Hsp60, l(1)BP5, heat shock protein 60, Hsp64, 12
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsp60A using the Feature Mapper tool.
Hsp60 protein is localized in striated muscles surrounding the egg chamber, and in oviduct muscles; and in follicle cells, nurse cells, and oocytes. Hsp60 protein is specifically localized to the A bands of striated muscles that enwrap the ovariole and individual egg chambers, and the striated muscles of the oviduct. Hsp60 protein localizes to the external face of follicle cells. At oogenesis stage S10-11, Hsp60 protein is present in nurse cell cytoplasm, where it overlaps the distribution of F-actin, particularly near the cell membrane. It also appears to colocalize with the actin skeleton surrounding the nuclei of nurse cells. Less expression is observed in oocytes. After oogenesis stage 13, Hsp60 is largely absent from oocytes, and in nurse cells is concentrated in a small region of the nurse cell-oocyte junction that will form the micropyle of the mature oocyte.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hsp60A in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hsp60A Hsp60
Renamed from 'Hsp60' to 'Hsp60A' following the nomenclature used in FBrf0190982, and to be consistent with nomenclature of the other three Hsp60 family members (Hsp60B, Hsp60C and Hsp60D).
May correspond to the l(1)10Ac locus.
Complementation relations among complementing alleles complex and vary according to temperature of rearing, some combinations being heat sensitive and others cold-sensitive. Allelism to Hsp60L12 established for the Russian alleles by Zhimulev et al. and for the G8 alleles by Geer et al. (1983).
dsRNA made from templates generated with primers directed against this gene results in a change in cell proliferation and cell size.
Sequence analysis of l(1)10Ac locus suggests it encodes Hsp60. Molecular analysis of a P-element insertion and genetic rescue experiments confirm l(1)10Ac encodes Hsp60. Hsp60 is differentially expressed throughout development, protein distribution is very dynamic during embryogenesis accumulating in specific cell types.
A protein crossreacting to mammalian CPN60 is detected in the mitochondria of SL2 cells.