roX2, roX, RNA on the X 2, RNA on the X2
non-coding RNA - dosage compensation - activation of male specific lethal proteins - Upstream of N-Ras is a conserved RNA-binding protein that promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
Gene model reviewed during 5.50
Gene model reviewed during 5.40
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
1.1 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lncRNA:roX2 using the Feature Mapper tool.
In adult males, roX2 transcripts are expressed in the cell bodies of the central brain and mushroom bodies, the neurons of the optic lobe, and the interneurons of the antennal lobes. They are also expressed in peripheral neurons including the photoreceptor cells and the olfactory neurons of the third antennal segment. Strong expression is observed in the thoracic ganglia and weak expression is seen in the gut. Expression appears to be confined to the nucleus. No expression is observed in females.
GBrowse - Visual display of RNA-Seq signalsView Dmel\lncRNA:roX2 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: lncRNA:roX2 roX2
The DNaseI hypersensitive site (DHS) within the roX2 transcription unit is not required for initiation of cis spreading of the MSL complex.
New annotation (CR32665) in release 3 of the genome annotation.
The roX2 gene is a nucleation site for MSL complex spreading into flanking chromatin in cis.
Complete and partial MSL complexes bind to a construct containing promoterless roX2 cDNA, indicating that the MSL proteins probably recognize exonic DNA.