Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the Mcm2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order Mcm2-Mcm6-Mcm4-Mcm7-Mcm3-Mcm5 (Probable). Interacts with Mcm10.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mcm2 using the Feature Mapper tool.
Mcm2 transcripts are maternally contributed to the embryo and disappear at cellularization. They are expressed uniformly at germ band extension and are subsequently restricted to a pattern that includes continuous expression in the CNS and transient expression in a number of other tissues, including the Malpighian tubules and the gut.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mcm2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Mcm2 CG7538
Physical interactions exist between three MCM proteins, dpa, Mcm2 and Mcm5. The three proteins reside predominantly in stable multi-protein complexes of about 600kD. Coimmunoprecipitation experiments indicate there are at least two distinct 600kD complexes, one of which includes Mcm5 and the other dpa.
For the yeast genes MCM stands for 'minichromosome maintenance'.