stbm, strabismus, stb, Van Gogh/Strabismus, Vang/Stbm
a four-pass transmembrane protein that localizes to cell junctions - part of the Frizzled-dependent planar polarity pathway that establishes planar polarity in epithelia - implicated in nervous system patterning - mutants show a disrupted orientation of ommatidia - Frizzled-induced Van Gogh phosphorylation by CK1epsilon promotes asymmetric localization of core PCP factors
Stop-codon suppression (UGA) postulated; FBrf0216884
Gene model reviewed during 5.44
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vang using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Vang in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Vang stbm
The Vang gene product is essential for fz signalling. The Vang gene does not fall into the usual fz-like or in-like classification, defining a new type of tissue polarity gene. The Vang gene product acts cell nonautonomously.
Flies homozygous for Vang alleles show a tissue polarity bristle phenotype on the wing, thorax, legs and abdomen. On the abdomen, bristles point almost orthogonally to the midline instead of posteriorly. Tarsal joints are often duplicated. Flies have rough eyes. Phenotypic data suggest that genetics of Vang and its interactions with pk are complex. Several, but not all, Vang alleles act as enhancers of the pk haploinsufficient tissue polarity phenotype, and the pkTBJ21 antimorphic phenotype. Mutations in pk can also act as suppressors of Vang dominant phenotypes.
Vang is involved in setting up polarity in the eye, legs and bristles. Mosaic analysis indicates Vang is required in all photoreceptors within an ommatidium to establish normal polarity of the ommatidium.
The definition of strabismus is: a disorder in vision due to a deviation from normal orientation of one or both eyes (the medical term for cross-eyed).
"Vang" was named after the artist, van Gogh, because the swirling wing hair patterns in the mutants bring to mind the swirling brush strokes van Gogh used in some of his paintings.