Shares 5' UTR with nested gene.
Gene model reviewed during 5.53
Genes with CDS overlap: CG46459 and isoforms of pug share promoter, first exon, and N-terminal coding sequences (23 residues).
Gene model reviewed during 6.32
This trifunctional enzyme consists of two major domains: a N-terminal part, containing the methylene-THF dehydrogenase and the methenyl-THF cyclohydrolase activities and a larger formyl-THF synthetase domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pug using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pug in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
It remains possible, given their map locations and mutant phenotypes, that "pug" and "dn" correspond to the same locus. pug is a different gene from Nmdmc; pug (at 86C) appears to encode the cytoplasmic form of methylenetetrahydrofolate dehydrogenase, Nmdmc (at 85C) appears to encode the mitochondrial form of methylenetetrahydrofolate dehydrogenase.