Drm-COR, COR, Dm-Crz
a secreted neuropeptide produced by dorsolateral peptidergic neurons with axon terminations in the corpora cardiaca, anterior aorta and intestine - regulates ethanol and trehalose metabolism and male reproductive activity - coordinates increased food intake and diminished energy stores during stress - coordinates sperm transfer and copulation duration - targets corazonin receptor in salivary glands and adipocytes
Please see the JBrowse view of Dmel\Crz for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.41
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Crz using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Crz colocalizes with ScerGAL4ATP7.PB expressing interneurons in the larval abdominal neuromere.
Crz is observed in 2 pairs of interneurons in the abdominal ganglion. Expression co-localises with that of ScerGAL4Crz.391.
Crz is expressed in the peptidergic CC-LP2 neurons in the larval brain.
Expression of Crz is expressed in a group of neurons that the authors call the DM ('Dorsomedial') and DL ('Dorsolateral') neurons in the protocerebrum, and the eight bilaterally symmetric 'vCrz' neurons of the ventral nerve cord.
Expression of Crz protein is seen within three pairs of neurosecretory cells located close to the Kenyon cells of the third instar larvae. These cells send projections to the ring gland and also express ScerGAL4NP6301. In the adult brain, expression of Crz protein is seen in a small group of neurosecretory cells in the dorsal protocerebrum called DLN1s.
Co-localisation of Crz and ScerGAL4dimm-929 is observed in a subset of Crz-positive neurons of the central nervous system.
Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Crz in JBrowse3-55
3-53.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
Isolation and characterisation of Crz.