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General Information
Symbol
Scer\FLP1
Species
S. cerevisiae
Name
FLIP recombinase
Annotation Symbol
Feature Type
FlyBase ID
FBgn0014444
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As

FLP, FLP1

Key Links
Tag or Foreign Gene Data

Foreign sequence; species == Saccharomyces cerevisiae; gene == FLP1; SGD:S000029654.

Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Scer\FLP1 using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Scer\FLP1 in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, Transgenic Constructs, and Aberrations
      Classical and Insertion Alleles ( 66 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 118 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of Scer\FLP1
      Transgenic constructs containing regulatory region of Scer\FLP1
      Aberrations (Deficiencies and Duplications) ( 0 )
      Inferred from experimentation ( 0 )
      Inferred from location ( 0 )
        Alleles Representing Disease-Implicated Variants
        Phenotypes
        For more details about a specific phenotype click on the relevant allele symbol.
        Lethality
        Allele
        Sterility
        Allele
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        Orthologs
        Human Orthologs (via DIOPT v8.0)
        Homo sapiens (Human) (0)
        No records found.
        Model Organism Orthologs (via DIOPT v8.0)
        Drosophila melanogaster (Fruit fly) (0)
        No records found.
        Ortholog(s) in Drosophila melanogaster (via OrthoDB v9.1) ( None identified )
        No D. melanogaster orthologies identified
        Human Disease Associations
        FlyBase Human Disease Model Reports
          Disease Model Summary Ribbon
          Disease Ontology (DO) Annotations
          Models Based on Experimental Evidence ( 0 )
          Allele
          Disease
          Evidence
          References
          Potential Models Based on Orthology ( 0 )
          Human Ortholog
          Disease
          Evidence
          References
          Modifiers Based on Experimental Evidence ( 0 )
          Allele
          Disease
          Interaction
          References
          Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
          Homo sapiens (Human)
          Gene name
          Score
          OMIM
          OMIM Phenotype
          DO term
          Complementation?
          Transgene?
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          Recombination map
          Cytogenetic map
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (3,354)
          Genomic Clones (0)
           
            cDNA Clones (0)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                    Other clones
                      RNAi and Array Information
                      Linkouts
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of
                      Source for database merge of
                      Additional comments
                      Other Comments

                      Scer\FRT-site insertion in third chromosome can influence second chromosome nondisjunction. The phenomenon demonstrates the behaviour of different pairs of homologous chromosomes in male meiosis are not independent.

                      The Scer\FLP1-Scer\FRT site-specific recombination system can be used to integrate DNA at a chromosomal Scer\FRT target site. Events are recovered using a w reporter gene.

                      The w+mW.hs mutation carried in the P{FRT(whs)} element can be excised from its site of integration by the induction of Scer\FLP1 synthesis. Scer\FLP1 can be used to excise an Scer\FRT-flanked gene after cell division has ceased and the gene, now present on an extrachromosomal circle, is expressed. Most position effects are reverted by the removal of this gene from the chromosome.

                      The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to study the zygotic lethal mutation.

                      A method that uses Cbβ\DT-A, the Scer\FLP1 recognition target sequences and the Scer\GAL4-Scer\UAS activation system can be used to ablate specific neurons in the embryo and to examine the consequences.

                      Clonal analysis has been used to characterise the somatic stem cells that give rise to ovarian follicle cells.

                      Scer\FLP1 recombinase can promote mitotic exchange during embryonic development.

                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 1 )
                      Other crossreferences
                      SGD - Saccharomyces Genome Database
                      Synonyms and Secondary IDs (14)
                      Reported As
                      Symbol Synonym
                      FLIP
                      FLP
                      (Cook, 2017.12.20, Awasaki et al., 2014, Awasaki et al., 2014, Awasaki et al., 2014, Chen and Krasnow, 2014, Chen and Zipursky, 2014.4.17, Gambetta and Müller, 2014, Gurudev et al., 2014, Aoyama et al., 2013, Fregoso Lomas et al., 2013, Greer et al., 2013, Jukam et al., 2013, Rousso et al., 2013, Gault et al., 2012, Moraru et al., 2012, Singh and Mlodzik, 2012, Zhang et al., 2012, Awasaki et al., 2011, Jenny, 2011, Leonardi et al., 2011, Molnar et al., 2011, Nern et al., 2011, Poulton et al., 2011, Roy et al., 2011, Stephan et al., 2011, Thum et al., 2011, Biehs et al., 2010, Cheng et al., 2010, Das Thakur et al., 2010, Elsaesser et al., 2010, Erokhin et al., 2010, Grönke et al., 2010, Gurudatta et al., 2010, Haruta et al., 2010, Herranz et al., 2010, Hudson and Cooley, 2010, Krivega et al., 2010, Monastirioti et al., 2010, Portela et al., 2010, Potter et al., 2010, Richardson and Pichaud, 2010, Roch et al., 2010, Silicheva et al., 2010, Swaminathan and Pile, 2010, Tsuda et al., 2010, Zheng et al., 2010, Bhattacharya and Baker, 2009, Choi et al., 2009, Patel et al., 2009, Awasaki et al., 2008, Berger et al., 2008, Bazigou et al., 2007, Bazigou et al., 2007, Hattori et al., 2007, Kracklauer et al., 2007, Millard et al., 2007, Millard et al., 2007, Rakovitsky et al., 2007, Song et al., 2007, Hofmeyer et al., 2006, LaLonde et al., 2006, Schimmelpfeng et al., 2006, Wernet et al., 2006, Djiane et al., 2005, Hiesinger et al., 2005, Mehta et al., 2005, Vaccari and Bilder, 2005, Wittwer et al., 2005, Chew et al., 2004, Komiyama et al., 2004, Lawrence et al., 2004, Ratnakumar and Desplan, 2004.3, Leismann and Lehner, 2003, Carroll et al., 2002, Clandinin et al., 2001, Maurel-Zaffran et al., 2001, Maurel-Zaffran and Treisman, 2000, Newsome et al., 2000, Tanentzapf et al., 2000, Luo et al., 1999, Percival-Smith and Bondy, 1999, Ahmad and Golic, 1998, Bellotto et al., 1998, Chen et al., 1998, Marin et al., 1998, Perrimon, 1998, Platero and Henikoff, 1998, Beumer, 1997.3.10, de Celis, 1997, Gorfinkiel et al., 1997, Kosman and Small, 1997, Mullor et al., 1997, Yang et al., 1997, Chou and Perrimon, 1996, Frise et al., 1996)
                      Scer\FLP1
                      Name Synonyms
                      FLIP recombinase
                      Flp DNA recombinase
                      Flp recombinase
                      Secondary FlyBase IDs
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        References (707)