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FB2025_05
,
released December 11, 2025
SIN3, dSin3A, dSin3
transcriptional corepressor; component of histone deacetylase complex that affects cell cycle progression
Please see the JBrowse view of Dmel\Sin3A for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 6.02
7.920, 6.252 (longest cDNA)
7.742 (compiled cDNA)
1773, 1751 (aa)
2061 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sin3A using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Sin3A is expressed ubiquitously during embryogenesis. The cDNA encoding the longest isoform may be ovary-specific, as it was found in all the clones from an ovarian library.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sin3A in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
DNA-protein interactions: genome-wide binding profile assayed for Sin3A protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Sin3A results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
Genetic interaction between EcRE261st and Sin3Ak07401 reported in FBrf0111507 is not evident when EcRC300Y is combined with Sin3A08269, suggesting that the original observed interaction could be due to background effects.
2 "ES2-3" alleles of Sin3A have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype.
Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.
l(2)k17019a may correspond to Sin3A: the P{lacW}l(2)k17019ak17019a insertion maps within the transcription unit.
