l(1)G0075, Ran GTPase
Ran GTPase activity required nucleo-cytoplasmic transport - also required for microtubule organization during mitosis and for alignment of chromosomes at the metaphase plate
Please see the JBrowse view of Dmel\Ran for information on other features
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Gene model reviewed during 5.51
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
Gene model reviewed during 5.56
Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Interacts with tamo (PubMed:12653959).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ran using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as ventral nerve cord anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as embryonic central brain mushroom body
Expression of ranprotein was inferred by the localization of human rhodamine labeled Ran injected into embryos. The protein was partially excluded from the chromatin. Based on the localization of mutant proteins locked into either the GTP or GDP bound states it was concluded that the majority of the labeled ran protein injected into the embryo was bound to GTP.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ran in GBrowse 21-33
1-33
1-34.8
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Ran ran
Source for merge of: ran CG1404
Source for merge of: ran l(1)G0075
Expression is enriched in embryonic gonads.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached.
Identification: Screen for genes required for late lineage CNS development.