COI, COXI, COX, cytochrome c oxidase subunit I, COX1
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mt:CoI using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\mt:CoI in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: mt:CoI anon- EST:fe1F8
New annotation (CG34067) in release 4.3 of the genome annotation.
Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.
Phylogeny of the hydei subgroup is inferred from 1,515 base pairs of mitochondrial DNA sequence of the cytochrome oxidase subunits I, II and III.
Steady state levels of mt:CoI RNA decrease as adult Drosophila age, and this change correlates with the shape of the life span curve.
Maternal mRNA localises to the pole region of the embryo.
During oogenesis RNA from mt:srRNA, mt:lrRNA, mt:ND2, mt:CoI, mt:CoII, mt:CoIII, mt:ND4, mt:ND5 and mt:Cyt-b shows fluctuations in RNA density after stage 9 in follicle and nurse cells.There is a correlation between the mtRNA level and the cell volume and/or the nuclear DNA content suggesting a global extra-mitochondrial, transcriptional control mechanism.