FlyBase Gene Report: Dmel\mt:CoI

General Information

Symbol

Dmel\mt:CoI

Species

D. melanogaster

Name

mitochondrial Cytochrome c oxidase subunit I

Annotation Symbol

CG34067

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013674

Gene Model Status

Current

Stock Availability

3 publicly available

Enzyme Name (EC)

cytochrome-c oxidase (7.1.1.9)

Gene Summary

mitochondrial Cytochrome c oxidase subunit I (mt:CoI) is a mitochondrial gene encoding one of the catalytic subunits of the mitochondrial electron transport chain complex IV, which reduces molecular oxygen to water. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

COI, COX1, COXI, cytochrome c oxidase subunit I, COX

Key Links

Genomic Location

Cytogenetic map

Sequence location

mitochondrion_genome:1,474..3,009 [+]

Recombination map

RefSeq locus

NC_024511 REGION:1474..3009

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cytochrome-c oxidase activity

inferred from mutant phenotype

(Chen et al., 2015, Hill et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables cytochrome-c oxidase activity

inferred from electronic annotation with InterPro:IPR000883, InterPro:IPR023615, InterPro:IPR023616

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P00401

(Gene Ontology Curators, 2002-)

enables heme binding

inferred from electronic annotation with InterPro:IPR000883

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in mitochondrial electron transport, cytochrome c to oxygen

inferred from mutant phenotype

(Chen et al., 2015, Hill et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in aerobic respiration

inferred from biological aspect of ancestor with PANTHER:PTN000046094

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000883

(InterPro Project Members, 2004-)

involved_in respiratory electron transport chain

inferred from biological aspect of ancestor with PANTHER:PTN000046094

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

inferred from mutant phenotype

(Chen et al., 2015)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000883

(InterPro Project Members, 2004-)

located_in mitochondrial inner membrane

inferred from sequence or structural similarity with UniProtKB:P00401

(Gene Ontology Curators, 2002-)

part_of respiratory chain complex IV

inferred by curator from GO:0004129,GO:0006123

(Hill et al., 2014)

inferred from electronic annotation with InterPro:IPR033944

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000046096

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - CORE SUBUNITS

MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT

MITOCHONDRIAL COMPLEX IV

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION

Protein Family (UniProt)

Belongs to the heme-copper respiratory oxidase family. (P00399)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cytochrome-c oxidase activity

4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out) (7.1.1.9)

RHEA 11436:

Summaries

Gene Snapshot

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - CORE SUBUNITS -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. Eukaryotic COX is a multimeric enzyme formed by subunits of dual genetic origin. The three subunits forming the catalytic core of the enzyme (COX1, COX2 and COX3) are encoded by the mitochondrial DNA. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)

Pathway (FlyBase)

OXIDATIVE PHOSPHORYLATION -: Oxidative phosphorylation (OXPHOS) is the coordinated transfer of electrons and protons leading to the production of ATP. The OXPHOS system is composed of five mitochondrial inner membrane complexes, Complexes I-IV comprise the electron respiratory chain and Complex V the ATP synthase. Complexes I and II oxidize the electron donors NADH and FADH2, respectively, derived from the tricarboxylic acid (TCA) cycle, and the electrons are transferred to the electron carrier ubiquinone which shuttles them to Complex III. Cytochrome c transfers electrons between Complex III and the terminal complex in the respiratory chain, Complex IV. Complex IV catalyzes electron transfer from reduced cytochrome c to oxygen. Complex I, II and IV couple electron transfer to proton transport across the inner mitochondrial membrane into the inner membrane space. This generates a proton electrochemical gradient which is used to drive the synthesis of ATP from ADP and inorganic phosphate by ATP synthase (Complex V). (Adapted from PMID:23356252 and PMID:11331900.)

Protein Function (UniProtKB)

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

(UniProt, P00399)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mt:CoI for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P00399)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mt:CoI-RA

FBtr0100861

1536

511

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

mt:CoI-PA

FBpp0100176

56.4

511

6.60

P00399

NP_008278

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

(UniProt, P00399)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P00399

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mt:CoI using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

inferred from mutant phenotype

(Chen et al., 2015)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mt:CoI in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mt:CoI

View exonic expression by tissue for Dmel\mt:CoI

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

192469/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013674

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013674

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mt:CoI

Transgenic constructs containing regulatory region of mt:CoI

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^332.3

mt:CoI^syn

lethal, with Scer\GAL4^Mef2.PR

mt:CoI^syn

lethal, with Scer\GAL4^αTub84B.PL

mt:CoI^syn

lethal - all die before end of P-stage | heat sensitive

mt:CoI^T300I

lethal - all die during P-stage | heat sensitive

mt:CoI^T300I

partially lethal - majority live, with Scer\GAL4^insc-Mz1407, Xvas\XhoI^{UASp.Tag:Mito(Cs1),Tag:MYC}

mt:CoI^T300I

viable

mt:CoI^T300I

Sterility

Allele

female semi-sterile

mt:CoI^R301S

male sterile

Other Phenotypes

Allele

abnormal developmental rate | larval stage

mt:CoI^R301S

abnormal locomotor behavior

mt:CoI^R301S

abnormal neuroanatomy

mt:CoI^R301S

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^ey.PH, Xvas\XhoI^{UASp.Tag:Mito(Cs1),Tag:MYC}

mt:CoI^T300I

decreased rate of adult locomotory behavior | progressive

mt:CoI^T300I

increased speed of aging

mt:CoI^R301S

short lived

mt:CoI^T300I

short lived, with Scer\GAL4^insc-Mz1407, Xvas\XhoI^{UASp.Tag:Mito(Cs1),Tag:MYC}

mt:CoI^T300I

short lived | heat sensitive

mt:CoI^T300I

Phenotype manifest in

Allele

eye photoreceptor cell | progressive, with Scer\GAL4^ey.PH, Xvas\XhoI^{UASp.Tag:Mito(Cs1),Tag:MYC}

mt:CoI^T300I

flight muscle cell

mt:CoI^R301S

germarium region 2b | heat sensitive

mt:CoI^T300I

mechanosensory chaeta

mt:CoI^R301S

mitochondrial membrane | female | heat sensitive

mt:CoI^T300I

ommatidium

mt:CoI^R301S

ovary | heat sensitive

mt:CoI^T300I

photoreceptor neuron

mt:CoI^R301S

respiratory chain complex IV | decreased number | pupal stage

mt:CoI^T300I

rhabdomere

mt:CoI^R301S

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\COX1

13 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\COX1

13 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\COX1

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\COX1

10 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\COX1

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\COX1

11 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\COX1

9 of 12

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\cox1

10 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\COX1

12 of 13

Yes

Scer\AI5_ALPHA

8 of 13

Yes

Scer\AI4

7 of 13

Yes

Scer\AI3

2 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cox1

9 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\cyoB

9 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mt:CoI. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

mitochondrial complex IV disorders, MT-CO1-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

mt:CoI^T300I

model of mitochondrial metabolism disease

CEA with Xvas\XhoI^{UASp.Tag:Mito(Cs1),Tag:MYC}

(Chen et al., 2015)

model of cytochrome-c oxidase deficiency disease

CEA

(Chiang et al., 2024)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MT-CO1; mitochondrially encoded cytochrome c oxidase I

13 of 14

516030

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

mt:CoI - COX4

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoI - COX5A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoI - COX5B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoI - COX6B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoI - COX7A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoI - COX7AL2

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoI - COX7B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoI - COX8

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoI - ND-MLRQ

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoI - cype

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoI - levy

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoI - mt:CoII

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoI - mt:CoIII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mt:CoI

suppressible

Letm1

(Chen et al., 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, P00399 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013674

MIST (protein-protein) - An integrated Molecular Interaction Database

19893533

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

OXIDATIVE PHOSPHORYLATION

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

mt_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

mitochondrion_genome

Recombination map

Cytogenetic map

Sequence location

mitochondrion_genome:1,474..3,009 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

81006

w^*; mt:CoI^T300I

77350

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05943}attP40

VDRC

v109391

P{KK115361}VIE-260B

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013674

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Matsushima et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG34067) in release 4.3 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

(Schmid and Tautz, 1997)

Phylogeny of the hydei subgroup is inferred from 1,515 base pairs of mitochondrial DNA sequence of the cytochrome oxidase subunits I, II and III.

(Spicer and Pitnick, 1996)

Steady state levels of mt:CoI RNA decrease as adult Drosophila age, and this change correlates with the shape of the life span curve.

(Calleja et al., 1993)

Maternal mRNA localises to the pole region of the embryo.

(Ding and Lipshitz, 1993)

mt:CoI has been cloned and sequenced, and compared to Dsim\mt:CoI, Dsec\mt:CoI and Dmau\mt:CoI.

(Satta and Takahata, 1990)

During oogenesis RNA from mt:srRNA, mt:lrRNA, mt:ND2, mt:CoI, mt:CoII, mt:CoIII, mt:ND4, mt:ND5 and mt:Cyt-b shows fluctuations in RNA density after stage 9 in follicle and nurse cells.There is a correlation between the mtRNA level and the cell volume and/or the nuclear DNA content suggesting a global extra-mitochondrial, transcriptional control mechanism.

(Tourmente et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: mt:CoI anon- EST:fe1F8

(FlyBase, 1996-)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (53)

Reported As

Symbol Synonym

C-IV s.1

(Gehrke et al., 2015)

CG34067

(Choo et al., 2015, Sanz et al., 2010, Tiefenböck et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2005)

(Burnell et al., 1991)

CO I

(Salminen and Vale, 2020, Azou and Bregliano, 2001)

CO1

(Seligmann, 2012)

COX

(Bouska et al., 2019, von Stockum et al., 2011, Tiefenböck et al., 2010, Walker and Benzer, 2004, Galloni, 2003, Maier et al., 2001)

COX I

(Humphrey et al., 2012, Sanchez-Martinez et al., 2012)

COX1

(Arshad et al., 2026, Meyer et al., 2024, Camus et al., 2023, Brischigliaro et al., 2022, Loewen and Ganetzky, 2018, Bratic et al., 2016, Aradska et al., 2015, Da-Rè et al., 2014)

COXI

(Huynh et al., 2020, Matsushima et al., 2017, Tsai et al., 2016, Humphrey et al., 2012, Peralta et al., 2012, Bratic et al., 2011, Matsushima and Kaguni, 2007)

CcO subunit I

(Sohal et al., 2008)

Co I

(Iijima-Ando et al., 2009, Lee et al., 2009, Chang and Min, 2005)

Co-I

(Mossman et al., 2016)

CoI

(Klucnika et al., 2023, Higareda Alvear et al., 2021, Vaught et al., 2020, Jaiswal et al., 2015, Sanz et al., 2010, Montooth et al., 2009, Nigro et al., 1991)

Cox I

(Liu et al., 2018)

Cox-1

(Branco et al., 2017)

Cox1

(Choo et al., 2015)

Cyt.ox.I

(Shaw et al., 2000)

(Szuplewski and Terracol, 2001)

Mt:CoI

(Taylor et al., 2024)

Mt:ColI

(Everman and Macdonald, 2024)

anon-EST:fe1F8

coI

(Sanz et al., 2010)

cox I

(Cagin et al., 2015)

cox1

(Stewart and Beckenbach, 2009, Torres et al., 2009)

coxI

(Baggio et al., 2014, Schwarze et al., 1998)

mt-CO1

(Peralta et al., 2012)

mt-cox1

(Wang et al., 2022)

mt:COI

(Nozawa et al., 2023)

mt:Col

(Palozzi et al., 2022)

mt:CoxI

(Barry and Thummel, 2016)

mt:co1

(Clemente et al., 2022)

mt:coI

(Murari et al., 2022)

Name Synonyms

COX subunit 1

(Tiefenböck et al., 2010)

COX subunit I

(Tiefenböck et al., 2010)

Cyclooxygenase 1

(Xia et al., 2020)

Cyclooxygenase-1

(Da-Rè et al., 2014)

Cytochrome c oxidase

(Kang et al., 2002)

Cytochrome c oxidase subunit I

(Montooth et al., 2009)

Cytochrome oxidase subunit I

(Kopp and Barmina, 2005)

anon-fast-evolving-1F8

cytochrome C oxidase I

(Raquin et al., 2018)

cytochrome c

(Caffrey and Cusanovich, 1994, Garber and Margoliash, 1994)

cytochrome c oxidase

(Galloni, 2003)

cytochrome c oxidase subunit I

(Hill et al., 2014, Humphrey et al., 2012, Sanz et al., 2010, Iijima-Ando et al., 2009, Lee et al., 2009, Sohal et al., 2008)

cytochrome oxidase

(Ma et al., 2014)

cytochrome oxidase C

(Hill et al., 2020)

cytochrome oxidase I

(Ballard, 2000)

cytochrome oxidase subunit I

(von Stockum et al., 2011, Goto et al., 2000)

mitochondrial Cytochrome c oxidase subunit I

mitochondrial cytochrome c oxidase subunit I

(Nunes et al., 2008)

mitochondrial cytochrome oxidase C (subunit I)

(Cirelli, 2003)

Secondary FlyBase IDs

FBgn0002867
FBgn0025247

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

192469

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

NP_008278

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P00399

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P00399

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P00399

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

192469/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013674

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013674

FlyMine - An integrated database for Drosophila genomics

FBgn0013674

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34067

MARRVEL_MODEL - MARRVEL (model organism gene)

192469

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013674

DRSC - Results frm RNAi screens

FBgn0013674

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013674

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

19893533

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (220)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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