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FB2021_04, released August 17, 2021

Gene: Dmel\Ran

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General Information
Symbol
Dmel\Ran
Species
D. melanogaster
Name
Ran
Annotation Symbol
CG1404
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020255
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis (By similarity). GTP-bound Ran modulates both spindle and nuclear envelope assembly, supporting a role during mitosis (PubMed:12121620). During oogenesis, modulates formation of Nup358-containing granules and biogenesis of the nuclear pore complex probably by mediating the transport of their components along microtubules (PubMed:31626769). (UniProt, Q9VZ23)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(1)G0075, Ran GTPase

Key Links
Genomic Location
Cytogenetic map
10A8-10A8
Sequence location
X:11,144,852..11,148,716 [-]
Recombination map
1-33
RefSeq locus
NC_004354 REGION:11144852..11148716
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:cno; FB:FBgn0259212
(Wee et al., 2011)
inferred from physical interaction with UniProtKB:Q9W1A4
(assigned by UniProt )
(Minakhina et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR002041, InterPro:IPR005225
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables GTPase activity
inferred from biological aspect of ancestor with PANTHER:PTN000632582
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with SGD:S000005711
(FlyBase Curators, 2008--)
Biological Process (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in establishment of mitotic spindle orientation
inferred from mutant phenotype
(Wee et al., 2011)
inferred from genetic interaction with FLYBASE:dlg1; FB:FBgn0001624
(Wee et al., 2011)
inferred from genetic interaction with FLYBASE:cno; FB:FBgn0259212
(Wee et al., 2011)
involved_in meiotic spindle organization
inferred from mutant phenotype
(Cesario and McKim, 2011)
involved_in nuclear pore complex assembly
inferred from mutant phenotype
(assigned by UniProt )
(Hampoelz et al., 2019)
involved_in regulation of mitotic cell cycle
inferred from direct assay
(Trieselmann and Wilde, 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in intracellular protein transport
traceable author statement
(assigned by UniProt )
(Trieselmann and Wilde, 2002)
involved_in protein export from nucleus
inferred from sequence or structural similarity with HGNC:9846
(FlyBase Curators, 2008--)
involved_in protein import into nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000632582
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in ribosomal subunit export from nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000632582
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Wee et al., 2011)
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Minakhina et al., 2003)
located_in mitotic spindle microtubule
inferred from direct assay
(assigned by UniProt )
(Trieselmann and Wilde, 2002)
located_in nucleus
inferred from direct assay
(Cesario and McKim, 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000632582
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000632582
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Ran family. (Q9VZ23)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RAN GTPASES -
Ran (Ras-like nuclear) GTPases are members of the Ras superfamily of small GTPases. Ran GTPases are principally involved in the nucleocytoplasmic transport of RNA and protein. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis (By similarity). GTP-bound Ran modulates both spindle and nuclear envelope assembly, supporting a role during mitosis (PubMed:12121620). During oogenesis, modulates formation of Nup358-containing granules and biogenesis of the nuclear pore complex probably by mediating the transport of their components along microtubules (PubMed:31626769).
(UniProt, Q9VZ23)
Summary (Interactive Fly)

Ran GTPase activity required nucleo-cytoplasmic transport - also required for microtubule organization during mitosis and for alignment of chromosomes at the metaphase plate

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Ran for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ran-RA
FBtr0073472
NM_143712
1667
216
Ran-RB
FBtr0073471
NM_167272
1127
216
Ran-RC
FBtr0340164
NM_001298182
1581
216
Ran-RD
FBtr0340165
NM_001298183
1263
216
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ran-PA
FBpp0073328
24.7
216
7.96
NP_651969
AAF48008
Ran-PB
FBpp0073327
24.7
216
7.96
NP_727499
AAN09287
Ran-PC
FBpp0309150
24.7
216
7.96
NP_001285111
AHN59581
Ran-PD
FBpp0309151
24.7
216
7.96
NP_001285112
AHN59582
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

216 aa isoforms: Ran-PA, Ran-PB, Ran-PC, Ran-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Interacts with tamo (PubMed:12653959).

(UniProt, Q9VZ23)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ran using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
embryonic central brain
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic central brain surface glia
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
mushroom body primordium

Comment: reported as embryonic central brain mushroom body

(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
distribution deduced from reporter or direct label
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
• spindle

Comment: mitosis

(Trieselmann and Wilde, 2002)
organism

Comment: interphase

(Trieselmann and Wilde, 2002)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Expression of ranprotein was inferred by the localization of human rhodamine labeled Ran injected into embryos. The protein was partially excluded from the chromatin. Based on the localization of mutant proteins locked into either the GTP or GDP bound states it was concluded that the majority of the labeled ran protein injected into the embryo was bound to GTP.

(Trieselmann and Wilde, 2002)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell cortex
inferred from direct assay
(Wee et al., 2011)
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
(Minakhina et al., 2003)
located_in mitotic spindle microtubule
inferred from direct assay
(assigned by UniProt )
(Trieselmann and Wilde, 2002)
located_in nucleus
inferred from direct assay
(Cesario and McKim, 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ran in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ran
Transgenic constructs containing regulatory region of Ran
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene duplicated in
Dp(1;3)DC235
(Popodi et al., 2010-, Venken et al., 2010)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal, with Scer\GAL4αTub84B.PL
lethal - all die before end of larval stage, with Scer\GAL4elav.PLu
lethal - all die before end of larval stage, with Scer\GAL4h-1J3
lethal - all die before end of larval stage, with Scer\GAL4nub.PK
lethal - all die before end of P-stage
lethal - all die before end of P-stage, with Scer\GAL4pros.PMG
partially lethal - majority die | recessive
viable
viable, with Scer\GAL4elav.PLu
viable, with Scer\GAL4h-1J3
viable, with Scer\GAL4nub.PK
viable, with Scer\GAL4pros.PMG
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4unspecified
viable, with Scer\GAL4αTub84B.PL
Sterility
Allele
female sterile, with Scer\GAL4VP16.nos.UTR
fertile
fertile, with Scer\GAL4VP16.nos.UTR
male sterile, with Scer\GAL4VP16.nos.UTR
Other Phenotypes
Allele
some die during larval stage, with Scer\GAL4elav.PLu
some die during larval stage, with Scer\GAL4h-1J3
some die during larval stage, with Scer\GAL4nub.PK
some die during pharate adult stage
some die during pharate adult stage, with Scer\GAL4pros.PMG
visible
visible, with Scer\GAL4sev.EP.M
wild-type, with Scer\GAL4dpp.blk1
wild-type, with Scer\GAL4GMR.PF
wild-type, with Scer\GAL4sev.EP.M
Phenotype manifest in
Allele
annulate lamellae | oogenesis, with Scer\GAL4VP16.nos.UTR
cone cell, with Scer\GAL4GMR.PF
eye
karyosome, with Scer\GAL4VP16.nos.UTR
meiotic spindle, with Scer\GAL4VP16.nos.UTR
ommatidium, with Scer\GAL4sev.EP.M
oocyte, with Scer\GAL4VP16.nos.UTR
photoreceptor cell, with Scer\GAL4GMR.PF
photoreceptor cell, with Scer\GAL4sev.EP.M
photoreceptor cell R7, with Scer\GAL4sev.EP.M
pigment cell, with Scer\GAL4GMR.PF
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RAN
13 of 15
Yes
Yes
0  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ran
13 of 15
Yes
Yes
Mmus\1700009N14Rik
9 of 15
No
Yes
Mmus\Rasl2-9
9 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Ran
11 of 13
Yes
Yes
Rnor\Rasl2-9
10 of 13
No
Yes
Rnor\RGD1306195
10 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\ran
10 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\ran
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ran-1
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\RAN2
9 of 9
Yes
Yes
Atha\RAN3
9 of 9
Yes
Yes
Atha\RAN-1
8 of 9
No
Yes
Atha\RAN4
3 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\GSP1
13 of 15
Yes
Yes
Scer\GSP2
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\spi1
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190EQS )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006912
Drosophila simulans
Dsim\GD24539
Drosophila sechellia
Dsec\GM11261
Drosophila erecta
Dere\GG18876
Drosophila yakuba
Dyak\ran
Drosophila ananassae
Dana\GF20389
Drosophila pseudoobscura pseudoobscura
Dpse\GA12719
Drosophila persimilis
Dper\GL20255
Drosophila willistoni
Dwil\GK17213
Drosophila virilis
Dvir\GJ16931
Drosophila mojavensis
Dmoj\GI15278
Drosophila grimshawi
Dgri\GH24573
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150A6U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004702
Glossina morsitans
Tsetse fly
Gmor\GMOY000905
Glossina morsitans
Tsetse fly
Gmor\GMOY004834
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04276
Mayetiola destructor
Hessian fly
Mdes\Mdes004218
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009287
Anopheles darlingi
American malaria mosquito
Adar\ADAC004927
Anopheles gambiae
Malaria mosquito
Agam\AGAP007699
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008595
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BHT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006751
Danaus plexippus
Monarch butterfly
Dple\DPOGS212140-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007729
Apis florea
Little honeybee
Aflo\2163579940
Apis mellifera
Western honey bee
Amel\ran
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22896
Bombus terrestris
Buff-tailed bumblebee
Bter\15210502
Linepithema humile
Argentine ant
Lhum\LH10986
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0000fa
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009302
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04346
Tribolium castaneum
Red flour beetle
Tcas\TC012793
Pediculus humanus
Human body louse
Phum\PHUM095420
Rhodnius prolixus
Kissing bug
Rpro\RPRC011075
Cimex lectularius
Bed bug
Clec\CLEC011878
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004024
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01785
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BFF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004591
Ixodes scapularis
Black-legged tick
Isca\ISCW023654
Ixodes scapularis
Black-legged tick
Isca\ISCW021828
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80570.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g01880
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305970
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0L3X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ran
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003944
Gallus gallus
Domestic chicken
Ggal\RAN
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ran-like
4 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RAN; RAN, member RAS oncogene family
    13 of 15
    601179
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Ran
        suppressible
        sub
        (Cesario and McKim, 2011)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        RanGAP
        suppressible
        Ran
        (Kusano et al., 2001)
        sub
        suppressible
        Ran
        (Cesario and McKim, 2011)
        External Data
        Subunit Structure (UniProtKB)
        Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity). Interacts with tamo (PubMed:12653959).
        (UniProt, Q9VZ23 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-33
        Cytogenetic map
        10A8-10A8
        Sequence location
        X:11,144,852..11,148,716 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        10A8-10A8
        Limits computationally determined from genome sequence between P{EP}EP1321EP1321&P{EP}CG2061EP1537 and P{EP}CG11756EP1610
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        10A7-10A9
        (determined by in situ hybridisation)
        (Koizumi et al., 2001)
        10A-10A
        (Frasch, 2000.2.11)
        10A4-10A9
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.6.15)
        9D-9D
        (determined by in situ hybridisation)
        (Schäfer et al., 1999.3.29)
        10A7-10A9
        (Stivers et al., 1997)
        Experimentally Determined Recombination Data
        Location

        1-33

        (FlyBase, 2016)

        1-34.8

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (7)
        Genomic Clones (14)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (302)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Ran ran

        (FlyBase, 2009-)
        Source for database merge of

        Source for merge of: ran CG1404

        (Bayraktaroglu, 2000.8.7)

        Source for merge of: ran l(1)G0075

        (Peter et al., 2002)
        Additional comments

        The ran-like gene may have been derived from the ran gene by retroposition.

        (Dai et al., 2006)
        Other Comments

        Expression is enriched in embryonic gonads.

        (Shigenobu et al., 2006)

        dsRNA made from templates generated with primers directed against ran that is transfected into S2 treated with Listeria monocytogenes reveals ran to be involved in Listeria monocytogenes entry and vacuolar escape.

        (Cheng et al., 2005)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells; cells become round and detached.

        (Kiger et al., 2003)

        Identification: Screen for genes required for late lineage CNS development.

        (Stivers et al., 1997)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 61 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB
        EMBL-EBI Single Cell Expression Atlas
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (11)
        Reported As
        Symbol Synonym
        AAF30287
        (Jekely, 2003)
        CG1404
        (Kolkhof et al., 2017, Hosono et al., 2015, Ding et al., 2014, McEachern et al., 2014, Yoshigi et al., 2013, Chen et al., 2012, Yano et al., 2012, Cammarato et al., 2011, Zhang et al., 2011, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Hughes et al., 2008, Ni et al., 2008, Sepp et al., 2008, Cermelli et al., 2006, Dai et al., 2006, Minakhina et al., 2003, Labourier et al., 2002, Peter et al., 2002, Ramet et al., 2002)
        Q9VZ23
        (Rojas et al., 2012)
        Ran
        (Ge et al., 2021, Mehta et al., 2020, Park et al., 2020, Hampoelz et al., 2019, Meltzer et al., 2019, Bo et al., 2018, Yao et al., 2018, Hu et al., 2017.6.13, Roubinet et al., 2017, Solis et al., 2017, Liu et al., 2016, Ribeiro et al., 2016, Wang et al., 2016, Freibaum et al., 2015, Jang et al., 2015, Zhang et al., 2015, Bonnay et al., 2014, McEachern et al., 2014, Ye and Zhang, 2013, Virágh et al., 2012, Bono et al., 2010, Li et al., 2010, Graham et al., 2009, Kategaya et al., 2009, Cesario and McKim, 2008, Hughes et al., 2008, McLean et al., 2008, Motiwale et al., 2008, Sepp et al., 2008, Silverman-Gavrila and Wilde, 2006, Baeg et al., 2005, Bernards, 2003, Jekely, 2003, Minakhina et al., 2003, Orian et al., 2003, Timinszky et al., 2002, Hawley, 2001, Kusano et al., 2001, Kusano et al., 2001, Szabad et al., 2001)
        RanGTP
        (Wee et al., 2011)
        dran
        (Stivers et al., 1997)
        l(1)G0075
        (Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)
        ran
        (Das et al., 2016, Gupta et al., 2014, Zhimulev et al., 2014, Kwon et al., 2013, Kwon et al., 2013, Neumüller et al., 2013, Yoshigi et al., 2013, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Yano et al., 2012, Cesario and McKim, 2011, Friedman et al., 2011, Lindquist et al., 2011, Kallappagoudar et al., 2010, Popodi et al., 2010-, Tracy et al., 2010, Venken et al., 2010, Babenko et al., 2009, Sepp et al., 2008, Somma et al., 2008, Zhou et al., 2008, Bai et al., 2007, Langille and Clark, 2007, Cermelli et al., 2006, Shigenobu et al., 2006, Moussian et al., 2005, Loop et al., 2004)
        ran10A
        (Frasch, 2000.2.11)
        Name Synonyms
        Ran
        Ran GTPase
        (Freibaum et al., 2015, Sepp et al., 2008)
        ran
        (Cammarato et al., 2011, Somma et al., 2008)
        ran GTPase
        (Lindquist et al., 2011)
        Secondary FlyBase IDs
        • FBgn0026685
        • FBgn0030273
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (129)