Camguk, Caki, cmg, Calcium/calmodulin-dependent protein kinase, CASK ortholog
Gene model reviewed during 6.19
Gene model reviewed during 5.52
Gene model reviewed during 5.56
Gene model reviewed during 6.32
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.47
7.0, 4.0 (northern blot)
571 (aa); 63 (kD predicted)
Interacts with eag. Interacts with CaMKII.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CASK using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\CASK in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: CASK Caki
CASK function is required in the α'/β' subset of the mushroom body neurons in the adult for middle-term, anesthesia-resistant and long-term memory formation.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
The Caki protein sequence is conserved in the catalytic and calmodulin-binding domains with other type II CaM kinases. In cultured cells Caki has the ability to stimulate the transcriptional activity of the Rous sarcoma virus long terminal repeat (RSV LTR).
Mutant flies, in which an encoding part of the gene is removed, display a substantial reduction in walking speed.
Expressed in nurse cells.