Gene model reviewed during 5.52
Gene model reviewed during 5.39
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Gene model reviewed during 5.55
2.4, 2.3, 1.8 (northern blot)
359 (aa); 42 (kD predicted)
Phosphorylated and activated by MAP kinase.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MAPk-Ak2 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\MAPk-Ak2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities and chromosome alignment defects are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
An evolutionarily conserved MAP kinase-like pathway that responds to stress but not to mitogenic signals exists, MAPk-Ak2 is part of this stress-responsive pathway.
Comparison of sequence with the mammalian counterpart reveals the catalytic domain, MAPK phosphorylation site and the nuclear targeting sequence are conserved.