FB2021_02, released April 13, 2021

Gene: Dmel\H15

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General Information
Symbol
Dmel\H15
Species
D. melanogaster
Name
H15
Annotation Symbol
CG6604
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016660
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
H15 (H15) encodes a T-box transcription factor that regulates the specification of cell fate in the heart and central nervous system. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Also Known As

nmr, nmr1, neuromancer, neuromancer 1, neuromancer1

Key Links
Genomic Location
Cytogenetic map
25E1-25E1
Sequence location
2L:5,404,280..5,416,593 [+]
Recombination map
2-17
RefSeq locus
NT_033779 REGION:5404280..5416593
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in cardioblast cell fate commitment
inferred from mutant phenotype
(Qian et al., 2005)
involved_in chorion-containing eggshell pattern formation
inferred from mutant phenotype
(Fregoso Lomas et al., 2013)
involved_in embryonic heart tube development
inferred from mutant phenotype
(Qian et al., 2005)
involved_in heart development
inferred from mutant phenotype
(Miskolczi-McCallum et al., 2005)
involved_in heart process
inferred from direct assay
(Qian et al., 2008)
involved_in leg disc pattern formation
inferred from genetic interaction with FLYBASE:mid; FB:FBgn0261963
(Svendsen et al., 2009)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Gaziova and Bhat, 2009)
involved_in regulation of cell fate specification
inferred from genetic interaction with FLYBASE:mid; FB:FBgn0261963
(Svendsen et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cell fate specification
inferred from biological aspect of ancestor with PANTHER:PTN000137774
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in heart development
inferred from biological aspect of ancestor with PANTHER:PTN002601330
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004251338
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
H15 (H15) encodes a T-box transcription factor that regulates the specification of cell fate in the heart and central nervous system. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
T-BOX TRANSCRIPTION FACTORS -
The T-box transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by a conserved DNA-binding immunoglobulin-fold domain of 180-200 amino acids, known as T-box, named after its founding member, the mouse T protein. (Adapted from FBrf0218841).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\H15 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
H15-RA
FBtr0079076
NM_135082
2617
660
H15-RB
FBtr0343225
NM_001298698
2926
659
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
H15-PA
FBpp0078710
72.4
660
8.94
NP_608926
AAF52249
H15-PB
FBpp0309914
72.2
659
8.94
NP_001285627
AHN54142
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\H15 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 15
dorsal vessel primordium
(Qian et al., 2005)
embryonic stage 13 -- 16
atrium
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic/larval dorsal vessel
(Fisher et al., 2012)
embryonic stage 16 -- 17
embryonic dorsal vessel
(Qian et al., 2005)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult heart
(Qian et al., 2008)
Additional Descriptive Data

H15 transcript is expressed in the developing dorsal vessel from embryonic stage 13.

(Qian et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroblast NB2-3
(Lacin and Truman, 2016)
neuroblast NB6-1
(Lacin and Truman, 2016)
larval stage
neuroblast NB2-3
(Lacin and Truman, 2016)
neuroblast NB6-1
(Lacin and Truman, 2016)
wandering third instar larval stage -- prepupal stage P2
photoreceptor cell
(Das et al., 2013)
adult stage
adult ostium
(Tang et al., 2013)
cardioblast
(Tang et al., 2013)
oogenesis stage S8 -- S10B & adult stage | female
main body follicle cell | posterior | subset
• nucleus
(Fregoso Lomas et al., 2013)
Additional Descriptive Data

H15 is expressed in oocyte-associated follicle cells covering roughly the posterior end of the egg chamber at stage 10B. Length-wise, the domain of H15 expression goes from the posterior tip of the egg chamber halfway towards where the dorsal appendage forming follicle cells begin.

(Fregoso Lomas et al., 2013)

Anti-H15 staining identifies small ostial

(Tang et al., 2013)

cell nuclei and larger myocardial cell (cardioblast) nuclei.

(Tang et al., 2013)
Marker for
 
adult ostium
(Tang et al., 2013)
cardioblast
(Tang et al., 2013)
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{PZ}H-15
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 16
B-subperineurial glial cell of abdomen
(Beckervordersandforth et al., 2008)
medial dorsal subperineurial glial cell
(Beckervordersandforth et al., 2008)
dorsal lateral subperineurial glial cell
(Beckervordersandforth et al., 2008)
medial ventral subperineurial glial cell
(Beckervordersandforth et al., 2008)
dorsal channel glial cell
(Beckervordersandforth et al., 2008)
longitudinal glial cell

Comment: lateral posterior

(Beckervordersandforth et al., 2008)
medial intersegmental nerve root glial cell
(Beckervordersandforth et al., 2008)
lateral intersegmental nerve root glial cell
(Beckervordersandforth et al., 2008)
lateral segmental nerve root glial cell
(Beckervordersandforth et al., 2008)
embryonic/larval neuron

Comment: lateral posterior

(Beckervordersandforth et al., 2008)
embryonic stage 12 -- 15
dorsal vessel primordium
(Griffin et al., 2000)
embryonic head
(Griffin et al., 2000)
embryonic/larval central nervous system | segmentally repeated | striped | ventral
(Griffin et al., 2000)
embryonic/larval peripheral nervous system
(Griffin et al., 2000)
epidermis | anterior | segmentally repeated | ventral
(Griffin et al., 2000)
embryonic stage 12 -- 17
embryonic peripheral glial cell 3
(von Hilchen et al., 2008)
embryonic peripheral glial cell 4
(von Hilchen et al., 2008)
embryonic peripheral glial cell 7
(von Hilchen et al., 2008)
embryonic peripheral glial cell 11
(von Hilchen et al., 2008)
third instar larval stage
imaginal disc | restricted
(Wilder and Perrimon, 1995)
imaginal disc | ventral
(Wilder and Perrimon, 1995)
adult stage
cardial cell
(Qian et al., 2008)
adult ostium
(Qian et al., 2008)
adult heart
(Qian et al., 2008)
oogenesis stage S8 -- S10B & adult stage | female
main body follicle cell | posterior | subset
• nucleus
(Fregoso Lomas et al., 2013)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\H15 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of H15
Transgenic constructs containing regulatory region of H15
Aberrations (Deficiencies and Duplications) ( 5 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TBX20
8 of 15
Yes
No
Hsap\MGA
3 of 15
No
Yes
Hsap\TBX6
3 of 15
No
No
Hsap\TBX15
3 of 15
No
No
Hsap\TBX18
3 of 15
No
No
Hsap\TBX19
3 of 15
No
No
Hsap\TBX22
3 of 15
No
Yes
Hsap\TBXT
3 of 15
No
No
Hsap\EOMES
2 of 15
No
Yes
Hsap\TBR1
2 of 15
No
Yes
Hsap\TBX1
2 of 15
No
No
Hsap\TBX2
2 of 15
No
No
4  
Hsap\TBX3
2 of 15
No
No
Hsap\TBX4
2 of 15
No
Yes
Hsap\TBX5
2 of 15
No
Yes
1  
Hsap\TBX10
2 of 15
No
No
Hsap\TBX21
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tbx20
8 of 15
Yes
No
Mmus\Tbx15
4 of 15
No
Yes
Mmus\Tbx22
4 of 15
No
Yes
Mmus\Mga
3 of 15
No
Yes
Mmus\Tbx6
3 of 15
No
No
Mmus\Tbx18
3 of 15
No
Yes
Mmus\T
3 of 15
No
No
1  
Mmus\Eomes
2 of 15
No
Yes
Mmus\Tbr1
2 of 15
No
Yes
Mmus\Tbx1
2 of 15
No
No
Mmus\Tbx2
2 of 15
No
No
Mmus\Tbx3
2 of 15
No
No
Mmus\Tbx4
2 of 15
No
Yes
Mmus\Tbx5
2 of 15
No
Yes
Mmus\Tbx19
2 of 15
No
No
Mmus\Tbx21
2 of 15
No
Yes
Mmus\Tbx10
1 of 15
No
No
Rattus norvegicus (Norway rat) (15)
Rnor\Tbx20
5 of 13
Yes
No
Rnor\Tbx22
4 of 13
No
Yes
Rnor\Mga
3 of 13
No
Yes
Rnor\Tbx6
3 of 13
No
No
Rnor\Tbx15
3 of 13
No
Yes
Rnor\Tbx18
3 of 13
No
Yes
Rnor\Tbx19
3 of 13
No
No
Rnor\Tbxt
3 of 13
No
No
Rnor\Tbx1
2 of 13
No
No
Rnor\Tbx2
2 of 13
No
No
Rnor\Tbx3
2 of 13
No
No
Rnor\Tbx4
2 of 13
No
Yes
Rnor\Tbx5
2 of 13
No
Yes
Rnor\Tbx21
2 of 13
No
Yes
Rnor\Tbx10
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\tbx20
7 of 12
Yes
No
Xtro\mga
3 of 12
No
Yes
Xtro\t2
3 of 12
No
No
Xtro\tbx22
3 of 12
No
Yes
Xtro\tbxt
3 of 12
No
No
Xtro\vegt
3 of 12
No
No
Xtro\eomes
2 of 12
No
Yes
Xtro\tbr1
2 of 12
No
Yes
Xtro\tbx1
2 of 12
No
No
Xtro\tbx2
2 of 12
No
No
Xtro\tbx3
2 of 12
No
No
Xtro\tbx4
2 of 12
No
Yes
Xtro\tbx5
2 of 12
No
Yes
Xtro\tbx15
2 of 12
No
Yes
Xtro\tbx18
2 of 12
No
Yes
Danio rerio (Zebrafish) (26)
Drer\tbx20
7 of 15
Yes
No
Drer\tbx6
3 of 15
No
No
Drer\tbx15
3 of 15
No
Yes
Drer\tbx16
3 of 15
No
No
Drer\tbx16l
3 of 15
No
Yes
Drer\tbx19
3 of 15
No
No
Drer\tbxta
3 of 15
No
No
Drer\tbxtb
3 of 15
No
No
Drer\eomesa
2 of 15
No
Yes
Drer\eomesb
2 of 15
No
Yes
Drer\grap2b
2 of 15
No
No
Drer\mgaa
2 of 15
No
Yes
Drer\tbr1a
2 of 15
No
Yes
Drer\tbr1b
2 of 15
No
Yes
Drer\tbx1
2 of 15
No
No
Drer\tbx2a
2 of 15
No
No
Drer\tbx2b
2 of 15
No
No
Drer\tbx3a
2 of 15
No
No
Drer\tbx3b
2 of 15
No
No
Drer\tbx4
2 of 15
No
Yes
Drer\tbx5a
2 of 15
No
Yes
Drer\tbx5b
2 of 15
No
Yes
Drer\tbx21
2 of 15
No
Yes
Drer\tbx22
2 of 15
No
Yes
Drer\LOC110439164
1 of 15
No
No
Drer\tbx18
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (22)
Cele\mab-9
8 of 15
Yes
No
Cele\mls-1
2 of 15
No
No
Cele\sea-1
1 of 15
No
No
Cele\tbx-2
1 of 15
No
No
Cele\tbx-8
1 of 15
No
No
Cele\tbx-9
1 of 15
No
No
Cele\tbx-11
1 of 15
No
No
Cele\tbx-30
1 of 15
No
No
Cele\tbx-31
1 of 15
No
No
Cele\tbx-32
1 of 15
No
No
Cele\tbx-33
1 of 15
No
No
Cele\tbx-34
1 of 15
No
No
Cele\tbx-35
1 of 15
No
No
Cele\tbx-36
1 of 15
No
No
Cele\tbx-37
1 of 15
No
No
Cele\tbx-38
1 of 15
No
No
Cele\tbx-39
1 of 15
No
No
Cele\tbx-40
1 of 15
No
No
Cele\tbx-41
1 of 15
No
No
Cele\tbx-42
1 of 15
No
No
Cele\tbx-43
1 of 15
No
No
Cele\ZK328.6
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AVZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000237
Drosophila simulans
Dsim\GD23340
Drosophila sechellia
Dsec\GM18547
Drosophila erecta
Dere\GG25071
Drosophila yakuba
Dyak\GE25406
Drosophila ananassae
Dana\GF14390
Drosophila pseudoobscura pseudoobscura
Dpse\GA25466
Drosophila persimilis
Dper\GL25841
Drosophila willistoni
Dwil\GK15084
Drosophila virilis
Dvir\GJ19565
Drosophila mojavensis
Dmoj\GI17985
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504MB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022278
Musca domestica
House fly
Mdoa\17022277
Glossina morsitans
Tsetse fly
Gmor\GMOY003396
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14383
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14381
Mayetiola destructor
Hessian fly
Mdes\Mdes007764
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013855
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014429
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015073
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008337
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008339
Anopheles darlingi
American malaria mosquito
Adar\ADAC004417
Anopheles gambiae
Malaria mosquito
Agam\AGAP008563
Anopheles gambiae
Malaria mosquito
Agam\AGAP008567
Anopheles gambiae
Malaria mosquito
Agam\AGAP008569
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007738
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MK1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012897
Bombyx mori
Silkmoth
Bmor\BGIBMGA013132
Bombyx mori
Silkmoth
Bmor\BGIBMGA002994
Bombyx mori
Silkmoth
Bmor\BGIBMGA003174
Bombyx mori
Silkmoth
Bmor\BGIBMGA003173
Danaus plexippus
Monarch butterfly
Dple\DPOGS211184-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212701-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211117-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS206923-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012426
Heliconius melpomene
Postman butterfly
Hmel\HMEL015536
Heliconius melpomene
Postman butterfly
Hmel\HMEL012427
Heliconius melpomene
Postman butterfly
Hmel\HMEL004265
Apis florea
Little honeybee
Aflo\2154237764
Apis florea
Little honeybee
Aflo\3376454356
Apis florea
Little honeybee
Aflo\2147484449
Apis florea
Little honeybee
Aflo\2147525857
Apis florea
Little honeybee
Aflo\4267726212
Apis florea
Little honeybee
Aflo\2863733812
Apis florea
Little honeybee
Aflo\2417179158
Apis mellifera
Western honey bee
Amel\GB45658
Apis mellifera
Western honey bee
Amel\GB49684
Apis mellifera
Western honey bee
Amel\LOC552311
Apis mellifera
Western honey bee
Amel\GB50858
Apis mellifera
Western honey bee
Amel\GB45715
Apis mellifera
Western honey bee
Amel\GB49683
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18848
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18937
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16076
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23776
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP23777
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20447
Bombus terrestris
Buff-tailed bumblebee
Bter\15217017
Bombus terrestris
Buff-tailed bumblebee
Bter\15203409
Bombus terrestris
Buff-tailed bumblebee
Bter\15202535
Bombus terrestris
Buff-tailed bumblebee
Bter\15205792
Bombus terrestris
Buff-tailed bumblebee
Bter\15216568
Bombus terrestris
Buff-tailed bumblebee
Bter\15215615
Linepithema humile
Argentine ant
Lhum\LH10745
Linepithema humile
Argentine ant
Lhum\LH20155
Linepithema humile
Argentine ant
Lhum\LH16418
Linepithema humile
Argentine ant
Lhum\LH20159
Linepithema humile
Argentine ant
Lhum\LH23371
Linepithema humile
Argentine ant
Lhum\LH26168
Linepithema humile
Argentine ant
Lhum\LH20152
Linepithema humile
Argentine ant
Lhum\LH20154
Linepithema humile
Argentine ant
Lhum\LH10744
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000af2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001437
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026b2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001436
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001439
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002b1a
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0026b0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019950
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019948
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009552
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003929
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004177
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00001
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10853
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06270
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10906
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10905
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06268
Tribolium castaneum
Red flour beetle
Tcas\Org-1
Tribolium castaneum
Red flour beetle
Tcas\TC033450
Tribolium castaneum
Red flour beetle
Tcas\mid
Tribolium castaneum
Red flour beetle
Tcas\TC033122
Tribolium castaneum
Red flour beetle
Tcas\Doc1
Pediculus humanus
Human body louse
Phum\PHUM322740
Pediculus humanus
Human body louse
Phum\PHUM147760
Pediculus humanus
Human body louse
Phum\PHUM147770
Pediculus humanus
Human body louse
Phum\PHUM322730
Pediculus humanus
Human body louse
Phum\PHUM625180
Pediculus humanus
Human body louse
Phum\PHUM607490
Pediculus humanus
Human body louse
Phum\PHUM322720
Rhodnius prolixus
Kissing bug
Rpro\RPRC007267
Rhodnius prolixus
Kissing bug
Rpro\RPRC001899
Rhodnius prolixus
Kissing bug
Rpro\RPRC009188
Rhodnius prolixus
Kissing bug
Rpro\RPRC001598
Cimex lectularius
Bed bug
Clec\CLEC007094
Cimex lectularius
Bed bug
Clec\CLEC006885
Cimex lectularius
Bed bug
Clec\CLEC007098
Cimex lectularius
Bed bug
Clec\CLEC007099
Cimex lectularius
Bed bug
Clec\CLEC004947
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008613
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001903
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000143
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI086926
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17383
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15936
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13184
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10669
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12368
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13183
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15935
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12638
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BIS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015389
Strigamia maritima
European centipede
Smar\SMAR009230
Strigamia maritima
European centipede
Smar\SMAR008438
Ixodes scapularis
Black-legged tick
Isca\ISCW019283
Ixodes scapularis
Black-legged tick
Isca\ISCW019280
Ixodes scapularis
Black-legged tick
Isca\ISCW003117
Ixodes scapularis
Black-legged tick
Isca\ISCW019287
Ixodes scapularis
Black-legged tick
Isca\ISCW019692
Ixodes scapularis
Black-legged tick
Isca\ISCW019282
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71503.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74503.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58866.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65879.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66498.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63700.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75925.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66496.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g00890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur33g01070
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g01390
Tetranychus urticae
Two-spotted spider mite
Turt\tetur32g01430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_16384
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59354
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_59366
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_3881
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_13272
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0I8R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx6/16
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx20_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_021963gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tbx2-3
Ciona intestinalis
Vase tunicate
Cint\tbx6b
Ciona intestinalis
Vase tunicate
Cint\tbx2/3
Ciona intestinalis
Vase tunicate
Cint\LOC100185942
Ciona intestinalis
Vase tunicate
Cint\tbx15/18/22
Ciona intestinalis
Vase tunicate
Cint\tbx6a
Ciona intestinalis
Vase tunicate
Cint\tbx1
Ciona intestinalis
Vase tunicate
Cint\tbx20
Gallus gallus
Domestic chicken
Ggal\TBX3
Gallus gallus
Domestic chicken
Ggal\TBX10
Gallus gallus
Domestic chicken
Ggal\TBX2
Gallus gallus
Domestic chicken
Ggal\TBX20
Gallus gallus
Domestic chicken
Ggal\TBX5
Gallus gallus
Domestic chicken
Ggal\TBX22
Gallus gallus
Domestic chicken
Ggal\TBX18
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008653
Gallus gallus
Domestic chicken
Ggal\TBX15
Gallus gallus
Domestic chicken
Ggal\TBX4
Gallus gallus
Domestic chicken
Ggal\TBX6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
mid
9 of 10
org-1
4 of 10
bi
3 of 10
byn
3 of 10
Doc1
3 of 10
Doc2
3 of 10
Doc3
3 of 10
ocm
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
H15nmr-614
model of  cardiomyopathy
CEA
(Qian et al., 2008)
model of  congenital heart disease
CEA
(Qian et al., 2008)
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
TBX20; T-box transcription factor 20
8 of 15
606061
MGA; MAX dimerization protein MGA
3 of 15
616061
      TBX6; T-box transcription factor 6
      3 of 15
      602427
      TBX15; T-box transcription factor 15
      3 of 15
      604127
        TBX18; T-box transcription factor 18
        3 of 15
        604613
        TBX19; T-box transcription factor 19
        3 of 15
        604614
        TBX22; T-box transcription factor 22
        3 of 15
        300307
        TBXT; T-box transcription factor T
        3 of 15
        601397
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Show neighbor-neighbor interactions:
          Select Layout:
          Legend:
          Protein
          RNA
          Selected Interactor(s)
          Interactions Browser
          View in Interactions Browser
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          H15 - Hr78
          two hybrid array
          (Shokri et al., 2019)
          H15 - Set1
          anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
          (Rhee et al., 2014)
          H15 - atms
          anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
          (Rhee et al., 2014)
          H15 - mid
          two hybrid array
          (Shokri et al., 2019)
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          mid
          enhanceable
          H15
          (Qian et al., 2005)
          pnr
          suppressible
          H15
          (Qian and Bodmer, 2009)
          External Data
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-17
          Cytogenetic map
          25E1-25E1
          Sequence location
          2L:5,404,280..5,416,593 [+]
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          25E1-25E1
          Limits computationally determined from genome sequence between P{lacW}vrik05901&P{PZ}cype03771 and P{lacW}Hel25Ek11511
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-17

          (FlyBase, 2016)

          2-18.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (5)
          Genomic Clones (32)
          cDNA Clones (3)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Leal et al., 2009)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of

              Source for identity of: H15 nmr

              (Qian, 2003.2.10)
              Source for database merge of
              Additional comments
              Other Comments

              mid and H15 are negative regulators of wg expression and act to break the symmetry of hh signaling during segmentation of the embryo.

              (Buescher et al., 2004)

              Loss of both mid and H15 produces defects that mimic a wg gain-of-function phenotype.

              (Buescher et al., 2004)

              H15 may have a role in heart formation.

              (Griffin et al., 2000)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 37 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Synonyms and Secondary IDs (17)
              Reported As
              Symbol Synonym
              CG6604
              (Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Klebes et al., 2005)
              Dm-H15
              (Prpic et al., 2003)
              H15
              (Shokri et al., 2019, Svendsen et al., 2019, Wittes and Schüpbach, 2019, Schwarz et al., 2018, Liu et al., 2017, Osterfield et al., 2017, Revaitis et al., 2017, Transgenic RNAi Project members, 2017-, van Tienen et al., 2017, Fregoso Lomas et al., 2016, Moulton and Letsou, 2016, Peng et al., 2016, Gill et al., 2015, Grotewiel and Bettinger, 2015, Kumar et al., 2015, Svendsen et al., 2015, Ocorr et al., 2014, Das et al., 2013, Fregoso Lomas et al., 2013, Jin et al., 2013, McKay and Lieb, 2013, Formaz-Preston et al., 2012, Johnson et al., 2011, Neumüller et al., 2011, Ryu et al., 2011, Neely et al., 2010, Gaziova and Bhat, 2009, Leal et al., 2009, Svendsen et al., 2009, Estella and Mann, 2008, Engström et al., 2007, Estella and Mann, 2007, Monier et al., 2007, Schwartz and Pirrotta, 2007, Buescher et al., 2006, Choksi et al., 2006, Joshi et al., 2006, Nguyen and Frasch, 2006, Zaffran et al., 2006, Copley, 2005, Hoskins et al., 2005, Ringrose et al., 2003)
              Nmr
              (Mann et al., 2007)
              Nmr-1
              (Lacin et al., 2014, Babaoglan et al., 2009)
              Nmr1
              (Ocorr et al., 2014, Tang et al., 2013)
              Tbx20
              (Qian et al., 2008)
              dm-H15
              (Papaioannou and Silver, 1998)
              nmr
              (Kumar et al., 2015, Qian et al., 2008, Qian, 2003.2.10, Qian et al., 2003, Cripps and Olson, 2002, Griffin et al., 2000, McGhee, 2000, Porsch et al., 1998)
              nmr1
              (Leal et al., 2009, Qian and Bodmer, 2009, Qian et al., 2008, Qian et al., 2005, Qian et al., 2005, Qian, 2004.2.25)
              nmrH15
              (Taghli-Lamallem et al., 2008)
              Name Synonyms
              H15
              (Osterfield et al., 2017)
              Neuromancer
              (Zhu et al., 2017, Mann et al., 2007)
              neuromancer
              (Ugur et al., 2016, Qian et al., 2008, Qian et al., 2003)
              neuromancer 1
              (Svendsen et al., 2009, Qian et al., 2008, Qian et al., 2005)
              neuromancer 2
              (Ryu et al., 2011)
              neuromancer-1
              (Neely et al., 2010)
              neuromancer1
              (Leal et al., 2009, Qian, 2004.2.25, Qian et al., 2004)
              Secondary FlyBase IDs
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                References (100)