FlyBase Gene Report: Dmel\kek2

General Information

Symbol

Dmel\kek2

Species

D. melanogaster

Name

kekkon 2

Annotation Symbol

CG4977

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015400

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

CT15962

Key Links

Genomic Location

Cytogenetic map

32F3-32F4

Sequence location

2L:11,581,937..11,626,883 [+]

Recombination map

2-44

RefSeq locus

NT_033779 REGION:11581937..11626883

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (1 term)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from sequence model

(Derheimer et al., 2004, Musacchio and Perrimon, 1996)

Gene Group (FlyBase)

KEKKONS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

KEKKONS -: Kekkons are transmembrane leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domain-containing (LIG) proteins. Kekkons may function in cell adhesion and the modulation of receptor tyrosine kinase signaling. (Adapted from FBrf0179316, FBrf0207272 and FBrf0107731).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\kek2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VKG1)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

kek2-RA

FBtr0080252

NM_078827

6939

894

Additional Transcript Data and Comments

Reported size (kB)

5.9 (northern blot)

(Musacchio and Perrimon, 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

kek2-PA

FBpp0079836

97.5

894

5.68

Q9VKG1

NP_523551

AAF53111

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

96 (kD predicted)

(Musacchio and Perrimon, 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kek2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kek2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

central nervous system | restricted

(Musacchio and Perrimon, 1996)

presumptive embryonic/larval peripheral nervous system

(Musacchio and Perrimon, 1996)

head | lateral

(Musacchio and Perrimon, 1996)

ventral midline of embryo

(Musacchio and Perrimon, 1996)

larval ventral nerve cord

(Ulian-Benitez et al., 2017)

larval peripheral nervous system

(Ulian-Benitez et al., 2017)

embryonic stage 11

ventral midline of embryo | precursor

(Musacchio and Perrimon, 1996)

Additional Descriptive Data

kek2 transcripts are first expressed in a small, segmentally repeated set of cells at the dorsal midline of the CNS at stage 11. It is then expressed in a ventral group of midline cells and then in many more cells in the CNS. In the PNS, expression is seen in a small group of lateral cell clusters and in a group of ventral cell clusters. It is also expressed transiently in a lateral patch in the head and in segmentally repeated ventrolateral patches outside of the CNS which correspond to the position of extending ventrolateral muscles.

(Musacchio and Perrimon, 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kek2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kek2

View exonic expression by tissue for Dmel\kek2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34582/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015400

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015400

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015400

Flygut - An atlas of the Drosophila adult midgut

FBgn0015400

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kek2

Transgenic constructs containing regulatory region of kek2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(2L)CRIMIC-CR70688

(Gene Disruption Project members, 2018-)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

kek2^GD14379

partially lethal - majority die, with Scer\GAL4^pnr-MD237

kek2^GD2505

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kek2^GD9

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

kek2^GD9

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kek2^GD9

some die during pupal stage, with Scer\GAL4^pnr-MD237

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (92)

Hsap\ADGRA3

2 of 14

Yes

Hsap\LINGO1

2 of 14

Yes

Hsap\LINGO2

2 of 14

Yes

Hsap\LINGO3

2 of 14

Yes

Hsap\LINGO4

2 of 14

Yes

Hsap\LRFN1

2 of 14

Yes

Hsap\LRRC4B

2 of 14

Yes

Hsap\LRRC4C

2 of 14

Yes

Hsap\LRRC4

2 of 14

Yes

Hsap\LRRC24

2 of 14

Yes

Hsap\OMG

2 of 14

Yes

Hsap\PXDN

2 of 14

Yes

Hsap\ADGRA2

1 of 14

Hsap\AMIGO1

1 of 14

Hsap\AMIGO2

1 of 14

Yes

Hsap\AMIGO3

1 of 14

Yes

Hsap\BGN

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\ELFN1

1 of 14

Hsap\FLRT2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\IGLV5-45

1 of 14

Yes

Hsap\IGLV11-55

1 of 14

Yes

Hsap\IGSF10

1 of 14

Hsap\IGSF11

1 of 14

Yes

Hsap\ISLR2

1 of 14

Hsap\ISLR

1 of 14

Hsap\JAML

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\LRRC26

1 of 14

Hsap\LRRC52

1 of 14

Hsap\LRRC55

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\MPZL1

1 of 14

Yes

Hsap\MPZL2

1 of 14

Yes

Hsap\MPZL3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RTN4RL1

1 of 14

Hsap\RTN4RL2

1 of 14

Hsap\SCN2B

1 of 14

Yes

Hsap\SCN4B

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\VSIG2

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (49)

Rnor\Lrrc24

4 of 14

Yes

Rnor\Adgra3

2 of 14

Rnor\Lingo4

2 of 14

Rnor\Lrfn1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Amigo3

1 of 14

Yes

Rnor\Chadl

1 of 14

Rnor\Elfn2

1 of 14

Rnor\Flrt2

1 of 14

Yes

Rnor\Igsf10

1 of 14

Rnor\Islr2

1 of 14

Rnor\Islr

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Lrfn3

1 of 14

Rnor\Lrfn4

1 of 14

Rnor\Lrfn5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Slitrk6

1 of 14

Yes

Mus musculus (laboratory mouse) (54)

Mmus\Lingo3

2 of 14

Yes

Mmus\Lingo4

2 of 14

Yes

Mmus\Lrfn1

2 of 14

Yes

Mmus\Lrrc4b

2 of 14

Yes

Mmus\Lrrc4c

2 of 14

Yes

Mmus\Lrrc4

2 of 14

Yes

Mmus\Lrrc19

2 of 14

Yes

Mmus\Lrrc24

2 of 14

Yes

Mmus\Slitrk6

2 of 14

Yes

Mmus\Adgra3

1 of 14

Mmus\Amigo1

1 of 14

Mmus\Amigo2

1 of 14

Yes

Mmus\Amigo3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lrfn3

1 of 14

Mmus\Lrfn4

1 of 14

Mmus\Lrfn5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Lrrc55

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Slitrk2

1 of 14

Yes

Mmus\Slitrk3

1 of 14

Yes

Mmus\Slitrk4

1 of 14

Yes

Mmus\Slitrk5

1 of 14

Yes

Mmus\Tlr5

1 of 14

Xenopus tropicalis (Western clawed frog) (69)

Xtro\lrrc24

3 of 13

Yes

Xtro\vasn

3 of 13

Yes

Xtro\adgra3

2 of 13

Xtro\LOC116409761

2 of 13

Yes

Xtro\lrfn1.1

2 of 13

Yes

Xtro\lrrc4b

2 of 13

Yes

Xtro\lrrc4c

2 of 13

Yes

Xtro\lrrc4

2 of 13

Yes

Xtro\pxdn

2 of 13

Xtro\adgra2

1 of 13

Xtro\amigo1

1 of 13

Yes

Xtro\amigo3

1 of 13

Yes

Xtro\cetn3

1 of 13

Yes

Xtro\chadl

1 of 13

Xtro\cpn2.2

1 of 13

Xtro\dusp4

1 of 13

Yes

Xtro\elfn1

1 of 13

Yes

Xtro\elfn2

1 of 13

Xtro\esam

1 of 13

Yes

Xtro\flrt1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lgi1

1 of 13

Yes

Xtro\lgi4

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101730428

1 of 13

Xtro\LOC101733331

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\mpzl2

1 of 13

Yes

Xtro\mpz

1 of 13

Yes

Xtro\mxra5

1 of 13

Xtro\nectin1

1 of 13

Yes

Xtro\pde6g

1 of 13

Xtro\rtn4rl2

1 of 13

Xtro\scn3b

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slitrk2

1 of 13

Yes

Xtro\slitrk3

1 of 13

Yes

Xtro\slitrk4

1 of 13

Yes

Xtro\slitrk5

1 of 13

Xtro\slitrk6

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (66)

Drer\lingo4a

4 of 14

Yes

Drer\lingo1a

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\lrfn4a

2 of 14

Yes

Drer\lrfn4b

2 of 14

Yes

Drer\lrfn5a

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\pxdn

2 of 14

Drer\si:cabz01090165.1

2 of 14

Drer\si:ch211-170a17.1

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\amigo3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\lrrc53

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch211-159i8.4

1 of 14

Drer\si:ch211-180f4.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\iglr-3

2 of 14

Yes

Cele\slt-1

2 of 14

Yes

Cele\sma-10

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP009138

8 of 12

Yes

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\AT1G03440

1 of 13

Yes

Atha\AT3G15410

1 of 13

Yes

Atha\AT3G17640

1 of 13

Yes

Atha\AT4G03010

1 of 13

Yes

Atha\PIRL8

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:kek2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

8 of 13

5 of 13

4 of 13

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Lrt

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

chp

1 of 13

Fili

1 of 13

haf

1 of 13

hfw

1 of 13

Lapsyn

1 of 13

lbk

1 of 13

otk

1 of 13

Pxn

1 of 13

rdo

1 of 13

sli

1 of 13

swi2

1 of 13

Toll-6

1 of 13

Toll-7

1 of 13

trn

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

kek2

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek2 - kek1

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek2 - kek5

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek2 - kek6

anti tag coimmunoprecipitation, anti tag western blot

(MacLaren et al., 2004)

kek2 - spz5

anti tag coimmunoprecipitation, anti tag western blot

(Ulian-Benitez et al., 2017)

RNA-RNA

Physical Interaction

Assay

References

kek2 - mir-184

luminiscence technology

(Iovino et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

spz5|NT1

suppressible

kek2

(Ulian-Benitez et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60635

DroID - A comprehensive database of gene and protein interactions.

FBgn0015400

MIST (protein-protein) - An integrated Molecular Interaction Database

34582

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Platelet degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-44

Cytogenetic map

32F3-32F4

Sequence location

2L:11,581,937..11,626,883 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

32F3-32F4

; Limits computationally determined from genome sequence between P{PZ}salm⁰³⁶⁰² and P{PZ}crol⁰⁴⁴¹⁸&P{EP}crol^EP1183

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-44

(FlyBase, 2016)

2-38.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38175

y¹ w^*; Mi{MIC}Mst33A^MI04845/SM6a

31874

y¹ sc^* v¹ sev²¹; P{TRiP.HM05267}attP2

Korea

11908

P{VT005948-GAL4}attP2

15946

P{VT005948-lexA}JK22C

NIG-Fly

HMJ21692

y¹ v¹; P{TRiP.HMJ21692}attP40

M2L-2018

y¹ w¹¹¹⁸; kek2^SK2 P{neoFRT}40A/CyO-Tb

M2L-2019

y¹ w¹¹¹⁸; kek2^SK5 P{neoFRT}40A/CyO-Tb

2LG-1611

y² VhaAC39-1^cho-1 v¹; P{U6-kek2.NIG.sgRNA}attP40/CyO

VDRC

v42450

w¹¹¹⁸; P{GD9}v42450

v4745

w¹¹¹⁸; P{GD2505}v4745

Genomic Clones (48)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (7)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015400

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015400

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

kek1 and kek2, or additional genes, may overlap in function in the assembly of the CNS.

(Musacchio and Perrimon, 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

The kek2 gene may have been derived from the kek6 gene by retroposition.

(Pan and Zhang, 2009)

Nomenclature History

Source for database identify of

Source for identity of: kek2 CG4977

(Zhong, 1999.11)

Nomenclature comments

Etymology

kek1 and kek2 represent the union of two superfamilies within one molecule (leucine-rich repeat and immunoglobulin superfamily), so they have been named "kekkon", the Japanese word for marriage.

(Musacchio and Perrimon, 1996)

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG4977

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Pan and Zhang, 2009, Perkins et al., 2009)

CT15962

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Kek2

(Berry et al., 2024, Musacchio and Perrimon, 1996)

NB7

(Musacchio and Perrimon, 1996)

kek-2

(Ulian-Benitez et al., 2017)

kek2

(Zhang et al., 2023, Velten et al., 2022, Ulian-Benitez et al., 2017, dos Santos, 2014, Ozkan et al., 2013, Kong et al., 2010, Iovino et al., 2009, Adryan et al., 2007, Chintapalli et al., 2007)

Name Synonyms

Kekkon-2

(Vogel et al., 2003)

kekkon

(Bogdan and Klämbt, 2001)

kekkon 2

kekkon-2

(Tsuda et al., 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 41 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34582

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VKG1

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VKG1

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34582/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015400

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015400

FlyMine - An integrated database for Drosophila genomics

FBgn0015400

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4977

MARRVEL_MODEL - MARRVEL (model organism gene)

34582

Linkouts

BioGRID - A database of protein and genetic interactions.

60635

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015400

DroID - A comprehensive database of gene and protein interactions.

FBgn0015400

DRSC - Results frm RNAi screens

FBgn0015400

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kek2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015400

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015400

Flygut - An atlas of the Drosophila adult midgut

FBgn0015400

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

34582

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Platelet degranulation

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

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