dpix, 38C.40, rhoGEF, pix
Alternative translation stop created by use of multiphasic reading frames within coding region.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.48
Gene model reviewed during 6.32
3.8 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RtGEF using the Feature Mapper tool.
Expression in stage P3 pupal leg discs is ubiquitous.
The RtGEF transcript is detected throughout oogenesis in nurse and follicle cells, and in the oocyte up to stage S9. During early embryogenesis, the RtGEF transcript is ubiquitous, but at gastrulation it is most abundant in or near cells involved in morphogenetic movements, such as the ventral and cephalic furrows, the posterior plate, and the midgut invaginations. Ventral neuroblasts express RtGEF at stage 11, and the transcript is detected along the ventral nerve cord at stages 12 to 15. At stage 11, RtGEF transcript is detecte in the anterior and posterior midgut, and the hindgut, and gut staining persists through stages 12-15.
GBrowse - Visual display of RNA-Seq signalsView Dmel\RtGEF in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RtGEF and Git regulate hpo-pathway dependent tissue growth. They appear to influence the activity of the hpo kinase by acting as a scaffold complex, promoting hpo dimerisation and autophosphorylation of hpo's activation loop.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
rtGEF is necessary for correct postsynaptic structure and assembly of postsynaptic proteins.
Encodes a guanine nucleotide exchange factor. Expressed throughout oogenesis and embryogenesis and in the embryo mRNA is abundant in cells undergoing morphogenetic movements.
"RhoGEF" gene symbol is temporary.