15

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AKW )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00000952

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915094T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Musca domestica

House fly

Musca domestica

House fly

Musca domestica

House fly

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY011596

Glossina morsitans

Tsetse fly

Gmor\GMOY002928

Glossina morsitans

Tsetse fly

Gmor\GMOY005069

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01349

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01350

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01348

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_01347

Mayetiola destructor

Hessian fly

Mdes\Mdes009461

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL010152

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005649

Anopheles darlingi

American malaria mosquito

Adar\ADAC000541

Anopheles gambiae

Malaria mosquito

Agam\AGAP009270

Anopheles gambiae

Malaria mosquito

Agam\AGAP009267

Anopheles gambiae

Malaria mosquito

Agam\AGAP009829

Anopheles gambiae

Malaria mosquito

Agam\AGAP009947

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005461

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ019515

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000380

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07DO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006342

Bombyx mori

Silkmoth

Bmor\BGIBMGA005271

Bombyx mori

Silkmoth

Bmor\BGIBMGA006339

Danaus plexippus

Monarch butterfly

Dple\DPOGS200207-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS205852-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS200205-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS213680-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL010723

Heliconius melpomene

Postman butterfly

Hmel\HMEL007737

Heliconius melpomene

Postman butterfly

Hmel\HMEL009101

Heliconius melpomene

Postman butterfly

Hmel\HMEL017547

Apis florea

Little honeybee

Aflo\3852500116

Apis florea

Little honeybee

Aflo\2147485409

Apis florea

Little honeybee

Aflo\3925900500

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00099d

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001aa7

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011855

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG029533

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011831

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM532860

Pediculus humanus

Human body louse

Phum\PHUM227380

Pediculus humanus

Human body louse

Phum\PHUM602480

Rhodnius prolixus

Kissing bug

Rpro\RPRC010511

Rhodnius prolixus

Kissing bug

Rpro\RPRC003569

Rhodnius prolixus

Kissing bug

Rpro\RPRC013643

Rhodnius prolixus

Kissing bug

Rpro\RPRC007203

Cimex lectularius

Bed bug

Clec\CLEC004280

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006040

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI36427

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI069550

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001748

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12308

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10015

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10572

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0A0L )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR010810

Strigamia maritima

European centipede

Smar\SMAR011897

Strigamia maritima

European centipede

Smar\SMAR009123

Ixodes scapularis

Black-legged tick

Isca\ISCW006655

Ixodes scapularis

Black-legged tick

Isca\ISCW017403

Ixodes scapularis

Black-legged tick

Isca\ISCW002636

Ixodes scapularis

Black-legged tick

Isca\ISCW024732

Ixodes scapularis

Black-legged tick

Isca\ISCW019662

Ixodes scapularis

Black-legged tick

Isca\ISCW008243

Ixodes scapularis

Black-legged tick

Isca\ISCW009755

Ixodes scapularis

Black-legged tick

Isca\ISCW010440

Ixodes scapularis

Black-legged tick

Isca\ISCW023055

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68176.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73074.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79693.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56728.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80441.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63029.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM78337.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75578.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80846.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76526.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69186.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72514.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM72481.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56670.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73856.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM56642.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80711.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM70879.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM57196.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g14240

Tetranychus urticae

Two-spotted spider mite

Turt\tetur25g00010

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g15030

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g14020

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g04520

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g14280

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g02740

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_5758

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_116627

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_253895

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_64077

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_61512

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0FQT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_418

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_007712gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ig/Itamc1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019364gn

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_3053

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_754

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (15)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

enzyme linked immunosorbent assay, bead aggregation assay, fluorescence microscopy, inferred by author, surface plasmon resonance, anti tag coimmunoprecipitation, western blot

(Ozkan et al., 2013, Ozkan et al., 2013, Siebert et al., 2009)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Pipes et al., 2001)

Nrg|beat-Ia|unc-5

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

suppressible

(Holmes and Heilig, 1999)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Zarin et al., 2014)

suppressible

(Landgraf et al., 1999)

suppressible

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

suppressible

(Holmes and Heilig, 1999)

suppressible

(Miller et al., 2011)

suppressible

(Siebert et al., 2009)

enhanceable

Fas2|Nrg|beat-Ia

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

enhanceable

(Zarin et al., 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60959

DroID - A comprehensive database of gene and protein interactions.

FBgn0013433

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34947

MIST (genetic) - An integrated Molecular Interaction Database

beat-Ia

MIST (protein-protein) - An integrated Molecular Interaction Database

beat-Ia

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-51

Cytogenetic map

Sequence location

2L:16,049,965..16,081,684 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

35E2-35E2

Limits computationally determined from genome sequence between P{lacW}CycE^k05007&P{lacW}CycE^k02602 and P{EP}crp^EP721&P{lacW}crp^k07829

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35E-35E

(Fambrough, 1996.8.15)

35E1-35E2

(determined by in situ hybridisation)

(Fambrough and Goodman, 1996)

Experimentally Determined Recombination Data

Location

2-51

(FlyBase, 2016)

2-49.1

(Comeron et al., 2012)

2-

(van Vactor et al., 1993)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

83066

y¹ v¹; M{WKO.3-B1}ZH-86Fb

19018

w¹¹¹⁸; PBac{WH}beat-Ia^f06843

29081

w¹¹¹⁸; Mi{ET1}beat-Ia^MB10019

54820

y¹ v¹; P{TRiP.HMJ21539}attP40

56131

y¹ w^*; Mi{MIC}beat-Ia^MI11181

4748

w^*; beat-Ia³ Fas3^E25/CyO, P{act-lacZ.B}CB1

64938

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05811}attP40

4742

y¹ w^*; In(2L)C163.41, beat-Ia^C163 l(2)CA7^C163/CyO

107854

In(2L)C163.41, beat-Ia^C163 l(2)CA7^C163/CyO

v4543

w¹¹¹⁸; P{GD1386}v4543

v4544

w¹¹¹⁸; P{GD1386}v4544

v46815

w¹¹¹⁸; P{GD17099}v46815

Genomic Clones (35)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (39)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE09303

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0013433

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013433

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34947

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Fambrough and Goodman, 1996)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: beat CG4846

(Kodira, 1999.11)

Source for database merge of

Source for merge of: beat tric

(Heilig, 1998.10.3)

Additional comments

Other Comments

The detachment of the Bolwig's organ precursors from the optic lobe during embryogenesis may involve interaction between beat-Ia and Fas2 proteins.

(Holmes and Heilig, 1999)

Identification: Ethyl methanesulfonate screen for mutations that disrupt the larval visual system: enumeration or adhesion of the larval photoreceptor cells.

(Holmes et al., 1998)

beat-Ia is required for the selective defasciculation of motor neurons at choice points along the major motor nerves. Mutant phenotype can be suppressed by mutations in Fas2 and Con suggesting beat-Ia provides an antiadhesive function. Rescue and ectopic expression experiments support the model that beat-Ia protein is secreted by motor axons where it functions to regulate their selective defasciculation at specific choice points.

(Fambrough and Goodman, 1996)

Identification: Screen for mutations affecting neuromuscular connectivity, using an antibody to Fas2.

(van Vactor et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34947

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013433

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0013433

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

beat-Ia_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4846

Flygut - An atlas of the Drosophila adult midgut

FBgn0013433

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34947

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4846

modMine - A data warehouse for the modENCODE project

FBgn0013433

Linkouts

BioGRID - A database of protein and genetic interactions.

60959

DroID - A comprehensive database of gene and protein interactions.

FBgn0013433

DRSC - Results frm RNAi screens

FBgn0013433

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0013433

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4846-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013433

FlyMine - An integrated database for Drosophila genomics

FBgn0013433

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

34947

MIST (genetic) - An integrated Molecular Interaction Database

beat-Ia

MIST (protein-protein) - An integrated Molecular Interaction Database

beat-Ia

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

BG:DS00913.3

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

Beat Ia

(Hobert et al., 2004)

Beat-Ia

(Li et al., 2017, Ozkan et al., 2013, Nose, 2012)

CCT

(Moshkin et al., 2009)

CG4846

(Ni et al., 2010.12.1, Perkins et al., 2009)

CT15567

(Hynes and Zhao, 2000)

Cct

(Monzo et al., 2010)

TRiC

(Moshkin et al., 2009)

beat Ia

(Zarin et al., 2014, Pipes et al., 2001)

beat-1a

(Lavergne et al., 2020)

beat-Ia

(Aberle, 2019, Hall et al., 2019, Meltzer et al., 2019, Rajpurohit et al., 2018, Wolfram et al., 2014, Ozkan et al., 2013, Ozkan et al., 2013)

beat1a

(Miller et al., 2011, Girard et al., 2006)

l(2)35Ea

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

l(2)35Eb

(Roote and Ashburner, 1998.2.17, Alexandrova et al., 1996)

l(2)br47

(The Moscow Regional Drosophila melanogaster Stock Center, Dubna)

l(2)br48

(Roote and Ashburner, 1998.2.17)

tric

(Holmes et al., 1998)

Name Synonyms

Beaten Path Ia

(Ozkan et al., 2013)

Beaten path Ia

(Siebert et al., 2009)

Chaperonin containing TCP-1

(Monzo et al., 2010)

beaten path

(Zarin et al., 2014, van Vactor et al., 1993)

beaten path Ia

triclops

(Holmes et al., 1998)

Secondary FlyBase IDs

FBgn0024596

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (86)