FlyBase Gene Report: Dmel\Rab18

General Information

Symbol

Dmel\Rab18

Species

D. melanogaster

Name

Rab18

Annotation Symbol

CG3129

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015794

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Rab-RP4, Rab-related protein 4, DmRab18

Key Links

Genomic Location

Cytogenetic map

5A11-5A11

Sequence location

X:5,670,827..5,671,812 [-]

Recombination map

1-12

RefSeq locus

NC_004354 REGION:5670827..5671812

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:rod; FB:FBgn0003268

(Gillingham et al., 2014)

inferred from physical interaction with FLYBASE:Zw10; FB:FBgn0004643

(Gillingham et al., 2014)

inferred from physical interaction with FLYBASE:spartin; FB:FBgn0037265

(Gillingham et al., 2014)

inferred from physical interaction with FLYBASE:TBC1D5; FB:FBgn0038129

(Gillingham et al., 2014)

inferred from physical interaction with FLYBASE:Lrrk; FB:FBgn0038816

(Gillingham et al., 2014)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables GTPase activity

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN001292747

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in intracellular protein transport

inferred from biological aspect of ancestor with PANTHER:PTN001292747

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in lipid droplet organization

inferred from biological aspect of ancestor with PANTHER:PTN000756441

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in Rab protein signal transduction

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(FlyBase Curators, 2008--)

involved_in vesicle-mediated transport

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(FlyBase Curators, 2008--)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in early endosome

inferred from high throughput direct assay

(Chan et al., 2011)

located_in endoplasmic reticulum

inferred from direct assay

(Gillingham et al., 2014)

located_in Golgi apparatus

inferred from direct assay

(Gillingham et al., 2014)

located_in neuronal cell body

inferred from high throughput direct assay

(Chan et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in endomembrane system

inferred from biological aspect of ancestor with PANTHER:PTN001292747

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN000756440

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in vesicle

inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790

(FlyBase Curators, 2008--)

Gene Group (FlyBase)

RAB GTPASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RAB GTPASES -: The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rab18 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.39

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rab18-RA

FBtr0070849

NM_080005

833

197

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Rab18-PA

FBpp0070814

22.1

197

4.97

NP_524744

AAF46057

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab18 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in early endosome

inferred from high throughput direct assay

(Chan et al., 2011)

located_in endoplasmic reticulum

inferred from direct assay

(Gillingham et al., 2014)

located_in Golgi apparatus

inferred from direct assay

(Gillingham et al., 2014)

located_in neuronal cell body

inferred from high throughput direct assay

(Chan et al., 2011)

Expression Deduced from Reporters

Reporter: PBac{I-SceI(FRT.Rab18-GAL4.ORF(loxP.3xP3-RFP))}

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage P6 -- P7

neuron of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)

mushroom body

Comment: 30-40h APF

(Jin et al., 2012, Chan et al., 2011)

neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)

glial cell of second optic chiasma

Comment: 30-40h APF

(Jin et al., 2012)

eye photoreceptor cell

Comment: 30-40h APF

(Jin et al., 2012)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rab18 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rab18

View exonic expression by tissue for Dmel\Rab18

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015794

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0015794

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3129-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3129

Flygut - An atlas of the Drosophila adult midgut

FBgn0015794

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rab18

Transgenic constructs containing regulatory region of Rab18

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Rab18^EYFP

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Rab18^GD10218

viable, with Scer\GAL4^Mef2.PR

Rab18^GD10218

viable, with Scer\GAL4^pnr-MD237

Rab18^GD10218

viable, with Scer\GAL4^tin.CΔ4

Rab18^GD10218

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\RAB18

13 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Rab18

11 of 15

Yes

Rattus norvegicus (Norway rat) (1)

Rnor\Rab18

11 of 13

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\rab18

12 of 12

Yes

Danio rerio (Zebrafish) (2)

Drer\rab18a

10 of 15

Yes

Drer\rab18b

10 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\rab-18

14 of 15

Yes

Cele\C52B11.5

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\RAB18

6 of 9

Yes

Atha\RABC2A

6 of 9

Yes

Atha\RABC2b

6 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\YPT11

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190FRW )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16152

Drosophila persimilis

Dper\GL18325

Drosophila willistoni

Dwil\GK21207

Drosophila willistoni

Dwil\GK19906

Drosophila virilis

Dvir\GJ16685

Drosophila mojavensis

Dmoj\GI16298

Drosophila grimshawi

Dgri\GH12045

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AVX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17027379

Musca domestica

House fly

Mdoa\17017566

Glossina morsitans

Tsetse fly

Gmor\GMOY002370

Mayetiola destructor

Hessian fly

Mdes\Mdes005623

Anopheles darlingi

American malaria mosquito

Adar\ADAC004327

Anopheles gambiae

Malaria mosquito

Agam\AGAP010875

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ004450

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CR3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA002203

Danaus plexippus

Monarch butterfly

Dple\DPOGS200210-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL014086

Apis florea

Little honeybee

Aflo\2851139284

Apis mellifera

Western honey bee

Amel\Rab-RP4

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP17629

Bombus terrestris

Buff-tailed bumblebee

Bter\15204589

Linepithema humile

Argentine ant

Lhum\LH18621

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG016039

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08308

Tribolium castaneum

Red flour beetle

Tcas\TC014110

Pediculus humanus

Human body louse

Phum\PHUM504120

Rhodnius prolixus

Kissing bug

Rpro\RPRC009243

Cimex lectularius

Bed bug

Clec\CLEC012485

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007125

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007125

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_05324

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CP0 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013231

Ixodes scapularis

Black-legged tick

Isca\ISCW016507

Stegodyphus mimosarum

African social velvet spider

Smim\KFM82763.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur38g00380

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_301483

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0MOO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Rab18

Ciona intestinalis

Vase tunicate

Cint\LOC100185576

Gallus gallus

Domestic chicken

Ggal\LOC425531

Gallus gallus

Domestic chicken

Ggal\RAB18

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (34)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

RAB18; RAB18, member RAS oncogene family

model of Warburg micro syndrome 3

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RAB18; RAB18, member RAS oncogene family

13 of 15

602207

WARBURG MICRO SYNDROME 3; WARBM3

Warburg micro syndrome 3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rab18 - CG15891

experimental knowledge based

(Guruharsha et al., 2011)

Rab18 - CG31935

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab18 - D2hgdh

pull down, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - Echs1

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab18 - Gdi

pull down, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - Lrrk

pull down, anti tag western blot, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - Rint1

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab18 - Slh

pull down, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - TBC1D5

pull down, anti tag western blot, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - Vps26

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Rab18 - Vps28

experimental knowledge based

(Guruharsha et al., 2011)

Rab18 - Vps37B

experimental knowledge based

(Guruharsha et al., 2011)

Rab18 - Zw10

pull down, anti tag western blot, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - rod

pull down, peptide massfingerprinting, anti tag western blot

(Gillingham et al., 2014, Gillingham et al., 2014)

Rab18 - spartin

pull down, peptide massfingerprinting, anti tag western blot

(Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Osbp

suppressible

Rab18

(Ma et al., 2012)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69006

DroID - A comprehensive database of gene and protein interactions.

FBgn0015794

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

44360

MIST (protein-protein) - An integrated Molecular Interaction Database

Rab18

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-12

Cytogenetic map

5A11-5A11

Sequence location

X:5,670,827..5,671,812 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5A11-5A11

Limits computationally determined from genome sequence between P{EP}CG3249^EP1400 and P{EP}Tre1^EP496

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

36A-36B

(Ozaki, 1996.4.3)

Experimentally Determined Recombination Data

Location

1-12

(FlyBase, 2016)

1-14.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Bloomington

21910

w¹¹¹⁸ P{EPg}Rab18^HP11051

27665

y¹ v¹; P{TRiP.JF02744}attP2

50779

P{UAST-YFP.Rab18.S19N}4, y¹ w^*

23238

y¹ w^*; P{UAST-YFP.Rab18.S19N}03

62551

y¹ w¹¹¹⁸ TI{TI}Rab18^EYFP

9796

y¹ w^*; P{UAST-YFP.Rab18}CG9775⁰¹

9797

y¹ w^*; P{UASp-YFP.Rab18.A64L}Ptp99A⁰²

9798

y¹ w^*; P{UASp-YFP.Rab18.A64L}brat^Rab12

23237

y¹ w^*; P{UAST-YFP.Rab18.S19N}CG33298⁰²

FlyORF

F003045

M{UAS-Rab18.ORF.3xHA.GW}ZH-86Fb

VDRC

v330084

P{VSH330084}attP40

v40228

w¹¹¹⁸; P{GD10218}v40228

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (34)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH11193

Other clones

DPiM_GH11193

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015794

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015794

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44360

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Rab18 Rab-RP4

(FlyBase, 2009-)

Source for database merge of

Source for merge of: Rab-RP4 CG3129

(Bayraktaroglu, 2000.4.17)

Additional comments

FlyBase curator comment: 'Rab-RP4' renamed to 'Rab18' to standardize the nomenclature of D. melanogaster Rab genes in accordance with the nomenclature (based on orthology to human genes) used in FBrf0141628 and FBrf0201049.

(FlyBase, 2009-)

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Kouranti et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R⁺ cells: cells become round and detached. Kc167 cells are unaffected.

(Kiger et al., 2003)

Isolated from a Drosophila head cDNA library.

(Satoh et al., 1997)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44360

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015794

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015794

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3129

Flygut - An atlas of the Drosophila adult midgut

FBgn0015794

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44360

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3129

modMine - A data warehouse for the modENCODE project

FBgn0015794

Linkouts

BioGRID - A database of protein and genetic interactions.

69006

DPiM - Drosophila Protein interaction map

FBgn0015794

DroID - A comprehensive database of gene and protein interactions.

FBgn0015794

DRSC - Results frm RNAi screens

FBgn0015794

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0015794

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3129-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015794

FlyMine - An integrated database for Drosophila genomics

FBgn0015794

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

44360

MIST (protein-protein) - An integrated Molecular Interaction Database

Rab18

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

24639915

(Rojas et al., 2012)

AAF46057

(Armstrong, 2000)

CG3129

(Meadows, 2017.1.11, Dunst et al., 2015, Hosono et al., 2015, Cammarato et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Sinka et al., 2008, Zhang et al., 2007, Colicelli, 2004)

DRABR4

(Kohno et al., 1994)

DRabRP4

(Satoh et al., 1997)

DmRab18

(Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)

O18337

(Rojas et al., 2012)

Rab-RP4

(Japanese National Institute of Genetics, 2012.5.21, Malone et al., 2012, Sinka et al., 2008, Bakal et al., 2007, Ramos et al., 2006)

Rab-r4

Rab18

(Johnson and Andrew, 2019, Krämer et al., 2019, Coutinho-Budd et al., 2017, Caviglia et al., 2016, Van Bortle et al., 2015, White et al., 2015, Choi et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Ma et al., 2012, Wang et al., 2012, Sinka et al., 2008, Zhang et al., 2007, Zhang et al., 2007, Kouranti et al., 2006)

Rab18/RP4

(Zhang et al., 2007)

rab18

(Jin et al., 2012, Chan et al., 2011)

Name Synonyms

Rab-related protein 4

(Cammarato et al., 2011)

Rab18

rab-related protein 4

(Ozaki, 1996.4.3)

Secondary FlyBase IDs

FBgn0029784

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

Rab_Effectors_interaction_map

interactome

Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.

References (75)

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