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General Information
H. sapiens
microtubule-associated protein tau
Annotation Symbol
Feature Type
FlyBase ID
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As

tau, hTau, MAPT, h-tau, human tau

Key Links
Tag or Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == MAPT; HGNC:6893.


Information on product gene function for non-D. melanogaster species is no longer provided by FlyBase.

Up-to-date information on gene product function can be found by searching UniProtKB for proteins or RNAcentral for non-coding RNAs.

Gene Model and Products
Number of Transcripts
Number of Unique Polypeptides
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
Structure New Section
Comments on Gene Model
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
External Data
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences


Additional Polypeptide Data and Comments
Reported size (kDa)
External Data
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Hsap\MAPT using the Feature Mapper tool.

    External Data
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
    Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
    Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
    as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Additional Descriptive Data
    Marker for
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
    Subcellular Localization
    CV Term
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Hsap\MAPT in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 7 )
    For All Classical and Insertion Alleles Show
    Other relevant insertions
    Transgenic Constructs ( 156 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Hsap\MAPT
    Transgenic constructs containing regulatory region of Hsap\MAPT
    Aberrations (Deficiencies and Duplications) ( 0 )
    Inferred from experimentation ( 0 )
    Inferred from location ( 0 )
      Alleles Representing Disease-Implicated Variants
      For more details about a specific phenotype click on the relevant allele symbol.
      Other Phenotypes
      Phenotype manifest in
      eye photoreceptor cell & neuron, with Scer\GAL4hs.2sev
      Human Orthologs (via DIOPT v8.0)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v8.0)
      Drosophila melanogaster (Fruit fly) (1)
      Species\Gene Symbol
      Best Score
      Best Reverse Score
      7 of 15
      Other Organism Orthologs (via OrthoDB)
      Human Disease Associations
      FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 98 )
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Modifiers Based on Experimental Evidence ( 32 )
      model of  tauopathy
      is ameliorated by Atg1Δ3D
      is ameliorated by S6kUAS.cUa
      is ameliorated by arm1
      is ameliorated by sgg1
      is exacerbated by panUAS.cWa
      is ameliorated by arm4
      is ameliorated by Vap33Δ448
      is exacerbated by Psa06226
      is ameliorated by AlkUAS.DN
      is ameliorated by POLDIP2EY08866
      is exacerbated by spinΔ2b
      model of  tauopathy
      is exacerbated by f+t13
      is ameliorated by Opa1s3475
      is ameliorated by MarfJF01650
      is exacerbated by WASpUAS.cBa
      is exacerbated by MarfUAS.cDa
      is exacerbated by sqhAX3
      is ameliorated by Drp1UAS.cDb
      is exacerbated by Drp1GD10456
      is exacerbated by zip1
      is ameliorated by NmnatUAS.PD
      is ameliorated by NmnatWR.UAS.PD
      is exacerbated by slo1
      is ameliorated by BtndGD5654
      is ameliorated by BtndPL59
      is exacerbated by HcsUAS.cLa
      is exacerbated by SmvtHMJ30134
      is exacerbated by SmvtMB04530
      is exacerbated by LamGL00577
      is ameliorated by AmphGD1311
      is ameliorated by Kdm3HMJ22328
      is ameliorated by Kdm2KK101783
      is ameliorated by Kdm4AGD9133
      is ameliorated by Kdm4BKK102089
      is ameliorated by sbr1
      is exacerbated by Klc8ex94
      is exacerbated by AmphEY09339
      is exacerbated by ClcDG23206
      is exacerbated by Chc1
      is exacerbated by Chc4
      is ameliorated by Rab26UAS.YFP
      is exacerbated by Rab26GD9927
      is exacerbated by AmphGD1311
      is exacerbated by p535A-1-4
      is exacerbated by p5311-1B-1
      is exacerbated by SytβDG10711
      is exacerbated by SytβJF02593
      is exacerbated by LerpGD306
      is exacerbated by gGD7158
      is exacerbated by SppGD786
      is exacerbated by DabGD4886
      is ameliorated by hepGD1461
      is exacerbated by krzGD8470
      is exacerbated by ttvGD1993
      is ameliorated by TetGD9718
      is exacerbated by Lkb1UAS.cWa
      is exacerbated by cathD1
      is ameliorated by rad50EP1
      model of  tauopathy
      is ameliorated by HDAC6KO
      is ameliorated by CalpB4062
      is ameliorated by twsUAS.cBa
      is exacerbated by hop2
      is ameliorated by CaMKIIGD9506
      is exacerbated by CaMKIIUAS.cKa
      is exacerbated by amosTft
      is exacerbated by PiezoKO
      is ameliorated by pbl3
      is exacerbated by ena210
      is exacerbated by ensΔC
      is exacerbated by h1
      is exacerbated by Thor2
      is exacerbated by Tlrv18
      is exacerbated by heph2
      is exacerbated by sdtXN
      is exacerbated by shn3
      is ameliorated by AlkUAS.DN
      is exacerbated by Klc8ex94
      is ameliorated by gEP514
      is ameliorated by MESR4EP386
      is ameliorated by svrEP356
      is ameliorated by mubEP3108
      model of  tauopathy
      is ameliorated by HDAC6KO
      is exacerbated by Diap1SL
      is ameliorated by αTub84BK40Q
      is ameliorated by αTub84BK40R
      is ameliorated by MycJF01761
      is exacerbated by SmD2GD7741
      is exacerbated by SmD2HMC03839
      is exacerbated by SmEGD13663
      is exacerbated by SmEHMS00074
      is exacerbated by snfJ210
      is exacerbated by LarGD14391
      is exacerbated by bru1GD8699
      is exacerbated by dopGD11940
      is exacerbated by dopGL00220
      is exacerbated by dopJF02778
      is ameliorated by oxtG4946
      is ameliorated by scbEY02806
      is ameliorated by scbEY10270
      is exacerbated by scbJF02696
      is exacerbated by scbPB.UAS
      is ameliorated by Act5CG0010
      is exacerbated by Act5CUAS.GFP
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      OMIM Phenotype
      DO term
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Selected Interactor(s)
      Interactions Browser

      Please see the Physical Interaction reports below for full details
      Physical Interaction
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      External Data
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      Recombination map
      Cytogenetic map
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      Experimentally Determined Cytological Location
      Cytogenetic map
      Experimentally Determined Recombination Data
      Left of (cM)
      Right of (cM)
      Stocks and Reagents
      Stocks (44)
      Genomic Clones (0)
        cDNA Clones (0)

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                  RNAi and Array Information
                  Antibody Information
                  Laboratory Generated Antibodies
                  Commercially Available Antibodies
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Additional comments

                  FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

                  Other Comments
                  Origin and Etymology
                  External Crossreferences and Linkouts ( 10 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  Synonyms and Secondary IDs (35)
                  Reported As
                  Symbol Synonym
                  (Pragati and Sarkar, 2021, Shafik et al., 2021, Abtahi et al., 2020, Brenman-Suttner et al., 2020, Chi et al., 2020, Tue et al., 2020, Chatterjee et al., 2019, Deshpande et al., 2019, Higham et al., 2019, Scarpelli et al., 2019, Shim et al., 2019, Bardai et al., 2018, Bardai et al., 2018, Chiku et al., 2018, Guo et al., 2018, Passarella and Goedert, 2018, Sekiya et al., 2018, Sun et al., 2018, Chanu and Sarkar, 2017, Dissel et al., 2017, Frenkel-Pinter et al., 2017, Frenkel-Pinter et al., 2017, Galasso et al., 2017, Kilian et al., 2017, Mao et al., 2017, Sealey et al., 2017, Ando et al., 2016, Ando et al., 2016, Frost et al., 2016, Iyer et al., 2016, Zhang et al., 2016, Huang et al., 2015, Menzies et al., 2015, Santa-Maria et al., 2015, Frost et al., 2014, Merlo et al., 2014, Soundararajan and Bullock, 2014, Chapuis et al., 2013, HGNC Curators and FlyBase Curators, 2013-, Sinadinos et al., 2013, Xiong et al., 2013, Ali et al., 2012, Caesar et al., 2012, Duboff et al., 2012, Park et al., 2012, Ambegaokar and Jackson, 2011, Singh and Mahoney, 2011.2.17, Falzone et al., 2010, Folwell et al., 2010, Iijima-Ando and Iijima, 2010, Iijima-Ando et al., 2010, Iijima et al., 2010, Khurana et al., 2010, Lin et al., 2010, Loewen and Feany, 2010, Moloney et al., 2010, Papanikolopoulou et al., 2010, Williamson and Hiesinger, 2010, Chatterjee et al., 2009, Cao et al., 2008, Blard et al., 2007, Ryoo et al., 2007, Steinhilb et al., 2007, Berger et al., 2006, Grammenoudi et al., 2006, Siyad et al., 2005, Warrick et al., 2005, Fortini, 2004, Mershin et al., 2004, Mudher et al., 2004, Nishimura et al., 2004, Scherzer et al., 2003, Jackson et al., 2002, Ferber, 2001, Wittmann et al., 2001)
                  Name Synonyms
                  G protein beta1/gamma2 subunit-interacting factor 1
                  Microtubule-associated protein tau
                  human MAPT
                  microtubule associated protein tau
                  microtubule-associated protein tau
                  microtubule-associated protein tau, isoform 4
                  protein phosphatase 1, regulatory subunit 103
                  Secondary FlyBase IDs
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project Type
                    Study result (0)
                    Result Type
                    References (257)