Drm-COR, Dm-Crz, COR
Gene model reviewed during 5.41
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Crz using the Feature Mapper tool.
Expression of Crz is expressed in a group of neurons that the authors call the DM ('Dorsomedial') and DL ('Dorsolateral') neurons in the protocerebrum, and the eight bilaterally symmetric 'vCrz' neurons of the ventral nerve cord.
Expression of Crz protein is seen within three pairs of neurosecretory cells located close to the Kenyon cells of the third instar larvae. These cells send projections to the ring gland and also express Scer\GAL4NP6301. In the adult brain, expression of Crz protein is seen in a small group of neurosecretory cells in the dorsal protocerebrum called DLN1s.
Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Crz in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The EcR-A isoform is not a signal transducer for programmed cell death in Crz-expressing ventral nerve cord neurons. EcR-B isoforms play significant roles in Crz-expressing ventral nerve cord neuron cell death.
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.