T-box transcription factor - involved in the combinatorial activation of somatic muscle lineage-specific targets - visceral mesoderm - gain of function causes antenna-to-leg transformations and shortened leg
Gene model reviewed during 5.52
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\org-1 using the Feature Mapper tool.
org-1 is expressed in a dynamic pattern in the developing embryonic mesoderm. In early stage 9, org-1 protein expression begins in narrow segmental stripes within the somatic mesoderm. By stage 10, org-1 expression also appears in 11 segmental clusters of trunk visceral mesoderm precursors. During stages 10-11 expression in the visceral mesoderm becomes restricted to the visceral muscle progenitor and founder cells. Somatic mesodermal expression also refines during stage 11 and remains active in a few somatic muscle progenitors per hemisegment. During stage 12, these muscle progenitors divide into somatic muscle founder cells. After myoblast fusion, the abdominal expression of org-1 was assigned to somatic muscles M5/LO1 (lateral oblique muscle 1)) and M25/VT1 (ventral transverse muscle 1), which are derived from sibling founder cells, M8/SBM (segment border muscle) and two lateral adult muscle precursors (lAMPs), one of which is a sibling of the M8 founder. In addition, org-1 is expressed in alary muscle, formed from one of the founder cells located in dorsolateral mesodermal areas. During stage 14, org-1 mRNA and protein expression becomes extinct in lateral oblique muscle 1 and segment border muscle.
GBrowse - Visual display of RNA-Seq signalsView Dmel\org-1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.