dTOR, mTOR, TORC1, FRAP/TOR, l(2)k17004
Phosphatidylinositol 3-kinase - involved in perception of nutrient status - pivotal member of the TOR pathway involved in regulation of growth and cell proliferation
Please see the JBrowse view of Dmel\Tor for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.48
None of the polypeptides share 100% sequence identity.
May be part of a minimal complex, TORC1, consisting of tor, raptor and lst8. May be part of a minimal complex, TORC2, consisting of tor, rictor and lst8 (By similarity). Self-associates; assembles into homomultimeric complexes. Component of a multiprotein complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tor using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Tor in GBrowse 22-47
2-43.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: l(2)k17004 Tor
Source for merge of: Tor CG5092
Tor is specifically required for developmental axon regrowth but not initial axon outgrowth.
dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.
Allelic series: TorR248stop = TorQ528stop = TorV2148D > TorG2256D = Tor2L1 > TorR97C = TorE161K = TorA948V = TorW1251R based on the stage of lethality.
Identified in an RNAi screen for host factors that alter infection of SL2 cells by L.monocytogenes.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, a decrease in cell size and a decrease in cytokinetic index is seen.
Loss of Tor activity causes induction of autophagy in normally fed animals.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.