FB2025_02 , released April 17, 2025
Gene: Dmel\Rab7
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General Information
Symbol
Dmel\Rab7
Species
D. melanogaster
Name
Rab7
Annotation Symbol
CG5915
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015795
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DmRab7, DRab7, Rab-protein 7

Key Links
Genomic Location
Cytogenetic map
95D5-95D5
Sequence location
Recombination map
3-82
RefSeq locus
NT_033777 REGION:23993008..23995452
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (31 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Plekhm1; FB:FBgn0034694
(Lőrincz et al., 2017)
enables protein-containing complex binding
inferred from physical interaction with FLYBASE:Vps35; FB:FBgn0034708
(Dong et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from electronic annotation with InterPro:IPR001806
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Biological Process (18 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
involved_in autophagosome-lysosome fusion
inferred from mutant phenotype
(Fujita et al., 2017, Lőrincz et al., 2017)
involved_in border follicle cell migration
inferred from mutant phenotype
(Chen et al., 2012)
involved_in clathrin-dependent endocytosis involved in vitellogenesis
inferred from direct assay
(Liu et al., 2015)
involved_in endocytic recycling
inferred from mutant phenotype
(Laiouar et al., 2020)
involved_in endocytosis
inferred from mutant phenotype
(Rives et al., 2006)
involved_in endosomal transport
inferred from mutant phenotype
(Entchev et al., 2000)
involved_in endosomal vesicle fusion
inferred from genetic interaction with UniProtKB:Q9VRX2
(Lőrincz et al., 2016)
involved_in endosome to lysosome transport via multivesicular body sorting pathway
inferred from direct assay
(Yousefian et al., 2013)
involved_in endosome to lysosome transport
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
(Entchev et al., 2000)
inferred from mutant phenotype
(Wilkin et al., 2008)
involved_in exosomal secretion
inferred from mutant phenotype
(Corrigan et al., 2014)
involved_in phagocytosis
inferred from expression pattern
(Szabó et al., 2023)
involved_in secretory granule-lysosome fusion
inferred from mutant phenotype
(Csizmadia et al., 2018)
involved_in symbiont entry into host cell
inferred from high throughput mutant phenotype
(Hodgson et al., 2019)
involved_in T-tubule organization
inferred from mutant phenotype
(Fujita et al., 2017)
involved_in wing disc dorsal/ventral pattern formation
inferred from mutant phenotype
(Wilkin et al., 2008)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in endosomal transport
traceable author statement
(Entchev et al., 2000)
involved_in endosome to lysosome transport
inferred from biological aspect of ancestor with PANTHER:PTN001178536
(GO Reference Genome Project, 2011-)
traceable author statement
(Entchev et al., 2000)
involved_in phagosome-lysosome fusion
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(GO Reference Genome Project, 2011-)
involved_in Rab protein signal transduction
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
involved_in vesicle-mediated transport
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Cellular Component (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Liu et al., 2015)
located_in late endosome membrane
inferred from direct assay
(Burgess et al., 2012)
located_in late endosome
inferred from direct assay
(Wilkin et al., 2008, Emery et al., 2005, Entchev et al., 2000)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
is_active_in phagocytic vesicle
inferred from direct assay
(Szabó et al., 2023)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in synapse
inferred from high throughput direct assay
(Chan et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in late endosome
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(GO Reference Genome Project, 2011-)
is_active_in lysosome
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(GO Reference Genome Project, 2011-)
is_active_in phagocytic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000635769
(GO Reference Genome Project, 2011-)
located_in vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rab family. (O76742)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (Probable). In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking (Probable). Involved in microtubule minus and plus end-directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (Probable). Governs early-to-late endosomal to lysosomal maturation (PubMed:23418349, PubMed:24327558). Controls endocytic cargo sorting towards the late endosome facilitating its eventual endolysosomal-mediated degradation (PubMed:11136982). Together with Rab2 involved in promoting fusion of autophagosomes and endosomes with lysosomes probably through recruitment of the HOPS tethering complex (PubMed:28063257, PubMed:28483915, PubMed:31194677). Involved in biosynthetic transport to lysosomes (Probable). Involved in establishing morphogen concentration gradients, for example of the TGF-beta homolog dpp/decapentaplegic, during pattern formation and organogenesis (PubMed:11136982). Together with the Mon1-Ccz1 complex, required for autolysosome formation in fat cells and autophagic degradation during starvation-induced basal and developmental autophagy (PubMed:27559127). Together with Mon1, regulates levels of postsynaptic glutamate receptor GluRIIA in the neuromuscular junction (NMJ) presynapse (PubMed:32658990). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257). Involved in intracellular trafficking of the carbohydrate transporter Tret1 in glial cells of the blood brain barrier, influencing its subcellular localization and protein levels (PubMed:34032568).
(UniProt, O76742)
Summary (Interactive Fly)

a small GTPase that acts downstream of Rab 5 to facilitates endosome maturation and fusion with lysosomes - required for autophagosome-lysosome fusion - regulates synaptic development

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O76742)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Rab7-RA
FBtr0084503
NM_079748
1515
207
Rab7-RB
FBtr0308611
NM_001260347
1269
207
Rab7-RC
FBtr0308612
NM_001260348
1280
207
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Rab7-PA
FBpp0083891
23.3
207
5.06
O76742
NP_524472
AAF56218
Rab7-PB
FBpp0300835
23.3
207
5.06
O76742
NP_001247276
AFH06594
Rab7-PC
FBpp0300836
23.3
207
5.06
O76742
NP_001247277
AFH06595
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

207 aa isoforms: Rab7-PA, Rab7-PB, Rab7-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.31

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
embryonic/larval tracheal section
(Dong et al., 2013)
larval stage
embryonic/larval hemocyte
(Rahman et al., 2012)
third instar larval stage
cell
(Yuva-Aydemir et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
organism
(Rahman et al., 2012)
Additional Descriptive Data

Rab7 protein is localized to phagocytic vesicles in hemocytes at an intermediate stage of phagocytosis.

(Rahman et al., 2012)
Marker for
 
late endosome
(Yuva-Aydemir et al., 2011)
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Liu et al., 2015)
located_in late endosome membrane
inferred from direct assay
(Burgess et al., 2012)
located_in late endosome
inferred from direct assay
(Wilkin et al., 2008, Emery et al., 2005, Entchev et al., 2000)
located_in neuronal cell body
inferred from high throughput direct assay
(Chan et al., 2011)
is_active_in phagocytic vesicle
inferred from direct assay
(Szabó et al., 2023)
located_in plasma membrane
inferred from high throughput direct assay
(Tan et al., 2009)
located_in synapse
inferred from high throughput direct assay
(Chan et al., 2011)
Expression Deduced from Reporters
Reporter: PBac{I-SceI(FRT.Rab7-GAL4.ORF(loxP.3xP3-RFP))}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
neuron | subset of larval brain
(Chan et al., 2011)
glial cell | subset of larval brain
(Chan et al., 2011)
embryonic/larval salivary gland | restricted
(Jin et al., 2012, Chan et al., 2011)
neuron | subset of larval ventral nerve cord
(Chan et al., 2011)
wing disc | restricted
(Jin et al., 2012, Chan et al., 2011)
eye disc | restricted
(Jin et al., 2012, Chan et al., 2011)
neuropil glial sheath
(Jin et al., 2012)
Bolwig organ | restricted
(Jin et al., 2012)
embryonic/larval mushroom body
(Jin et al., 2012)
embryonic/larval optic stalk surface glial cell
(Jin et al., 2012)
leg disc | restricted
(Jin et al., 2012)
pupal stage P6 -- P7
neuron | subset of pupal brain

Comment: 30-40h APF

(Chan et al., 2011)
mushroom body

Comment: 30-40h APF

(Jin et al., 2012, Chan et al., 2011)
neuropil glial sheath

Comment: 30-40h APF

(Jin et al., 2012)
glial cell of second optic chiasma | intense

Comment: 30-40h APF

(Jin et al., 2012)
neuron of adult optic lobe | faint

Comment: 30-40h APF

(Jin et al., 2012)
eye photoreceptor cell | intense

Comment: 30-40h APF

(Jin et al., 2012)
adult stage
neuron | subset of adult brain | ubiquitous
(Chan et al., 2011)
adult ensheathing glial cell
(Jin et al., 2012)
adult inner optic chiasma giant glial cell | intense
(Jin et al., 2012)
neuron of adult optic lobe
(Jin et al., 2012)
adult mushroom body
(Jin et al., 2012)
adult antennal lobe
(Jin et al., 2012)
adult insulin secreting cell of pars intercerebralis
(Jin et al., 2012)
neuron of lamina | intense
(Jin et al., 2012)
ellipsoid body
(Jin et al., 2012)
fan-shaped body
(Jin et al., 2012)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab7 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab7
Transgenic constructs containing regulatory region of Rab7
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel6196
(Ryder, 2004.4.26)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive, with Scer\GAL4Rab7-Gal4-KO
lethal - all die before end of P-stage
lethal - all die before end of pupal stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4Rab7-Gal4-KO
viable, with Scer\GAL4tin.CΔ4
viable (with Rab7Gal4-KO), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7K157N.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7L129F.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7N161T.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7Q67L.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7T22N.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
viable (with Rab7V162M.UAS.Venus), with Scer\GAL4Rab7-Gal4-KO
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal cell migration, with Scer\GAL4slbo.2.6
abnormal immune response | adult stage, with Scer\GAL4Hml.Δ
abnormal locomotor behavior | larval stage, with Scer\GAL4futsch-C380
abnormal neuroanatomy, with Scer\GAL4da.G32
abnormal neuroanatomy, with Scer\GAL4en-e16E
abnormal neuroanatomy | adult stage | dominant
abnormal neuroanatomy | adult stage | progressive | somatic clone
abnormal neurophysiology | adult stage | dominant
abnormal neurophysiology | adult stage | progressive | somatic clone
abnormal neurophysiology | larval stage | somatic clone
decreased rate of adult locomotory behavior | progressive, with Scer\GAL4Ddc.PL
increased cell number | adult stage, with Scer\GAL4NP5130
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
increased size | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
short lived, with Scer\GAL4Ddc.PL
short lived, with Scer\GAL4Mef2.PR
visible, with Scer\GAL4en-e16E
Phenotype manifest in
Allele
adult gut, with Scer\GAL4NP0001
adult midgut epithelium, with Scer\GAL4esg.PU
adult midgut epithelium, with Scer\GAL4NP5130
autolysosome | third instar larval stage (with Df(3R)Exel6196)
autophagosome | adult stage, with Scer\GAL4Ddc.PL
autophagosome | larval stage | somatic clone, with Scer\GAL4Act.PU
autophagosome | third instar larval stage
autophagosome | third instar larval stage (with Df(3R)Exel6196)
border follicle cell, with Scer\GAL4slbo.2.6
egg chamber, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval fat body | larval stage | somatic clone, with Scer\GAL4Act.PU
embryonic/larval fat body | third instar larval stage
embryonic/larval fat body | third instar larval stage (with Df(3R)Exel6196)
embryonic/larval hemocyte | increased number | third instar larval stage
embryonic/larval plasmatocyte | larval stage, with Scer\GAL4Hml.Δ
endosome, with Scer\GAL4hh-Gal4
endosome, with Scer\GAL4ptc-559.1
enteroblast of posterior adult midgut epithelium, with Scer\GAL4NP5130
extracellular exosome, with Scer\GAL4dsx.KI
eye disc, with Scer\GAL4da.G32
filamentous actin | oogenesis, with Scer\GAL4VP16.mat.αTub67C
garland cell, with Scer\GAL4pros.PU
glial cell, with Scer\GAL4da.G32
hemocyte | adult stage, with Scer\GAL4Hml.Δ
intestinal stem cell of posterior adult midgut epithelium, with Scer\GAL4NP5130
larval dorsal multidendritic neuron ddaC, with Scer\GAL4en-e16E
late endosome, with Scer\GAL4pros.PU
late endosome, with Scer\GAL4unspecified
lysosome, with Scer\GAL4CY2
lysosome, with Scer\GAL4pros.PU
male accessory gland secondary cell, with Scer\GAL4dsx.KI
mitochondrial derivative, with Scer\GAL4VP16.mat.αTub67C
multivesicular body, with Scer\GAL4ptc-559.1
oocyte, with Scer\GAL4VP16.mat.αTub67C
phagocytic vesicle, with Scer\GAL4Hml.Δ
photoreceptor
photoreceptor | progressive | somatic clone
rhabdomere
rhabdomere | progressive | somatic clone
synapse
synapse | progressive | somatic clone
vesicle, with Scer\GAL4eg-Mz360
vesicle | adult stage | female, with Scer\GAL4VP16.mat.αTub67C
wing, with Scer\GAL4unspecified
wing blade posterior compartment, with Scer\GAL4en-e16E
yolk granule, with Scer\GAL4VP16.mat.αTub67C
yolk granule | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (71)
Hsap\RAB7A
12 of 14
Yes
Yes
 
5  
Hsap\RAB7B
4 of 14
No
Yes
Hsap\RAB9A
3 of 14
No
No
1  
Hsap\RAB9B
2 of 14
No
No
1  
Hsap\ARL8A
1 of 14
No
No
1  
Hsap\DIRAS1
1 of 14
No
No
1  
Hsap\DIRAS2
1 of 14
No
No
1  
Hsap\IFT22
1 of 14
No
Yes
Hsap\RAB1A
1 of 14
No
No
Hsap\RAB1B
1 of 14
No
No
Hsap\RAB1C
1 of 14
No
No
Hsap\RAB2A
1 of 14
No
No
1  
Hsap\RAB2B
1 of 14
No
No
Hsap\RAB3B
1 of 14
No
No
Hsap\RAB3C
1 of 14
No
No
Hsap\RAB3D
1 of 14
No
No
Hsap\RAB4A
1 of 14
No
No
Hsap\RAB4B
1 of 14
No
No
Hsap\RAB5A
1 of 14
No
No
1  
Hsap\RAB5B
1 of 14
No
No
Hsap\RAB5C
1 of 14
No
No
1  
Hsap\RAB6A
1 of 14
No
No
Hsap\RAB6B
1 of 14
No
No
Hsap\RAB8A
1 of 14
No
No
1  
Hsap\RAB8B
1 of 14
No
No
Hsap\RAB10
1 of 14
No
No
1  
Hsap\RAB11A
1 of 14
No
No
Hsap\RAB11B
1 of 14
No
No
1  
Hsap\RAB12
1 of 14
No
No
Hsap\RAB13
1 of 14
No
No
Hsap\RAB14
1 of 14
No
No
1  
Hsap\RAB15
1 of 14
No
No
Hsap\RAB17
1 of 14
No
No
Hsap\RAB18
1 of 14
No
No
1  
Hsap\RAB19
1 of 14
No
No
Hsap\RAB20
1 of 14
No
No
Hsap\RAB21
1 of 14
No
No
Hsap\RAB22A
1 of 14
No
No
Hsap\RAB23
1 of 14
No
No
1  
Hsap\RAB25
1 of 14
No
No
Hsap\RAB27A
1 of 14
No
No
1  
Hsap\RAB27B
1 of 14
No
No
1  
Hsap\RAB28
1 of 14
No
No
Hsap\RAB29
1 of 14
No
No
Hsap\RAB30
1 of 14
No
No
1  
Hsap\RAB31
1 of 14
No
No
Hsap\RAB32
1 of 14
No
No
1  
Hsap\RAB33A
1 of 14
No
No
Hsap\RAB34
1 of 14
No
No
Hsap\RAB35
1 of 14
No
No
Hsap\RAB37
1 of 14
No
No
Hsap\RAB38
1 of 14
No
No
Hsap\RAB43
1 of 14
No
No
1  
Hsap\RABL2A
1 of 14
No
No
Hsap\RABL2B
1 of 14
No
No
Hsap\RABL6
1 of 14
No
No
Hsap\RALA
1 of 14
No
No
1  
Hsap\RALB
1 of 14
No
No
1  
Hsap\RAN
1 of 14
No
No
Hsap\RAP1A
1 of 14
No
No
3  
Hsap\RAP1B
1 of 14
No
No
3  
Hsap\RAP2A
1 of 14
No
No
Hsap\RAP2B
1 of 14
No
No
Hsap\RAP2C
1 of 14
No
No
Hsap\RASD1
1 of 14
No
No
1  
Hsap\RASL10A
1 of 14
No
No
Hsap\RASL10B
1 of 14
No
No
1  
Hsap\RHEB
1 of 14
No
No
1  
Hsap\RHEBL1
1 of 14
No
No
Hsap\RIT1
1 of 14
No
No
1  
Hsap\RIT2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
Rnor\Rab7a
12 of 14
Yes
Yes
Rnor\Rab7b
4 of 14
No
Yes
Rnor\Rab9a
3 of 14
No
No
Rnor\Rab9b
3 of 14
No
No
Rnor\Ift22
1 of 14
No
Yes
Rnor\Rab1a
1 of 14
No
No
Rnor\Rab1b
1 of 14
No
No
Rnor\Rab2b
1 of 14
No
No
Rnor\Rab3b
1 of 14
No
No
Rnor\Rab3c
1 of 14
No
No
Rnor\Rab3d
1 of 14
No
No
Rnor\Rab4a
1 of 14
No
No
Rnor\Rab4b
1 of 14
No
No
Rnor\Rab5al1
1 of 14
No
No
Rnor\Rab5a
1 of 14
No
No
Rnor\Rab5b
1 of 14
No
No
Rnor\Rab5c
1 of 14
No
No
Rnor\Rab6a
1 of 14
No
No
Rnor\Rab6b
1 of 14
No
No
Rnor\Rab8a
1 of 14
No
No
Rnor\Rab8b
1 of 14
No
No
Rnor\Rab10
1 of 14
No
No
Rnor\Rab11a
1 of 14
No
No
Rnor\Rab11b
1 of 14
No
No
Rnor\Rab12
1 of 14
No
No
Rnor\Rab13
1 of 14
No
No
Rnor\Rab14
1 of 14
No
No
Rnor\Rab20
1 of 14
No
No
Rnor\Rab21
1 of 14
No
No
Rnor\Rab22a
1 of 14
No
No
Rnor\Rab23
1 of 14
No
No
Rnor\Rab27b
1 of 14
No
No
Rnor\Rab28
1 of 14
No
No
Rnor\Rab29
1 of 14
No
No
Rnor\Rab30
1 of 14
No
No
Rnor\Rab31
1 of 14
No
No
Rnor\Rab32
1 of 14
No
No
Rnor\Rab35
1 of 14
No
No
Rnor\Rab37
1 of 14
No
No
Rnor\Rab38
1 of 14
No
No
Rnor\Rabl2
1 of 14
No
No
Rnor\Rabl6
1 of 14
No
No
Rnor\Ran
1 of 14
No
No
Rnor\Rasl2-9
1 of 14
No
No
Rnor\RGD1306195
1 of 14
No
No
Mus musculus (laboratory mouse) (46)
Mmus\Rab7
12 of 14
Yes
Yes
Mmus\Rab7b
3 of 14
No
Yes
Mmus\Rab9b
3 of 14
No
No
Mmus\Rab9
3 of 14
No
No
Mmus\1700009N14Rik
1 of 14
No
No
Mmus\Ift22
1 of 14
No
Yes
Mmus\Rab1a
1 of 14
No
No
1  
Mmus\Rab1b
1 of 14
No
No
Mmus\Rab2b
1 of 14
No
No
Mmus\Rab3b
1 of 14
No
No
Mmus\Rab3c
1 of 14
No
No
Mmus\Rab3d
1 of 14
No
No
Mmus\Rab4a
1 of 14
No
No
Mmus\Rab4b
1 of 14
No
No
Mmus\Rab5a
1 of 14
No
No
Mmus\Rab5b
1 of 14
No
No
Mmus\Rab5c
1 of 14
No
No
Mmus\Rab6a
1 of 14
No
No
Mmus\Rab6b
1 of 14
No
No
Mmus\Rab8a
1 of 14
No
No
Mmus\Rab8b
1 of 14
No
No
Mmus\Rab10
1 of 14
No
No
Mmus\Rab11a
1 of 14
No
No
Mmus\Rab11b
1 of 14
No
No
Mmus\Rab12
1 of 14
No
No
Mmus\Rab13
1 of 14
No
No
Mmus\Rab14
1 of 14
No
No
Mmus\Rab17
1 of 14
No
No
Mmus\Rab20
1 of 14
No
No
Mmus\Rab21
1 of 14
No
No
Mmus\Rab22a
1 of 14
No
No
Mmus\Rab23
1 of 14
No
No
Mmus\Rab27b
1 of 14
No
No
Mmus\Rab28
1 of 14
No
No
Mmus\Rab29
1 of 14
No
No
Mmus\Rab30
1 of 14
No
No
Mmus\Rab31
1 of 14
No
No
Mmus\Rab32
1 of 14
No
No
Mmus\Rab34
1 of 14
No
No
Mmus\Rab35
1 of 14
No
No
Mmus\Rab38
1 of 14
No
No
Mmus\Rab42
1 of 14
No
No
Mmus\Rabl2
1 of 14
No
No
Mmus\Rabl6
1 of 14
No
No
Mmus\Ran
1 of 14
No
No
Mmus\Rasl2-9
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (42)
Xtro\rab7a
6 of 13
Yes
Yes
Xtro\diras2
1 of 13
No
No
Xtro\diras3
1 of 13
No
No
Xtro\ift22
1 of 13
No
Yes
Xtro\MGC75872
1 of 13
No
Yes
Xtro\mtres1
1 of 13
No
No
Xtro\plvap
1 of 13
No
No
Xtro\rab1a
1 of 13
No
No
Xtro\rab2b
1 of 13
No
No
Xtro\rab3d
1 of 13
No
No
Xtro\rab4b
1 of 13
No
No
Xtro\rab5b
1 of 13
No
No
Xtro\rab5d
1 of 13
No
No
Xtro\rab6b
1 of 13
No
No
Xtro\rab7b
1 of 13
No
No
Xtro\rab8b
1 of 13
No
No
Xtro\rab9a
1 of 13
No
No
Xtro\rab9b
1 of 13
No
No
Xtro\rab11b.1
1 of 13
No
No
Xtro\rab12
1 of 13
No
No
Xtro\rab18
1 of 13
No
No
Xtro\rab19
1 of 13
No
No
Xtro\rab20
1 of 13
No
No
Xtro\rab28
1 of 13
No
Yes
Xtro\rab29
1 of 13
No
No
Xtro\rab32
1 of 13
No
No
Xtro\rab33a
1 of 13
No
Yes
Xtro\rab35l
1 of 13
No
No
Xtro\rab35
1 of 13
No
No
Xtro\rab38
1 of 13
No
No
Xtro\rabl2b
1 of 13
No
Yes
Xtro\ran
1 of 13
No
No
Xtro\rap1b
1 of 13
No
No
Xtro\rap2a
1 of 13
No
No
Xtro\rap2c
1 of 13
No
No
Xtro\rasd1
1 of 13
No
No
Xtro\rasd2
1 of 13
No
No
Xtro\rasl10b
1 of 13
No
No
Xtro\rhebl1
1 of 13
No
No
Xtro\tnks
1 of 13
No
No
Xtro\trpv5
1 of 13
No
Yes
Xtro\XB5873314
1 of 13
No
No
Danio rerio (Zebrafish) (59)
Drer\rab7a
12 of 14
Yes
Yes
Drer\zgc:100918
12 of 14
Yes
Yes
Drer\rab7b
11 of 14
No
Yes
Drer\rab9a
3 of 14
No
No
Drer\si:dkey-13a21.4
3 of 14
No
Yes
Drer\rab9b
2 of 14
No
No
Drer\arl8a
1 of 14
No
No
Drer\cracr2aa
1 of 14
No
No
Drer\cracr2ab
1 of 14
No
No
Drer\ift22
1 of 14
No
Yes
Drer\rab1aa
1 of 14
No
No
Drer\rab1ab
1 of 14
No
No
Drer\rab1ba
1 of 14
No
No
Drer\rab1bb
1 of 14
No
No
Drer\rab3aa
1 of 14
No
No
Drer\rab3ab
1 of 14
No
No
Drer\rab3da
1 of 14
No
No
Drer\rab3db
1 of 14
No
No
Drer\rab4a
1 of 14
No
No
Drer\rab4b
1 of 14
No
No
Drer\rab5aa
1 of 14
No
No
Drer\rab5b
1 of 14
No
No
Drer\rab6a
1 of 14
No
No
Drer\rab6ba
1 of 14
No
No
Drer\rab6bb
1 of 14
No
No
Drer\rab8a
1 of 14
No
No
Drer\rab8b
1 of 14
No
No
Drer\rab10
1 of 14
No
No
Drer\rab11a
1 of 14
No
No
Drer\rab11al
1 of 14
No
No
Drer\rab11ba
1 of 14
No
No
Drer\rab11bb
1 of 14
No
No
Drer\rab12
1 of 14
No
No
Drer\rab13
1 of 14
No
No
Drer\rab14
1 of 14
No
No
Drer\rab14l
1 of 14
No
No
Drer\rab18a
1 of 14
No
No
Drer\rab20
1 of 14
No
No
Drer\rab21
1 of 14
No
No
Drer\rab22a
1 of 14
No
No
Drer\rab32a
1 of 14
No
No
Drer\rab32b
1 of 14
No
No
Drer\rab33a
1 of 14
No
No
Drer\rab35a
1 of 14
No
No
Drer\rab35b
1 of 14
No
No
Drer\rab38b
1 of 14
No
No
Drer\rab38c
1 of 14
No
No
Drer\rab41
1 of 14
No
No
Drer\rab42a
1 of 14
No
No
Drer\rab43
1 of 14
No
No
Drer\rabl2
1 of 14
No
No
Drer\rabl6a
1 of 14
No
Yes
Drer\rabl6b
1 of 14
No
No
Drer\ran
1 of 14
No
No
Drer\rnd3b
1 of 14
No
No
Drer\si:dkey-16l2.16
1 of 14
No
No
Drer\zgc:101559
1 of 14
No
No
Drer\zgc:162171
1 of 14
No
No
Drer\zgc:171927
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (29)
Cele\rab-7
12 of 14
Yes
Yes
Cele\aex-6
1 of 14
No
No
Cele\arl-8
1 of 14
No
No
Cele\drn-1
1 of 14
No
No
Cele\F08G12.1
1 of 14
No
No
Cele\F11A5.4
1 of 14
No
No
Cele\glo-1
1 of 14
No
No
Cele\ifta-2
1 of 14
No
Yes
Cele\K02E10.1
1 of 14
No
No
Cele\rab-1
1 of 14
No
No
Cele\rab-3
1 of 14
No
No
Cele\rab-5
1 of 14
No
No
Cele\rab-6.2
1 of 14
No
No
Cele\rab-8
1 of 14
No
No
Cele\rab-10
1 of 14
No
No
Cele\rab-11.1
1 of 14
No
No
Cele\rab-14
1 of 14
No
No
Cele\rab-19
1 of 14
No
No
Cele\rab-21
1 of 14
No
No
Cele\rab-28
1 of 14
No
No
Cele\rab-35
1 of 14
No
No
Cele\rab-37
1 of 14
No
No
Cele\ral-1
1 of 14
No
No
Cele\ran-1
1 of 14
No
No
Cele\rap-1
1 of 14
No
No
Cele\rap-2
1 of 14
No
No
Cele\rheb-1
1 of 14
No
No
Cele\ssr-2
1 of 14
No
No
Cele\unc-108
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (26)
Agam\AgaP_AGAP001617
10 of 12
Yes
Yes
Agam\AgaP_AGAP009846
3 of 12
No
No
Agam\AgaP_AGAP000671
1 of 12
No
No
Agam\AgaP_AGAP001211
1 of 12
No
No
Agam\AgaP_AGAP001874
1 of 12
No
No
Agam\AgaP_AGAP001902
1 of 12
No
No
Agam\AgaP_AGAP002563
1 of 12
No
No
Agam\AgaP_AGAP003028
1 of 12
No
No
Agam\AgaP_AGAP004146
1 of 12
No
No
Agam\AgaP_AGAP004204
1 of 12
No
No
Agam\AgaP_AGAP004559
1 of 12
No
No
Agam\AgaP_AGAP005248
1 of 12
No
No
Agam\AgaP_AGAP005393
1 of 12
No
No
Agam\AgaP_AGAP006025
1 of 12
No
No
Agam\AgaP_AGAP006873
1 of 12
No
No
Agam\AgaP_AGAP007096
1 of 12
No
No
Agam\AgaP_AGAP007369
1 of 12
No
No
Agam\AgaP_AGAP007654
1 of 12
No
No
Agam\AgaP_AGAP007699
1 of 12
No
No
Agam\AgaP_AGAP007901
1 of 12
No
No
Agam\AgaP_AGAP008419
1 of 12
No
No
Agam\AgaP_AGAP010875
1 of 12
No
No
Agam\AgaP_AGAP011306
1 of 12
No
No
Agam\AgaP_AGAP011363
1 of 12
No
No
Agam\AgaP_AGAP012108
1 of 12
No
No
Agam\AgaP_AGAP012348
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (54)
Atha\RABG3c
12 of 13
Yes
Yes
Atha\RABG3d
12 of 13
Yes
Yes
Atha\RAB7B
11 of 13
No
Yes
Atha\RABG3B
11 of 13
No
Yes
Atha\RABG3E
11 of 13
No
Yes
Atha\RABG3A
10 of 13
No
Yes
Atha\RAB7A
8 of 13
No
Yes
Atha\RABG1
3 of 13
No
Yes
Atha\ARA-2
1 of 13
No
No
Atha\ARA4
1 of 13
No
No
Atha\ARA7
1 of 13
No
No
Atha\ARFB1A
1 of 13
No
No
Atha\ArRABA1h
1 of 13
No
No
Atha\AT5G59840
1 of 13
No
No
Atha\ATFP8
1 of 13
No
No
Atha\GB2
1 of 13
No
No
Atha\RA-5
1 of 13
No
No
Atha\RAB1A
1 of 13
No
No
Atha\RAB1C
1 of 13
No
No
Atha\RAB6A
1 of 13
No
No
Atha\RAB8
1 of 13
No
No
Atha\RAB8C
1 of 13
No
No
Atha\RAB11c
1 of 13
No
No
Atha\RAB18
1 of 13
No
No
Atha\RABA1b
1 of 13
No
No
Atha\RABA1c
1 of 13
No
No
Atha\RABA1d
1 of 13
No
No
Atha\RABA1e
1 of 13
No
No
Atha\RABA1f
1 of 13
No
No
Atha\RABA1g
1 of 13
No
No
Atha\RABA1i
1 of 13
No
No
Atha\RABA2b
1 of 13
No
No
Atha\RABA2c
1 of 13
No
No
Atha\RABA2D
1 of 13
No
No
Atha\RABA4a
1 of 13
No
No
Atha\RABA4B
1 of 13
No
No
Atha\RABA4C
1 of 13
No
No
Atha\RABA4D
1 of 13
No
No
Atha\RABA5a
1 of 13
No
No
Atha\RABA5b
1 of 13
No
No
Atha\RABA5d
1 of 13
No
No
Atha\RABA5E
1 of 13
No
No
Atha\RABA6b
1 of 13
No
No
Atha\RABB1a
1 of 13
No
No
Atha\RABB1C
1 of 13
No
No
Atha\RABC2A
1 of 13
No
No
Atha\RABC2b
1 of 13
No
No
Atha\RABE1c
1 of 13
No
No
Atha\RABE1e
1 of 13
No
No
Atha\RABH1c
1 of 13
No
No
Atha\RAN2
1 of 13
No
No
Atha\RAN3
1 of 13
No
No
Atha\RAN4
1 of 13
No
No
Atha\RHA1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\YPT7
10 of 13
Yes
Yes
Scer\GSP1
1 of 13
No
No
Scer\GSP2
1 of 13
No
No
Scer\SEC4
1 of 13
No
No
Scer\VPS21
1 of 13
No
No
Scer\YPT1
1 of 13
No
No
Scer\YPT6
1 of 13
No
No
Scer\YPT10
1 of 13
No
No
Scer\YPT31
1 of 13
No
No
Scer\YPT52
1 of 13
No
No
Scer\YPT53
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (13)
Spom\ypt7
10 of 12
Yes
Yes
Spom\ypt71
3 of 12
No
Yes
Spom\rho1
1 of 12
No
No
Spom\rho2
1 of 12
No
No
Spom\rho4
1 of 12
No
No
Spom\rho5
1 of 12
No
No
Spom\ryh1
1 of 12
No
No
Spom\spg1
1 of 12
No
Yes
Spom\spi1
1 of 12
No
No
Spom\ypt1
1 of 12
No
No
Spom\ypt2
1 of 12
No
No
Spom\ypt3
1 of 12
No
No
Spom\ypt4
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rab7. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (41)
Rab9
5 of 13
Rab1
2 of 13
Rab2
2 of 13
Rab4
2 of 13
Rab5
2 of 13
Rab6
2 of 13
Rab8
2 of 13
Rab9Fb
2 of 13
Rab10
2 of 13
Rab11
2 of 13
Rab14
2 of 13
Rab19
2 of 13
Rab21
2 of 13
Rab26
2 of 13
Rab27
2 of 13
Rab30
2 of 13
Rab32
2 of 13
Rab35
2 of 13
Rab39
2 of 13
RabX2
2 of 13
RabX5
2 of 13
CG4789
1 of 13
CG8500
1 of 13
CG8641
1 of 13
CG13375
1 of 13
CG14669
1 of 13
CG30158
1 of 13
Rab3
1 of 13
Rab9Db
1 of 13
Rab9D
1 of 13
Rab9E
1 of 13
Rab9Fa
1 of 13
Rab18
1 of 13
Rab23
1 of 13
RabX1
1 of 13
RabX4
1 of 13
Rala
1 of 13
Ran-like
1 of 13
Ran
1 of 13
Rap1
1 of 13
Rheb
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Rab7Gal4-KO
model of  Charcot-Marie-Tooth disease type 2
CEA
(Cherry et al., 2013)
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
RAB7A; RAB7A, member RAS oncogene family
model of  Charcot-Marie-Tooth disease type 2B
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 10 )
Allele
Disease
Interaction
References
Rab7Tub.Venus
ameliorates  retinal disease
modeled by PisdNIG.5991R
(Midorikawa et al., 2010)
Rab7Q67L.UAS
ameliorates  brain cancer
modeled by Vps35E42
(Li et al., 2018)
Rab7UAS.GFP
ameliorates  Parkinson's disease
modeled by Hsap\SNCAA53T.UAS
(Dinter et al., 2016)
exacerbates  Alzheimer's disease 1
modeled by Hsap\APP2xAPP.SP.UAS
(Yu et al., 2020)
Rab7Gal4-KO
ameliorates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ20
(Mao et al., 2019)
ameliorates  autosomal dominant adult-onset proximal spinal muscular atrophy
modeled by Vap33Δ20
(Mao et al., 2019)
exacerbates  Alzheimer's disease 1
modeled by Appld
(Kessissoglou et al., 2020)
exacerbates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPUAS.cUa
(Liu et al., 2017)
modeled by Hsap\TARDBPG298S.UAS
(Liu et al., 2017)
Rab7Q67L.UAS.Venus
exacerbates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPUAS.cUa
(Liu et al., 2017)
modeled by Hsap\TARDBPG298S.UAS
(Liu et al., 2017)
Rab7T22N.UAS.Venus
exacerbates  amyotrophic lateral sclerosis type 10
modeled by Hsap\TARDBPUAS.cUa
(Liu et al., 2017)
modeled by Hsap\TARDBPG298S.UAS
(Liu et al., 2017)
Rab7T22N.UAS
ameliorates  Huntington's disease
modeled by Hsap\HTTQ138.UAS.mRFP1
(Akbergenova and Littleton, 2017)
Rab7UASp.YFP
ameliorates  frontotemporal dementia and/or amyotrophic lateral sclerosis 1
modeled by Zzzz\GGGGCC30.UAS.EGFP
(Cunningham et al., 2020)
ameliorates  motor neuron disease
modeled by scatHMS01910
(Patel et al., 2020)
Rab7T22N.UASp.YFP
ameliorates  tauopathy
modeled by Hsap\MAPTGMR.Ex.PJ
(Bakhoum et al., 2014)
ameliorates  motor neuron disease
modeled by scatHMS01910
(Patel et al., 2020)
exacerbates  tauopathy
modeled by Hsap\MAPTUAS.2N4R.cSa
(Asadzadeh et al., 2022)
Rab7JF02377
ameliorates  lung adenocarcinoma
modeled by Hsap\KIF5B::Hsap\RETUAS.cDa
(Das and Cagan, 2017)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
RAB7A; RAB7A, member RAS oncogene family
12 of 14
602298
 
RAB7B; RAB7B, member RAS oncogene family
4 of 14
      RAB9A; RAB9A, member RAS oncogene family
      3 of 14
      300284
           
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Dmel gene
          Ortholog showing functional complementation
          Supporting References
          Rab7
          Hsap\RAB7A
          (Cherry et al., 2013)
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Rab7 - Aprt
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - CCT6
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - CCT8
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - CG12012
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - CG1416
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - CG33303
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - CG9662
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Cyp12d1-p
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - DEF8
          pull down, peptide massfingerprinting
          (Gillingham et al., 2014)
          Rab7 - E(spl)m8-HLH
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Epg5
          pull down, peptide massfingerprinting
          (Gillingham et al., 2014)
          Rab7 - Fnta
          pull down, peptide massfingerprinting
          (Gillingham et al., 2014)
          Rab7 - Gdi
          pull down, peptide massfingerprinting, anti tag coimmunoprecipitation, experimental knowledge based
          (Gillingham et al., 2014, Rhee et al., 2014)
          Rab7 - KdelR
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Lrrk
          anti tag coimmunoprecipitation, anti tag western blot
          (Dodson et al., 2012)
          Rab7 - Mcad
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Mec2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Mer
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Kwon et al., 2013)
          Rab7 - Mon1
          protein three hybrid
          (Hegedűs et al., 2016)
          Rab7 - Plekhm1
          two hybrid, pull down, peptide massfingerprinting, anti tag western blot
          (Lőrincz et al., 2017, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
          Rab7 - Rab1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Rab14
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Rab2
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Rab5
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Rab6
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Rdh1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Rpn1
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - ScsβG
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - Sec24AB
          pull down, peptide massfingerprinting
          (Gillingham et al., 2014)
          Rab7 - Vps13
          anti bait coimmunoprecipitation, western blot
          (Vonk et al., 2017)
          Rab7 - Vps35
          pull down, anti tag western blot, anti tag coimmunoprecipitation
          (Asadzadeh et al., 2022, Dong et al., 2013)
          Rab7 - c11.1
          pull down, peptide massfingerprinting, two hybrid
          (Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014)
          Rab7 - fliI
          pull down, peptide massfingerprinting
          (Gillingham et al., 2014)
          Rab7 - jagn
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - wal
          experimental knowledge based
          (Guruharsha et al., 2011)
          Rab7 - zip
          pull down, peptide massfingerprinting
          (Gillingham et al., 2014)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Rab7
          suppressible
          EndoB
          (Tsai et al., 2014)
          Rab7
          enhanceable
          Lrrk
          (Dodson et al., 2012)
          Rab7
          suppressible
          Lrrk
          (Dodson et al., 2012)
          Rab7
          suppressible
          Rab11
          (Zhang et al., 2019)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Atg8a
          suppressible
          Rab7
          (Midorikawa et al., 2010)
          egr
          suppressible
          Rab7
          (Ruan et al., 2016)
          egr
          enhanceable
          Rab7
          (Ruan et al., 2016)
          FIG4
          suppressible
          Rab7
          (Bharadwaj et al., 2016)
          FIG4
          enhanceable
          Rab7
          (Bharadwaj et al., 2016)
          l(2)gd1
          suppressible
          Rab7
          (Schneider et al., 2013)
          Lrrk
          suppressible
          Rab7
          (Dodson et al., 2012)
          Mon1
          suppressible
          Rab7
          (Basargekar et al., 2020)
          NimB4
          suppressible
          Rab7
          (Petrignani et al., 2021)
          Ocrl
          suppressible
          Rab7
          (Del Signore et al., 2017)
          Osbp
          suppressible
          Rab7
          (Ma et al., 2012)
          Pi3K59F
          enhanceable
          Rab7
          (O'Farrell et al., 2017)
          Pisd
          suppressible
          Rab7
          (Midorikawa et al., 2010)
          Rab2
          suppressible
          Rab7
          (Lőrincz et al., 2017)
          RhoGAP68F
          enhanceable
          Rab7
          (de Madrid et al., 2015)
          scat
          suppressible
          Rab7
          (Patel et al., 2020)
          sky
          suppressible
          Rab7
          (Fernandes et al., 2014)
          Vps29
          suppressible
          Rab7
          (Ye et al., 2020)
          Vps35
          suppressible
          Rab7
          (Li et al., 2018)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3R
          Recombination map
          3-82
          Cytogenetic map
          95D5-95D5
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          95D5-95D5
          Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          95D1-95D6
          (Entchev, 2000.5.3, Rong, 1998.7.21)
          95D-95D
          (Ozaki, 1999.12.9)
          Experimentally Determined Recombination Data
          Location

          3-82

          (FlyBase, 2016)

          3-82.5

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (21)
          Genomic Clones (22)
          cDNA Clones (208)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          monoclonal

          (Riedel et al., 2016)

          polyclonal

          (Chinchore et al., 2009, Tanaka and Nakamura, 2008)
          Commercially Available Antibodies
           
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Rab7 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.

              (Politi et al., 2014)

              dsRNA has been made from templates generated with primers directed against this gene.

              (Kouranti et al., 2006)
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: Rab7 CG5915

              (Kodira, 1999.11)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (17)
              Reported As
              Symbol Synonym
              AAF56218
              (Armstrong, 2000)
              CG5915
              (Yamaguchi and Takashima, 2018, Kolkhof et al., 2017, Dunst et al., 2015, Hoffmann et al., 2013, Krahmer et al., 2013, Cammarato et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009.3.31, Sinka et al., 2008, Zhang et al., 2007, Cermelli et al., 2006, Dorer et al., 2006, Saleh et al., 2006, Colicelli, 2004, Fulton et al., 2001, Verstreken and Bellen, 2000.9.4)
              DRAB7
              (Kohno et al., 1994)
              DRab7
              (Rives et al., 2006, Entchev et al., 2000)
              Dm Rab7
              (Jekely, 2003)
              DmRab7
              (Fetchko et al., 2002, Pereira-Leal and Seabra, 2001, Pereira-Leal and Seabra, 2001)
              Drab7
              (Satoh et al., 1997)
              O76742
              (Rojas et al., 2012)
              RAB7
              (Cox et al., 2021, Yamaguchi et al., 2021, Guan et al., 2020, Baron, 2012, Dorer et al., 2006, Rong and Golic, 1997)
              Rab-7
              (Jiang et al., 2019, Akbar et al., 2011, Gorski et al., 2003)
              Rab-r7
              Rab7
              (Kim et al., 2024, Meyer et al., 2024, Mira-Osuna and Borgne, 2024, Nan et al., 2024, Sachan et al., 2024, Sharma and Chaudhary, 2024, Shweta et al., 2024, Srivastav et al., 2024, Sung and Lloyd, 2024, Szypulski et al., 2024, Tsap et al., 2024, Wilkin et al., 2024, Xu et al., 2024, Yu et al., 2024, Zhang et al., 2024, Bertin et al., 2023, Bonello et al., 2023, Joshi et al., 2023, Koehler and Huber, 2023, Lewis et al., 2023, Li et al., 2023, Liu et al., 2023, Maddison et al., 2023, Maruzs et al., 2023, Mitchell et al., 2023, Pradhan et al., 2023, Saha et al., 2023, Scholl et al., 2023, Szinyákovics et al., 2023, Tsarouhas et al., 2023, Vöing et al., 2023, Xu et al., 2023, Zhang et al., 2023, Zhou et al., 2023, Zhou et al., 2023, Zhuang et al., 2023, Chaudhry et al., 2022, Chen and He, 2022, González-Ramírez et al., 2022, Hodgson et al., 2022, Kunduri et al., 2022, Lang et al., 2022, Lauzier et al., 2022, Linnemannstöns et al., 2022, Marshall and Dionne, 2022, Meyer et al., 2022, Miao et al., 2022, Palozzi et al., 2022, Rai and Kumar Roy, 2022, Reed et al., 2022, Sanchez-Lopez et al., 2022, Schnute et al., 2022, Sung and Lloyd, 2022, Tanasic et al., 2022, Wang et al., 2022, Xu et al., 2022, Chan et al., 2021, Hertenstein et al., 2021, Hounjet and Vooijs, 2021, Kim et al., 2021, Lakatos et al., 2021, Lattao et al., 2021, Lund et al., 2021, Ma and Brill, 2021, Martinez-Arroyo et al., 2021, Neuman et al., 2021, Petrignani et al., 2021, Ricolo et al., 2021, Rigon et al., 2021, Sechi et al., 2021, Sharma et al., 2021, Wang et al., 2021, Yamaguchi et al., 2021, Yin et al., 2021, Yu et al., 2021, Zhang et al., 2021, Basargekar et al., 2020, Csizmadia and Juhász, 2020, Cunningham et al., 2020, Dehnen et al., 2020, Du et al., 2020, Gohel et al., 2020, Hoshika et al., 2020, Kessissoglou et al., 2020, Kitani-Morii and Noto, 2020, Langemeyer et al., 2020, Mathew et al., 2020, Medina-Yáñez et al., 2020, Nakamura et al., 2020, Patel et al., 2020, Qin et al., 2020, Wen et al., 2020, Witte et al., 2020, Ye et al., 2020, Yu et al., 2020, Bäumers et al., 2019, Boda et al., 2019, Bourouis et al., 2019, Hodgson et al., 2019, Imler et al., 2019, Johnson and Andrew, 2019, Khezri and Rusten, 2019, Krämer et al., 2019, Mao et al., 2019, Melcarne et al., 2019, Meltzer et al., 2019, Prince et al., 2019, Sinha et al., 2019, Texada et al., 2019, Troha et al., 2019, Wang et al., 2019, Xu et al., 2019, Zhang et al., 2019, Ayala et al., 2018, Csizmadia et al., 2018, Gene Disruption Project members, 2018-, Jin et al., 2018, Li et al., 2018, Liu et al., 2018, Lund et al., 2018, Ma et al., 2018, Rosa-Ferreira et al., 2018, Vukoja et al., 2018, Yamaguchi and Takashima, 2018, Akbergenova and Littleton, 2017, Beer and Wehman, 2017, Bussmann and Storkebaum, 2017, Court et al., 2017, Coutinho-Budd et al., 2017, Del Signore et al., 2017, Fujita et al., 2017, Galluzzi et al., 2017, Gao et al., 2017, Kamalesh et al., 2017, Liu et al., 2017, Lőrincz et al., 2017, O'Farrell et al., 2017, Sato and Sato, 2017, Sellin et al., 2017, Transgenic RNAi Project members, 2017-, Vonk et al., 2017, Zheng et al., 2017, Bharadwaj et al., 2016, Caviglia et al., 2016, Dinter et al., 2016, Fang et al., 2016, Hegedűs et al., 2016, Iwanami et al., 2016, Karlikow et al., 2016, Lőrincz et al., 2016, Luo et al., 2016, Meehan et al., 2016, Mukherjee et al., 2016, Nagy et al., 2016, Pueyo et al., 2016, Riedel et al., 2016, Deivasigamani et al., 2015, de Madrid et al., 2015, Jean et al., 2015, Lee et al., 2015, Liu et al., 2015, Parchure et al., 2015, Portela et al., 2015, Sanhueza et al., 2015, Sopko et al., 2015, Van Bortle et al., 2015, Wang et al., 2015, White et al., 2015, Bakhoum et al., 2014, Chen et al., 2014, Corrigan et al., 2014, Couturier et al., 2014, de Vreede et al., 2014, Dodson et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Han et al., 2014, Janssens et al., 2014, Liu et al., 2014, Parsons et al., 2014, Politi et al., 2014, Shimizu et al., 2014, Szatmári et al., 2014, Thomas and Strutt, 2014, Tsai et al., 2014, Valzania et al., 2014, Wang et al., 2014, Abdallah et al., 2013, Aoyama et al., 2013, Bader et al., 2013, Bechtel et al., 2013, Cherry et al., 2013, Couturier et al., 2013, Dong et al., 2013, Dong et al., 2013, Fan et al., 2013, Gross et al., 2013, Hermle et al., 2013, Hoffmann et al., 2013, Krahmer et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Macleod et al., 2013, Pepperl et al., 2013, Petzoldt et al., 2013, Sanchez-Garcia et al., 2013, Satoh et al., 2013, Schneider et al., 2013, Shandala et al., 2013, Thomae et al., 2013, Xiong and Bellen, 2013, Yousefian et al., 2013, Zuo et al., 2013, Burgess et al., 2012, Capilla et al., 2012, Chen et al., 2012, Dodson et al., 2012, Gailite et al., 2012, Gault et al., 2012, Haberman et al., 2012, Hibbard and O'Tousa, 2012, Jean et al., 2012, Kametaka et al., 2012, Laflamme et al., 2012, Lloyd et al., 2012, Ma et al., 2012, Nezis, 2012, Rahman et al., 2012, Singh and Mlodzik, 2012, Wang et al., 2012, Wong et al., 2012, Xia et al., 2012, Xiong et al., 2012, Yamakawa et al., 2012, Ben El Kadhi et al., 2011, Bhuin and Roy, 2011, Burgess et al., 2011, Dalton et al., 2011, Gilbert et al., 2011, Mateus et al., 2011, Mitra et al., 2011, Otani et al., 2011, Ribeiro et al., 2011, Sun et al., 2011, Swetha et al., 2011, Tanaka et al., 2011, Tjota et al., 2011, Wang and Pai, 2011, Yuva-Aydemir et al., 2011, Becam et al., 2010, Cheli et al., 2010, Haberman et al., 2010, Haglund et al., 2010, Ho et al., 2010, Janssens et al., 2010, Kawahashi and Hayashi, 2010, Kim et al., 2010, Li et al., 2010, Lone et al., 2010, Midorikawa et al., 2010, Mottola et al., 2010, Mukai et al., 2010, Pirraglia et al., 2010, Stempfle et al., 2010, Velichkova et al., 2010, Williamson et al., 2010, Williamson et al., 2010, Abe et al., 2009, Akbar et al., 2009, Dworkin et al., 2009, Fetting et al., 2009, Gupta et al., 2009, Khaliullina et al., 2009, Polevoy et al., 2009, Soukup et al., 2009, Tan et al., 2009, Thomas et al., 2009, Warner and Longmore, 2009, Yan et al., 2009, Albertson et al., 2008, Chang et al., 2008, Denef et al., 2008, Harris and Tepass, 2008, Miura et al., 2008, Philips et al., 2008, Sinka et al., 2008, Strutt and Strutt, 2008, Tanaka and Nakamura, 2008, Velichkova et al., 2008, Wilkin et al., 2008, Yu et al., 2008, Bakal et al., 2007, Coutelis and Ephrussi, 2007, Curtis et al., 2007, Jiang et al., 2007, Korolchuk et al., 2007, Stuart et al., 2007, Tsarouhas et al., 2007, Tsruya et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Bokel et al., 2006, Cermelli et al., 2006, Gallagher and Knoblich, 2006, Glittenberg et al., 2006, Hennig et al., 2006, Kouranti et al., 2006, Rusten et al., 2006, Saleh et al., 2006, Seto and Bellen, 2006, Sweeney et al., 2006, Sweeney et al., 2006, Emery et al., 2005, Hutterer and Knoblich, 2005, Jutras et al., 2005, Lu and Bilder, 2005, Somers and Chia, 2005, Strigini, 2005, Wu et al., 2005, Guha et al., 2003)
              Rab7A
              (Jolly et al., 2016)
              dRab7
              (Gupta et al., 2014)
              drab7
              (Gupta et al., 2014)
              rab7
              (Hu et al., 2022, Baeumers et al., 2020, Zhang et al., 2020, Lőrincz et al., 2019, Das and Cagan, 2017, Lammers et al., 2017, Ruan et al., 2016, Xu and Wang, 2016, Chance and Bashaw, 2015, Fernandes et al., 2014, Cherry et al., 2013, Lee et al., 2013, van den Brink et al., 2013, Jin et al., 2012, Troost et al., 2012, Chan et al., 2011, Assaker et al., 2010, McPhee et al., 2010, Midorikawa et al., 2010, Chinchore et al., 2009, Lim and Kraut, 2009, O'Connor-Giles et al., 2008, Akbar et al., 2007, Devergne et al., 2007, Walthall et al., 2007, Jaekel and Klein, 2006, Rong, 1998.7.21)
              Name Synonyms
              Rab-protein 7
              (Cammarato et al., 2011)
              Rab7
              Secondary FlyBase IDs
                Datasets (1)
                Study focus (1)
                Experimental Role
                Project
                Project Type
                Title
                • bait_protein
                Rab_Effectors_interaction_map
                Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 68 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (512)