FB2021_02, released April 13, 2021

Gene: Dmel\Max

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General Information
Symbol
Dmel\Max
Species
D. melanogaster
Name
Max
Annotation Symbol
CG9648
Feature Type
protein_coding_gene
FlyBase ID
FBgn0017578
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Max (Max) encodes a member of the basic-helix-loop-helix-zipper family of transcription factors. It specifically forms heterodimers with the products of Myc and Mnt enabling the binding and transcriptional activity of the heterodimeric complex, which regulate genes involved in cell and organismal growth. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dMax

Key Links
Genomic Location
Cytogenetic map
76A3-76A3
Sequence location
3L:19,262,232..19,264,184 [-]
Recombination map
3-45
RefSeq locus
NT_037436 REGION:19262232..19264184
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from direct assay
(assigned by UniProt )
(Gallant et al., 1996)
enables protein heterodimerization activity
inferred from physical interaction with FLYBASE:Mnt; FB:FBgn0023215
(Loo et al., 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from biological aspect of ancestor with PANTHER:PTN002232681
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Loo et al., 2005)
involved_in regulation of transcription, DNA-templated
inferred from direct assay
(assigned by UniProt )
(Gallant et al., 1996)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN002232681
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of MLL1 complex
inferred from electronic annotation with InterPro:IPR037933
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in nucleus
inferred by curator from GO:0006355
(assigned by UniProt )
(Gallant et al., 1996)
part_of RNA polymerase II transcription regulator complex
inferred from biological aspect of ancestor with PANTHER:PTN002232681
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the MAX family. (P91664)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Max (Max) encodes a member of the basic-helix-loop-helix-zipper family of transcription factors. It specifically forms heterodimers with the products of Myc and Mnt enabling the binding and transcriptional activity of the heterodimeric complex, which regulate genes involved in cell and organismal growth. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor.
(UniProt, P91664)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Max for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Max-RA
FBtr0075018
NM_140840
995
161
Max-RC
FBtr0310276
NM_001259904
822
161
Max-RD
FBtr0345391
NM_001300185
1289
161
Additional Transcript Data and Comments
Reported size (kB)

1.2 (northern blot)

(Gallant et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Max-PA
FBpp0074785
18.5
161
4.90
NP_649097
AAF49179
Max-PC
FBpp0301959
18.5
161
4.90
NP_001246833
AFH04504
Max-PD
FBpp0311541
18.5
161
4.90
NP_001287114
AHN58139
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

161 aa isoforms: Max-PA, Max-PC, Max-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

161 (aa)

(Gallant et al., 1996)
Comments
External Data
Subunit Structure (UniProtKB)

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD.

(UniProt, P91664)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Max using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
posterior midgut primordium
(Gallant et al., 1996)
anterior midgut primordium
(Gallant et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Gallant et al., 1996)
mesoderm | presumptive
(Gallant et al., 1996)
embryonic stage -- adult stage
(Gallant et al., 1996)
Additional Descriptive Data

The Max transcript is expressed at essentially constant levels throughout development, from embryos to adults. In situ hybridization experiments show embryonic expression of Max in a pattern similar to that of dm, in tissues undergoing DNA replication, but at lower levels. Max is additionally expressed in the developing embryonic central nervous system.

(Gallant et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Max in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 3 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Max
Transgenic constructs containing regulatory region of Max
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(3L)fz2)
lethal | larval stage | recessive
lethal | pharate adult stage | recessive
lethal | recessive
lethal - all die before end of pupal stage, with Df(3L)fz2, Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage, with Max1, Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage, with MaxdsRNA.UAS.IR, Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage, with Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage (with Max1), with Scer\GAL4Act5C.PI
lethal - all die before end of pupal stage (with MaxdsRNA.UAS.IR), with Scer\GAL4Act5C.PI
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
abnormal developmental rate | recessive | third instar larval stage
decreased body size, with Scer\GAL4Act5C.PI
decreased body size | larval stage | recessive
decreased body size | pharate adult stage | recessive
decreased body size | pupal stage | recessive
some die during pupal stage, with Df(3L)fz2, Scer\GAL4Act5C.PI
some die during pupal stage, with Max1, Scer\GAL4Act5C.PI
some die during pupal stage, with MaxdsRNA.UAS.IR, Scer\GAL4Act5C.PI
some die during pupal stage, with Scer\GAL4Act5C.PI
some die during pupal stage (with Max1), with Scer\GAL4Act5C.PI
some die during pupal stage (with MaxdsRNA.UAS.IR), with Scer\GAL4Act5C.PI
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-109-68
visible | somatic clone
Phenotype manifest in
Allele
anterior pupal spiracle
anterior scutellar bristle, with Scer\GAL4dpp.blk1
chaeta | somatic clone
mouth hook | third instar larval stage
posterior scutellar bristle, with Scer\GAL4dpp.blk1
scutellar bristle, with Scer\GAL4sca-109-68
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4ap-md544
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MAX
13 of 15
Yes
Yes
Hsap\MNT
1 of 15
No
No
Hsap\MXD1
1 of 15
No
Yes
Hsap\MXD3
1 of 15
No
No
Hsap\MXD4
1 of 15
No
Yes
Hsap\MXI1
1 of 15
No
No
Hsap\MYC
1 of 15
No
No
5  
Hsap\USF1
1 of 15
No
No
Hsap\USF2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Max
12 of 15
Yes
Yes
Mmus\Bmyc
1 of 15
No
Yes
Mmus\Mnt
1 of 15
No
No
Mmus\Mxd1
1 of 15
No
Yes
Mmus\Mxd3
1 of 15
No
No
Mmus\Mxd4
1 of 15
No
Yes
Mmus\Mxi1
1 of 15
No
No
Mmus\Myc
1 of 15
No
No
Mmus\Usf1
1 of 15
No
No
Mmus\Usf2
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Max
10 of 13
Yes
Yes
Rnor\Bmyc
1 of 13
No
Yes
Rnor\Mnt
1 of 13
No
No
Rnor\Mxd1
1 of 13
No
Yes
Rnor\Mxd3
1 of 13
No
Yes
Rnor\Mxd4
1 of 13
No
Yes
Rnor\Mxi1
1 of 13
No
Yes
Rnor\Myc
1 of 13
No
No
Rnor\Usf1
1 of 13
No
No
Rnor\Usf2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\max
8 of 12
Yes
Yes
Xtro\LOC100487261
1 of 12
No
Yes
Xtro\mnt
1 of 12
No
No
Xtro\mxd3
1 of 12
No
No
Xtro\mxd4
1 of 12
No
Yes
Xtro\mxi1
1 of 12
No
Yes
Xtro\myc
1 of 12
No
No
Xtro\usf1
1 of 12
No
No
Xtro\usf2
1 of 12
No
No
Danio rerio (Zebrafish) (14)
Drer\max
13 of 15
Yes
Yes
Drer\myca
2 of 15
No
No
Drer\mych
2 of 15
No
Yes
Drer\mntb
1 of 15
No
No
Drer\mxd1
1 of 15
No
Yes
Drer\mxd3
1 of 15
No
No
Drer\mxd4
1 of 15
No
Yes
Drer\mxi1
1 of 15
No
No
Drer\mycb
1 of 15
No
No
Drer\mycla
1 of 15
No
Yes
Drer\usf1
1 of 15
No
No
Drer\usf1l
1 of 15
No
No
Drer\usf2
1 of 15
No
No
Drer\usf2l
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\mxl-1
8 of 15
Yes
Yes
Cele\mxl-3
8 of 15
Yes
Yes
Cele\mdl-1
1 of 15
No
No
Cele\mxl-2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\BIM3
1 of 9
Yes
Yes
Atha\MYC4
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\RTG3
2 of 15
Yes
No
Scer\CBF1
1 of 15
No
No
Scer\HMS1
1 of 15
No
No
Scer\TYE7
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\esc1
2 of 12
Yes
Yes
Spom\SPAC3F10.12c
1 of 12
No
No
Spom\sre1
1 of 12
No
No
Spom\sre2
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190J6R )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD12293
Drosophila sechellia
Dsec\GM14884
Drosophila erecta
Dere\GG13417
Drosophila yakuba
Dyak\GE22514
Drosophila yakuba
Dyak\GE22918
Drosophila ananassae
Dana\GF10774
Drosophila pseudoobscura pseudoobscura
Dpse\GA21938
Drosophila persimilis
Dper\GL20913
Drosophila willistoni
Dwil\GK19684
Drosophila virilis
Dvir\GJ11907
Drosophila mojavensis
Dmoj\GI13548
Drosophila grimshawi
Dgri\GH14421
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150E2S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023693
Glossina morsitans
Tsetse fly
Gmor\GMOY000997
Glossina morsitans
Tsetse fly
Gmor\GMOY004436
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11599
Mayetiola destructor
Hessian fly
Mdes\Mdes009393
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012237
Anopheles darlingi
American malaria mosquito
Adar\ADAC001242
Anopheles gambiae
Malaria mosquito
Agam\AGAP003177
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003297
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0H8J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001440
Bombyx mori
Silkmoth
Bmor\BGIBMGA004944
Danaus plexippus
Monarch butterfly
Dple\DPOGS202288-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003993
Apis florea
Little honeybee
Aflo\3389038884
Apis mellifera
Western honey bee
Amel\Max
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25135
Bombus terrestris
Buff-tailed bumblebee
Bter\15208238
Linepithema humile
Argentine ant
Lhum\LH20585
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003094
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG037162
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG037163
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10563
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10562
Tribolium castaneum
Red flour beetle
Tcas\TC009976
Pediculus humanus
Human body louse
Phum\PHUM220200
Rhodnius prolixus
Kissing bug
Rpro\RPRC007173
Rhodnius prolixus
Kissing bug
Rpro\RPRC015255
Cimex lectularius
Bed bug
Clec\CLEC011217
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005523
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02936
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HAD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006257
Strigamia maritima
European centipede
Smar\SMAR002175
Ixodes scapularis
Black-legged tick
Isca\ISCW013570
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68307.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g05490
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_230745
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G1312 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Max
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022626
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028248
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Mnt
1 of 10
Myc
1 of 10
Usf
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    MAX; MYC associated factor X
    model of  pheochromocytoma
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    MaxGD4743
    ameliorates  brain glioma
    modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
    (Read et al., 2009)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MAX; MYC associated factor X
    13 of 15
    154950
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Myc
    suppressible
    Max
    (Steiger et al., 2008, Steiger et al., 2008)
    Pi3K92E|btl::Egfr
    suppressible
    Max
    (Read et al., 2009)
    External Data
    Subunit Structure (UniProtKB)
    Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD.
    (UniProt, P91664 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-45
    Cytogenetic map
    76A3-76A3
    Sequence location
    3L:19,262,232..19,264,184 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    76A3-76A3
    Limits computationally determined from genome sequence between P{EP}MESR6EP3142 and P{lacW}l(3)L3809L3809
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-45

    (FlyBase, 2016)

    3-42.5

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (10)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (42)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Steiger et al., 2008)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    DNA-protein interactions: genome-wide binding profile assayed for Max protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

    (Filion et al., 2010)

    Many activities of the dm protein do not, or only partly, require association with the Max protein.

    (Steiger et al., 2008)

    Identified as a binding partner for dm product in a two hybrid library screen.

    (Gallant et al., 1996)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 44 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (7)
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    FBGSE22069
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    References (84)