FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\mTor
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General Information
Symbol
Dmel\mTor
Species
D. melanogaster
Name
mechanistic Target of rapamycin
Annotation Symbol
CG5092
Feature Type
protein_coding_gene
FlyBase ID
FBgn0021796
Gene Model Status
Current
Stock Availability
26 publicly available
Gene Summary
Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Regulates growth during animal development by coupling growth factor signaling to nutrient availability (PubMed:11069888). Central regulators of autophagy (PubMed:18604198, PubMed:19225150). May be involved in atg1 phosphorylation (PubMed:19225150). May also be involved, directly or indirectly, in the control of neuronal function (PubMed:15454083). Phosphorylates S6K/p70S6K, in vitro (PubMed:11069888). May regulate the activity of S6K (PubMed:11069885). Overexpression inhibits growth and reduces cell size (PubMed:14505573). Affects the timing of neuronal cell differentiation (PubMed:15454083). Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation (PubMed:15454083). Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism (PubMed:14505573). As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR (PubMed:25920570). REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation (PubMed:25920570). When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function (PubMed:25920570). This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes (PubMed:25920570). In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Rag GTPases act as activators of TORC1 in response to amino acid signals (PubMed:18604198). (UniProt, Q9VK45)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Tor, dTOR, target of rapamycin, TORC1, target-of-rapamycin

Key Links
Genomic Location
Cytogenetic map
34A4-34A4
Sequence location
Recombination map
2-47
RefSeq locus
NT_033779 REGION:13004480..13013197
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (39 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables chromatin DNA binding
inferred from direct assay
(Filer et al., 2017)
enables protein binding
inferred from physical interaction with UniProtKB:Q9W328
(Wang et al., 2012)
enables protein kinase activity
inferred from direct assay
(Bolukbasi et al., 2017)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables kinase activity
inferred from electronic annotation with InterPro:IPR018936
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from sequence model
(Zhang et al., 2006)
inferred from sequence or structural similarity with UniProtKB:P42345
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR026683
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000124197
(GO Reference Genome Project, 2011-)
enables protein-containing complex binding
inferred from electronic annotation with InterPro:IPR009076, InterPro:IPR036738
(InterPro Project Members, 2004-)
Biological Process (30 terms)
Terms Based on Experimental Evidence (29 terms)
CV Term
Evidence
References
involved_in apical protein localization
inferred from mutant phenotype
(Francis and Ghabrial, 2015)
involved_in cellular response to nutrient
inferred from direct assay
(Parisi et al., 2011)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Koike-Kumagai et al., 2009)
involved_in determination of adult lifespan
inferred from mutant phenotype
(Kapahi et al., 2004)
involved_in endocytic recycling
inferred from direct assay
(Hennig et al., 2006)
involved_in germarium-derived cystoblast division
inferred from mutant phenotype
(Wei et al., 2014)
involved_in germline cell cycle switching, mitotic to meiotic cell cycle
inferred from mutant phenotype
(Wei et al., 2014)
involved_in gonad development
inferred from mutant phenotype
(Zhang et al., 2006)
involved_in insulin receptor signaling pathway
inferred from direct assay
(Parisi et al., 2011)
inferred from mutant phenotype
(Wu et al., 2007)
involved_in lamellocyte differentiation
inferred from direct assay
(Dragojlovic-Munther and Martinez-Agosto, 2013)
involved_in larval midgut cell programmed cell death
inferred from mutant phenotype
(Xu et al., 2015)
involved_in macroautophagy
inferred from mutant phenotype
(Xu et al., 2015)
involved_in multicellular organism growth
inferred from mutant phenotype
(Zhang et al., 2006)
involved_in negative regulation of apoptotic process
inferred from mutant phenotype
(Tran et al., 2013)
involved_in negative regulation of macroautophagy
inferred from mutant phenotype
(Scott et al., 2004)
involved_in negative regulation of proteasomal protein catabolic process
inferred from direct assay
(Parisi et al., 2011)
involved_in positive regulation of axon guidance
inferred from genetic interaction with FLYBASE:Rheb; FB:FBgn0041191
(Dimitroff et al., 2012)
involved_in positive regulation of cell size
inferred from mutant phenotype
(Cully et al., 2010, Sims et al., 2009, Hall et al., 2007)
inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198
(Cully et al., 2010)
involved_in positive regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(Yang et al., 2006)
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from mutant phenotype
(Wu et al., 2007, Yang et al., 2006, Sarbassov et al., 2005)
involved_in positive regulation of ribosome biogenesis
inferred from mutant phenotype
(Hall et al., 2007)
involved_in positive regulation of synaptic assembly at neuromuscular junction
inferred from genetic interaction with FLYBASE:Rheb; FB:FBgn0041191
(Dimitroff et al., 2012)
involved_in positive regulation of transcription by RNA polymerase III
inferred from mutant phenotype
(Filer et al., 2017)
involved_in positive regulation of wound healing
inferred from mutant phenotype
(Kakanj et al., 2016)
involved_in regulation of cell growth
inferred from direct assay
(Hennig et al., 2006)
involved_in regulation of response to drug
inferred from mutant phenotype
(Dar et al., 2012)
involved_in terminal branching, open tracheal system
inferred from mutant phenotype
(Francis and Ghabrial, 2015)
involved_in TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013)
inferred from mutant phenotype
(Wang et al., 2012)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Tran et al., 2013)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in negative regulation of macroautophagy
inferred from biological aspect of ancestor with PANTHER:PTN000124327
(GO Reference Genome Project, 2011-)
involved_in TORC1 signaling
inferred from biological aspect of ancestor with PANTHER:PTN000124328
(GO Reference Genome Project, 2011-)
involved_in TORC2 signaling
inferred from biological aspect of ancestor with PANTHER:PTN000124328
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
part_of TORC1 complex
inferred from mutant phenotype
(Wang et al., 2012)
part_of TORC2 complex
inferred from direct assay
(Wang et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of TORC1 complex
inferred from sequence or structural similarity with UniProtKB:P42345
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN001673232
(GO Reference Genome Project, 2011-)
part_of TORC2 complex
inferred from biological aspect of ancestor with PANTHER:PTN001673232
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P42345
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the PI3/PI4-kinase family. (Q9VK45)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
TORC1 COMPLEX -
TOR complex 1 (TORC1) is a target of rapamycin (Tor) kinase-containing complex that mediates the response to a variety of stimuli including stress, insulin-like peptides and amino acids. TORC1 regulates processes such as translation, cell growth and autophagy. It can be inhibited by rapamycin. (Adapted from FBrf0238220).
TORC2 COMPLEX -
TOR complex 2 (TORC2) is a target of rapamycin (Tor) kinase-containing complex that phosphorylates several AGC family kinases, including Akt1 (PKB). mTORC2 regulates a variety of cellular processes such as insulin signaling and actin reorganization. It is insensitive to rapamycin. (Adapted from FBrf0238220).
Pathway (FlyBase)
POSITIVE REGULATORS OF INSULIN-LIKE RECEPTOR SIGNALING PATHWAY -
Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
PVR SIGNALING PATHWAY CORE COMPONENTS -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Promotes cell and tissue growth, maintains tissue homeostatis and controls responses to environmental stress and aging (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Regulates growth during animal development by coupling growth factor signaling to nutrient availability (PubMed:11069888). Central regulators of autophagy (PubMed:18604198, PubMed:19225150). May be involved in atg1 phosphorylation (PubMed:19225150). May also be involved, directly or indirectly, in the control of neuronal function (PubMed:15454083). Phosphorylates S6K/p70S6K, in vitro (PubMed:11069888). May regulate the activity of S6K (PubMed:11069885). Overexpression inhibits growth and reduces cell size (PubMed:14505573). Affects the timing of neuronal cell differentiation (PubMed:15454083). Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation (PubMed:15454083). Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism (PubMed:14505573). As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR (PubMed:25920570). REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation (PubMed:25920570). When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function (PubMed:25920570). This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes (PubMed:25920570). In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Rag GTPases act as activators of TORC1 in response to amino acid signals (PubMed:18604198).
(UniProt, Q9VK45)
Summary (Interactive Fly)

Phosphatidylinositol 3-kinase - involved in perception of nutrient status - pivotal member of the TOR pathway involved in regulation of growth and cell proliferation

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\mTor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VK45)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mTor-RA
FBtr0080422
NM_080152
7984
2470
mTor-RB
FBtr0336615
NM_001273498
7987
2471
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mTor-PA
FBpp0080003
281.0
2470
6.91
Q9VK45
NP_524891
AAF53237
mTor-PB
FBpp0307598
281.2
2471
6.91
M9PFS0
NP_001260427
AGB92962
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

May be part of a minimal complex, TORC1, consisting of mTor, raptor and lst8. May be part of a minimal complex, TORC2, consisting of mTor, rictor and lst8 (By similarity). Self-associates; assembles into homomultimeric complexes. Component of a multiprotein complex.

(UniProt, Q9VK45)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mTor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.85

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
part_of TORC1 complex
inferred from mutant phenotype
(Wang et al., 2012)
part_of TORC2 complex
inferred from direct assay
(Wang et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mTor in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mTor
Transgenic constructs containing regulatory region of mTor
Aberrations (Deficiencies and Duplications) ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | somatic clone
lethal
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4ap-md544
lethal, with Scer\GAL4da.G32
lethal, with Scer\GAL4ey.PH
lethal (with mTorA948V)
lethal (with mTorE161K)
lethal (with mTorG2256D)
lethal (with mTorQ528stop)
lethal (with mTorR97C)
lethal (with mTorR248stop)
lethal (with mTorV2148D)
lethal (with mTorW1251R)
lethal (with mTorΔP)
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage | recessive
lethal - all die before end of second instar larval stage | recessive
Sterility
Allele
female sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
sterile | recessive
Other Phenotypes
Allele
abnormal body size | adult stage
abnormal body size | second instar larval stage
abnormal cell cycle | germline clone
abnormal cell number | P-stage, with Scer\GAL4Mef2.247
abnormal cell number | P-stage, with Scer\GAL4phtm.PO, Scer\GAL80spok.1.45
abnormal cell size
abnormal cold stress response | larval stage, with Scer\GAL4nSyb.PP
abnormal developmental rate
abnormal developmental rate, with Scer\GAL4Bx-MS1096
abnormal developmental rate, with Scer\GAL4en-e16E
abnormal developmental rate, with Scer\GAL4phtm.PU
abnormal developmental rate, with Scer\GAL4ppl.PP
abnormal developmental rate | recessive
abnormal heat stress response | larval stage, with Scer\GAL4nSyb.PP
abnormal locomotor behavior | adult stage
abnormal mitotic cell cycle | somatic clone
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
abnormal neuroanatomy | larval stage | somatic clone, with Scer\GAL4ppk.PG
abnormal neuroanatomy | somatic clone
abnormal neurophysiology | adult stage | somatic clone
abnormal neurophysiology | larval stage, with Scer\GAL4G14
abnormal neurophysiology | larval stage, with Scer\GAL4GluRIIB-MI03631-TG4.2
abnormal neurophysiology | larval stage, with Scer\GAL4Mhc.PW
abnormal neurophysiology | larval stage (with mTorE161K)
abnormal neurophysiology | larval stage (with mTorΔP)
abnormal neurophysiology | third instar larval stage, with Scer\GAL4Mhc.PW
abnormal osmotic stress response | larval stage, with Scer\GAL4nSyb.PP
abnormal size, with Scer\GAL4en.PU
abnormal size, with Scer\GAL4ey.PH
abnormal size, with Scer\GAL4MD-638
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL4Bx-MS1096
abnormal size | adult stage, with Scer\GAL4en.PU
abnormal size | adult stage, with Scer\GAL4eya.enh1+E+2
abnormal size | adult stage (with mTor2L1)
abnormal size | adult stage (with mTork17004)
abnormal size | adult stage | heat sensitive, with Scer\GAL4hs.PU
abnormal size | adult stage | somatic clone
abnormal size | P-stage, with Scer\GAL4NP0001
abnormal size | third instar larval stage, with Scer\GAL4NP0001
abnormal starvation stress response | larval stage, with Scer\GAL4Cg.PU
abnormal stress response | larval stage, with Scer\GAL4nSyb.PP
chemical sensitive | dominant
decreased body size
decreased body size, with Scer\GAL4en-e16E
decreased body size | adult stage, with Scer\GAL4Ilp2.PR
decreased body size | adult stage | recessive
decreased body size | larval stage (with mTor2L1)
decreased body size | larval stage (with mTor2L19)
decreased body size | larval stage | recessive
decreased body size | nutrition conditional, with Scer\GAL4ppl.PP
decreased body size | recessive | third instar larval stage
decreased cell death | P-stage, with Scer\GAL4NP0001
decreased cell number, with Scer\GAL4Bx-MS1096
decreased cell number, with Scer\GAL4en-e16E
decreased cell number, with Scer\GAL4nub-AC-62
decreased cell number | larval stage | progressive | somatic clone
decreased cell number | oogenesis, with Scer\GAL4VP16.nanos.UTR
decreased cell number | somatic clone
decreased cell number | somatic clone - Minute background | third instar larval stage
decreased cell size
decreased cell size, with Scer\GAL4nub-AC-62
decreased cell size | adult stage | somatic clone
decreased cell size | larval stage, with Scer\GAL4Act5C.PP
decreased cell size | larval stage | somatic clone
decreased cell size | somatic clone
decreased cell size | somatic clone, with Scer\GAL4Act5C.PP
decreased cell size | somatic clone, with Scer\GAL4Act.PU
decreased cell size | somatic clone - Minute background | third instar larval stage
decreased occurrence of cell division | larval stage, with Scer\GAL4Act5C.PP
decreased occurrence of cell division | second instar larval stage
decreased occurrence of cell division | somatic clone | third instar larval stage
decreased rate of adult locomotory behavior, with Scer\GAL4elav.PU
decreased size | larval stage (with mTorE161K)
decreased size | larval stage (with mTorΔP)
decreased size | P-stage, with Scer\GAL4Mef2.247
decreased size | spermatogenesis (with mTorA948V)
decreased size | spermatogenesis (with mTork17004)
increased body size | larval stage, with Scer\GAL4Cg.PU
increased body size | pupal stage, with Scer\GAL4Cg.PA
increased cell death
increased cell death, with Scer\GAL4en.PU
increased cell death, with Scer\GAL4Ugt36A1.PK
increased cell death | adult stage | heat sensitive, with Scer\GAL4hs.PU
increased cell death | embryonic stage 7 | maternal effect, with Scer\GAL4VP16.mat.αTub67C
increased cell death | oogenesis, with Scer\GAL4nanos.PG
increased cell death | recessive
increased cell death | third instar larval stage, with Scer\GAL4NP0001
increased cell size, with Scer\GAL4en-e16E
increased occurrence of cell division | larval stage, with Scer\GAL4en.PU
long lived, with Scer\GAL4da.G32
long lived, with Scer\GAL4Lk6-DJ634
majority die during embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
some die during larval stage
some die during pupal stage | recessive
some die during second instar larval stage | recessive
some die during third instar larval stage | recessive
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
visible | adult stage
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4eya.enh1+E+2
visible | adult stage | somatic clone
visible | larval stage, with Scer\GAL4Cg.PU
wild-type
wild-type, with Scer\GAL4Act5C.PI
wild-type, with Scer\GAL4ap-md544
wild-type, with Scer\GAL4Bx-MS1096
wild-type, with Scer\GAL4en-e16E
wild-type, with Scer\GAL4ey.PH
wild-type, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
adult somatic muscle cell of thorax | heat sensitive, with Scer\GAL4hs.PU
anterior fascicle & synapse, with Scer\GAL4elav-C155
autophagosome, with Scer\GAL4GMR.PU
autophagosome, with Scer\GAL4Lsp2.PH
axon | somatic clone
cell cycle
dendrite | adult stage | somatic clone
dendrite | somatic clone
dendritic arborizing neuron | somatic clone
distal medullary amacrine neuron Dm8a | adult stage | somatic clone
dorsal mesothoracic disc & nucleolus
egg chamber | germline clone
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval fat body
embryonic/larval fat body, with Scer\GAL4ppl.PP
embryonic/larval fat body | larval stage, with Scer\GAL4Cg.PA
embryonic/larval fat body | larval stage, with Scer\GAL4Cg.PU
embryonic/larval fat body | larval stage, with Scer\GAL4r4
embryonic/larval midgut | P-stage, with Scer\GAL4NP0001
embryonic/larval midgut | third instar larval stage, with Scer\GAL4NP0001
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4elav-C155
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4G14
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4GluRIIB-MI03631-TG4.2
embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4Mhc.PW
embryonic/larval neuromuscular junction | larval stage (with mTorE161K)
embryonic/larval neuromuscular junction | larval stage (with mTorΔP)
embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4Mhc.PW
embryonic/larval salivary gland
embryonic myoblast
enteroendocrine cell | P-stage | decreased number, with Scer\GAL4Mef2.247
enteroendocrine cell | P-stage | decreased number, with Scer\GAL4phtm.PO, Scer\GAL80spok.1.45
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4eya.enh1+E+2
eye, with Scer\GAL4GMR.PU
eye | adult stage | somatic clone
eye-antennal disc primordium
eye disc | somatic clone
eye disc | somatic clone | third instar larval stage
eye photoreceptor cell | adult stage | somatic clone
fat body
fat body, with Scer\GAL4Lsp2.PH
fat body | second instar larval stage
fat body | somatic clone
fat body | somatic clone, with Scer\GAL4Act5C.PP
female germline stem cell, with Scer\GAL4nanos.PG
female germline stem cell | decreased number, with Scer\GAL4VP16.nanos.UTR
follicle cell | somatic clone
gastric caecum | P-stage, with Scer\GAL4NP0001
gastric caecum | third instar larval stage, with Scer\GAL4NP0001
germarium, with Scer\GAL4nanos.PG
head | somatic clone
hemocyte | larval stage, with Scer\GAL4He.PZ
intestinal stem cell | chemical conditional, with Scer\GAL4NP5130
larva
larval fat cell | somatic clone - Minute background | third instar larval stage
larval intersegmental nerve, with Scer\GAL4elav-C155
larval multidendritic class IV neuron
larval multidendritic class IV neuron | somatic clone, with Scer\GAL4ppk.PG
larval neuroblast
larval salivary gland & nucleus (with mTor2L1)
larval salivary gland & nucleus (with mTork17004)
larval somatic muscle (with mTorE161K)
larval somatic muscle (with mTorΔP)
larval somatic muscle cell
lysosome, with Scer\GAL4Lsp2.PH
mitotic cell cycle | somatic clone, with Scer\GAL4Act5C.PP
muscle system | P-stage, with Scer\GAL4Mef2.247
nucleus
nucleus | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
oocyte, with Scer\GAL4VP16.nanos.UTR
ovary
salivary gland imaginal ring
segment border muscle cell
segment border muscle cell, with Scer\GAL4kirre.PU
spermatocyte (with mTorA948V)
spermatocyte (with mTork17004)
synapse | larval stage, with Scer\GAL4elav-C155
terminal bouton, with Scer\GAL4elav-C155
terminal tracheal cell, with Scer\GAL4bs.PM
testis
vesicle
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4MD-638
wing, with Scer\GAL4nub-AC-62
wing | adult stage | somatic clone
wing | posterior, with Scer\GAL4en-e16E
wing blade
wing disc | larval stage, with Scer\GAL4Act5C.PP
wing disc posterior compartment, with Scer\GAL4en.PU
wing posterior compartment, with Scer\GAL4en.PU
yolk | embryonic stage | maternal effect, with Scer\GAL4VP16.mat.αTub67C
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\MTOR
14 of 14
Yes
Yes
1  
Hsap\ATR
3 of 14
No
No
2  
Hsap\PRKDC
3 of 14
No
Yes
Hsap\SMG1
3 of 14
No
No
Hsap\ATM
2 of 14
No
No
Hsap\TRRAP
2 of 14
No
No
Hsap\BOLA2
1 of 14
No
No
1  
Hsap\BOLA2-SMG1P6
1 of 14
No
Yes
Hsap\PI4KA
1 of 14
No
No
2  
Hsap\PI4KB
1 of 14
No
No
2  
Hsap\PIK3C2A
1 of 14
No
No
Hsap\PIK3C2B
1 of 14
No
No
Hsap\PIK3C2G
1 of 14
No
No
Hsap\PIK3C3
1 of 14
No
No
Hsap\PIK3CA
1 of 14
No
No
Hsap\PIK3CD
1 of 14
No
No
2  
Hsap\PIK3CG
1 of 14
No
No
Hsap\SH3PXD2A
1 of 14
No
Yes
Hsap\SH3PXD2B
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Mtor
14 of 14
Yes
Yes
Rnor\Atr
3 of 14
No
No
Rnor\Atm
2 of 14
No
No
Rnor\Prkdc
2 of 14
No
Yes
Rnor\Pi4kb
1 of 14
No
No
Rnor\Pik3c2a
1 of 14
No
No
Rnor\Pik3c2b
1 of 14
No
No
Rnor\Pik3c2g
1 of 14
No
No
Rnor\Pik3c3
1 of 14
No
No
Rnor\Pik3cb
1 of 14
No
No
Rnor\Pik3cd
1 of 14
No
No
Rnor\Smg1
1 of 14
No
Yes
Mus musculus (laboratory mouse) (16)
Mmus\Mtor
13 of 14
Yes
Yes
Mmus\Atr
3 of 14
No
No
Mmus\Prkdc
3 of 14
No
Yes
Mmus\Smg1
3 of 14
No
No
Mmus\Atm
2 of 14
No
No
Mmus\Trrap
2 of 14
No
No
Mmus\Pi4ka
1 of 14
No
No
Mmus\Pi4kb
1 of 14
No
No
Mmus\Pik3c2a
1 of 14
No
No
Mmus\Pik3c2b
1 of 14
No
No
Mmus\Pik3c3
1 of 14
No
No
Mmus\Pik3cb
1 of 14
No
No
Mmus\Pik3cd
1 of 14
No
No
Mmus\Pik3cg
1 of 14
No
No
Mmus\Sh3pxd2a
1 of 14
No
Yes
Mmus\Sh3pxd2b
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\mtor
7 of 13
Yes
Yes
Xtro\atm
2 of 13
No
No
Xtro\pdlim2
2 of 13
No
No
Xtro\smg1
2 of 13
No
No
Xtro\alox12b
1 of 13
No
Yes
Xtro\atr
1 of 13
No
No
Xtro\cpt1al
1 of 13
No
No
Xtro\prkdc
1 of 13
No
Yes
Xtro\slc25a28
1 of 13
No
No
Xtro\trrap
1 of 13
No
No
Danio rerio (Zebrafish) (18)
Drer\mtor
13 of 14
Yes
Yes
Drer\prkdc
3 of 14
No
Yes
Drer\smg1
3 of 14
No
No
Drer\atm
2 of 14
No
No
Drer\atr
2 of 14
No
No
Drer\pi4kaa
1 of 14
No
No
Drer\pi4kab
1 of 14
No
No
Drer\pi4kb
1 of 14
No
No
Drer\pik3c2a
1 of 14
No
No
Drer\pik3c2b
1 of 14
No
No
Drer\pik3c3
1 of 14
No
No
Drer\pik3ca
1 of 14
No
No
Drer\pik3cb
1 of 14
No
No
Drer\pik3cd
1 of 14
No
No
Drer\pik3cg
1 of 14
No
No
Drer\si:rp71-17i16.5
1 of 14
No
No
Drer\trrap
1 of 14
No
No
Drer\zgc:158659
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\let-363
11 of 14
Yes
Yes
Cele\atm-1
2 of 14
No
No
Cele\age-1
1 of 14
No
No
Cele\pifk-1
1 of 14
No
No
Cele\piki-1
1 of 14
No
No
Cele\smg-1
1 of 14
No
No
Cele\trr-1
1 of 14
No
No
Cele\Y75B8A.24
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP007873
12 of 12
Yes
Yes
Agam\AgaP_AGAP000368
3 of 12
No
No
Agam\AgaP_AGAP003967
3 of 12
No
Yes
Agam\AgaP_AGAP010313
3 of 12
No
No
Agam\AgaP_AGAP005533
2 of 12
No
No
Agam\AgaP_AGAP009632
2 of 12
No
No
Agam\AgaP_AGAP000018
1 of 12
No
No
Agam\AgaP_AGAP010273
1 of 12
No
No
Agam\AgaP_AGAP010801
1 of 12
No
No
Agam\AgaP_AGAP011036
1 of 12
No
No
Agam\AgaP_AGAP012631
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\TOR
13 of 13
Yes
Yes
Atha\AT2G17930
2 of 13
No
No
Atha\AT4G36080
2 of 13
No
No
Atha\ATR
2 of 13
No
No
Atha\AT1G51040
1 of 13
No
No
Atha\ATM
1 of 13
No
No
Atha\ATPI4K ALPHA
1 of 13
No
No
Atha\PI-4KBETA1
1 of 13
No
No
Atha\PI-4KBETA2
1 of 13
No
No
Atha\VPS34
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (8)
Scer\TOR2
12 of 13
Yes
Yes
Scer\TOR1
11 of 13
No
Yes
Scer\MEC1
2 of 13
No
No
Scer\TRA1
2 of 13
No
No
Scer\PIK1
1 of 13
No
No
Scer\STT4
1 of 13
No
No
Scer\TEL1
1 of 13
No
No
Scer\VPS34
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (9)
Spom\tor2
12 of 12
Yes
Yes
Spom\tor1
10 of 12
No
Yes
Spom\rad3
2 of 12
No
No
Spom\tra1
2 of 12
No
No
Spom\tra2
2 of 12
No
No
Spom\pik1
1 of 12
No
No
Spom\pik3
1 of 12
No
No
Spom\stt4
1 of 12
No
No
Spom\tel1
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mTor. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (10)
mei-41
5 of 13
nonC
4 of 13
tefu
4 of 13
Nipped-A
3 of 13
Pi3K68D
2 of 13
CG30184
1 of 13
fwd
1 of 13
Pi3K59F
1 of 13
Pi3K92E
1 of 13
Pi4KIIIα
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    PRKDC; protein kinase, DNA-activated, catalytic subunit
    model of  immunodeficiency 26
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 8 )
    Allele
    Disease
    Interaction
    References
    mTorHMS00904
    ameliorates  amyotrophic lateral sclerosis
    modeled by Vap33P58S.cRa.UAS
    (Deivasigamani et al., 2014)
    mTorΔP
    ameliorates  Parkinson's disease
    modeled by LrrkUAS.cIa
    (Penney et al., 2016)
    ameliorates  viral infectious disease
    modeled by EBV\BRLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    exacerbates  viral infectious disease
    modeled by EBV\BZLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    ameliorates  infectious mononucleosis
    modeled by EBV\BRLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    exacerbates  infectious mononucleosis
    modeled by EBV\BZLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    ameliorates  Epstein-Barr virus hepatitis
    modeled by EBV\BRLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    exacerbates  Epstein-Barr virus hepatitis
    modeled by EBV\BZLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    ameliorates  kidney cancer
    modeled by Ras85DV12.UAS
    (Zeng et al., 2010)
    mTorTED.UAS
    exacerbates  dentatorubral-pallidoluysian atrophy
    modeled by Gug75QN.UAS
    (Nisoli et al., 2010)
    modeled by Gug66QC.UAS
    (Nisoli et al., 2010)
    ameliorates  brain glioma
    modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
    (Read et al., 2009)
    ameliorates  amyotrophic lateral sclerosis
    modeled by Vap33P58S.cRa.UAS
    (Deivasigamani et al., 2014)
    ameliorates  Alzheimer's disease 1
    modeled by Hsap\APP2xAPP.SP.UAS
    (Jang et al., 2024)
    ameliorates  carcinoma
    modeled by ykiHMS00041
    (Bhattacharya et al., 2024)
    mTorWT.UAS.Tag:FLAG
    exacerbates  neuronal ceroid lipofuscinosis
    modeled by cathD1
    (Kuronen et al., 2009)
    ameliorates  Parkinson's disease 6
    modeled by Pink1RNAi.UAS.cYa
    (Liu and Lu, 2010)
    mTork17004
    ameliorates  viral infectious disease
    modeled by EBV\BRLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    exacerbates  viral infectious disease
    modeled by EBV\BZLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    ameliorates  infectious mononucleosis
    modeled by EBV\BRLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    exacerbates  infectious mononucleosis
    modeled by EBV\BZLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    ameliorates  Epstein-Barr virus hepatitis
    modeled by EBV\BRLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    exacerbates  Epstein-Barr virus hepatitis
    modeled by EBV\BZLF1GMR.PA
    (Adamson et al., 2014, Adamson and Lajeunesse, 2012)
    ameliorates  hereditary spastic paraplegia 3A
    modeled by atlRNAi.UAS
    (Xu et al., 2017)
    mTorGL00156
    ameliorates  prostate cancer
    modeled by Ras85DV12.UAS
    (Rambur et al., 2020)
    ameliorates  amyotrophic lateral sclerosis type 8
    modeled by Vap33P58S.cRa.UAS
    (Chaplot et al., 2019)
    mTorNIG.5092R
    ameliorates  cancer
    modeled by Ptp61FΔ, Ras85DV12.cUa.UAS
    (Liu et al., 2022)
    mTorUAS.cUa
    ameliorates  myotonic dystrophy type 1
    modeled by Zzzz\CTGi480.UAS.cGa
    (Bargiela et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MTOR; mechanistic target of rapamycin kinase
    14 of 14
    601231
       
      ATR; ATR checkpoint kinase
      3 of 14
      601215
       
      PRKDC; protein kinase, DNA-activated, catalytic subunit
      3 of 14
      600899
      SMG1; SMG1 nonsense mediated mRNA decay associated PI3K related kinase
      3 of 14
      607032
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          mTor
          anti tag coimmunoprecipitation, anti tag western blot
          (Zhang et al., 2006)
          mTor - Atg1
          anti tag coimmunoprecipitation, anti tag western blot
          (Chang and Neufeld, 2009)
          mTor - CCT4
          anti bait coimmunoprecipitation, western blot
          (Kim and Choi, 2019)
          mTor - Lst8
          anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, anti tag western blot
          (Wang et al., 2012, Glatter et al., 2011)
          mTor - PRAS40
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - REPTOR
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Tiebe et al., 2015)
          mTor - Sin1
          anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
          (Wu et al., 2013, Glatter et al., 2011)
          mTor - Socs36E
          anti tag coimmunoprecipitation, anti tag western blot
          (Kang et al., 2018)
          mTor - Thor
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - Tsc1
          anti tag coimmunoprecipitation, anti tag western blot
          (Gao et al., 2002)
          mTor - Tti1
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - fkh
          anti tag coimmunoprecipitation, anti tag western blot
          (Bolukbasi et al., 2017)
          mTor - gig
          anti tag coimmunoprecipitation, anti tag western blot
          (Gao et al., 2002)
          mTor - hppy
          pull down, autoradiography
          (Resnik-Docampo and de Celis, 2011)
          mTor - lqfR
          anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - pont
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - raptor
          anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
          (Tsokanos et al., 2016, Wang et al., 2012, Glatter et al., 2011)
          mTor - rept
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - rictor
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - spag
          anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - unk
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (Glatter et al., 2011)
          mTor - wcy
          anti tag coimmunoprecipitation, peptide massfingerprinting
          (David-Morrison et al., 2016)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          mTor
          suppressible
          Acn
          (Haberman et al., 2010)
          mTor
          enhanceable
          acs
          (Goberdhan et al., 2005)
          mTor
          enhanceable
          Atg1
          (Scott et al., 2007, Scott et al., 2004)
          mTor
          suppressible
          Atg1
          (Kuhn et al., 2015, Xu et al., 2015, Lee et al., 2007)
          mTor
          enhanceable
          Atg5
          (Scott et al., 2004)
          mTor
          suppressible
          babo
          (Luo et al., 2020)
          mTor
          suppressible
          brp
          (Penney et al., 2012)
          mTor
          suppressible
          CycE
          (Zhang et al., 2000)
          mTor
          suppressible
          eIF4E1
          (Penney et al., 2012)
          mTor
          enhanceable
          hppy
          (Resnik-Docampo and de Celis, 2011)
          mTor
          suppressible
          hppy
          (Resnik-Docampo and de Celis, 2011)
          mTor
          enhanceable
          Hsc70-4
          (Hennig et al., 2006)
          Pten|mTor
          enhanceable
          ImpL2
          (Nowak et al., 2013)
          mTor
          suppressible
          Lrrk
          (Penney et al., 2016)
          mTor
          suppressible
          Myc
          (Wang and Huang, 2009, Hennig and Neufeld, 2002)
          mTor
          enhanceable
          path
          (Goberdhan et al., 2005)
          mTor
          suppressible
          Phae1
          (Matsumura et al., 2025)
          mTor
          enhanceable
          Pi3K92E
          (Hennig and Neufeld, 2002)
          mTor
          suppressible
          Pten
          (Devilliers et al., 2021)
          mTor
          suppressible
          REPTOR
          (Tiebe et al., 2015)
          mTor
          suppressible
          S6k
          (Penney et al., 2012, Scott et al., 2004, Zhang et al., 2000)
          mTor|Tsc1
          suppressible
          S6k
          (Radimerski et al., 2002)
          Rheb|mTor
          suppressible
          S6k
          (Stocker et al., 2003)
          mTor
          suppressible
          sev
          (Luo et al., 2020)
          mTor
          enhanceable
          shi
          (Hennig et al., 2006)
          mTor
          suppressible
          SREBP
          (Luo et al., 2020)
          mTor
          suppressible
          srl
          (Mukherjee and Duttaroy, 2013)
          mTor
          enhanceable
          Tsc1
          (Hennig et al., 2006)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Acc
          suppressible
          mTor
          (Amartuvshin et al., 2025)
          acs
          enhanceable
          mTor
          (Goberdhan et al., 2005)
          AMPKα
          suppressible
          mTor
          (Onyenwoke et al., 2015, Johnson et al., 2010)
          Atg1
          suppressible
          mTor
          (Kuhn et al., 2015, Xu et al., 2015)
          Atg1
          enhanceable
          mTor
          (Scott et al., 2004)
          Atg9
          suppressible
          mTor
          (Wen et al., 2017)
          babo
          suppressible
          mTor
          (Luo et al., 2020)
          cathD
          enhanceable
          mTor
          (Kuronen et al., 2009)
          Cul1
          suppressible
          mTor
          (Wong et al., 2013)
          Dcp-1
          suppressible
          mTor
          (Kim et al., 2010)
          foxo
          enhanceable
          mTor|path
          (Goberdhan et al., 2005)
          gig
          suppressible
          mTor
          (Zhang et al., 2006)
          GluRIIA
          suppressible
          mTor
          (Penney et al., 2012)
          Gug
          enhanceable
          mTor
          (Nisoli et al., 2010)
          hppy
          enhanceable
          mTor
          (Resnik-Docampo and de Celis, 2011)
          hrm
          suppressible
          mTor
          (Velentzas et al., 2018)
          L
          enhanceable
          mTor
          (Wang and Huang, 2009)
          Lpin
          enhanceable
          mTor
          (Schmitt et al., 2015)
          Lrrk
          suppressible
          mTor
          (Penney et al., 2016)
          Madm
          suppressible
          mTor
          (Mushtaq et al., 2022)
          Nprl2
          suppressible
          mTor
          (Wei et al., 2016)
          Nprl3
          suppressible
          mTor
          (Wei et al., 2016)
          path
          enhanceable
          mTor
          (Goberdhan et al., 2005)
          pHCl-2
          enhanceable
          mTor
          (Redhai et al., 2020)
          Pi3K92E
          suppressible
          mTor
          (Gass et al., 2022, Berry and Baehrecke, 2007)
          Pi3K92E
          enhanceable
          mTor
          (Coelho et al., 2005)
          Pi3K92E|btl::Egfr
          suppressible
          mTor
          (Read et al., 2009)
          Pten
          suppressible
          mTor
          (Mensah et al., 2015, Nowak et al., 2013, Oldham et al., 2000)
          Ras85D
          suppressible
          mTor
          (Zeng et al., 2010, Berry and Baehrecke, 2007)
          Ras85D|dlg1
          suppressible
          mTor
          (Willecke et al., 2011)
          Rheb
          suppressible
          mTor
          (Dimitroff et al., 2012, Stocker et al., 2003)
          Rps6kc1
          enhanceable
          mTor
          (Planas-Serra et al., 2025)
          Rps6kc1
          suppressible
          mTor
          (Planas-Serra et al., 2025)
          S6k|Tsc1
          suppressible
          mTor
          (Radimerski et al., 2002)
          sev
          suppressible
          mTor
          (Luo et al., 2020)
          Sgsf
          suppressible
          mTor
          (Li et al., 2022)
          Tsc1
          suppressible
          mTor
          (Gao et al., 2002, Radimerski et al., 2002)
          Vap33
          suppressible
          mTor
          (Deivasigamani et al., 2014)
          vtd
          suppressible
          mTor
          (Liu et al., 2016)
          wcy
          suppressible
          mTor
          (David-Morrison et al., 2016)
          External Data
          Subunit Structure (UniProtKB)
          May be part of a minimal complex, TORC1, consisting of mTor, raptor and lst8. May be part of a minimal complex, TORC2, consisting of mTor, rictor and lst8 (By similarity). Self-associates; assembles into homomultimeric complexes. Component of a multiprotein complex.
          (UniProt, Q9VK45 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-47
          Cytogenetic map
          34A4-34A4
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          34A4-34A4
          Limits computationally determined from genome sequence between P{lacW}l(2)k07015k07015&P{PZ}l(2)rK639rK639 and P{lacW}l(2)k11328k11328&P{lacW}l(2)k10105k10105
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          34A3-34A4
          (determined by in situ hybridisation)
          (Spradling et al., 1999)
          34A3-34A4
          (BDGP Project Members, 1994-1999)
          Experimentally Determined Recombination Data
          Location

          2-47

          (FlyBase, 2016)

          2-43.1

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (26)
          Genomic Clones (12)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (6)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Nagy et al., 2014)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
              Other Comments

              Tor is specifically required for developmental axon regrowth but not initial axon outgrowth.

              (Yaniv et al., 2012)

              dsRNA made from templates generated with primers directed against this gene results in a reduced mean cell diameter and a corresponding decrease in S6k phosphorylation. Silencing Tor generates a cell-expression profile similar to that of rapamycin-treated cells.

              (Guertin et al., 2006)

              dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.

              (Yang et al., 2006)

              dsRNA made from templates generated with primers directed against this gene decreases the level of phosphorylation of both Akt1 and S6k in S2 cells.

              (Yang et al., 2006)

              Allelic series: TorR248stop = TorQ528stop = TorV2148D > TorG2256D = Tor2L1 > TorR97C = TorE161K = TorA948V = TorW1251R based on the stage of lethality.

              (Zhang et al., 2006)

              Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.

              (Agaisse et al., 2005)

              When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, a decrease in cell size and a decrease in cytokinetic index is seen.

              (Bettencourt-Dias et al., 2004)

              Signaling through Tor and its upstream regulators Pi3K92E/Pi3K21B and Rheb is necessary and sufficient to suppress starvation-induced autophagy in the fat body. Tor suppresses autophagy independently of S6k.

              (Scott et al., 2004)

              Loss of Tor activity causes induction of autophagy in normally fed animals.

              (Scott et al., 2004)

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Tor CG5092

              (Zhang et al., 2000)
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: l(2)k17004 Tor

              (Oldham et al., 2000)

              Source for identity of: mTor Tor

              (FlyBase, 2009-)
              Nomenclature comments

              Changed gene symbol 'Tor' to 'mTor' to reflect the symbol used for the vertebrate ortholog and to eliminate the case-insensitive duplication with the 'tor' (torso) gene symbol.

              (FlyBase, 2009-)
              Etymology
              Synonyms and Secondary IDs (35)
              Reported As
              Symbol Synonym
              5092
              (Ravi et al., 2009)
              CG5092
              (National Institute of Genetics Fly Stocks, 2022-, Meadows, 2018.10.31, Kondo et al., 2017, Fukuoh et al., 2014, Christis and Munro, 2012, Glatter et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Sun et al., 2010, Holloway et al., 2008, Derré et al., 2007, Sarbassov et al., 2004, Song et al., 2004)
              CT16317
              (Morrison et al., 2000)
              CT24745
              (Morrison et al., 2000)
              CT24817
              (Morrison et al., 2000)
              DmTOR
              (Zhang et al., 2025, Chen et al., 2006)
              FRAP/TOR
              (Morrison et al., 2000, Morrison et al., 2000)
              MTOR
              Mtor
              (Yheskel et al., 2023, Subaraja et al., 2020, Monribot-Villanueva et al., 2017)
              TOR
              (Ding et al., 2026, Ahrentløv et al., 2025, Scopelliti et al., 2025, Wang et al., 2025, Yadav et al., 2025, Zhang et al., 2025, Delescluse et al., 2024, Jeong, 2024, Lee and Min, 2024, Luo et al., 2024, Matsuka et al., 2024, Nagata and Igaki, 2024, Tan et al., 2024, Zhu et al., 2024, Kang et al., 2023, Sanal et al., 2023, Bahuguna et al., 2022, Koehler et al., 2022, Mushtaq et al., 2022, Neophytou and Pitsouli, 2022, Noguchi et al., 2022, Wu et al., 2022, Bailey et al., 2021, Cai et al., 2021, Heier et al., 2021, Joy et al., 2021, Kannangara et al., 2021, Kim et al., 2021, Lam Wong and Verheyen, 2021, Lehmann, 2021, Léopold, 2021, McDonald et al., 2021, Meschi and Delanoue, 2021, Moraes and Montagne, 2021, Morin-Poulard et al., 2021, Osman and Pek, 2021, Parra-Peralbo et al., 2021, Sood et al., 2021, Tiwari and Mandal, 2021, Voo et al., 2021, Ahmad et al., 2020, Bakshi and Joshi, 2020, Blatt et al., 2020, Ding et al., 2020, Gohel et al., 2020, Grenier and Leulier, 2020, Kanda and Igaki, 2020, Koyama et al., 2020, Lee et al., 2020, Li et al., 2020, Luo et al., 2020, Malita and Rewitz, 2020, Nakajima et al., 2020, Shin et al., 2020, Strilbytska et al., 2020, Tafesh-Edwards and Eleftherianos, 2020, Texada et al., 2020, Toprak et al., 2020, Wolterhoff et al., 2020, Zeng et al., 2020, Basar et al., 2019, Bayliak et al., 2019, Borreguero-Muñoz et al., 2019, Chaplot et al., 2019, Hansen et al., 2019, Kim and Choi, 2019, Zheng et al., 2019, Gáliková and Klepsatel, 2018, Kang et al., 2018, Kounatidis and Chtarbanova, 2018, Lee et al., 2018, Lehmann, 2018, Tang et al., 2018, Filer et al., 2017, Haller et al., 2017, Hoedjes et al., 2017, Kamalesh et al., 2017, Kim et al., 2017, Liu et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Romero-Pozuelo et al., 2017, Strilbytska et al., 2017, Tue et al., 2017, Xiang et al., 2017, Alfa and Kim, 2016, Cannon and Bodmer, 2016, Kuleesha et al., 2016, Li et al., 2016, Marmor-Kollet and Schuldiner, 2016, Niwa and Niwa, 2016, Purice et al., 2016, Rabinovich et al., 2016, Tsokanos et al., 2016, Yaniv and Schuldiner, 2016, Burn et al., 2015, Diop and Bodmer, 2015, Diop et al., 2015, Homem et al., 2015, Ma et al., 2015, Mitchell et al., 2015, Nässel et al., 2015, Obata and Miura, 2015, Schmitt et al., 2015, Tiebe et al., 2015, Wang et al., 2015, Barrio et al., 2014, Frank, 2014, Ghosh et al., 2014, Mulakkal et al., 2014, Nagy et al., 2014, Owusu-Ansah and Perrimon, 2014, Varma et al., 2014, Xu and Cherry, 2014, Callier and Nijhout, 2013, Esslinger et al., 2013, Gems and Partridge, 2013, Laslo et al., 2013, Lee and Brey, 2013, Luo et al., 2013, Mukherjee and Duttaroy, 2013, Nowak et al., 2013, Rajan and Perrimon, 2013, Rallis et al., 2013, Tixier et al., 2013, Tran et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Eleftherianos and Castillo, 2012, Ferguson et al., 2012, Grewal, 2012, Kayashima et al., 2012, Marshall et al., 2012, Rincon-Limas et al., 2012, Yaniv et al., 2012, Boyd et al., 2011, Glatter et al., 2011, Lindquist et al., 2011, Oldham, 2011, Parker, 2011, Partridge et al., 2011, Rajan and Perrimon, 2011, Birse et al., 2010, Bjedov et al., 2010, Bryk et al., 2010, Chang and Neufeld, 2010, Iijima-Ando and Iijima, 2010, Lee et al., 2010, Li et al., 2010, Liu and Lu, 2010, Ribeiro and Dickson, 2010, Vargas et al., 2010, Chang and Neufeld, 2009, Kourtis and Tavernarakis, 2009, Dutta and Baehrecke, 2008, Kaplan et al., 2008, Layalle et al., 2008, Lee et al., 2008, Leopold and Layalle, 2008, McNeill et al., 2008, Oldham et al., 2008, Teleman et al., 2008, Ballard and Wharton, 2007, Berry and Baehrecke, 2007, Grewal et al., 2007, Hall et al., 2007, Hoshizaki and Gibbs, 2007, Lee et al., 2007, Ocorr et al., 2007, Wessells et al., 2007, Edgar, 2006, Goraksha and Neufeld, 2006, Guertin et al., 2006, Hennig et al., 2006, Khurana et al., 2006, Min et al., 2006, Mosimann et al., 2006, Ruvinsky, 2006, Takacs-Vellai, 2006, Wu and Brown, 2006, Yang et al., 2006, Bodmer, 2005, Cygnar et al., 2005, Goberdhan et al., 2005, Grewal et al., 2005, Scott et al., 2005, Shingleton, 2005, Teleman et al., 2005, Hay and Sonenberg, 2004, Pan et al., 2004, Scott et al., 2004, Scott et al., 2004, Stocker et al., 2004, Tatar et al., 2004, Tu and Tatar, 2004, Bergmann and Lane, 2003, Nijhout, 2003, Saucedo et al., 2003, Saucedo et al., 2003, Scott and Neufeld, 2003, Stocker et al., 2003, Oldham et al., 2001)
              TOR-C1
              (Galenza and Foley, 2019)
              TORC1
              (Huang and Perrimon, 2026, Bjedov and Rallis, 2020, Funk et al., 2020, Rodriguez-Fernandez et al., 2020, Xu et al., 2020, Camus et al., 2019, Mirzoyan et al., 2019, Kang et al., 2018, Liu and Jin, 2017, Serbus et al., 2015, Zhang et al., 2015, Andersen et al., 2013)
              Tor
              (GenetiVision Corporation, 2026-, Toprak, 2026, Dong et al., 2025, Lee et al., 2025, Park et al., 2025, Qin et al., 2025, Tahan Zadeh et al., 2025, Tyszka et al., 2025, Ma et al., 2024, Mikropoulou et al., 2024, Wang et al., 2024, Zhang et al., 2024, Zirin et al., 2024, Cachoux et al., 2023, Gui et al., 2023, Huang et al., 2023, Kanaoka et al., 2023, Nagai et al., 2023, Roy et al., 2023, Alves et al., 2022, Dalton et al., 2022, Damulewicz et al., 2022, Dong et al., 2022, Huang et al., 2022, Ji et al., 2022, Kakanj et al., 2022, Kamiyama and Niwa, 2022, Li et al., 2022, Liu et al., 2022, Molina et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Palozzi et al., 2022, Suzuta et al., 2022, Tahanzadeh et al., 2022, Weina et al., 2022, Yu et al., 2022, Azuma et al., 2021, Bilder et al., 2021, Bonfini et al., 2021, Buhlman et al., 2021, Fabian et al., 2021, Fan et al., 2021, Jacomin et al., 2021, Johnson and Leatherman, 2021, Kim and O'Connor, 2021, Kim et al., 2021, Lee et al., 2021, Liguori et al., 2021, Nishida et al., 2021, Ohhara et al., 2021, Ostalé et al., 2021, Semaniuk et al., 2021, Zhou et al., 2021, Bosch et al., 2020, Colombani and Andersen, 2020, Cui et al., 2020, Funk et al., 2020, Ishibashi et al., 2020, Jacomin et al., 2020, Jeon et al., 2020, Khan et al., 2020, Luo et al., 2020, Ma et al., 2020, Murakawa et al., 2020, Nakamura et al., 2020, Perez-Gomez et al., 2020, Rambur et al., 2020, Redhai et al., 2020, Sanaki et al., 2020, Sênos Demarco et al., 2020, Wang et al., 2020, Zhao et al., 2020, Bhattacharjee et al., 2019, Birnbaum et al., 2019, Blice-Baum et al., 2019, Bouska et al., 2019, Brown et al., 2019, Chen et al., 2019, Drummond-Barbosa, 2019, Evangelakou et al., 2019, Hegazi et al., 2019, Huang et al., 2019, Johnson and Toettcher, 2019, Kim et al., 2019, Kumar Chaudhary and Rizvi, 2019, Li et al., 2019, Li et al., 2019, Lin et al., 2019, Loeffler, 2019, Meltzer et al., 2019, Mirth et al., 2019, Ramanathan et al., 2019, Sênos Demarco et al., 2019, Singh et al., 2019, Su, 2019, Tang et al., 2019, Tettamanti and Casartelli, 2019, Texada et al., 2019, Westfall et al., 2019, Xi et al., 2019, Yoshinari et al., 2019, Cara et al., 2018, Gene Disruption Project members, 2018-, Ignesti et al., 2018, Kang et al., 2018, Kuo et al., 2018, Lee et al., 2018, Leow et al., 2018, Tamirisa et al., 2018, Tsai et al., 2018, Velentzas et al., 2018, Galluzzi et al., 2017, Lee et al., 2017, Lin et al., 2017, Perry et al., 2017, Song et al., 2017, Wen et al., 2017, Xu et al., 2017, Xu et al., 2017, Yan et al., 2017, Di Cara and King-Jones, 2016, Kučerová et al., 2016, Liu et al., 2016, Penney et al., 2016, Puah and Wasser, 2016, Sarov et al., 2016, Wei et al., 2016, Aradska et al., 2015, Diop et al., 2015, Francis and Ghabrial, 2015, Frankel et al., 2015, Gilboa, 2015, Lin et al., 2015, Mensah et al., 2015, Okada et al., 2015, Onyenwoke et al., 2015, Parker and Struhl, 2015, Stratoulias and Heino, 2015, Wu et al., 2015, Xu et al., 2015, Adamson et al., 2014, Deivasigamani et al., 2014, Gómez-Lamarca et al., 2014, Hasygar and Hietakangas, 2014, Moy et al., 2014, Pathak et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Wei et al., 2014, Brianti et al., 2013, Lanet et al., 2013, Luo et al., 2013, O'Farrell et al., 2013, Soh et al., 2013, Tang et al., 2013, Tixier et al., 2013, Tixier et al., 2013, Vilmos et al., 2013, Adamson and Lajeunesse, 2012, Alvarez-Ponce et al., 2012, Avet-Rochex et al., 2012, Chakrabarti et al., 2012, Dar et al., 2012, Dimitroff et al., 2012, Garcia et al., 2012, Penney et al., 2012, Pritchett and McCall, 2012, Tokusumi et al., 2012, Zhang et al., 2012, Zitserman et al., 2012, Djiane et al., 2011, Friedman et al., 2011, Lindquist et al., 2011, Read, 2011, Resnik-Docampo and de Celis, 2011, Sousa-Nunes et al., 2011, Tang et al., 2011, Turner et al., 2011, Willecke et al., 2011, Ballard et al., 2010, Blanco et al., 2010, Bülow et al., 2010, Cully et al., 2010, Fernández-Ayala et al., 2010, Haberman et al., 2010, Hsieh et al., 2010, Johnson et al., 2010, Kim et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Nisoli et al., 2010, Robinson et al., 2010, Sun et al., 2010, Sun et al., 2010, Zeng et al., 2010, Zhang et al., 2010, Zheng and Sehgal, 2010, Alvarez-Ponce et al., 2009, Chittaranjan et al., 2009, Koike-Kumagai et al., 2009, Kuronen et al., 2009, Nuzhdin et al., 2009, Patch et al., 2009, Sims et al., 2009, Wang and Huang, 2009, Harvey et al., 2008, Holloway et al., 2008, Hou et al., 2008, Juhász et al., 2008, Rehmann et al., 2008, Song et al., 2008, Derré et al., 2007, Frei et al., 2007, Grewal et al., 2007, Juhász et al., 2007, Kim and Yoo, 2007, Knox et al., 2007, Martin et al., 2007, Miranda-Saavedra and Barton, 2007, Parisi et al., 2007, Scott et al., 2007, Scott et al., 2007, Chen et al., 2006, Friedman and Perrimon, 2006, Hariharan, 2006, Patel and Tamanoi, 2006, Walker et al., 2006, Bateman and McNeill, 2005, Mandal et al., 2005, Teleman et al., 2005, Terashima and Bownes, 2005)
              Tor-C1
              (Das and Dobens, 2015)
              Torc1
              (Kuhn et al., 2015)
              dTOR
              (Liu et al., 2026, Nan et al., 2025, Serebrovska et al., 2025, Dai et al., 2023, Demir and Kacew, 2023, Frappaolo and Giansanti, 2023, Dabrowska et al., 2022, Koranteng et al., 2022, Nayak and Mishra, 2022, Santalla et al., 2022, Singh and Agrawal, 2022, Wang et al., 2022, Sciambra and Chtarbanova, 2021, Wen et al., 2021, Gou et al., 2020, Koliada et al., 2020, Moretti et al., 2020, Lushchak et al., 2019, Westfall et al., 2019, Staats et al., 2018, Westfall et al., 2018, Bolukbasi et al., 2017, Brookheart and Duncan, 2016, David-Morrison et al., 2016, Erdogan et al., 2016, Sanchez et al., 2016, Wu and Storey, 2016, Chen et al., 2015, Kohlmaier et al., 2015, Merkling and van Rij, 2013, Mockett and Nobles, 2013, Shim et al., 2013, Wu et al., 2013, Eleftherianos and Castillo, 2012, Taillebourg et al., 2012, Kamakura, 2011, Nishimura et al., 2011, Partridge et al., 2011, Dekanty et al., 2010, Karbowniczek et al., 2010, Thomson and Johnson, 2010, Zirin and Perrimon, 2010, Wang and Huang, 2009, Wessells et al., 2009, Mattila et al., 2008, Findlay et al., 2007, Lasko and Sonenberg, 2007, Lee et al., 2007, Wu et al., 2007, Guertin et al., 2006, Inoki and Guan, 2006, Luong et al., 2006, Wullschleger, 2006, Yang et al., 2006, Dekanty et al., 2005, Goraksha and Neufeld, 2005, Sarbassov et al., 2005, Buch et al., 2004, Jorgensen and Tyers, 2004, Kapahi et al., 2004, Kapahi et al., 2004, Oldham et al., 2004, Ruhf et al., 2004, Sarbassov et al., 2004, Sarbassov et al., 2004, Bradley and Leevers, 2003, Hennig et al., 2003, Jacinto and Hall, 2003, Lee and Orr-Weaver, 2003, Manning and Cantley, 2003, Miron et al., 2003, Oldham and Hafen, 2003, Hennig and Neufeld, 2002, Hennig and Neufeld, 2002, Kozma and Thomas, 2002, Marygold and Leevers, 2002, Montagne et al., 2002, Radimerski et al., 2002, Radimerski et al., 2002, Cho et al., 2001, Gingras et al., 2001, Potter and Xu, 2001, Prober and Edgar, 2001, Radimerski et al., 2001, Rhode et al., 2001, Oldham et al., 2000, Oldham et al., 2000, Zhang et al., 2000)
              dTORC1
              (Fan et al., 2020)
              dTor
              (Chen et al., 2025, Gillette et al., 2021, Chattopadhyay and Thirumurugan, 2020, Ahmad et al., 2018, Palmer et al., 2018, Lei et al., 2017, Moy and Cherry, 2013, Dar et al., 2012, Katewa and Kapahi, 2011, Cully et al., 2010, Read et al., 2009, Song et al., 2008, DiAngelo and Birnbaum, 2006, Kockel et al., 2005, Oldham et al., 2005, Wang et al., 2005, Radimerski et al., 2002)
              dtor
              (Li et al., 2010, Lee and Orr-Weaver, 2003)
              l(2)k17004
              (Spradling et al., 1999)
              mTOR
              (Bevinakoppamath et al., 2026, Wang et al., 2026, Amartuvshin et al., 2025, Frappaolo et al., 2025, Lee et al., 2025, Kumar et al., 2024, Feng et al., 2023, Han et al., 2021, Hou and Pei, 2021, Millet-Boureima et al., 2021, Song et al., 2021, Yang et al., 2021, Arnés et al., 2020, Bjedov and Rallis, 2020, Frank et al., 2020, Ghosh et al., 2020, Halim et al., 2020, Hou et al., 2020, Liu et al., 2020, Wu et al., 2019, Piper and Partridge, 2018, Brace and DiAntonio, 2017, Brill et al., 2016, Lees et al., 2016, Demontis et al., 2013, Lin et al., 2013, Findlay et al., 2005, McManus and Alessi, 2002)
              mTor
              (González-Blanco et al., 2026, Ribeiro et al., 2026, Wang et al., 2026, Chen et al., 2025, Glineburg and Nguyen, 2025, Planas-Serra et al., 2025, Sun et al., 2025, Taoka et al., 2025, Xue et al., 2025, Zhu et al., 2025, Clémot et al., 2024, Grmai et al., 2024, Rodríguez-Vázquez et al., 2024, Saez-Carrion et al., 2024, Srivastav et al., 2024, Zhang et al., 2024, Rodrigues et al., 2023, Spratt et al., 2023, Yamada et al., 2023, Sadasivan et al., 2022, Boumard and Bardin, 2021, Ma et al., 2021, Chatterjee et al., 2019, Mensah et al., 2017, Androschuk et al., 2015)
              mtor
              tor
              (Sharmin et al., 2024, Ziech et al., 2023, Everetts et al., 2021, Chen et al., 2019, Hall et al., 2019, Meltzer et al., 2016, Xie et al., 2015, Das et al., 2013, Killip and Grewal, 2012, Wang et al., 2012, Li et al., 2010, Kuronen et al., 2009, Parrish et al., 2009, Saucedo et al., 2003)
              Name Synonyms
              Mechanistic Target of rapamycin
              (Koehler and Huber, 2023)
              Target Of Rapamycin
              (Mockett and Nobles, 2013, Ocorr et al., 2007)
              Target of Rapamycin
              (Kannangara et al., 2021, Callier and Nijhout, 2013, Wong et al., 2013, Eleftherianos and Castillo, 2012, Leopold and Layalle, 2008, Ballard and Wharton, 2007)
              Target of rapamycin
              (Oyovwi et al., 2025, Kamalesh et al., 2017, Kondo et al., 2017, Denton et al., 2015, Homem et al., 2015, Gems and Partridge, 2013, Vilmos et al., 2013, Haberman et al., 2010, Kim et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Patch et al., 2009, Martin et al., 2007, Hennig et al., 2006, Yang et al., 2006, Terashima and Bownes, 2005, Oldham et al., 2000)
              Target-of-Rapamycin
              (Ghosh et al., 2014)
              Target-of-rapamycin
              (Patel and Tamanoi, 2006)
              mTOR
              (Puram and Bonni, 2013)
              mechanistic Target of rapamycin
              (Shafer, 2025)
              target of rapamycin
              (Bayliak et al., 2019, Gáliková and Klepsatel, 2018, Staats et al., 2018, Cannon and Bodmer, 2016, Marmor-Kollet and Schuldiner, 2016, Diop and Bodmer, 2015, Francis and Ghabrial, 2015, Mulakkal et al., 2014, Owusu-Ansah and Perrimon, 2014, Varma et al., 2014, Lee and Brey, 2013, Rajan and Perrimon, 2013, Tixier et al., 2013, Grewal, 2012, Pritchett and McCall, 2012, Rincon-Limas et al., 2012, Glatter et al., 2011, Ballard et al., 2010, Cully et al., 2010, Iijima-Ando and Iijima, 2010, Lee et al., 2010, Ribeiro and Dickson, 2010, Sun et al., 2010, Vargas et al., 2010, Koike-Kumagai et al., 2009, Wang et al., 2009, Wessells et al., 2009, Dutta and Baehrecke, 2008, Harvey et al., 2008, Grewal et al., 2007, Hall et al., 2007, Kim and Yoo, 2007, Lee et al., 2007)
              target of rapamycin complex 1
              (Zhang et al., 2015)
              target of rapamycin kinase
              (Khurana et al., 2006)
              target-of-rapamycin
              (Laslo et al., 2013, Marshall et al., 2012, Takacs-Vellai, 2006, Davies et al., 2005)
              Secondary FlyBase IDs
              • FBgn0032466
              Datasets (1)
              Study focus (1)
              Experimental Role
              Project
              Project Type
              Title
              • bait_protein
              PPI_InR-Tor_interaction_map
              Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 79 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              References (822)