pro-apoptotic protein whose N-terminus functions by disrupting IAP binding to caspases - an additional mitochondrial-dependent apoptotic function carried out by a centrally located GH3 domain
Please see the JBrowse view of Dmel\grim for information on other features
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Gene model reviewed during 5.46
1.6 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
138 (aa)
Interacts with Diap2 (via BIR2 domain).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\grim using the Feature Mapper tool.
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
GBrowse - Visual display of RNA-Seq signals
View Dmel\grim in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: grim BcDNA:RE28551
Source for merge of grim BcDNA:RE28551 was a shared cDNA ( date:030728 ).
The N-terminal and GH3 domains within grim activate independent apoptotic pathways.
grim may participate in initiating apoptosis by stably blocking K+ channels.
grim expression induces apoptosis in mammalian cells by specifically acting on mitochondrial apoptotic pathways executed by endogenous caspases.
Characterisation of grim suggests the encoded apoptotic function is upstream of putative Cys proteases and grim activity parallels that of rpr and W. Because grim triggered extensive apoptosis in at least one developmental context where rpr was not sufficient, it is possible that these proteins enter a common apoptotic pathway at different sites.
By virtue of its proximity to rpr (reaper) and its potent cell killing activity the gene is named "grim".