FB2020_06, released Dec 22, 2020

Gene: Dmel\Dref

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General Information
Symbol
Dmel\Dref
Species
D. melanogaster
Name
DNA replication-related element factor
Annotation Symbol
CG5838
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015664
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Snapshot
DNA replication-related element factor (Dref) encodes a BED finger-type transcription factor that binds to the DRE sequence (TATCGATA). The Dref product is involved in tumor suppressor, TOR, JNK and EGFR signalling pathways. It also plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. [Date last reviewed: 2018-09-20]
Other Summaries
Also Known As

DRE-binding factor, dDREF, DNA replication-related element-binding factor, DNA replication-related element binding factor

Key Links
Genomic Location
Cytogenetic map
30F2-30F3
Sequence location
2L:9,964,147..9,967,229 [-]
Recombination map

2-38

RefSeq locus
NT_033779 REGION:9964147..9967229
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables DNA binding
inferred from direct assay
(Ida et al., 2009)
contributes_to RNA polymerase II core promoter sequence-specific DNA binding
inferred from physical interaction with FLYBASE:Trf2; FB:FBgn0261793
(Hochheimer et al., 2002)
enables transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Nakamura et al., 2008, Ida et al., 2007, Phuong Thao et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables calcium ion binding
inferred from sequence or structural similarity with UniProtKB:Q96RR4
(assigned by UniProt )
(UniProt Curators, 2002-)
Biological Process (15 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in chaeta development
inferred from mutant phenotype
(Kawamori and Yamaguchi, 2011)
involved_in compound eye development
inferred from mutant phenotype
(Hirose et al., 2001)
involved_in compound eye morphogenesis
inferred from mutant phenotype
(Hirose et al., 2001)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Iyer et al., 2013)
involved_in DNA endoreduplication
inferred from mutant phenotype
(Kawamori and Yamaguchi, 2011)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Ida et al., 2009)
involved_in positive regulation of transcription, DNA-templated
inferred from mutant phenotype
(Nakamura et al., 2008)
involved_in regulation of apoptotic process
inferred from direct assay
(Hirose et al., 2001)
involved_in regulation of cell proliferation involved in compound eye morphogenesis
inferred from direct assay
(Jasper et al., 2002)
involved_in regulation of DNA biosynthetic process
inferred from direct assay
(Hirose et al., 2001)
involved_in regulation of mitochondrial depolarization
inferred from mutant phenotype
(Kim et al., 2007)
involved_in regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Hochheimer et al., 2002)
involved_in sensory organ precursor cell division
inferred from mutant phenotype
(Kawamori and Yamaguchi, 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in protein autophosphorylation
inferred from sequence or structural similarity with UniProtKB:Q96RR4
(assigned by UniProt )
(UniProt Curators, 2002-)
involved_in protein phosphorylation
inferred from sequence or structural similarity with UniProtKB:Q96RR4
(assigned by UniProt )
(UniProt Curators, 2002-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN005285218
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ida et al., 2009, Hochheimer et al., 2002)
located_in polytene chromosome
inferred from direct assay
(Valadez-Graham et al., 2012)
part_of transcription regulator complex
inferred from physical interaction with FLYBASE:Trf2; FB:FBgn0261793
(Hochheimer et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN005285218
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Dref for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

5' terminus determined by primer extension (FBrf0086456)

Gene model reviewed during 5.43

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Dref-RA
FBtr0079889
NM_078805
2872
709
Dref-RB
FBtr0310483
NM_001273382
2739
709
Additional Transcript Data and Comments
Reported size (kB)

2.9 (northern blot)

(Hirose et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Dref-PA
FBpp0079485
80.7
709
5.71
NP_523529
AAF52841
Dref-PB
FBpp0302627
80.7
709
5.71
NP_001260311
AGB92846
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

709 aa isoforms: Dref-PA, Dref-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

709 (aa)

(Takahashi et al., 1999)

701 (aa); 80 (kD predicted)

(Hirose et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dref using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
wandering third instar larval stage
wing pouch | restricted
(Molnar et al., 2012)
wing hinge primordium | restricted
(Molnar et al., 2012)
third instar larval stage
eye disc anterior to the morphogenetic furrow
(Hyun et al., 2005)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Hirose et al., 1996)
Additional Descriptive Data

Dref expression is high in the dividing and growing cells of the third instar larval eye disc, which are located anterior to the morphogenetic furrow.

(Hyun et al., 2005)

Dref transcripts are detected at the highest levels in 4-8hr embryos, in moderately high levels in unfertilized eggs, 2-4hr embryos, and adult females and at low levels in larvae, pupae, and adult males on northern blots.

(Hirose et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
cultured cell-line
• nucleus

Comment: D1 cells

(Hart et al., 1999)
embryonic stage 3 -- 13
organism | ubiquitous
• nucleus
(Hart et al., 1999)
embryonic stage 5 -- 13
cell
• nucleus
(Hart et al., 1999)
wandering third instar larval stage
eye disc anterior to the morphogenetic furrow

Comment: cells entering G1 phase

(Hirose et al., 2001)
eye disc posterior to the morphogenetic furrow

Comment: cells in S-phase zone of second mitotic wave

(Hirose et al., 2001)
adult stage | male
testis | apical
(Ida et al., 2009)
adult stage
intestinal stem cell
(Park et al., 2010)
enteroblast
(Park et al., 2010)
third instar larval stage
prothoracic gland
(Park et al., 2012)
oogenesis & adult stage | female
nurse cell
(Park et al., 2012)
adult stage | female & oogenesis
follicle cell
(Park et al., 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Ovarian expression of Dref is strong in nurse cells and follicle cells at 5 days post eclosion, but by 60 days post eclosion very little remains.

(Park et al., 2012)

Dref is detected in the nuclei in most cells of the adult midgut including intestinal stem cells and enteroblasts.

(Park et al., 2010)

Up until nuclear cycle 7, weak staining is observed in the nuclei and surrounding cytoplasm of embryos. After cycle 8, strong and uniform nuclear staining is observed.

(Hirose et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Ida et al., 2009, Hochheimer et al., 2002)
located_in polytene chromosome
inferred from direct assay
(Valadez-Graham et al., 2012)
part_of transcription regulator complex
inferred from physical interaction with FLYBASE:Trf2; FB:FBgn0261793
(Hochheimer et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Dref in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Dref
Transgenic constructs containing regulatory region of Dref
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL43735
lethal, with Scer\GAL4ap-md544
lethal, with Scer\GAL4dpp.blk1
lethal, with Scer\GAL4en-e16E
lethal, with Scer\GAL4hs.PB
lethal | larval stage, with Scer\GAL4T80
lethal | pupal stage, with Scer\GAL4T80
lethal - all die before end of larval stage, with Scer\GAL432B
lethal - all die before end of larval stage, with Scer\GAL4Act5C.PHb
lethal - all die before end of larval stage, with Scer\GAL4Cg.PA
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage, with Scer\GAL432B
lethal - all die before end of pupal stage, with Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage, with Scer\GAL4dpp.blk1
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable
viable, with Scer\GAL4GMR.PS
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile, with Scer\GAL4GMR.PS
Other Phenotypes
Allele
decreased cell number | adult stage, with Scer\GAL4GMR.PS
decreased occurrence of cell division | larval stage
decreased occurrence of cell division | larval stage, with Scer\GAL4l(1)BP-1
developmental rate defective, with Scer\GAL4hs.PB
endomitotic cell cycle defective, with Scer\GAL4sca-109-68
increased cell death, with Scer\GAL4ap-md544
increased cell death, with Scer\GAL4en-e16E
increased cell death, with Scer\GAL4GMR.PS
increased cell death | larval stage, with Scer\GAL4GMR.PS
increased occurrence of cell division | larval stage, with Scer\GAL4GMR.PS
increased occurrence of cell division | larval stage, with Scer\GAL4l(1)BP-1
melanotic mass phenotype
melanotic mass phenotype, with Scer\GAL4Cg.PA
melanotic mass phenotype, with Scer\GAL4hs.PB
melanotic mass phenotype | larval stage, with Scer\GAL4Cg.PA
mitotic cell cycle defective, with Scer\GAL4GMR.PS
neuroanatomy defective, with Scer\GAL4221
neuroanatomy defective, with Scer\GAL4ppk.1.9
neuroanatomy defective | larval stage
size defective | embryonic stage, with Scer\GAL4l(1)BP-1
some die during larval stage, with Scer\GAL432B
some die during larval stage, with Scer\GAL4Act5C.PHb
some die during larval stage, with Scer\GAL4Cg.PA
some die during pupal stage
some die during pupal stage, with Scer\GAL432B
some die during pupal stage, with Scer\GAL4Act5C.PI
some die during pupal stage, with Scer\GAL4dpp.blk1
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL41854
visible, with Scer\GAL4Act88F.PD
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4Dll-md23
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PS
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4ptc-559.1
visible | cold sensitive, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
adult thorax, with Scer\GAL4pnr-MD237
adult thorax | dorsal, with Scer\GAL4pnr-MD237
anterior dorsocentral bristle, with Scer\GAL4sca-109-68
anterior scutellar bristle, with Scer\GAL4sca-109-68
embryonic/larval salivary gland | embryonic stage, with Scer\GAL4l(1)BP-1
external sensory organ precursor cell, with Scer\GAL4sca-109-68
eye
eye, with Scer\GAL41854
eye, with Scer\GAL4Act88F.PD
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PS
eye, with Scer\GAL4ptc-559.1
eye disc, with Scer\GAL4l(1)BP-1
eye disc | larval stage, with Scer\GAL4GMR.PS
eye disc | third instar larval stage
eye disc posterior compartment | ectopic | larval stage, with Scer\GAL4l(1)BP-1
eye disc posterior to the morphogenetic furrow | larval stage
eye disc posterior to the morphogenetic furrow | larval stage, with Scer\GAL4GMR.PS
ganglion mother cell | larval stage
interommatidial bristle, with Scer\GAL4GMR.PS
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaD, with Scer\GAL4221
larval neuroblast | larval stage
larval ventral multidendritic neuron vdaB, with Scer\GAL4ppk.1.9
macrochaeta, with Scer\GAL4pnr-MD237
macrochaeta, with Scer\GAL4sca-109-68
melanotic mass
melanotic mass, with Scer\GAL4Cg.PA
melanotic mass, with Scer\GAL4hs.PB
microchaeta, with Scer\GAL4ap-md544
mitochondrial membrane | third instar larval stage, with Scer\GAL4GMR.PS
nucleolus, with Scer\GAL4sca-109-68
nucleus, with Scer\GAL4sca-109-68
ommatidium, with Scer\GAL41854
ommatidium, with Scer\GAL4Act88F.PD
ommatidium, with Scer\GAL4GMR.PS
ommatidium, with Scer\GAL4ptc-559.1
photoreceptor cell
photoreceptor cell, with Scer\GAL4GMR.PS
photoreceptor cell R1, with Scer\GAL4GMR.PS
photoreceptor cell R6, with Scer\GAL4GMR.PS
photoreceptor cell R7, with Scer\GAL4GMR.PS
pigment cell
pigment cell, with Scer\GAL4GMR.PS
posterior dorsocentral bristle, with Scer\GAL4sca-109-68
posterior notopleural bristle, with Scer\GAL4sca-109-68
posterior scutellar bristle, with Scer\GAL4sca-109-68
presutural bristle, with Scer\GAL4sca-109-68
scutellar bristle | ectopic, with Scer\GAL4ptc-559.1
tormogen cell, with Scer\GAL4sca-109-68
trichogen cell, with Scer\GAL4sca-109-68
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4ptc-559.1
wing | cold sensitive, with Scer\GAL4Bx-MS1096
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc | dorsal, with Scer\GAL4ap-md544
wing disc posterior compartment, with Scer\GAL4en-e16E
wing margin, with Scer\GAL4Dll-md23
wing margin bristle | somatic clone, with Scer\GAL4Act5C.PI
wing vein L5, with Scer\GAL4en-e16E
wing vein L5 | distal, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ZBED1
3 of 15
Yes
No
Hsap\DHRSX
2 of 15
No
No
Hsap\ZBED6
2 of 15
No
No
Hsap\ALG12
1 of 15
No
No
Hsap\ZBED4
1 of 15
No
No
Hsap\ZNF618
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Zbed4
2 of 15
Yes
No
Mmus\Zbed6
1 of 15
No
No
Mmus\Zfp618
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Zbed4
1 of 13
Yes
No
Rnor\Zbed6
1 of 13
Yes
Yes
Rnor\Zfp618
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (9)
Xtro\LOC100486384
2 of 12
Yes
Yes
Xtro\LOC105945140
2 of 12
Yes
No
Xtro\zbed1
2 of 12
Yes
No
Xtro\zbed4
2 of 12
Yes
No
Xtro\LOC101731619
1 of 12
No
No
Xtro\LOC105946827
1 of 12
No
No
Xtro\LOC108644464
1 of 12
No
No
Xtro\zbed6cl
1 of 12
No
No
Xtro\znf618
1 of 12
No
Yes
Danio rerio (Zebrafish) (24)
Drer\si:ch211-152f22.4
4 of 15
Yes
No
Drer\si:dkey-13n23.3
4 of 15
Yes
No
Drer\zgc:161969
3 of 15
No
No
Drer\mybl2a
2 of 15
No
No
Drer\si:dkey-5n7.2
2 of 15
No
No
Drer\si:dkey-109j17.5
2 of 15
No
No
Drer\si:dkeyp-117b8.4
2 of 15
No
Yes
Drer\zbed4
2 of 15
No
No
Drer\LOC100333415
1 of 15
No
No
Drer\LOC100334312
1 of 15
No
Yes
Drer\LOC101884285
1 of 15
No
No
Drer\LOC101885930
1 of 15
No
Yes
Drer\LOC101886897
1 of 15
No
No
Drer\LOC103910645
1 of 15
No
Yes
Drer\LOC103911321
1 of 15
No
Yes
Drer\LOC108179993
1 of 15
No
No
Drer\LOC108180016
1 of 15
No
No
Drer\LOC108180722
1 of 15
No
Yes
Drer\LOC108183756
1 of 15
No
Yes
Drer\LOC110438673
1 of 15
No
No
Drer\LOC110439531
1 of 15
No
Yes
Drer\si:dkeyp-106c3.2
1 of 15
No
No
Drer\sinhcafl
1 of 15
No
No
Drer\znf618
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (19)
Cele\bed-3
3 of 15
Yes
Yes
Cele\C10A4.1
3 of 15
Yes
No
Cele\K09A11.1
3 of 15
Yes
No
Cele\B0545.4
2 of 15
No
No
Cele\C53D6.6
2 of 15
No
No
Cele\ets-6
2 of 15
No
No
Cele\F19F10.11
2 of 15
No
Yes
Cele\F46F2.4
2 of 15
No
No
Cele\gon-14
2 of 15
No
No
Cele\sdz-19
2 of 15
No
Yes
Cele\Y67D8C.3
2 of 15
No
No
Cele\ZK662.5
2 of 15
No
No
Cele\bed-2
1 of 15
No
Yes
Cele\F28A10.4
1 of 15
No
Yes
Cele\H25P06.5
1 of 15
No
Yes
Cele\lin-15B
1 of 15
No
Yes
Cele\T23E1.3
1 of 15
No
Yes
Cele\Y32B12B.4
1 of 15
No
Yes
Cele\Y105C5A.15
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT1G18560
1 of 9
Yes
No
Atha\DAYSLEEPER
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\ENV11
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903JJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000422
Drosophila simulans
Dsim\GD22316
Drosophila sechellia
Dsec\GM12069
Drosophila erecta
Dere\GG23986
Drosophila yakuba
Dyak\Dref
Drosophila ananassae
Dana\Dref
Drosophila pseudoobscura pseudoobscura
Dpse\Dref
Drosophila persimilis
Dper\GL19191
Drosophila willistoni
Dwil\GK14535
Drosophila virilis
Dvir\Dref
Drosophila mojavensis
Dmoj\Dref
Drosophila grimshawi
Dgri\GH10661
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501YO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009702
Glossina morsitans
Tsetse fly
Gmor\GMOY006740
Mayetiola destructor
Hessian fly
Mdes\Mdes012322
Mayetiola destructor
Hessian fly
Mdes\Mdes018324
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01LZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA014060
Bombyx mori
Silkmoth
Bmor\BGIBMGA014343
Apis florea
Little honeybee
Aflo\4355792196
Apis mellifera
Western honey bee
Amel\GB49604
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24471
Bombus terrestris
Buff-tailed bumblebee
Bter\15211987
Linepithema humile
Argentine ant
Lhum\LH11830
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001614
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG029434
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007037
Pediculus humanus
Human body louse
Phum\PHUM222180
Cimex lectularius
Bed bug
Clec\CLEC002608
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI28891
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI51144
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI22156
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI087072
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI32286
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073292
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI39125
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI24347
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI060504
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI089486
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI20572
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI23558
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI50416
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI29129
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI42913
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI31694
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI26298
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI26143
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18610
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HN5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63234.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02700
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_232346
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_316403
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303599
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_324460
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_122497
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_336890
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_320025
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_319016
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_333991
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG16863
4 of 10
CG13775
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ZBED1; zinc finger BED-type containing 1
    3 of 15
    300178
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Dref
        two hybrid, two hybrid array
        (Shokri et al., 2019, Hu et al., 2017.6.13)
        Dref - Akt1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Dref - BEAF-32
        anti bait coimmunoprecipitation, western blot
        (Lhoumaud et al., 2014)
        Dref - BuGZ
        two hybrid array
        (Shokri et al., 2019)
        Dref - CG10465
        two hybrid
        (Hu et al., 2017.6.13)
        Dref - CG4820
        two hybrid array, bimolecular fluorescence complementation, fluorescence microscopy
        (Shokri et al., 2019)
        Dref - CG5515
        two hybrid
        (Hu et al., 2017.6.13)
        Dref - Caf1-55
        anti bait coimmunoprecipitation, western blot
        (Hochheimer et al., 2002)
        Dref - Dll
        pull down, autoradiography, two hybrid array
        (Shokri et al., 2019, Hayashi et al., 2006)
        Dref - Dsp1
        two hybrid array
        (Shokri et al., 2019)
        Dref - Iswi
        anti bait coimmunoprecipitation, western blot
        (Hochheimer et al., 2002)
        Dref - Mlf
        anti bait coimmunoprecipitation, western blot
        (Yanai et al., 2014)
        Dref - Pdk1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Dref - Rpn13
        two hybrid
        (Hu et al., 2017.6.13)
        Dref - S6k
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Dref - Sox21b
        two hybrid array
        (Shokri et al., 2019)
        Dref - Sry-δ
        two hybrid array
        (Shokri et al., 2019)
        Dref - Trf2
        anti bait coimmunoprecipitation, western blot
        (Hochheimer et al., 2002)
        Dref - Ubx
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        Dref - Vsx2
        two hybrid array
        (Shokri et al., 2019)
        Dref - XNP
        pull down, autoradiography, two hybrid, anti bait coimmunoprecipitation, western blot
        (Valadez-Graham et al., 2012)
        Dref - abd-A
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        Dref - exd
        bimolecular fluorescence complementation, fluorescence microscopy
        (Bischof et al., 2018)
        Dref - eyg
        two hybrid array
        (Shokri et al., 2019)
        Dref - gig
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Dref - prd
        two hybrid array
        (Shokri et al., 2019)
        Dref - pzg
        two hybrid array
        (Shokri et al., 2019)
        Dref - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Dref
        suppressible
        BEAF-32
        (Yoshida et al., 2001)
        Dref
        suppressible
        bib
        (Park et al., 2008)
        Dref
        suppressible
        brm
        (Hirose et al., 2001)
        Dref
        suppressible
        bsk
        (Yoshioka et al., 2012)
        Dref
        suppressible
        crol
        (Ida et al., 2009)
        Dref
        suppressible
        Cul3
        (Ida et al., 2009)
        Dref
        suppressible
        Cyt-c-d
        (Ida et al., 2009)
        Dref
        suppressible
        Diap1
        (Hirose et al., 2001)
        Dref
        suppressible
        Diap2
        (Hirose et al., 2001)
        Dref
        enhanceable
        Dll
        (Hirose et al., 2001)
        Dref
        enhanceable
        dome
        (Ida et al., 2009)
        Dref
        enhanceable
        ds
        (Ida et al., 2009)
        Dref
        suppressible
        E2f1
        (Hirose et al., 2001)
        Dref
        suppressible
        E(Pc)
        (Hirose et al., 2001)
        Dref
        suppressible
        eIF4A
        (Ida et al., 2009, Ida et al., 2007)
        Dref
        enhanceable
        fs(1)h
        (Ida et al., 2009)
        Dref
        suppressible
        HP6
        (Ida et al., 2009)
        Dref
        enhanceable
        HP6
        (Ida et al., 2009)
        Dref
        suppressible
        Hsf
        (Ida et al., 2009)
        Dref
        suppressible
        J29
        (Ida et al., 2009)
        Dref
        suppressible
        Kdm5
        (Ida et al., 2009)
        Dref
        suppressible
        l(1)G0004
        (Ida et al., 2009)
        Dref
        enhanceable
        l(1)G0196
        (Ida et al., 2009)
        Dref
        enhanceable
        l(1)G0219
        (Ida et al., 2009)
        Dref
        enhanceable
        l(1)G0228
        (Ida et al., 2009)
        Dref
        suppressible
        l(1)G0287
        (Ida et al., 2009)
        Dref
        enhanceable
        l(1)G0332
        (Ida et al., 2009)
        Dref
        enhanceable
        l(1)G0372
        (Ida et al., 2009)
        Dref
        suppressible
        l(2)10685
        (Ida et al., 2009)
        Dref
        suppressible
        l(2)k05448
        (Ida et al., 2009)
        Dref
        enhanceable
        l(2)k06107
        (Ida et al., 2009)
        Dref
        suppressible
        l(2)k06506
        (Ida et al., 2009)
        Dref
        suppressible
        l(2)k07219
        (Ida et al., 2009)
        Dref
        suppressible
        l(2)k07308
        (Ida et al., 2009)
        Dref
        suppressible
        lace
        (Ida et al., 2009)
        Dref
        suppressible
        MESK2
        (Ida et al., 2009)
        Dref
        suppressible
        MFS14
        (Ida et al., 2009)
        Dref
        suppressible
        Mlf
        (Ohno et al., 2000)
        Dref
        suppressible
        mor
        (Nakamura et al., 2008, Hirose et al., 2001)
        Dref
        enhanceable
        mys
        (Ida et al., 2009)
        Dref
        suppressible
        osa
        (Nakamura et al., 2008, Hirose et al., 2001)
        Dref
        suppressible
        p53
        (Trong-Tue et al., 2010)
        Dref
        enhanceable
        Phf7
        (Ida et al., 2009)
        Dref
        enhanceable
        pigeon
        (Ida et al., 2009)
        Dref
        suppressible
        Rab6
        (Ida et al., 2009)
        Dref
        suppressible
        Raf
        (Yoshida et al., 2004)
        Dref
        suppressible
        RpS26
        (Ida et al., 2009)
        Dref
        enhanceable
        S
        (Ida et al., 2009)
        Dref
        suppressible
        schlank
        (Ida et al., 2009)
        Dref
        suppressible
        SkpA
        (Phuong Thao et al., 2006)
        Dref
        suppressible
        stau
        (Ida et al., 2009)
        Dref
        suppressible
        sw
        (Ida et al., 2009)
        Dref
        suppressible
        TAF1C-like
        (Ida et al., 2009)
        Dref
        enhanceable
        Tom40
        (Ida et al., 2009)
        Dref
        enhanceable
        Trf2
        (Ida et al., 2009)
        Dref
        suppressible
        Xbp1
        (Ida et al., 2009)
        Dref
        suppressible
        XNP
        (Valadez-Graham et al., 2012)
        Dref
        enhanceable
        Ykt6
        (Ida et al., 2009)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-38

        Cytogenetic map
        30F2-30F3
        Sequence location
        2L:9,964,147..9,967,229 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        30F2-30F3
        Limits computationally determined from genome sequence between P{EP}CG5899EP701 and P{EP}CG4747EP594&P{lacW}l(2)k13305k13305
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        30F-30F
        (Hirose, 1998.1.31)
        Experimentally Determined Recombination Data
        Location

        2-38

        (FlyBase, 2016)

        2-32.4

        (Comeron et al., 2012)

        2-

        (Hirose, 1998.1.31)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (15)
        Genomic Clones (15)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (94)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Vo et al., 2014, Trong-Tue et al., 2010, Hart et al., 1999, Yamaguchi et al., 1995)

        monoclonal

        (Lhoumaud et al., 2014)

        monoclonal, polyclonal

        (Hirose et al., 1996)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        Other Comments

        Dref regulations transcription of p53.

        (Trong-Tue et al., 2010)

        RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

        (Goshima et al., 2007)

        Dref overexpression stimulates Cat gene transcription.

        (Park et al., 2004)

        Dref and BEAF-32 may compete for binding to overlapping sites in vivo.

        (Hart et al., 1999)

        Dref is required for normal DNA replication in both the mitotic cell cycle and endo cycle.

        (Hirose et al., 1999)

        A Dref cDNA has been cloned and sequenced. Deletion analysis indicates that part of the N-terminal basic amino acid region is responsible for the specific binding of Dref to the DNA replication-related element (DRE).

        (Hirose et al., 1996)

        Analysis of DNApol-α73-Ecol\CAT deletion constructs shows that full promoter activity is located within the region from -285 to +129bp of DNApol-α73. Three DREs (DNA-replication related elements) are located within this region, and DNA footprinting analysis shows that Dref can bind to all three sites. Mutation of any one of the DRE sites causes extensive reductions in promoter activity and Dref binding to the promoter fragment.

        (Takahashi et al., 1996)

        Expression pattern and subcellular distribution of the protein during development is studied using antibodies.

        (Yamaguchi et al., 1995)

        DNApol-α180 and mus209 are negatively regulated by zen protein. This repression is mediated by the DRE (DNA replication-related element) sites in the DNApol-α180 and mus209 promoters. The amount of Dref is reduced in transfected Kc cells expressing zen, suggesting that zen represses expression of DNA replication-related genes by reducing the amount of Dref.

        (Hirose et al., 1994)

        Specific binding factor that binds to the 8bp palindrome required for high expression of DNApol-α and mus209. The 86kD gene product has been purified.

        (Hirose et al., 1993)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 44 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (17)
        Reported As
        Symbol Synonym
        CG5838
        (Hosono et al., 2015, Ni et al., 2011.7.19, Rees et al., 2011, Perkins et al., 2009, Goshima et al., 2007, Molnar et al., 2006, Brody et al., 2002)
        DREF
        (Dong et al., 2020, Mouawad et al., 2020, Texada et al., 2020, Neves and Eisenman, 2019, Kim et al., 2018, Afik et al., 2017, Baumann and Gilmour, 2017, Cubeñas-Potts et al., 2017, Liu et al., 2017, Mourad et al., 2017, Tue et al., 2017, Kwon et al., 2016, Hull et al., 2015, Li et al., 2015, Liu et al., 2015, Nikalayevich and Ohkura, 2015, Lhoumaud et al., 2014, Rhee et al., 2014, Van Bortle et al., 2014, Yanai et al., 2014, Fernández-Moreno et al., 2013, Gurudatta et al., 2013, Iyer et al., 2013, Kawamori et al., 2013, Kawamori et al., 2013, Merzetti et al., 2013, Morozov and Ioshikhes, 2013, Bruni et al., 2012, Takács et al., 2012, Valadez-Graham et al., 2012, Yoshioka et al., 2012, Kawamori and Yamaguchi, 2011, Park et al., 2011, Roy et al., 2011, Stenberg and Larsson, 2011, Avet-Rochex et al., 2010, Park et al., 2010, Trong-Tue et al., 2010, Fernández-Moreno et al., 2009, Ida et al., 2009, Suyari et al., 2009, Emberly et al., 2008, Nakamura et al., 2008, Park et al., 2008, Villanyi et al., 2008, Ida et al., 2007, Isogai et al., 2007, Kim et al., 2007, Kugler and Nagel, 2007, Plessis et al., 2007, Tsuchiya et al., 2007, Hayashi et al., 2006, Martin-Lanneree et al., 2006, Phuong Thao et al., 2006, Seto et al., 2006, Okudaira et al., 2005, Choi et al., 2004, Choi et al., 2004, Jin et al., 2004, Kwon et al., 2004, Park et al., 2004, Davidson, 2003, Hochheimer and Tjian, 2003, Levine and Tjian, 2003, Masson et al., 2003, Orian et al., 2003, Yoshida et al., 2003, Geyer and Clark, 2002, Hochheimer et al., 2002, Jasper et al., 2002, Sharkov et al., 2002, Takata et al., 2002, Gerasimova and Corces, 2001, Hirose et al., 2001, Takata et al., 2001, Yoshida et al., 2001, Aravind, 2000, Choi et al., 2000, Hart et al., 2000, Ohno et al., 2000, Ruiz de Mena et al., 2000, Hart et al., 1999, Hirose et al., 1999, Hirose, 1998.1.31, Sawado et al., 1998, Takahashi, 1998.11.4, Hayashi et al., 1997, Hirose et al., 1996, Matsukage et al., 1995, Yamaguchi et al., 1995, Hirose et al., 1994)
        DmDREF
        (Kwon et al., 2003)
        Dmel_DREF
        (Ma et al., 2009)
        Dref
        (Hao et al., 2020, Luo et al., 2020, Omura and Lott, 2020, Hall et al., 2019, Henderson et al., 2019, Shokri et al., 2019, Vo Ngoc et al., 2019, Bischof et al., 2018, Haines and Eisen, 2018, Batut and Gingeras, 2017, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Ables et al., 2016, Boija and Mannervik, 2015, Schertel et al., 2015, Vedanayagam and Garrigan, 2015, Zabidi et al., 2015, Zimmermann et al., 2015, Kim and Choe, 2014, Darbo et al., 2013, de Celis et al., 2013.9.11, Iyer et al., 2013, Kwon et al., 2013, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Friedman et al., 2011, Rees et al., 2011, Sultana et al., 2011, Avet-Rochex et al., 2010, Kallappagoudar et al., 2010, Kong et al., 2010, Bai et al., 2009, Harbison et al., 2009, Aerts et al., 2007, Buszczak et al., 2007, Goshima et al., 2007, Molnar et al., 2006, De Lucia et al., 2005, Greene et al., 2005, Hyun et al., 2005, Brodsky et al., 2004, Hirose et al., 2001)
        dDREF
        (Park et al., 2012, Thao et al., 2008, Ida et al., 2007, Hayashi et al., 2006, Yamaguchi et al., 2003, Hirose et al., 2002)
        dref
        (Killip and Grewal, 2012, Kim et al., 2007, Phuong Thao et al., 2006, Yoshida et al., 2004, Kazemi-Esfarjani and Benzer, 2002)
        p80
        (Hochheimer et al., 2002)
        p80/DREF
        (Hochheimer et al., 2002)
        Name Synonyms
        DNA
        (Kwon et al., 2004)
        DNA replication-related element binding factor
        (Park et al., 2011, Hayashi et al., 2006)
        DNA replication-related element factor
        (Iyer et al., 2013, Bai et al., 2009, Plessis et al., 2007, Martin-Lanneree et al., 2006, Hyun et al., 2005)
        DNA replication-related element-binding factor
        (Tue et al., 2017, Kawamori and Yamaguchi, 2011, Trong-Tue et al., 2010, Ida et al., 2009, Ida et al., 2007)
        DNA-replication-related element factor
        (Pedersen et al., 2008)
        DRE (DNA replication-related element) binding factor
        (Choi et al., 2004)
        DRE-binding factor
        (Zabidi et al., 2015, Kim et al., 2007, Tsuchiya et al., 2007, Okudaira et al., 2005, Choi et al., 2004, Jin et al., 2004, Park et al., 2004, Hirose et al., 2001)
        replication-related element-binding factor
        (Kwon et al., 2004)
        Secondary FlyBase IDs
        • FBgn0010077
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        References (194)