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General Information
H. sapiens
microtubule-associated protein tau
Annotation Symbol
Feature Type
FlyBase ID
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As

tau, hTau, MAPT, h-tau, human tau

Tag or Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == MAPT; HGNC:6893.

GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Protein Signatures (InterPro)
    Gene Model and Products
    Number of Transcripts
    Number of Unique Polypeptides
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    External Data
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences


    Additional Polypeptide Data and Comments
    Reported size (kDa)
    External Data
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Hsap\MAPT using the Feature Mapper tool.

      External Data
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
      Subcellular Localization
      CV Term
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Hsap\MAPT in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, Transgenic Constructs, and Aberrations
      Classical and Insertion Alleles ( 7 )
      For All Classical and Insertion Alleles Show
      Other relevant insertions
      Transgenic Constructs ( 142 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of Hsap\MAPT
      Transgenic constructs containing regulatory region of Hsap\MAPT
      Aberrations (Deficiencies and Duplications) ( 0 )
      Inferred from experimentation ( 0 )
      Inferred from location ( 0 )
        For more details about a specific phenotype click on the relevant allele symbol.
        Other Phenotypes
        Phenotype manifest in
        eye photoreceptor cell & neuron, with Scer\GAL4hs.2sev
        Human Orthologs (via DIOPT v8.0)
        Homo sapiens (Human) (0)
        No records found.
        Model Organism Orthologs (via DIOPT v8.0)
        Drosophila melanogaster (Fruit fly) (1)
        Species\Gene Symbol
        Best Score
        Best Reverse Score
        7 of 15
        Ortholog(s) in Drosophila melanogaster (via OrthoDB v9.1) ( None identified )
        No D. melanogaster orthologies identified
        Human Disease Associations
        FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 61 )
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Modifiers Based on Experimental Evidence ( 26 )
        model of  tauopathy
        is ameliorated by Atg1Δ3D
        is ameliorated by S6kUAS.cUa
        is ameliorated by arm1
        is ameliorated by sgg1
        is ameliorated by arm4
        is exacerbated by panUAS.cWa
        is ameliorated by Vap33Δ448
        is exacerbated by Psa06226
        is ameliorated by POLDIP2EY08866
        is exacerbated by spinΔ2b
        model of  tauopathy
        is exacerbated by f+t13
        is ameliorated by Drp1UAS.cDb
        is ameliorated by Opa1s3475
        is ameliorated by MarfJF01650
        is exacerbated by MarfUAS.cDa
        is exacerbated by WASpUAS.cBa
        is exacerbated by sqhAX3
        is exacerbated by zip1
        is exacerbated by Drp1GD10456
        is exacerbated by LamGL00577
        is ameliorated by Kdm3HMJ22328
        is ameliorated by Kdm2KK101783
        is ameliorated by Kdm4AGD9133
        is ameliorated by Kdm4BKK102089
        is ameliorated by sbr1
        is exacerbated by Klc8ex94
        is exacerbated by AmphEY09339
        is exacerbated by ClcDG23206
        is exacerbated by Chc1
        is exacerbated by Chc4
        is ameliorated by Rab26UAS.YFP
        is exacerbated by Rab26GD9927
        is exacerbated by SytβDG10711
        is exacerbated by p535A-1-4
        is exacerbated by p5311-1B-1
        is exacerbated by SytβJF02593
        is exacerbated by AmphGD1311
        is exacerbated by LerpGD306
        is exacerbated by gGD7158
        is exacerbated by SppGD786
        is exacerbated by DabGD4886
        is ameliorated by TetGD9718
        is exacerbated by ttvGD1993
        is ameliorated by hepGD1461
        is exacerbated by krzGD8470
        is exacerbated by Lkb1UAS.cWa
        is exacerbated by cathD1
        model of  tauopathy
        is ameliorated by HDAC6KO
        is ameliorated by CalpB4062
        is ameliorated by twsUAS.cBa
        is exacerbated by hop2
        is ameliorated by CaMKIIGD9506
        is exacerbated by CaMKIIUAS.cKa
        is exacerbated by Klc8ex94
        is ameliorated by gEP514
        is ameliorated by MESR4EP386
        is ameliorated by svrEP356
        is ameliorated by mubEP3108
        model of  tauopathy
        is ameliorated by HDAC6KO
        is exacerbated by Diap1SL
        is ameliorated by αTub84BK40Q
        is ameliorated by αTub84BK40R
        is ameliorated by MycJF01761
        is exacerbated by SmD2GD7741
        is exacerbated by SmD2HMC03839
        is exacerbated by SmEGD13663
        is exacerbated by SmEHMS00074
        is exacerbated by snfJ210
        is exacerbated by dopGL00220
        is exacerbated by dopJF02778
        is ameliorated by oxtG4946
        is ameliorated by scbEY02806
        is ameliorated by scbEY10270
        is exacerbated by scbJF02696
        is exacerbated by scbPB.UAS
        is exacerbated by LarGD14391
        is exacerbated by bru1GD8699
        is exacerbated by dopGD11940
        is ameliorated by Act5CG0010
        is exacerbated by Act5CUAS.GFP
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        OMIM Phenotype
        DO term
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Dmel gene
        Ortholog showing functional complementation
        Supporting References
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
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        Selected Interactor(s)
        Interactions Browser

        Please see the Physical Interaction reports below for full details
        Physical Interaction
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        External Data
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Experimentally Determined Recombination Data
        Left of (cM)
        Right of (cM)
        Stocks and Reagents
        Stocks (39)
        Genomic Clones (0)
          cDNA Clones (0)

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Antibody Information
                    Laboratory Generated Antibodies
                    Commercially Available Antibodies
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments

                    FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

                    Other Comments
                    Origin and Etymology
                    External Crossreferences and Linkouts ( 8 )
                    Synonyms and Secondary IDs (34)
                    Reported As
                    Symbol Synonym
                    (Chi et al., 2020, Tue et al., 2020, Chatterjee et al., 2019, Deshpande et al., 2019, Higham et al., 2019, Scarpelli et al., 2019, Shim et al., 2019, Bardai et al., 2018, Bardai et al., 2018, Chiku et al., 2018, Guo et al., 2018, Passarella and Goedert, 2018, Sekiya et al., 2018, Sun et al., 2018, Chanu and Sarkar, 2017, Dissel et al., 2017, Frenkel-Pinter et al., 2017, Frenkel-Pinter et al., 2017, Galasso et al., 2017, Kilian et al., 2017, Mao et al., 2017, Sealey et al., 2017, Ando et al., 2016, Ando et al., 2016, Frost et al., 2016, Iyer et al., 2016, Zhang et al., 2016, Huang et al., 2015, Menzies et al., 2015, Santa-Maria et al., 2015, Frost et al., 2014, Merlo et al., 2014, Soundararajan and Bullock, 2014, Chapuis et al., 2013, HGNC Curators and FlyBase Curators, 2013-, Sinadinos et al., 2013, Xiong et al., 2013, Ali et al., 2012, Caesar et al., 2012, Duboff et al., 2012, Park et al., 2012, Ambegaokar and Jackson, 2011, Singh and Mahoney, 2011.2.17, Falzone et al., 2010, Folwell et al., 2010, Iijima-Ando and Iijima, 2010, Iijima-Ando et al., 2010, Iijima et al., 2010, Khurana et al., 2010, Lin et al., 2010, Loewen and Feany, 2010, Moloney et al., 2010, Papanikolopoulou et al., 2010, Williamson and Hiesinger, 2010, Chatterjee et al., 2009, Cao et al., 2008, Blard et al., 2007, Ryoo et al., 2007, Steinhilb et al., 2007, Berger et al., 2006, Grammenoudi et al., 2006, Siyad et al., 2005, Warrick et al., 2005, Fortini, 2004, Mershin et al., 2004, Mudher et al., 2004, Nishimura et al., 2004, Scherzer et al., 2003, Jackson et al., 2002, Ferber, 2001, Wittmann et al., 2001)
                    Name Synonyms
                    G protein beta1/gamma2 subunit-interacting factor 1
                    Microtubule-associated protein tau
                    human MAPT
                    microtubule associated protein tau
                    microtubule-associated protein tau
                    microtubule-associated protein tau, isoform 4
                    protein phosphatase 1, regulatory subunit 103
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project Type
                      References (214)