DmRab7, DRab7, Rab-protein 7
a small GTPase that acts downstream of Rab 5 to facilitates endosome maturation and fusion with lysosomes - required for autophagosome-lysosome fusion - regulates synaptic development
Please see the JBrowse view of Dmel\Rab7 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.49
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab7 using the Feature Mapper tool.
Comment: maternally deposited
Rab7 protein is localized to phagocytic vesicles in hemocytes at an intermediate stage of phagocytosis.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Rab7 in GBrowse 23-82
3-82.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
Source for identity of: Rab7 CG5915
Rab7 is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.
dsRNA has been made from templates generated with primers directed against this gene.
