ssm, sesame, Dhh
histone chaperone - required for nucleosome assembly during sperm nucleus decondensation - GAGA factor and FACT-dependent replacement of methylated histone H3 by H3.3 occurs through association with Hira
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hira using the Feature Mapper tool.
Hira transcripts are detected at all stages of development on northern blots but are strongest in adult females, unfertilized eggs, and 0-3hr embryos. Transcripts are ubiquitously distributed in blastoderm embryos. By cellularization, transcript levels decrease significantly. In ovaries, Hira transcripts are first detected in mid stage nurse cells. Later they are detected at high levels in oocytes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hira in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Hira ssm
Mutation in Hira affects maternal histone incorporation in the male pronucleus.
Called sesame (ssm) for Sperm Escaping Syngamy, A Maternal Effect.