FlyBase Gene Report: Dmel\Fab-7

General Information

Symbol

Dmel\Fab-7

Species

D. melanogaster

Name

Fab-7

Annotation Symbol

Feature Type

insulator

FlyBase ID

FBgn0020011

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

Frontabdominal-7, Fab-7 PRE

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fab-7 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fab-7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fab-7

View exonic expression by tissue for Dmel\Fab-7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 26 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fab-7

Transgenic constructs containing regulatory region of Fab-7

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Fab-7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Fab-7

(Bantignies et al., 2003)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0020011

MIST (genetic) - An integrated Molecular Interaction Database

5657585

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

insulator

(Mishra et al., 1997, Hagstrom et al., 1996, Zhou et al., 1996)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

Cytogenetic map

89E2-89E3

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

89E2-89E3

Left limit from (method unavailable) (FBrf0091909) Right limit from (method unavailable) (FBrf0091909)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

89E2-89E3

(Mishra et al., 1997)

Experimentally Determined Recombination Data

Location

(Mishra et al., 1997)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (0)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Fab-7 and MCP-PRE appear to have two distinct roles; they regulate the expression of their flanking genes in cis, but they also mediate long-distance regulatory interactions with Hox genes in the Antennapedia complex.

(Bantignies et al., 2011)

Continuous transcription through the Fab-7 PRE in a transgene, producing either sense or antisense Fab-7 RNA, leads to the epigenetic activation of the Fab-7 element.

(Schmitt et al., 2005)

Trl protein-binding sites are necessary but not sufficient for full Fab-7 enhancer-blocking activity. Distinct Trl protein-binding sites within the Fab-7 element are required for different enhancer-blocking activities at different stages of development.

(Schweinsberg et al., 2004)

Fab-7 sites exhibit epigenetic inheritance of depressed chromatin states.

(Bantignies et al., 2003)

A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor.

(Cavalli, 1999)

Fab-7 can be switched to an active or a silencing mode. Both epigenetically determined states can be transmitted to a fraction of progeny in the next generation through the female germline. This suggests that a protein-based cellular memory mechanism can be propogated through meiosis.

(Cavalli and Paro, 1998)

iab-7 PRE.

(Hagstrom et al., 1997)

The Fab-7 region can be subdivided into a chromatin domain boundary and a Polycomb-response element.

(Mihaly et al., 1997)

Chromatin domain boundary element in the Bithorax-complex. Fab-7 can be functionally subdivided into enhancer block and Pc response elements.

(Mishra et al., 1997)

Deletion of the Fab-7 element results in fusion of the iab-6 and iab-7 cis-regulatory domains into a single regulatory domain that inappropriately regulates Abd-B. This result suggests Fab-7 is a chromatin domain boundary within the context of the bithorax complex that normally functions to ensure the autonomous activity of the iab-6 and iab-7 cis-regulatory domains.

(Hagstrom et al., 1996)

A specialised DNA element, Fab-7, is proposed to function as a boundary element that separates the iab-6 and iab-7 cis regulatory regions within the Abd-B domain of the BX-C. Studies suggest Fab-7 functions as an attenuator which weakens gene expression by reducing enhancer-promoter interactions. Fab-7 selectively blocks distal enhancers in an orientation-independent fashion and can function when far from either the distal enhancer or target promoter.

(Zhou et al., 1996)

The role of Fab-7 as a boundary element may be restricted to particular tissues in which the homeotic genes are active.

(Zink and Paro, 1995)

The Fab-7 element shows an orientation-dependent silencing of w^+mC but this silencing varies between different insertion lines.

(Zink and Paro, 1995)

The sequence and chromatin organisation of Fab-7 and Mcp have been compared.

(Karch et al., 1994)

The 3' flanking region of Abd-B includes three silencer regulatory regions, IAB5, MCP and Fab-7, whose function is dependent on segmentation gene products.

(Busturia and Bienz, 1993)

The expression of the P{bluetail} insertion into the PS12-specific regulatory domain in Abd-B^blt allows dissection of the neighboring cis-regulatory region into independent domains.

(Galloni et al., 1993)

Boundary elements in the bithorax complex, such as Fab-7 organize the parasegment specific cis-regulatory sub-regions into a series of autonomous domains, insulating each domain from the regulatory influences of the adjacent ones.

(Galloni et al., 1993)

An insulating boundary element in the 'Fab7' region is characterized by an unusual chromatin structure.

(Galloni et al., 1993)

Fab-7 and Mcp region chromatin structure contain distinct chromatin structures that display similarities to the scs and scs' structures of the Hsp70A locus, and are constitutive. Deletion analysis demonstrates that the DNA segment required for Fab-7 function contains 3 nuclease hypersensitive regions and that for Mcp function contains 1 major hypersensitive region and 3 minor nuclease hypersensitive regions.

(Vazquez et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

FAB-7

(Zaret and Wolffe, 2001)

Fab-7

(Kyrchanova et al., 2023, Chetverina et al., 2021, Hime et al., 2021, Peterson et al., 2021, Sabirov et al., 2021, Kyrchanova et al., 2020, Akmammedov et al., 2019, Kyrchanova et al., 2019, Kyrchanova et al., 2019, Fedotova et al., 2018, Kyrchanova et al., 2018, Postika et al., 2018, Ciabrelli et al., 2017, Cleard et al., 2017, Kaye et al., 2017, Kyrchanova et al., 2017, Jiang et al., 2016, Kyrchanova et al., 2016, Kyrchanova et al., 2016, Peng et al., 2016, Wolle et al., 2015, Fujioka et al., 2013, Kyrchanova et al., 2013, Aoki et al., 2012, Bantignies et al., 2011, Gohl et al., 2011, Kyrchanova et al., 2011, Kyrchanova et al., 2011, Lin et al., 2011, Okulski et al., 2011, Strübbe et al., 2011, Iampietro et al., 2010, Schwartz et al., 2010, Aoki et al., 2008, Chopra et al., 2008, Fedorova et al., 2008, Iampietro et al., 2008, Pérez-Lluch et al., 2008, Salvaing et al., 2008, Holohan et al., 2007, Iampietro et al., 2007, Mito et al., 2007, Nakayama et al., 2007, Ringrose and Paro, 2007, Rodin et al., 2007, Schuettengruber et al., 2007, Blastyak et al., 2006, Budde, 2006, Cleard et al., 2006, Kavi et al., 2006, Lei and Corces, 2006, Maeda and Karch, 2006, Schwartz et al., 2006, Canudas et al., 2005, Rodin and Georgiev, 2005, Kullyev et al., 2004)

Fab-7 PRE

(McElroy et al., 2014, Dejardin and Cavalli, 2002)

Fab7 PRE

(Lloyd, 2000)

Name Synonyms

Fab-7

(Holohan et al., 2007)

Frontabdominal-7

(Lin et al., 2011, Okulski et al., 2011, Pérez-Lluch et al., 2008)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 2 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0020011

MIST (genetic) - An integrated Molecular Interaction Database

5657585

References (175)

NA

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