FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\beat-Ia
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General Information
Symbol
Dmel\beat-Ia
Species
D. melanogaster
Name
beaten path Ia
Annotation Symbol
CG4846
Feature Type
protein_coding_gene
FlyBase ID
FBgn0013433
Gene Model Status
Current
Stock Availability
32 publicly available
Gene Summary
beaten path Ia (beat-Ia) encodes a transmembrane protein and the founding member of the beat family of proteins, which is part of the immunoglobulin superfamily. It is required for the selective defasciculation of motor axons. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

beat, beaten path, tric, l(2)35Eb, BG:DS00913.3

Key Links
Genomic Location
Cytogenetic map
35E2-35E2
Sequence location
Recombination map
2-51
RefSeq locus
NT_033779 REGION:16049965..16081684
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from genetic interaction with FLYBASE:SoxN; FB:FBgn0029123
(Girard et al., 2006)
involved_in Bolwig's organ morphogenesis
inferred from mutant phenotype
(Holmes and Heilig, 1999)
involved_in defasciculation of motor neuron axon
inferred from mutant phenotype
(Fambrough and Goodman, 1996)
inferred from genetic interaction with FLYBASE:beat-Ic; FB:FBgn0028644
(Pipes et al., 2001)
involved_in heterophilic cell-cell adhesion
inferred from genetic interaction with FLYBASE:beat-Ic; FB:FBgn0028644
(Pipes et al., 2001)
involved_in motor neuron axon guidance
inferred from mutant phenotype
(Zarin et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in axon choice point recognition
traceable author statement
(Chiba, 1999)
involved_in motor neuron axon guidance
inferred from biological aspect of ancestor with PANTHER:PTN000479537
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from sequence or structural similarity
(Fambrough and Goodman, 1996)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
beaten path Ia (beat-Ia) encodes a transmembrane protein and the founding member of the beat family of proteins, which is part of the immunoglobulin superfamily. It is required for the selective defasciculation of motor axons. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
BEAT FAMILY -
BEAT is a multigene family encoding immunoglobulin superfamily proteins. They can interact with SIDE family members. Interactions between beat-Ia and side have been shown to play a role in the control of motor axon guidance. (Adapted from FBrf0141485, FBrf0207934 and FBrf0222007).
Summary (Interactive Fly)

transmembrane Ig superfamily protein - required for subsets of motor axons to correctly defasciculate from other motor axons at specific choice points

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\beat-Ia for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry X2J8L2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
beat-Ia-RA
FBtr0080806
NM_058160
2840
427
beat-Ia-RB
FBtr0343728
NM_001299046
2870
437
Additional Transcript Data and Comments
Reported size (kB)

3.0 (northern blot)

(Fambrough and Goodman, 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
beat-Ia-PA
FBpp0080364
47.9
427
9.88
Q94534
NP_477508
AAF53500
beat-Ia-PB
FBpp0310300
49.2
437
9.78
X2J8L2
NP_001285975
AHN54489
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

427 (aa); 43 (kD observed); 48, 44 (kD predicted)

(Fambrough and Goodman, 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\beat-Ia using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval VO2 motor neuron
(Fambrough and Goodman, 1996)
larval DA1 motor neuron
(Fambrough and Goodman, 1996)
larval VL3/4 motor neuron
(Fambrough and Goodman, 1996)
embryonic stage 12 -- 17
presumptive embryonic/larval central nervous system | presumptive
(Fambrough and Goodman, 1996)
motor neuron
(Fambrough and Goodman, 1996)
embryonic stage 15
larval DA1 motor neuron
(Zarin et al., 2014)
larval RP2 motor neuron
(Zarin et al., 2014)
Additional Descriptive Data

beat expression is first observed in a subset of CNS neurons. It is thought to be expressed by all motor neurons and exclusively by motor neurons. Expression peaks at stage 13, drops to a lower level after stage 14 and continues through stage 17. beat is expressed at higher levels in some motor neurons than others. For example, expression is stronger in RP1 and RP3 than in aCC.

(Fambrough and Goodman, 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Fambrough and Goodman, 1996)
Additional Descriptive Data

beat protein localizes to motor neurons in embryos. It is found around axons and growth cones, especially in choice point regions during the period of branch formation. It may be secreted at choice point regions where motor neurons diverge.

(Fambrough and Goodman, 1996)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\beat-Ia in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of beat-Ia
Transgenic constructs containing regulatory region of beat-Ia
Aberrations (Deficiencies and Duplications) ( 11 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2L)BSC278)
lethal | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal neuroanatomy, with Df(2R)eve, Scer\GAL4eve.RN2
Phenotype manifest in
Allele
Bolwig organ
larval abdominal intersegmental nerve
larval abdominal segmental nerve
larval abdominal segmental nerve, with Scer\GAL4how-24B
larval intersegmental nerve
larval intersegmental nerve, with Df(2R)eve, Scer\GAL4eve.RN2
larval intersegmental nerve | distal, with Scer\GAL4how-24B
larval segmental nerve
motor neuron
muscle cell of A1-7 dorsal acute muscle 1, with Scer\GAL4Mef2.PR
muscle cell of A1-7 dorsal acute muscle 1 (with beat-Ia3)
muscle cell of A1-7 dorsal acute muscle 1 (with beat-IaC163)
muscle cell of A1-7 dorsal acute muscle 2, with Scer\GAL4Mef2.PR
muscle cell of A1-7 dorsal acute muscle 2 (with beat-Ia3)
muscle cell of A1-7 dorsal acute muscle 2 (with beat-IaC163)
muscle cell of A1-7 dorsal oblique muscle 1, with Scer\GAL4Mef2.PR
muscle cell of A1-7 dorsal oblique muscle 1 (with beat-Ia3)
muscle cell of A1-7 dorsal oblique muscle 1 (with beat-IaC163)
muscle cell of A1-7 dorsal oblique muscle 2, with Scer\GAL4Mef2.PR
muscle cell of A1-7 dorsal oblique muscle 2 (with beat-Ia3)
muscle cell of A1-7 dorsal oblique muscle 2 (with beat-IaC163)
muscle cell of A1-7 ventral longitudinal muscle 1 (with beat-Ia3)
muscle cell of A1-7 ventral longitudinal muscle 1 (with beat-IaC163)
muscle cell of A1-7 ventral longitudinal muscle 2 (with beat-Ia3)
muscle cell of A1-7 ventral longitudinal muscle 2 (with beat-IaC163)
muscle cell of A1-7 ventral longitudinal muscle 3 (with beat-Ia3)
muscle cell of A1-7 ventral longitudinal muscle 3 (with beat-IaC163)
muscle cell of A1-7 ventral longitudinal muscle 4 (with beat-Ia3)
muscle cell of A1-7 ventral longitudinal muscle 4 (with beat-IaC163)
photoreceptor
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (16)
Hsap\AGER
1 of 14
Yes
Yes
Hsap\BCAM
1 of 14
Yes
Yes
Hsap\CADM1
1 of 14
Yes
No
Hsap\CADM2
1 of 14
Yes
No
Hsap\CADM3
1 of 14
Yes
No
Hsap\CEACAM6
1 of 14
Yes
No
Hsap\DSCAML1
1 of 14
Yes
No
2  
Hsap\ESAM
1 of 14
Yes
Yes
Hsap\F11R
1 of 14
Yes
Yes
Hsap\HMCN1
1 of 14
Yes
No
Hsap\KIRREL3
1 of 14
Yes
No
Hsap\NECTIN3
1 of 14
Yes
No
Hsap\NECTIN4
1 of 14
Yes
No
Hsap\NPHS1
1 of 14
Yes
No
10  
Hsap\SIRPG
1 of 14
Yes
Yes
Hsap\TTN
1 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Ager
1 of 14
Yes
Yes
Rnor\Bcam
1 of 14
Yes
Yes
Rnor\Cadm1
1 of 14
Yes
No
Rnor\Cadm2
1 of 14
Yes
No
Rnor\Cadm3
1 of 14
Yes
No
Rnor\Cd22
1 of 14
Yes
No
Rnor\Ceacam6
1 of 14
Yes
Yes
Rnor\Chl1
1 of 14
Yes
No
Rnor\Dscaml1
1 of 14
Yes
No
Rnor\Esam
1 of 14
Yes
Yes
Rnor\Hmcn1
1 of 14
Yes
No
Rnor\Kirrel3
1 of 14
Yes
No
Rnor\Nectin3
1 of 14
Yes
No
Rnor\Nectin4
1 of 14
Yes
No
Rnor\Nphs1
1 of 14
Yes
No
Mus musculus (laboratory mouse) (13)
Mmus\Bcam
1 of 14
Yes
Yes
Mmus\Cadm1
1 of 14
Yes
No
Mmus\Cadm2
1 of 14
Yes
No
Mmus\Cadm3
1 of 14
Yes
No
Mmus\Chl1
1 of 14
Yes
No
Mmus\Dscaml1
1 of 14
Yes
No
Mmus\Esam
1 of 14
Yes
Yes
Mmus\Hmcn1
1 of 14
Yes
No
Mmus\Hmcn2
1 of 14
Yes
No
Mmus\Kirrel3
1 of 14
Yes
No
1  
Mmus\Nectin3
1 of 14
Yes
No
Mmus\Nectin4
1 of 14
Yes
No
Mmus\Nphs1
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\bcam
1 of 13
Yes
No
Xtro\cadm2
1 of 13
Yes
No
Xtro\hmcn1
1 of 13
Yes
No
Xtro\hmcn2
1 of 13
Yes
No
Xtro\jam2
1 of 13
Yes
Yes
Xtro\LOC100496188
1 of 13
Yes
Yes
Xtro\nectin4
1 of 13
Yes
Yes
Danio rerio (Zebrafish) (28)
Drer\jam2a
2 of 14
Yes
Yes
Drer\jam2b
2 of 14
Yes
Yes
Drer\alcama
1 of 14
No
Yes
Drer\bcam
1 of 14
No
No
Drer\cadm1a
1 of 14
No
No
Drer\cadm1b
1 of 14
No
No
Drer\cadm2a
1 of 14
No
No
Drer\cadm2b
1 of 14
No
No
Drer\cadm3
1 of 14
No
No
Drer\ceacam1
1 of 14
No
No
Drer\chl1a
1 of 14
No
No
Drer\dscama
1 of 14
No
No
Drer\f11r.2
1 of 14
No
No
Drer\hmcn1
1 of 14
No
No
Drer\hmcn2
1 of 14
No
No
Drer\jam3b
1 of 14
No
Yes
Drer\kirrel3a
1 of 14
No
No
Drer\kirrel3b
1 of 14
No
No
Drer\kirrel3l
1 of 14
No
No
Drer\nectin3a
1 of 14
No
No
Drer\nectin4a
1 of 14
No
No
Drer\nfasca
1 of 14
No
No
Drer\nphs1
1 of 14
No
No
Drer\si:ch73-22o12.1
1 of 14
No
No
Drer\si:ch211-222f23.6
1 of 14
No
No
Drer\si:ch211-286b5.8
1 of 14
No
No
Drer\si:dkey-24p1.7
1 of 14
No
No
Drer\vsig10
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\him-4
1 of 14
Yes
No
Cele\igcm-1
1 of 14
Yes
No
Cele\syg-2
1 of 14
Yes
No
Cele\unc-89
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (30)
Agam\AgaP_AGAP009267
9 of 12
Yes
Yes
Agam\AgaP_AGAP000522
6 of 12
No
Yes
Agam\AgaP_AGAP009829
5 of 12
No
No
Agam\AgaP_AGAP009947
5 of 12
No
Yes
Agam\AgaP_AGAP009270
4 of 12
No
No
Agam\AgaP_AGAP001769
3 of 12
No
No
Agam\AgaP_AGAP007930
3 of 12
No
No
Agam\AgaP_AGAP007932
3 of 12
No
No
Agam\AgaP_AGAP007933
3 of 12
No
No
Agam\AgaP_AGAP001658
2 of 12
No
No
Agam\AgaP_AGAP001766
2 of 12
No
No
Agam\AgaP_AGAP004369
2 of 12
No
No
Agam\AgaP_AGAP004577
2 of 12
No
No
Agam\AgaP_AGAP000937
1 of 12
No
Yes
Agam\AgaP_AGAP000938
1 of 12
No
No
Agam\AgaP_AGAP001410
1 of 12
No
No
Agam\AgaP_AGAP001633
1 of 12
No
No
Agam\AgaP_AGAP001674
1 of 12
No
No
Agam\AgaP_AGAP003849
1 of 12
No
No
Agam\AgaP_AGAP009596
1 of 12
No
No
Agam\AgaP_AGAP009683
1 of 12
No
No
Agam\AgaP_AGAP010555
1 of 12
No
No
Agam\AgaP_AGAP010742
1 of 12
No
No
Agam\AgaP_AGAP010821
1 of 12
No
No
Agam\AgaP_AGAP010822
1 of 12
No
No
Agam\AgaP_AGAP010823
1 of 12
No
No
Agam\AgaP_AGAP011578
1 of 12
No
No
Agam\AgaP_AGAP012693
1 of 12
No
No
Agam\AgaP_AGAP013021
1 of 12
No
No
Agam\AgaP_AGAP013433
1 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:beat-Ia. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (22)
beat-Ib
8 of 13
beat-Ic
7 of 13
beat-IIIb
6 of 13
beat-IIIc
6 of 13
beat-IIIa
5 of 13
beat-IIa
4 of 13
beat-IIb
4 of 13
beat-IV
4 of 13
beat-Va
4 of 13
beat-Vc
4 of 13
beat-Vb
3 of 13
beat-VI
3 of 13
CG5597
3 of 13
CG13532
3 of 13
beat-VII
2 of 13
Fas3
1 of 13
hbs
1 of 13
kirre
1 of 13
rst
1 of 13
side-II
1 of 13
side
1 of 13
sns
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    beat-Ia
    suppressible
    beat-Ic
    (Pipes et al., 2001)
    beat-Ia|unc-5|Nrg
    enhanceable
    Fas2
    (Zarin et al., 2014)
    beat-Ia
    enhanceable
    Fas2
    (Zarin et al., 2014)
    beat-Ia
    suppressible
    Fas2
    (Holmes and Heilig, 1999)
    beat-Ia
    enhanceable
    Fas2|unc-5
    (Zarin et al., 2014)
    beat-Ia
    enhanceable
    Nrg
    (Zarin et al., 2014)
    beat-Ia
    enhanceable
    unc-5
    (Zarin et al., 2014)
    beat-Ia
    enhanceable
    unc-5|Nrg
    (Zarin et al., 2014)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    eve
    suppressible
    beat-Ia
    (Landgraf et al., 1999)
    eve
    enhanceable
    beat-Ia|unc-5
    (Zarin et al., 2014)
    eve
    suppressible
    beat-Ia|unc-5
    (Zarin et al., 2014)
    eve
    enhanceable
    beat-Ia
    (Zarin et al., 2014)
    Fas2
    suppressible
    beat-Ia
    (Holmes and Heilig, 1999)
    frac
    suppressible
    beat-Ia
    (Miller et al., 2011)
    side
    suppressible
    beat-Ia
    (Siebert et al., 2009)
    unc-5
    enhanceable
    beat-Ia
    (Zarin et al., 2014)
    unc-5
    enhanceable
    eve|beat-Ia
    (Zarin et al., 2014)
    unc-5
    enhanceable
    beat-Ia|Nrg
    (Zarin et al., 2014)
    unc-5
    enhanceable
    Fas2|beat-Ia|Nrg
    (Zarin et al., 2014)
    unc-5|Nrg
    enhanceable
    beat-Ia
    (Zarin et al., 2014)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-51
    Cytogenetic map
    35E2-35E2
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    35E2-35E2
    Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    35E-35E
    (Fambrough, 1996.8.15)
    35E1-35E2
    (determined by in situ hybridisation)
    (Fambrough and Goodman, 1996)
    Experimentally Determined Recombination Data
    Location

    2-51

    (FlyBase, 2016)

    2-49.1

    (Comeron et al., 2012)

    2-

    (van Vactor et al., 1993)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (32)
    Genomic Clones (35)
    cDNA Clones (39)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Fambrough and Goodman, 1996)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          The detachment of the Bolwig's organ precursors from the optic lobe during embryogenesis may involve interaction between beat-Ia and Fas2 proteins.

          (Holmes and Heilig, 1999)

          Identification: Ethyl methanesulfonate screen for mutations that disrupt the larval visual system: enumeration or adhesion of the larval photoreceptor cells.

          (Holmes et al., 1998)

          beat-Ia is required for the selective defasciculation of motor neurons at choice points along the major motor nerves. Mutant phenotype can be suppressed by mutations in Fas2 and Con suggesting beat-Ia provides an antiadhesive function. Rescue and ectopic expression experiments support the model that beat-Ia protein is secreted by motor axons where it functions to regulate their selective defasciculation at specific choice points.

          (Fambrough and Goodman, 1996)

          Identification: Screen for mutations affecting neuromuscular connectivity, using an antibody to Fas2.

          (van Vactor et al., 1993)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: beat tric

          (Heilig, 1998.10.3)
          Additional comments
          Nomenclature History
          Source for database identify of

          Source for identity of: beat CG4846

          (Kodira, 1999.11)
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (25)
          Reported As
          Symbol Synonym
          BG:DS00913.3
          (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
          Beat Ia
          (Hobert et al., 2004)
          Beat-Ia
          (Li et al., 2017, Ozkan et al., 2013, Nose, 2012)
          CCT
          (Moshkin et al., 2009)
          CG4846
          (National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1, Perkins et al., 2009)
          CT15567
          (Hynes and Zhao, 2000)
          Cct
          (Monzo et al., 2010)
          TRiC
          (Moshkin et al., 2009)
          beat
          (Heymann et al., 2022, Malin and Desplan, 2021, Kinold et al., 2018, Siebert et al., 2009, Bolshakov et al., 2002, Halfon et al., 2002, Salamov and Solovyev, 2000, Ashburner et al., 1999, Ashraf et al., 1999, Chisholm and Tessier-Lavigne, 1999, Holmes and Heilig, 1999, Landgraf et al., 1999, Landgraf et al., 1999, Tear, 1999, Alexandrova, 1998.1.26, Heilig, 1998.10.3, Holt and Harris, 1998, Kaufmann et al., 1998, Van Vactor, 1998, Van Vactor et al., 1998, Winberg et al., 1998, Bazan and Goodman, 1997, deLapeyriere and Henderson, 1997, Goodman et al., 1997, Mushegian, 1997, Tessier-Lavigne and Goodman, 1996, Seeger, 1994, Broadie et al., 1993, Goodman and Doe, 1993, van Vactor et al., 1993, Wilson, 1993)
          beat Ia
          (Zarin et al., 2014, Pipes et al., 2001)
          beat-1a
          (Jeong, 2021, Lavergne et al., 2020)
          beat-Ia
          (Corthals et al., 2023, Yang et al., 2023, Velten et al., 2022, Aberle, 2019, Hall et al., 2019, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Rajpurohit et al., 2018, Wolfram et al., 2014, Ozkan et al., 2013, Ozkan et al., 2013)
          beat1a
          (Miller et al., 2011, Girard et al., 2006)
          beat_1a
          (Kumar et al., 2021)
          l(2)35Ea
          (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
          l(2)35Eb
          (Roote and Ashburner, 1998.2.17, Alexandrova et al., 1996)
          l(2)br47
          (The Moscow Regional Drosophila melanogaster Stock Center, Dubna)
          l(2)br48
          (Roote and Ashburner, 1998.2.17)
          tric
          (Holmes et al., 1998)
          Name Synonyms
          Beaten Path Ia
          (Ozkan et al., 2013)
          Beaten path Ia
          (Siebert et al., 2009)
          Chaperonin containing TCP-1
          (Monzo et al., 2010)
          beaten path
          (Zarin et al., 2014, van Vactor et al., 1993)
          beaten path Ia
          triclops
          (Holmes et al., 1998)
          Secondary FlyBase IDs
          • FBgn0024596
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 45 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          References (99)