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FB2026_01
,
released March 12, 2026
laggard, Ste20-like, l(3)07551
serine/threonine kinase - PAK family - required for normal axonal ensheathment
Please see the JBrowse view of Dmel\fray for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Shares 5' UTR with downstream gene: RNA-Seq junction evidence that two separate promoters are shared.
Gene model reviewed during 6.03
Gene model reviewed during 6.32
552 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fray using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
fray transcripts are first apparent in preblastoderm embryos. Zygotic expression is first observed in embryonic stage 12 in anterior and posterior regions that will develop into the gut. By stage 15, strong expression is apparent in the proventriculus and hindgut and moderate expression is seen in the midgut. In the abdominal body wall, a single muscle fiber 17 (abdominal ventral oblique muscle 6) is stained. Expression is also observed in the dorsal median cells of the thorax which lie just outside the CNS. They are present at the dorsal midline of the CNS. By stage 17, all dorsal median cells are stained along with muscle fiber 17 and the gut. In the CNS, expression is observed in the exit glia. Later in development, expression is seen in a small subset of nerve-associated cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\fray in JBrowse3-64
3-63.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in mitotic index, spindle abnormalities, and chromosome alignment defects are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
fray is required for axonal ensheathment.
fray is required maternally for normal mitoses in syncytial embryos.
fray is required by a small subset of nerve-associated glia to mediate or maintain proper axon fasciculation, possibly by regulation of axonal or axon-glial adhesion.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
Source for merge of: fray Ste20-like
