FB2025_02 , released April 17, 2025
Gene: Dmel\Rab7
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General Information
Symbol
Dmel\Rab7
Species
D. melanogaster
Name
Rab7
Annotation Symbol
CG5915
Feature Type
FlyBase ID
FBgn0015795
Gene Model Status
Stock Availability
Gene Summary
Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
Also Known As

DmRab7, DRab7, Rab-protein 7

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-82
RefSeq locus
NT_033777 REGION:23993008..23995452
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (31 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Plekhm1; FB:FBgn0034694
inferred from physical interaction with FLYBASE:Vps35; FB:FBgn0034708
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225
inferred from electronic annotation with InterPro:IPR001806
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
Biological Process (18 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in endocytosis
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q9VRX2
inferred from genetic interaction with FLYBASE:dpp; FB:FBgn0000490
inferred from mutant phenotype
involved_in exosomal secretion
inferred from mutant phenotype
involved_in phagocytosis
inferred from expression pattern
inferred from mutant phenotype
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001178536
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000635769
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
Cellular Component (9 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
is_active_in phagocytic vesicle
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
located_in synapse
inferred from high throughput direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in late endosome
inferred from biological aspect of ancestor with PANTHER:PTN000635769
is_active_in lysosome
inferred from biological aspect of ancestor with PANTHER:PTN000635769
is_active_in phagocytic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000635769
located_in vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rab family. (O76742)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rab7 (Rab7) encodes a small GTPase that contributes to vesicle trafficking regulation. It is involved in endosome maturation and fusion with lysosomes. [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states (Probable). In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking (Probable). Involved in microtubule minus and plus end-directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (Probable). Governs early-to-late endosomal to lysosomal maturation (PubMed:23418349, PubMed:24327558). Controls endocytic cargo sorting towards the late endosome facilitating its eventual endolysosomal-mediated degradation (PubMed:11136982). Together with Rab2 involved in promoting fusion of autophagosomes and endosomes with lysosomes probably through recruitment of the HOPS tethering complex (PubMed:28063257, PubMed:28483915, PubMed:31194677). Involved in biosynthetic transport to lysosomes (Probable). Involved in establishing morphogen concentration gradients, for example of the TGF-beta homolog dpp/decapentaplegic, during pattern formation and organogenesis (PubMed:11136982). Together with the Mon1-Ccz1 complex, required for autolysosome formation in fat cells and autophagic degradation during starvation-induced basal and developmental autophagy (PubMed:27559127). Together with Mon1, regulates levels of postsynaptic glutamate receptor GluRIIA in the neuromuscular junction (NMJ) presynapse (PubMed:32658990). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257). Involved in intracellular trafficking of the carbohydrate transporter Tret1 in glial cells of the blood brain barrier, influencing its subcellular localization and protein levels (PubMed:34032568).
(UniProt, O76742)
Summary (Interactive Fly)

a small GTPase that acts downstream of Rab 5 to facilitates endosome maturation and fusion with lysosomes - required for autophagosome-lysosome fusion - regulates synaptic development

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O76742)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.39

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0084503
1515
207
FBtr0308611
1269
207
FBtr0308612
1280
207
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0083891
23.3
207
5.06
FBpp0300835
23.3
207
5.06
FBpp0300836
23.3
207
5.06
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

207 aa isoforms: Rab7-PA, Rab7-PB, Rab7-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.31

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Rab7 protein is localized to phagocytic vesicles in hemocytes at an intermediate stage of phagocytosis.

Marker for
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
is_active_in phagocytic vesicle
inferred from direct assay
located_in plasma membrane
inferred from high throughput direct assay
located_in synapse
inferred from high throughput direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab7 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab7
Transgenic constructs containing regulatory region of Rab7
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (71)
12 of 14
Yes
Yes
 
5  
4 of 14
No
Yes
3 of 14
No
No
1  
2 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
3  
1 of 14
No
No
3  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1  
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
12 of 14
Yes
Yes
4 of 14
No
Yes
3 of 14
No
No
3 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Mus musculus (laboratory mouse) (46)
12 of 14
Yes
Yes
3 of 14
No
Yes
3 of 14
No
No
3 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1  
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (42)
6 of 13
Yes
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
Danio rerio (Zebrafish) (59)
12 of 14
Yes
Yes
12 of 14
Yes
Yes
11 of 14
No
Yes
3 of 14
No
No
2 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (29)
12 of 14
Yes
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (26)
10 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (54)
12 of 13
Yes
Yes
12 of 13
Yes
Yes
11 of 13
No
Yes
11 of 13
No
Yes
11 of 13
No
Yes
10 of 13
No
Yes
8 of 13
No
Yes
3 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (11)
10 of 13
Yes
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (13)
10 of 12
Yes
Yes
3 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rab7. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (41)
5 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
2 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 10 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
Interaction Browsers

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
Interaction Browsers

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-82
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
95D5-95D5
Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (21)
Genomic Clones (22)
cDNA Clones (208)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      Rab7 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.

      dsRNA has been made from templates generated with primers directed against this gene.

      Relationship to Other Genes
      Source for database merge of
      Additional comments
      Nomenclature History
      Source for database identify of

      Source for identity of: Rab7 CG5915

      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (17)
      Reported As
      Symbol Synonym
      AAF56218
      Dm Rab7
      Rab-r7
      Rab7
      (Kim et al., 2024, Meyer et al., 2024, Mira-Osuna and Borgne, 2024, Nan et al., 2024, Sachan et al., 2024, Sharma and Chaudhary, 2024, Shweta et al., 2024, Srivastav et al., 2024, Sung and Lloyd, 2024, Szypulski et al., 2024, Tsap et al., 2024, Wilkin et al., 2024, Xu et al., 2024, Yu et al., 2024, Zhang et al., 2024, Bertin et al., 2023, Bonello et al., 2023, Joshi et al., 2023, Koehler and Huber, 2023, Lewis et al., 2023, Li et al., 2023, Liu et al., 2023, Maddison et al., 2023, Maruzs et al., 2023, Mitchell et al., 2023, Pradhan et al., 2023, Saha et al., 2023, Scholl et al., 2023, Szinyákovics et al., 2023, Tsarouhas et al., 2023, Vöing et al., 2023, Xu et al., 2023, Zhang et al., 2023, Zhou et al., 2023, Zhou et al., 2023, Zhuang et al., 2023, Chaudhry et al., 2022, Chen and He, 2022, González-Ramírez et al., 2022, Hodgson et al., 2022, Kunduri et al., 2022, Lang et al., 2022, Lauzier et al., 2022, Linnemannstöns et al., 2022, Marshall and Dionne, 2022, Meyer et al., 2022, Miao et al., 2022, Palozzi et al., 2022, Rai and Kumar Roy, 2022, Reed et al., 2022, Sanchez-Lopez et al., 2022, Schnute et al., 2022, Sung and Lloyd, 2022, Tanasic et al., 2022, Wang et al., 2022, Xu et al., 2022, Chan et al., 2021, Hertenstein et al., 2021, Hounjet and Vooijs, 2021, Kim et al., 2021, Lakatos et al., 2021, Lattao et al., 2021, Lund et al., 2021, Ma and Brill, 2021, Martinez-Arroyo et al., 2021, Neuman et al., 2021, Petrignani et al., 2021, Ricolo et al., 2021, Rigon et al., 2021, Sechi et al., 2021, Sharma et al., 2021, Wang et al., 2021, Yamaguchi et al., 2021, Yin et al., 2021, Yu et al., 2021, Zhang et al., 2021, Basargekar et al., 2020, Csizmadia and Juhász, 2020, Cunningham et al., 2020, Dehnen et al., 2020, Du et al., 2020, Gohel et al., 2020, Hoshika et al., 2020, Kessissoglou et al., 2020, Kitani-Morii and Noto, 2020, Langemeyer et al., 2020, Mathew et al., 2020, Medina-Yáñez et al., 2020, Nakamura et al., 2020, Patel et al., 2020, Qin et al., 2020, Wen et al., 2020, Witte et al., 2020, Ye et al., 2020, Yu et al., 2020, Bäumers et al., 2019, Boda et al., 2019, Bourouis et al., 2019, Hodgson et al., 2019, Imler et al., 2019, Johnson and Andrew, 2019, Khezri and Rusten, 2019, Krämer et al., 2019, Mao et al., 2019, Melcarne et al., 2019, Meltzer et al., 2019, Prince et al., 2019, Sinha et al., 2019, Texada et al., 2019, Troha et al., 2019, Wang et al., 2019, Xu et al., 2019, Zhang et al., 2019, Ayala et al., 2018, Csizmadia et al., 2018, Gene Disruption Project members, 2018-, Jin et al., 2018, Li et al., 2018, Liu et al., 2018, Lund et al., 2018, Ma et al., 2018, Rosa-Ferreira et al., 2018, Vukoja et al., 2018, Yamaguchi and Takashima, 2018, Akbergenova and Littleton, 2017, Beer and Wehman, 2017, Bussmann and Storkebaum, 2017, Court et al., 2017, Coutinho-Budd et al., 2017, Del Signore et al., 2017, Fujita et al., 2017, Galluzzi et al., 2017, Gao et al., 2017, Kamalesh et al., 2017, Liu et al., 2017, Lőrincz et al., 2017, O'Farrell et al., 2017, Sato and Sato, 2017, Sellin et al., 2017, Transgenic RNAi Project members, 2017-, Vonk et al., 2017, Zheng et al., 2017, Bharadwaj et al., 2016, Caviglia et al., 2016, Dinter et al., 2016, Fang et al., 2016, Hegedűs et al., 2016, Iwanami et al., 2016, Karlikow et al., 2016, Lőrincz et al., 2016, Luo et al., 2016, Meehan et al., 2016, Mukherjee et al., 2016, Nagy et al., 2016, Pueyo et al., 2016, Riedel et al., 2016, Deivasigamani et al., 2015, de Madrid et al., 2015, Jean et al., 2015, Lee et al., 2015, Liu et al., 2015, Parchure et al., 2015, Portela et al., 2015, Sanhueza et al., 2015, Sopko et al., 2015, Van Bortle et al., 2015, Wang et al., 2015, White et al., 2015, Bakhoum et al., 2014, Chen et al., 2014, Corrigan et al., 2014, Couturier et al., 2014, de Vreede et al., 2014, Dodson et al., 2014, Garg and Wu, 2014, Gillingham et al., 2014, Gillingham et al., 2014, Gillingham et al., 2014, Han et al., 2014, Janssens et al., 2014, Liu et al., 2014, Parsons et al., 2014, Politi et al., 2014, Shimizu et al., 2014, Szatmári et al., 2014, Thomas and Strutt, 2014, Tsai et al., 2014, Valzania et al., 2014, Wang et al., 2014, Abdallah et al., 2013, Aoyama et al., 2013, Bader et al., 2013, Bechtel et al., 2013, Cherry et al., 2013, Couturier et al., 2013, Dong et al., 2013, Dong et al., 2013, Fan et al., 2013, Gross et al., 2013, Hermle et al., 2013, Hoffmann et al., 2013, Krahmer et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Macleod et al., 2013, Pepperl et al., 2013, Petzoldt et al., 2013, Sanchez-Garcia et al., 2013, Satoh et al., 2013, Schneider et al., 2013, Shandala et al., 2013, Thomae et al., 2013, Xiong and Bellen, 2013, Yousefian et al., 2013, Zuo et al., 2013, Burgess et al., 2012, Capilla et al., 2012, Chen et al., 2012, Dodson et al., 2012, Gailite et al., 2012, Gault et al., 2012, Haberman et al., 2012, Hibbard and O'Tousa, 2012, Jean et al., 2012, Kametaka et al., 2012, Laflamme et al., 2012, Lloyd et al., 2012, Ma et al., 2012, Nezis, 2012, Rahman et al., 2012, Singh and Mlodzik, 2012, Wang et al., 2012, Wong et al., 2012, Xia et al., 2012, Xiong et al., 2012, Yamakawa et al., 2012, Ben El Kadhi et al., 2011, Bhuin and Roy, 2011, Burgess et al., 2011, Dalton et al., 2011, Gilbert et al., 2011, Mateus et al., 2011, Mitra et al., 2011, Otani et al., 2011, Ribeiro et al., 2011, Sun et al., 2011, Swetha et al., 2011, Tanaka et al., 2011, Tjota et al., 2011, Wang and Pai, 2011, Yuva-Aydemir et al., 2011, Becam et al., 2010, Cheli et al., 2010, Haberman et al., 2010, Haglund et al., 2010, Ho et al., 2010, Janssens et al., 2010, Kawahashi and Hayashi, 2010, Kim et al., 2010, Li et al., 2010, Lone et al., 2010, Midorikawa et al., 2010, Mottola et al., 2010, Mukai et al., 2010, Pirraglia et al., 2010, Stempfle et al., 2010, Velichkova et al., 2010, Williamson et al., 2010, Williamson et al., 2010, Abe et al., 2009, Akbar et al., 2009, Dworkin et al., 2009, Fetting et al., 2009, Gupta et al., 2009, Khaliullina et al., 2009, Polevoy et al., 2009, Soukup et al., 2009, Tan et al., 2009, Thomas et al., 2009, Warner and Longmore, 2009, Yan et al., 2009, Albertson et al., 2008, Chang et al., 2008, Denef et al., 2008, Harris and Tepass, 2008, Miura et al., 2008, Philips et al., 2008, Sinka et al., 2008, Strutt and Strutt, 2008, Tanaka and Nakamura, 2008, Velichkova et al., 2008, Wilkin et al., 2008, Yu et al., 2008, Bakal et al., 2007, Coutelis and Ephrussi, 2007, Curtis et al., 2007, Jiang et al., 2007, Korolchuk et al., 2007, Stuart et al., 2007, Tsarouhas et al., 2007, Tsruya et al., 2007, Zhang et al., 2007, Zhang et al., 2007, Bokel et al., 2006, Cermelli et al., 2006, Gallagher and Knoblich, 2006, Glittenberg et al., 2006, Hennig et al., 2006, Kouranti et al., 2006, Rusten et al., 2006, Saleh et al., 2006, Seto and Bellen, 2006, Sweeney et al., 2006, Sweeney et al., 2006, Emery et al., 2005, Hutterer and Knoblich, 2005, Jutras et al., 2005, Lu and Bilder, 2005, Somers and Chia, 2005, Strigini, 2005, Wu et al., 2005, Guha et al., 2003)
      Name Synonyms
      Rab-protein 7
      Rab7
      Secondary FlyBase IDs
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 68 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (512)