FB2021_02, released April 13, 2021

Gene: Dmel\Clk

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General Information
Symbol
Dmel\Clk
Species
D. melanogaster
Name
Clock
Annotation Symbol
CG7391
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023076
Gene Model Status
Current
Stock Availability
17 publicly available
Gene Summary
Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters. (UniProt, O61735)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

dClk, dClock, Jrk

Key Links
Genomic Location
Cytogenetic map
66A12-66A12
Sequence location
3L:7,763,233..7,775,603 [-]
Recombination map
3-21
RefSeq locus
NT_037436 REGION:7763233..7775603
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (27 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Kozlov et al., 2017)
enables DNA binding
inferred from direct assay
(Yu et al., 2006)
enables protein binding
inferred from physical interaction with FLYBASE:nej; FB:FBgn0261617
(Hung et al., 2007)
enables protein heterodimerization activity
inferred from physical interaction with UniProtKB:O61734
(Maurer et al., 2009)
inferred from physical interaction with FLYBASE:cyc; FB:FBgn0023094
(Lee et al., 1999)
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from physical interaction with FLYBASE:cyc; FB:FBgn0023094
(Lee et al., 1999)
enables transcription factor binding
inferred from physical interaction with FLYBASE:per; FB:FBgn0003068
(Lee et al., 1999)
inferred from physical interaction with FLYBASE:tim; FB:FBgn0014396
(Lee et al., 1999)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA binding
non-traceable author statement
(assigned by UniProt )
(Allada et al., 1998, Darlington et al., 1998)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN001126940
(assigned by GO_Central )
(Gaudet et al., 2011)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001126940
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (16 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in circadian regulation of gene expression
inferred from mutant phenotype
(Li et al., 2017, Lee et al., 2016, Hung et al., 2007)
involved_in circadian regulation of heart rate
inferred from mutant phenotype
(Gill et al., 2015)
involved_in circadian rhythm
inferred from mutant phenotype
(Lee et al., 2016, Zhao et al., 2003, Ceriani et al., 2002)
inferred from mutant phenotype
(assigned by UniProt )
(Allada et al., 1998)
involved_in entrainment of circadian clock
inferred from mutant phenotype
(Lee et al., 2014)
involved_in locomotor rhythm
inferred from mutant phenotype
(Allada et al., 2003, Zhao et al., 2003)
involved_in negative regulation of apoptotic process
inferred from mutant phenotype
(Means et al., 2015)
involved_in positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Li et al., 2017, Kadener et al., 2007)
involved_in positive regulation of transcription, DNA-templated
inferred from genetic interaction with UniProtKB:P07663
(assigned by UniProt )
(Allada et al., 1998, Darlington et al., 1998)
inferred from genetic interaction with UniProtKB:P49021
(assigned by UniProt )
(Allada et al., 1998, Darlington et al., 1998)
involved_in regulation of circadian sleep/wake cycle, sleep
inferred from mutant phenotype
(Shaw et al., 2002)
involved_in response to light stimulus
inferred from direct assay
(Lee et al., 2016)
involved_in response to temperature stimulus
inferred from mutant phenotype
(Lee et al., 2014)
inferred from direct assay
(Lee et al., 2016)
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
involved_in behavioral response to cocaine
non-traceable author statement
(Sokolowski, 2001)
traceable author statement
(Rothenfluh and Heberlein, 2002)
involved_in circadian regulation of gene expression
inferred from biological aspect of ancestor with PANTHER:PTN001126940
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in circadian rhythm
non-traceable author statement
(Sokolowski, 2001)
non-traceable author statement
(assigned by UniProt )
(Bae et al., 1998, Darlington et al., 1998)
traceable author statement
(Emery and Reppert, 2004, Glossop and Hardin, 2002, Panda et al., 2002, Hardin, 2000)
involved_in eclosion rhythm
traceable author statement
(Stanewsky, 2003)
non-traceable author statement
(Sokolowski, 2001)
involved_in locomotor rhythm
non-traceable author statement
(Sokolowski, 2001)
traceable author statement
(Stanewsky, 2003)
involved_in negative regulation of transcription by RNA polymerase II
non-traceable author statement
(Hardin, 2000)
involved_in positive regulation of transcription by RNA polymerase II
non-traceable author statement
(Hardin, 2000)
traceable author statement
(Stanewsky, 2003)
involved_in positive regulation of transcription, DNA-templated
non-traceable author statement
(Panda et al., 2002)
traceable author statement
(Glossop and Hardin, 2002)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001126940
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in rhythmic behavior
traceable author statement
(Stanewsky, 2003)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of CLOCK-BMAL transcription complex
inferred from direct assay
(Lee et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of CLOCK-BMAL transcription complex
inferred from biological aspect of ancestor with PANTHER:PTN001126940
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytoplasm
inferred from electronic annotation with InterPro:IPR001067
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
located_in nucleus
non-traceable author statement
(Panda et al., 2002)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters.
(UniProt, O61735)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Clk: Clock (J.C. Hall)
The normal 24 hour period of the circadian rhythms of adult locomotor activity and of eclosion are shortened by approximately 1.5 hours. Clk/+ heterozygotes have a period phenotype intermediate between wild-type and mutant homozygotes. The period of the phase-resetting response of the activity rhythm is shortened by 1-2 hours per cycle; adults entrain well to 12 hour light: twelve hour dark cycles, but evening peak of locomotor activity is advanced relative to wild-type; courtship song rhythms of mutant males have essentially normal one-minute periods. Temperature compensation of circadian period is normal (Q10 approximately equal to 1.0), in tests of locomotor activity rhythms.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Clk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Clk-RA
FBtr0076785
NM_079240
4422
1023
Clk-RD
FBtr0100132
NM_001014576
3697
1027
Clk-RF
FBtr0100134
NM_001014574
3695
961
Clk-RG
FBtr0334647
NM_170628
3028
895
Clk-RH
FBtr0334648
NM_206299
3765
895
Additional Transcript Data and Comments
Reported size (kB)

5 (northern blot)

(Darlington et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Clk-PA
FBpp0076500
115.7
1023
6.30
NP_523964
AAF50516
Clk-PD
FBpp0099478
116.1
1027
6.30
NP_001014576
AAX52753
Clk-PF
FBpp0099480
108.6
961
6.17
NP_001014574
AAX52754
Clk-PG
FBpp0306709
100.9
895
6.43
NP_729294
AAN12019
Clk-PH
FBpp0306710
100.9
895
6.43
NP_996021
AAS65057
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

895 aa isoforms: Clk-PG, Clk-PH
Additional Polypeptide Data and Comments
Reported size (kDa)

1015 (aa)

(Allada et al., 1998)

1027 (aa); 116 (kD predicted)

(Bae et al., 1998)

1023 (aa)

(Darlington et al., 1998)

130-150 (kD observed)

(Lee et al., 1998)
Comments

The shorter form of Clk protein is missing the bHLH and PASA domains but contains the PASB domain.

(Allada et al., 1998)

Clk protein is phosphorylated.

(Lee et al., 1998)
External Data
Subunit Structure (UniProtKB)

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with Cycle.

(UniProt, O61735)
Domain

Contains three polyglutamine repeats which could correspond to the transactivation domain. The length of the repeats is polymorphic. In the arrhythmic mutant JRK, deletion of this region leads to the loss of circadian rhythmicity and altered light response.

(UniProt, O61735)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Clk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Kadener et al., 2006)
adult brain

Comment: Clk mRNA expression is lower in ZT16 than in ZT4.

(Kadener et al., 2006)
adult fat body

Comment: cyclical, peak ZT1-4

(Xu et al., 2011)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Zheng et al., 2009)
adult oenocyte

Comment: displays circadian cycling

(Krupp et al., 2008)
adult stage | male
organism

Comment: circadian oscillating expression

(Rakshit et al., 2012)
Additional Descriptive Data

Expression oscillates with the circadian cycle and peaks at ZT0. The relative amount of mRNA is less in bodies compared to heads.

(Rakshit et al., 2012)

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

RT-PCR analysis indicates that the levels of the Clk transcript cycle when in light:dark conditions, in anti-phase with the levels of the per transcript. Clk transcript levels decrease gradually from ZT02 to ZT14, and increase after that until ZT20. In conditions of constant darkness the cycling behaviour is abolished. Clk transcript levels gradually increase from CT02 until CT14 and are maintained after that until CT20.

(Zheng et al., 2009)

Clk is expressed in adult oenocytes and shows a sinusoidal expression pattern with a peak during the day and a trough at night.

(Krupp et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
LP neuron
(Liu et al., 2015)
larval s-LNv Pdf neuron
(Liu et al., 2015)
larval LNd neuron
(Liu et al., 2015)
larval DN period neuron
(Liu et al., 2015)
adult stage
LNd neuron

Comment: at CT09

(Zheng et al., 2009)
LNv neuron

Comment: at CT09

(Zheng et al., 2009)
DN1 neuron

Comment: at ZT11

(Zheng et al., 2009)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Zheng et al., 2009)
adult fat body

Comment: displays circadian cycling

(Xu et al., 2008)
Additional Descriptive Data

Expression of Clk protein was analyzed at zeitgeber time 12 and 22.

(Liu et al., 2015)

The Clk protein is detected in the dorsal and ventral lateral (LNd and LNv) and dorsal (DN1) clock neurons in the adult brain. Western blot analysis in adult head extracts indicates that in light:dark conditions, Clk protein shows a cycling behaviour, with its peak level at ZT08. In conditions of constant darkness, cycling is dampened.

(Zheng et al., 2009)

Clk protein levels undergo circadian cycling. In adult heads, protein levels reach a peak between (zeitgeber times) ZT23.5 and ZT4 and a minimum between ZT11.5 and ZT16. The time course for the accumulation of Clk mRNA and Clk protein is similar. Circadian cycling of Clk protein levels continues for at least 2 days under dark conditions.

(Lee et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of CLOCK-BMAL transcription complex
inferred from direct assay
(Lee et al., 2016)
Expression Deduced from Reporters
Reporter: P{Clk-GAL4.1.5}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
DN1p neuron | subset
(Zhang et al., 2010)
DN1p neuron
(Cavanaugh et al., 2014)
DN1 neuron
(Guo et al., 2016)
Reporter: P{Clk-GAL4.8.0}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
LNv neuron
(Lear et al., 2005)
LNd neuron | subset
(Lear et al., 2005)
DN1 neuron | subset
(Lear et al., 2005)
DN3 neuron | subset
(Lear et al., 2005)
Reporter: P{Clk-GAL4.-84}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
Bolwig nerve
(Gummadova et al., 2009)
embryonic/larval brain | restricted
(Gummadova et al., 2009)
larval DN period neuron | subset
(Gummadova et al., 2009)
larval LN period neuron | subset
(Gummadova et al., 2009)
adult stage
DN1a neuron
(Gummadova et al., 2009)
DN2 neuron
(Gummadova et al., 2009)
LNd neuron | subset
(Gummadova et al., 2009)
l-LNv neuron | subset
(Gummadova et al., 2009)
Reporter: P{Clk-GAL4.-206}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval DN period neuron | subset
(Gummadova et al., 2009)
larval LN period neuron | subset
(Gummadova et al., 2009)
adult stage
s-LNv neuron
(Gummadova et al., 2009)
DN1a neuron
(Gummadova et al., 2009)
DN2 neuron
(Gummadova et al., 2009)
LNd neuron
(Gummadova et al., 2009)
l-LNv neuron | subset
(Gummadova et al., 2009)
Reporter: P{Clk-GAL4.-856}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
LN period neuron
(Gummadova et al., 2009)
adult DN period neuron
(Gummadova et al., 2009)
LP neuron | faint
(Gummadova et al., 2009)
s-LNv neuron
(Fujiwara et al., 2018)
l-LNv neuron
(Fujiwara et al., 2018)
Reporter: P{Clk-GAL4.-1982}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
LN period neuron
(Gummadova et al., 2009)
adult DN period neuron
(Gummadova et al., 2009)
eye photoreceptor cell
(Gummadova et al., 2009)
Kenyon cell
(Gummadova et al., 2009)
local interneuron of adult antennal lobe | subset
(Gummadova et al., 2009)
adult brain | restricted
(Gummadova et al., 2009)
Reporter: P{Clk-GAL4.-6939}
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
larval DN period neuron
(Gummadova et al., 2009)
larval LN period neuron
(Gummadova et al., 2009)
first instar larval stage
larval DN period neuron
(Gummadova et al., 2009)
larval LN period neuron
(Gummadova et al., 2009)
third instar larval stage
larval DN period neuron
(Gummadova et al., 2009)
larval LN period neuron
(Gummadova et al., 2009)
adult stage
LN period neuron
(Gummadova et al., 2009)
adult DN period neuron
(Gummadova et al., 2009)
eye photoreceptor cell
(Gummadova et al., 2009)
Kenyon cell
(Gummadova et al., 2009)
LP neuron | faint
(Gummadova et al., 2009)
LNv neuron
(Alejevski et al., 2019)
LNd neuron
(Alejevski et al., 2019)
LP neuron
(Alejevski et al., 2019)
DN1 neuron
(Alejevski et al., 2019)
DN2 neuron
(Alejevski et al., 2019)
DN3 neuron | subset
(Alejevski et al., 2019)
Reporter: P{Clk-GAL4.int1-3}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
DN2 neuron
(Kaneko et al., 2012)
s-LNv Pdf neuron
(Kaneko et al., 2012)
Reporter: P{Clk-lexA.4.1M}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
DN1p neuron
(Cavanaugh et al., 2014)
DN1 neuron
(Guo et al., 2016)
Reporter: P{GMR43D05-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult pacemaker neuron
(Kunst et al., 2014)
Reporter: PBac{Clk-V5-GFP}
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage
larval DN1 neuron

Comment: 48h AEL

(Liu et al., 2015)
larval DN2 neuron

Comment: 48h AEL

(Liu et al., 2015)
larval s-LNv Pdf neuron

Comment: 48h AEL

(Liu et al., 2015)
second instar larval stage
larval DN1 neuron

Comment: 60h AEL

(Liu et al., 2015)
larval DN2 neuron

Comment: 60h AEL

(Liu et al., 2015)
larval LNd neuron

Comment: 72h AEL

(Liu et al., 2015)
larval s-LNv Pdf neuron

Comment: 60h AEL

(Liu et al., 2015)
third instar larval stage
LP neuron
(Liu et al., 2015)
larval s-LNv Pdf neuron
(Liu et al., 2015)
larval LNd neuron
(Liu et al., 2015)
larval DN period neuron
(Liu et al., 2015)
pupal stage P6 -- P7
LP neuron
(Liu et al., 2015)
s-LNv neuron
(Liu et al., 2015)
pupal DN period neuron
(Liu et al., 2015)
pupal stage P7
LNv neuron
(Liu et al., 2015)
pharate adult stage P8 -- adult stage
LP neuron
(Liu et al., 2015)
LNv neuron
(Liu et al., 2015)
s-LNv neuron
(Liu et al., 2015)
LNd neuron
(Liu et al., 2015)
DN1 neuron
(Liu et al., 2015)
DN2 neuron
(Liu et al., 2015)
DN3 neuron
(Liu et al., 2015)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Clk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Clk
Transgenic constructs containing regulatory region of Clk
Aberrations (Deficiencies and Duplications) ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4unspecified
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4cry.PE
viable, with Scer\GAL4cry.PZ
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4MJ162A
viable, with Scer\GAL4P2.4.Pdf
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal behavior
abnormal circadian behavior, with Scer\GAL4P2.4.Pdf
abnormal circadian rhythm
abnormal circadian rhythm, with Scer\GAL4cry.PE
abnormal circadian rhythm, with Scer\GAL4cry.PZ
abnormal circadian rhythm, with Scer\GAL4Or22a.8197
abnormal circadian rhythm, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal circadian rhythm, with Scer\GAL4tim.PE
abnormal circadian rhythm, with Scer\GAL4to.PD
abnormal circadian rhythm, with Scer\GAL4yolk
abnormal circadian rhythm (with Clkout)
abnormal circadian rhythm (with ClkS258A.Tag:V5)
abnormal circadian rhythm (with ClkS476A.S482A.S487A.Tag:V5)
abnormal circadian rhythm (with ClkS476A.S482A.Tag:V5)
abnormal circadian rhythm (with ClkS487A.Tag:V5)
abnormal circadian rhythm (with ClkS525A.Tag:V5)
abnormal circadian rhythm (with ClkS859A.Tag:V5)
abnormal circadian rhythm (with ClkS912A.Tag:V5)
abnormal circadian rhythm (with Df(3L)BSC631)
abnormal circadian rhythm | adult stage
abnormal circadian rhythm | adult stage, with Clkout
abnormal circadian rhythm | adult stage, with ClkTag:V5.WT
abnormal circadian rhythm | adult stage, with ClkΔ657-707.Tag:V5
abnormal eclosion rhythm
abnormal feeding behavior, with Scer\GAL4Orco.2.642.Hsim\VP22
abnormal feeding behavior, with Scer\GAL4to.PD
abnormal locomotor rhythm
abnormal locomotor rhythm, with Clk15A.Tag:V5
abnormal locomotor rhythm, with Clkout
abnormal locomotor rhythm, with Scer\GAL4cry.PE
abnormal locomotor rhythm, with Scer\GAL4cry.PZ
abnormal locomotor rhythm, with Scer\GAL4P0.5.Pdf
abnormal locomotor rhythm, with Scer\GAL4P2.4.Pdf
abnormal locomotor rhythm, with Scer\GAL4tim.PE
abnormal locomotor rhythm, with Scer\GAL4tim.UAS
abnormal locomotor rhythm, with Scer\GAL4to.PD
abnormal locomotor rhythm (with Clkar)
abnormal locomotor rhythm (with ClkJrk)
abnormal locomotor rhythm (with ClkZ3-0084)
abnormal locomotor rhythm (with Df(3L)HnD-1)
abnormal locomotor rhythm | adult stage, with Scer\GAL4P2.4.Pdf
abnormal locomotor rhythm | dominant
abnormal locomotor rhythm | recessive
abnormal locomotor rhythm | semidominant
abnormal sleep
abnormal sleep, with Scer\GAL4P2.4.Pdf
abnormal temperature response
abnormal temperature response, with Clk15A.Tag:V5
abnormal temperature response, with Clkout
abnormal visual behavior
increased cell death | progressive
visible, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
adult heart
head
larval LN period neuron
Pdf neuron
pupal Pdf neuron
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CLOCK
10 of 15
Yes
Yes
Hsap\NPAS2
10 of 15
Yes
Yes
Hsap\PASD1
4 of 15
No
Yes
Hsap\ARNTL2
2 of 15
No
No
Hsap\ARNT2
1 of 15
No
No
Hsap\ARNT
1 of 15
No
No
Hsap\ARNTL
1 of 15
No
No
Hsap\MIR5572
1 of 15
No
Yes
Hsap\NCOA1
1 of 15
No
No
Hsap\NCOA2
1 of 15
No
No
Hsap\NCOA3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Clock
10 of 15
Yes
Yes
0  
Mmus\Npas2
10 of 15
Yes
Yes
Mmus\Arnt2
2 of 15
No
No
Mmus\Arntl2
2 of 15
No
No
Mmus\Arntl
1 of 15
No
No
Mmus\Arnt
1 of 15
No
No
Mmus\Ncoa1
1 of 15
No
No
Mmus\Ncoa2
1 of 15
No
No
Mmus\Ncoa3
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
Rnor\Clock
8 of 13
Yes
Yes
Rnor\Npas2
8 of 13
Yes
Yes
Rnor\Arnt2
2 of 13
No
No
Rnor\Arntl2
1 of 13
No
No
Rnor\Arntl
1 of 13
No
No
Rnor\Arnt
1 of 13
No
No
Rnor\Hif3a
1 of 13
No
No
Rnor\Ncoa1
1 of 13
No
No
Rnor\Ncoa2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\clock
4 of 12
Yes
Yes
Xtro\pasd1
4 of 12
Yes
Yes
Xtro\arnt2
2 of 12
No
No
Xtro\npas2
2 of 12
No
Yes
Xtro\arntl
1 of 12
No
No
Xtro\arnt
1 of 12
No
No
Xtro\ncoa1
1 of 12
No
No
Xtro\ncoa2
1 of 12
No
No
Xtro\ncoa3
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\clocka
10 of 15
Yes
Yes
Drer\npas2
9 of 15
No
Yes
Drer\clockb
8 of 15
No
Yes
Drer\arnt2
2 of 15
No
No
Drer\arnt
1 of 15
No
No
Drer\arntl1a
1 of 15
No
No
Drer\arntl1b
1 of 15
No
No
Drer\arntl2
1 of 15
No
No
Drer\ncoa1
1 of 15
No
No
Drer\ncoa2
1 of 15
No
No
Drer\ncoa3
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\aha-1
1 of 15
Yes
No
Cele\hif-1
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091903NC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007800
Drosophila simulans
Dsim\GD13034
Drosophila sechellia
Dsec\GM24988
Drosophila erecta
Dere\GG14938
Drosophila yakuba
Dyak\GE20389
Drosophila ananassae
Dana\GF24152
Drosophila pseudoobscura pseudoobscura
Dpse\GA20318
Drosophila persimilis
Dper\GL17825
Drosophila willistoni
Dwil\GK10694
Drosophila virilis
Dvir\GJ11427
Drosophila mojavensis
Dmoj\GI12195
Drosophila grimshawi
Dgri\GH16514
Drosophila grimshawi
Dgri\GH23567
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501Y1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020134
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08700
Mayetiola destructor
Hessian fly
Mdes\Mdes006237
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012562
Anopheles darlingi
American malaria mosquito
Adar\ADAC005680
Anopheles gambiae
Malaria mosquito
Agam\CLK
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002146
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01Q9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000498
Danaus plexippus
Monarch butterfly
Dple\DPOGS206046-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008784
Apis florea
Little honeybee
Aflo\2454890980
Apis mellifera
Western honey bee
Amel\GB48028
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24793
Bombus terrestris
Buff-tailed bumblebee
Bter\15210692
Linepithema humile
Argentine ant
Lhum\LH21853
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002b77
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG031986
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03736
Tribolium castaneum
Red flour beetle
Tcas\Clk
Pediculus humanus
Human body louse
Phum\PHUM426300
Rhodnius prolixus
Kissing bug
Rpro\clk
Cimex lectularius
Bed bug
Clec\CLEC000211
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004812
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07054
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01O9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW010910
Ixodes scapularis
Black-legged tick
Isca\ISCW007040
Ixodes scapularis
Black-legged tick
Isca\ISCW010173
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g07600
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_346996
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G11CV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Clock
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hif2a
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000009063
Gallus gallus
Domestic chicken
Ggal\CLOCK
Gallus gallus
Domestic chicken
Ggal\NPAS2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (5)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
gce
2 of 10
Met
2 of 10
tgo
2 of 10
cyc
1 of 10
tai
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CLOCK; clock circadian regulator
    10 of 15
    601851
        NPAS2; neuronal PAS domain protein 2
        10 of 15
        603347
            PASD1; PAS domain containing repressor 1
            4 of 15
            300993
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                Clk - Bap111
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Kwok et al., 2015)
                Clk - Bap55
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Kwok et al., 2015)
                Clk - Bap60
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Kwok et al., 2015)
                Clk - CkIIα
                anti tag coimmunoprecipitation, western blot
                (Szabó et al., 2013)
                Clk - CkIIβ
                anti tag coimmunoprecipitation, western blot
                (Szabó et al., 2013)
                Clk - Cka
                anti bait coimmunoprecipitation, anti tag western blot
                (Andreazza et al., 2015)
                Clk - Nipped-A
                anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot
                (Mahesh et al., 2020)
                Clk - Oga
                anti tag coimmunoprecipitation, western blot, anti tag western blot
                (Kaasik et al., 2013)
                Clk - SNF4Aγ
                anti tag coimmunoprecipitation, anti tag western blot
                (Cho et al., 2019)
                Clk - Snr1
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Kwok et al., 2015)
                Clk - Strip
                anti bait coimmunoprecipitation, anti tag western blot
                (Andreazza et al., 2015)
                Clk - Usp8
                anti tag coimmunoprecipitation, anti tag western blot, western blot
                (Luo et al., 2012)
                Clk - brm
                anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, anti tag western blot
                (Kwok et al., 2015, Kwok et al., 2015)
                Clk - cyc
                anti tag coimmunoprecipitation, autoradiography, anti tag western blot, pull down, tag visualisation, two hybrid, anti bait coimmunoprecipitation
                (Liu et al., 2017, Lee et al., 2016, Lee et al., 2014, Cheng et al., 2013, Kazemian et al., 2013, Maurer et al., 2009, Hung et al., 2007, Ceriani et al., 1999, Lee et al., 1999, Darlington et al., 1998)
                Clk - dco
                anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
                (Menet et al., 2010, Yu et al., 2009)
                Clk - mor
                anti tag coimmunoprecipitation, Identification by mass spectrometry
                (Kwok et al., 2015)
                Clk - nej
                anti bait coimmunoprecipitation, autoradiography
                (Hung et al., 2007)
                Clk - nonA
                anti tag coimmunoprecipitation, western blot, tandem affinity purification, Identification by mass spectrometry
                (Luo et al., 2018)
                Clk - per
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, coimmunoprecipitation
                (Li et al., 2019, Agrawal et al., 2017, Fu et al., 2016, Lee et al., 2016, Lee et al., 2014, Kaasik et al., 2013, Menet et al., 2010, Sun et al., 2010, Kim et al., 2007, Lee et al., 1999)
                Clk - sxc
                anti tag coimmunoprecipitation, anti tag western blot
                (Kaasik et al., 2013)
                Clk - tim
                anti tag coimmunoprecipitation, western blot, autoradiography, anti bait coimmunoprecipitation, anti tag western blot
                (Lee et al., 2016, Menet et al., 2010, Sun et al., 2010, Lee et al., 1999)
                RNA-protein
                Physical Interaction
                Assay
                References
                Clk - Atx2
                anti tag coimmunoprecipitation, quantitative reverse transcription pcr, primer specific pcr
                (Lee et al., 2017, Lim and Allada, 2013)
                RNA-RNA
                Physical Interaction
                Assay
                References
                Clk - mir-ban
                luminiscence technology, necessary binding region
                (Kadener et al., 2009)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Clk
                suppressible
                cyc
                (Kadener et al., 2008)
                Clk
                suppressible
                wake
                (Liu et al., 2014)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                nmo
                enhanceable
                Clk
                (Mahesh et al., 2014)
                shn
                suppressible
                Clk
                (Beckwith et al., 2013)
                External Data
                Subunit Structure (UniProtKB)
                Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with Cycle.
                (UniProt, O61735 )
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3L
                Recombination map
                3-21
                Cytogenetic map
                66A12-66A12
                Sequence location
                3L:7,763,233..7,775,603 [-]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                66A12-66A12
                Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                66A-66A
                (Darlington, 1998.5.21)
                66C-66C
                (Allada, 1998.5.13)
                66A-66A
                (determined by in situ hybridisation)
                (Allada et al., 1998, Darlington et al., 1998)
                Experimentally Determined Recombination Data
                Location

                3-21

                (FlyBase, 2016)

                3-17.8

                (Comeron et al., 2012)

                3-

                (Allada et al., 1998)
                Left of (cM)
                Right of (cM)
                Notes

                Maps near h.

                (Allada et al., 1998)
                Stocks and Reagents
                Stocks (17)
                Genomic Clones (13)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (11)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Cai et al., 2021, Kim et al., 2007, Lim et al., 2007, Lee et al., 1998)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of
                  Additional comments
                  Other Comments

                  DNA-protein interactions: genome-wide binding profile (ChIP-chip) assayed for Clk protein in adult heads; see GEO_GSE32613 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32613).

                  (Abruzzi et al., 2011)

                  Clk and cyc proteins interact in the cytoplasm of S2R+ cells and heterodimerisation promotes nuclear import as well as phosphorylation of cytoplasmic Clk protein.

                  (Maurer et al., 2009)

                  cry functions as a repressor of Clk/cyc-activated transcription.

                  (Collins et al., 2006)

                  dco-mediated hyperphosphorylation of Clk does not require cyc or the DNA-binding domain of Clk.

                  (Kim and Edery, 2006)

                  Clk makes a major contribution to the strength and amplitude of circadian rhythms.

                  (Allada et al., 2003)

                  Clk is able to induce and organise the core elements of interdependent feedback loops necessary for circadian rhythms.

                  (Zhao et al., 2003)

                  Posttranscriptional mechanisms make substantial contributions to the temporal changes in the abundance of Clk protein.

                  (Kim et al., 2002)

                  Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and increased expression in ClkJrk background.

                  (Claridge-Chang et al., 2001)

                  Identified as one of 10 highest fold cycling genes as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

                  (McDonald and Rosbash, 2001)

                  Clk protein is present in limiting amounts and is probably the main component regulating the daily abundance of transcriptionally active Clk-cyc complexes.

                  (Bae et al., 2000)

                  Clk and cyc, along with other circadian genes per and dco (but not tim) have roles in regulating cocaine sensitization and may function as regulators of Tdc.

                  (Andretic et al., 1999)

                  Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for per, dco, Clk, and cyc but not tim.

                  (Andretic et al., 1999)

                  Clk mRNA cycling is regulated by per-tim-mediated release of Clk- and cyc-dependent repression.

                  (Glossop et al., 1999)

                  Daily cycles in the association of per and tim proteins with the Clk-cyc complex may contribute to rhythmic expression of per and tim.

                  (Lee et al., 1999)

                  Mutation of the Clk gene severely disrupts cycling transcription of the per and tim genes.

                  (Allada et al., 1998)

                  Identification: Low stringency screen using the mouse Clock gene (bHLH and PAS domains) as a probe.

                  (Darlington et al., 1998)

                  The Clk gene induces transcription of its own inhibitors, per and tim.

                  (Darlington et al., 1998)

                  Arrhythmic mutant. per and tim transcription levels are low and constant in Clk mutants.

                  (So et al., 1997)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 65 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (20)
                  Reported As
                  Symbol Synonym
                  CG7391
                  (Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Stevens et al., 2008, Stevens et al., 2008, Mack et al., 2006)
                  CLK
                  (George and Stanewsky, 2021, Damulewicz and Mazzotta, 2020, Mahesh et al., 2020, Schubert et al., 2020, Li et al., 2019, Xue et al., 2019, Zhao et al., 2019, Giebultowicz, 2018, Krzeptowski et al., 2018, Luo et al., 2018, Pilorz et al., 2018, Xue and Zhang, 2018, Zheng et al., 2018, Dubowy and Sehgal, 2017, He et al., 2017, Liu et al., 2017, Ito and Tomioka, 2016, Mazzoccoli et al., 2016, Mezan et al., 2016, Westermark, 2016, Jaumouillé et al., 2015, Ki et al., 2015, Kwok et al., 2015, Lerner et al., 2015, Anderson and Adolphs, 2014, Tataroglu and Emery, 2014, Cheng et al., 2013, Erion and Sehgal, 2013, Garbe et al., 2013, Górska-Andrzejak, 2013, Itoh et al., 2013, Luo et al., 2012, Abruzzi et al., 2011, Goda et al., 2011, Lan and Mezić, 2011, Lim et al., 2011, Staiger and Koster, 2011, Weber et al., 2011, Allada and Chung, 2010, Fathallah-Shaykh, 2010, Hamasaka et al., 2010, Gummadova et al., 2009, Yu et al., 2009, Hart and Warrick, 2008, Sehgal, 2008, Taylor and Hardin, 2008, Kuczenski et al., 2007, Weber et al., 2007, Collins et al., 2006, Dunlap, 2006, Reppert, 2006, Yu et al., 2006)
                  CLOCK
                  (Uriu and Tei, 2019, Erion and Sehgal, 2013, Itoh et al., 2013, Goda et al., 2011, Bae, 1998.6.2, Darlington, 1998.5.21)
                  Clk
                  (Gunawardhana et al., 2021, Kula-Eversole et al., 2021, Ma et al., 2021, Mahesh et al., 2020, Pegoraro et al., 2020, Wang et al., 2020, Xia et al., 2020, Baik et al., 2019, Boomgarden et al., 2019, Brunet Avalos et al., 2019, Cho et al., 2019, Grima et al., 2019, Harbison et al., 2019, Hegazi et al., 2019, Kozlov and Nagoshi, 2019, Luhur et al., 2019, Martin Anduaga et al., 2019, Meltzer et al., 2019, Mendoza and Vanotti, 2019, Nian et al., 2019, Ni et al., 2019, Ri et al., 2019, Solovev et al., 2019, Xue et al., 2019, Zhao et al., 2019, Arganda-Carreras et al., 2018, Du et al., 2018, Filošević et al., 2018, Morioka et al., 2018, Tabuchi et al., 2018, Teets and Hahn, 2018, Abruzzi et al., 2017, Agrawal et al., 2017, Gunawardhana and Hardin, 2017, Lee et al., 2017, Li et al., 2017, Liu et al., 2017, Nippe et al., 2017, Transgenic RNAi Project members, 2017-, Vaccaro et al., 2017, Cho et al., 2016, Kim et al., 2016, Lone et al., 2016, Giebultowicz and Long, 2015, Head et al., 2015, Lerner et al., 2015, Liu et al., 2015, Means et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Tomita et al., 2015, Yurgel et al., 2015, Zwarts et al., 2015, Chen et al., 2014, DeSalvo et al., 2014, Hermann-Luibl et al., 2014, Kumar et al., 2014, Lee et al., 2014, Liu et al., 2014, Mahesh et al., 2014, Pegoraro et al., 2014, Shi et al., 2014, Weiss et al., 2014, Zheng et al., 2014, Beckwith et al., 2013, Joiner et al., 2013, Kaasik et al., 2013, Krupp et al., 2013, Lim and Allada, 2013, Pandey et al., 2013, Pohl et al., 2013, Rakshit and Giebultowicz, 2013, Rakshit et al., 2013, Rodriguez et al., 2013, Bradley et al., 2012, Bywalez et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kumar et al., 2012, Ling et al., 2012, Luo and Sehgal, 2012, Mizrak et al., 2012, Rakshit et al., 2012, Vanin et al., 2012, Vodala et al., 2012, Abruzzi et al., 2011, Diangelo et al., 2011, Ito et al., 2011, Itoh et al., 2011, Jackson, 2011, Peschel and Helfrich-Förster, 2011, Xu et al., 2011, Benito et al., 2010, Blanchard et al., 2010, Fernández-Ayala et al., 2010, Keene et al., 2010, Kula-Eversole et al., 2010, Nagoshi et al., 2010, Thimgan et al., 2010, Wu et al., 2010, Zhang et al., 2010, Zhang et al., 2010, Bahn et al., 2009, Gummadova et al., 2009, Hung et al., 2009, Hung et al., 2009, Kempinger et al., 2009, Kilman and Allada, 2009, Kilman et al., 2009, Maurer et al., 2009, Sehadova et al., 2009, Zheng et al., 2009, Dunlap, 2008, Fujii et al., 2008, Houl et al., 2008, Kadener et al., 2008, Kivimäe et al., 2008, Krupp et al., 2008, Lee and Edery, 2008, Lu et al., 2008, T et al., 2008, Wu et al., 2008, Xu et al., 2008, Yang et al., 2008, Benito et al., 2007, Boothroyd et al., 2007, Busza et al., 2007, Hung et al., 2007, Junion et al., 2007, Kadener et al., 2007, Lim et al., 2007, Matsumoto et al., 2007, Nawathean et al., 2007, Vosshall, 2007, Yuan et al., 2007, Chen et al., 2006, Ganguly-Fitzgerald et al., 2006, Houl et al., 2006, Kadener et al., 2006, Van Gelder, 2006, Wijnen et al., 2006, Yu and Hardin, 2006, Choi et al., 2005, Mazzoni et al., 2005, Yoshii et al., 2005, Jaramillo et al., 2004, Smolen et al., 2004, Beaver et al., 2003, Hall, 2003, Hendricks et al., 2003, Gim et al., 2001, Darlington et al., 2000)
                  Clock
                  (Top et al., 2018)
                  Jerk
                  (Giebultowicz, 1999)
                  Jrk
                  (Loudon et al., 2000, Leloup and Goldbeter, 1999, Subramanian and Lakhotia, 1999, Allada et al., 1998, Reppert, 1998, Van Gelder, 1998)
                  PAS1
                  bHLHe10
                  (Stevens et al., 2008)
                  clk
                  (Cai et al., 2021, Khyati et al., 2021, Zhao et al., 2019, Baik et al., 2018, Top et al., 2018, Nikhil et al., 2016, Andreazza et al., 2015, Donelson and Sanyal, 2015, Gill et al., 2015, Tataroglu and Emery, 2015, Taylor et al., 2014, Mehta and Cheng, 2013, Sivachenko et al., 2013, Luo et al., 2012, Vodala et al., 2012, Lamaze et al., 2011, Scribner and Fathallah-Shaykh, 2011, Menet et al., 2010, Xie et al., 2010, Fathallah-Shaykh et al., 2009, Kadener et al., 2009, Zhao et al., 2009, Bagheri et al., 2008, Ito et al., 2008, Kadener et al., 2008, Richier et al., 2008, Hart and Warrick, 2007, Keegan et al., 2007, Krupp et al., 2007, Kuczenski et al., 2007, Looby and Loudon, 2005, Overton, 2003.2.19, Whitfield et al., 2002, Brown and Schibler, 2001, Hendricks et al., 2001, Jackson et al., 2001, McDonald and Rosbash, 2001, Lakin-Thomas, 2000, Ceriani et al., 1999)
                  clock
                  (Shafer and Keene, 2021, Andreazza et al., 2015, Itskov and Ribeiro, 2013, Kaun et al., 2012, Wolf and Heberlein, 2003, Rothenfluh and Heberlein, 2002, Leloup and Goldbeter, 2000)
                  dCLK
                  (Young, 2018, Fu et al., 2016, Lee et al., 2016, Dunlap, 2008, Lim et al., 2007, Merrow, 2006, Schoning and Staiger, 2005, McDonald et al., 2001, Wang et al., 2001, Darlington et al., 2000, Lyons et al., 2000, Blau and Young, 1999)
                  dCLK/JRK
                  (Ripperger and Schibler, 2001)
                  dCLOCK
                  (Smolen et al., 2002, Ishida et al., 2001, Smolen et al., 2001, Hastings and Maywood, 2000, Andretic and Hirsh, 1999, Bae et al., 1999, Lee et al., 1999, Aasland, 1998, Aasland, 1998, Bae et al., 1998, Lee et al., 1998)
                  dClck
                  (Lucas and Foster, 1999)
                  dClk
                  (Faragó et al., 2019, Zordan and Sandrelli, 2015, Lee et al., 2013, Chen et al., 2012, Kobelková et al., 2010, Li et al., 2010, Sun et al., 2010, Miura et al., 2008, Ogawa et al., 2008, Shimizu et al., 2008, Kim et al., 2007, Ko et al., 2007, Lim et al., 2007, Yoshii et al., 2007, Emery and Reppert, 2004, Sakai et al., 2004, Beaver et al., 2003, Chang and Reppert, 2003, Chang and Reppert, 2003, Cyran et al., 2003, Weber and Kay, 2003, Glossop and Hardin, 2002, Kim et al., 2002, Kim et al., 2002, Lin et al., 2002, Panda et al., 2002, Scully et al., 2002, Ueda et al., 2002, Yoshii et al., 2002, Giebultowicz, 2001, Kloss et al., 2001, Rosato and Kyriacou, 2001, Ueda et al., 2001, Bae et al., 2000, Hardin, 2000, Scully and Kay, 2000, Young, 2000, Blau and Young, 1999, Glossop et al., 1999, Hao et al., 1999, Hardin and Glossop, 1999)
                  dClock
                  (Ueda et al., 2004)
                  dclk
                  (Merbitz-Zahradnik and Wolf, 2015, Choi et al., 2009, Kurata et al., 2007)
                  jrk
                  (Roenneberg and Merrow, 2001, Green, 1998, So et al., 1997)
                  Name Synonyms
                  CLOCK
                  (Damulewicz and Mazzotta, 2020, Nishihara, 2020, Huang, 2018, Luo et al., 2018, Mendoza-Viveros et al., 2017, Jaumouillé et al., 2015, Kwok et al., 2015, Lerner et al., 2015, Kumar et al., 2014, Weiss et al., 2014, Zheng et al., 2014, Garbe et al., 2013, Luo et al., 2012, Abruzzi et al., 2011, DiTacchio et al., 2011, Zhang et al., 2010, Zhang et al., 2010, Yu et al., 2009, Dunlap, 2008, Houl et al., 2008, Collins et al., 2006, Dunlap, 2006, Houl et al., 2006, Yu et al., 2006)
                  Clock
                  (Ulgherait et al., 2020, Baik et al., 2018, Noreen et al., 2018, Tomita et al., 2017, Mazzoccoli et al., 2016, Men et al., 2016, Tsoumtsa et al., 2016, Donelson and Sanyal, 2015, Head et al., 2015, Lerner et al., 2015, Yurgel et al., 2015, Krupp et al., 2013, Potdar and Sheeba, 2013, Rakshit et al., 2013, Bywalez et al., 2012, Rakshit et al., 2012, Xu et al., 2012, Diangelo et al., 2011, Sehgal and Mignot, 2011, Benito et al., 2010, Blanchard et al., 2010, Keene et al., 2010, Li et al., 2010, McDonald and Keene, 2010, Bahn et al., 2009, Gummadova et al., 2009, Kilman et al., 2009, Zheng et al., 2009, Krupp et al., 2008, Lu et al., 2008, T et al., 2008, Xu et al., 2008, Boothroyd et al., 2007, Lim et al., 2007, Vosshall, 2007, Yuan et al., 2007, Lee et al., 2006, Van Gelder, 2006, Yu and Hardin, 2006, Choi et al., 2005, Cirelli et al., 2005, Mazzoni et al., 2005, Jaramillo et al., 2004, Beaver et al., 2003, Hendricks et al., 2003, Gim et al., 2001)
                  clock
                  (Delventhal et al., 2019, Perry et al., 2017, Di Cara and King-Jones, 2016, Nikhil et al., 2016, Hangartner et al., 2015, Paparazzo et al., 2015, Menet et al., 2010, Kadener et al., 2009, Bagheri et al., 2008, Ito et al., 2008, Lee and Edery, 2008, Krupp et al., 2007, Hall, 2003)
                  dCLOCK
                  (Choi et al., 2009, Xu and Cai, 2009, Wang et al., 2008, Lyons et al., 2000)
                  dClock
                  (Young, 2018, Beckwith et al., 2013, Lee et al., 2013, Wang et al., 2008, Sakai et al., 2004, Hendricks, 2003, Glossop and Hardin, 2002, Blau et al., 2001, Darlington et al., 2000, Loudon et al., 2000, Lee et al., 1999, Allada et al., 1998, Green, 1998, Hardin, 1998, Kaneko, 1998, Rosbash, 1998, Van Gelder, 1998, Whitmore et al., 1998, Wilsbacher and Takahashi, 1998)
                  dclock
                  (Xu and Cai, 2009, Li and Lang, 2008, Crosthwaite, 2004, Smolen et al., 2004, Ishida et al., 1999, Subramanian and Lakhotia, 1999, Darlington et al., 1998, Reppert, 1998, Van Gelder, 1998)
                  Secondary FlyBase IDs
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (504)