ari, ariadne, HL-V
Gene model reviewed during 5.53
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
4.3 (northern blot)
503 (aa); 59 (kD observed); 59 (kD predicted)
Can form homodimers (PubMed:10880484, PubMed:29689197). Interacts (via RING-type 1 zinc finger) with Ubc10 (PubMed:10880484, PubMed:29689197). Interacts with the LINC complex member koi (PubMed:29689197). Interacts with park (PubMed:29689197). Interacts with ari-2 (PubMed:29689197). Specifically interacts with isoform ECR-A of EcR (PubMed:21900267).
Members of the RBR family are atypical E3 ligases. They interact with E2 conjugating enzymes such as Ubc10 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger. The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ari-1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ari-1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The name "ariadne" refers to the loss of clues to find the correct path of axonal projection, and it evokes the Greek myth of the thread that Ariadne gave to Theseus to find his way in the Minotaur's labyrinth.