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FB2025_05
,
released December 11, 2025
stbm, strabismus, Vang/Stbm, stb, Van Gogh/Strabismus
a four-pass transmembrane protein that localizes to cell junctions - part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia - implicated in nervous system patterning - mutants show a disrupted orientation of ommatidia - Frizzled-induced Van Gogh phosphorylation by CK1epsilon promotes asymmetric localization of core PCP factors
Please see the JBrowse view of Dmel\Vang for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Stop-codon suppression (UGA) postulated; FBrf0216884
Gene model reviewed during 5.44
Gene model reviewed during 5.49
3.4 (longest cDNA)
None of the polypeptides share 100% sequence identity.
584 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vang using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Vang protein is expressed in cells immediately dorsal to and ventral to the dorsal/ventral compartment boundary of the wing disc. No expression is observed in the haltere disc.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Vang in JBrowse2-60
2-58.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
New stable cell line derived from S2R+-NPT005 : The S2R+-NPT005ΔDshΔStbmΔFz cell line was created containing large deletions in the dsh, Vang (also known as Stbm), and fz genes. The deletions were characterized as follows: dsh : 664 bp deletion of bp 65-728 (between the two gRNAs); Vang : 452 bp deletion of bp 284-735 (between the two gRNAs) on one chromosome, 5 bp deletion of bp 323-327 on another; fz : 532 bp deletion of bp 34-565 (between the two gRNAs).
Flies homozygous for Vang alleles show a tissue polarity bristle phenotype on the wing, thorax, legs and abdomen. On the abdomen, bristles point almost orthogonally to the midline instead of posteriorly. Tarsal joints are often duplicated. Flies have rough eyes. Phenotypic data suggest that genetics of Vang and its interactions with pk are complex. Several, but not all, Vang alleles act as enhancers of the pk haploinsufficient tissue polarity phenotype, and the pkTBJ21 antimorphic phenotype. Mutations in pk can also act as suppressors of Vang dominant phenotypes.
Vang is required to establish polarity in the eye, legs and bristles.
The definition of strabismus is: a disorder in vision due to a deviation from normal orientation of one or both eyes (the medical term for cross-eyed).
Source for merge of: Vang stbm
"Vang" was named after the artist, van Gogh, because the swirling wing hair patterns in the mutants bring to mind the swirling brush strokes van Gogh used in some of his paintings.
