membrane associated or secreted antagonist of FGF signaling - functions during tracheal development - mutant follicle-cell clones demonstrates an essential role for Sprouty in restricting Egfr activation throughout oogenesis
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Gene model reviewed during 5.56
591 (aa); 63 (kD predicted)
Interacts with DRK and RasGAP1 proteins of the Ras pathway.
The Cys-rich domain is responsible for the localization of the protein to the plasma membrane.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sty using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sty in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: sty CG1921
Loss of sty in the eye imaginal discs results in transformations of cone cell to R7 and mystery cells to outer photoreceptors. Loss of sty in the embryonic chordotonal organ precursors and embryonic midline glia results in supernumerary neurons, or supernumerary glia, respectively. Overexpression results in phenotypes that resemble loss of function Egfr phenotypes.
sty acts nonautonomously in the tracheal tip cells to inhibit induction of nearby stalk cells.
sty mutations cause ectopic branches to form on the stalks of primary branches in the tracheal system.