FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\bon
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General Information
Symbol
Dmel\bon
Species
D. melanogaster
Name
bonus
Annotation Symbol
CG5206
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023097
Gene Model Status
Current
Stock Availability
21 publicly available
Enzyme Name (EC)
Gene Summary
bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
92F2-92F3
Sequence location
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20593139..20612540
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Beckstead et al., 2005)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from biological aspect of ancestor with PANTHER:PTN002816340
(GO Reference Genome Project, 2011-)
enables protein kinase activity
inferred from sequence or structural similarity with UniProtKB:Q64127
(Gene Ontology Curators, 2002-)
enables ubiquitin protein ligase activity
inferred from biological aspect of ancestor with PANTHER:PTN008619076
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:O15164
(Gene Ontology Curators, 2002-)
enables ubiquitin-protein transferase activity
inferred from sequence or structural similarity with UniProtKB:O15164
(Jain and Barton, 2009)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR000315
(InterPro Project Members, 2004-)
inferred from sequence model
(Ying et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from mutant phenotype
(Beckstead et al., 2005)
involved_in epidermal cell fate specification
inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970
(Zhao et al., 2023)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in chromatin organization
inferred from biological aspect of ancestor with PANTHER:PTN002816340
(GO Reference Genome Project, 2011-)
involved_in protein ubiquitination
inferred from sequence or structural similarity with UniProtKB:O15164
(Jain and Barton, 2009)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(Singari et al., 2014)
located_in nucleus
inferred from direct assay
(Beckstead et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ubiquitin protein ligase activity
Summaries
Gene Snapshot
bonus (bon) encodes a nuclear receptor cofactor involved in axon guidance and chromatin organization. [Date last reviewed: 2019-07-11]
Gene Group (FlyBase)
TRIM UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. The TRIM family are E3 ligases characterized a TRIpartite Motif, which consists of a RING domain, one or two B-box motifs and a coiled-coil region. As well as ubiquitination, TRIM proteins are also involved in ubiquitin-like modifications such as SUMOylation and ISGylation. (Adapted from PMID:18673550).
ATYPICAL PROTEIN KINASES -
Atypical kinases are protein kinases or putative protein kinases that do not share clear sequence similarity with conventional eukaryotic protein kinases, but they or their orthologs have been shown experimentally to have protein kinase activity. Atypical kinases are defined in FBrf0201870.
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\bon for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KGE5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
bon-RA
FBtr0083912
NM_079985
5811
1133
bon-RB
FBtr0300617
NM_001170194
4871
1125
bon-RC
FBtr0330043
NM_001275836
5811
1207
bon-RD
FBtr0334637
NM_001275837
5769
1119
bon-RE
FBtr0334638
NM_001275838
5787
1125
bon-RF
FBtr0334639
NM_001275839
5778
1122
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
bon-PA
FBpp0083320
122.0
1133
6.96
Q9VDK5
NP_524724
AAF55786
bon-PB
FBpp0289844
121.1
1125
6.90
A8WHL4
NP_001163665
ACZ94961
bon-PC
FBpp0303076
130.1
1207
6.53
A0A0B4KGE5
NP_001262765
AGB96145
bon-PD
FBpp0306699
120.4
1119
6.90
A0A0B4KH12
NP_001262766
AGB96146
bon-PE
FBpp0306700
121.0
1125
6.90
A0A0B4KHT0
NP_001262767
AGB96147
bon-PF
FBpp0306701
120.7
1122
6.90
A0A0B4KHG7
NP_001262768
AGB96148
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bon using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.82

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
wing pouch | restricted
(Molnar et al., 2012)
wing hinge primordium | restricted
(Molnar et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(Singari et al., 2014)
located_in nucleus
inferred from direct assay
(Beckstead et al., 2005)
Expression Deduced from Reporters
Reporter: P{lacW}bonS024108
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | segmentally repeated
(Salzberg et al., 1997)
Reporter: P{lacW}bonS024912
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Salzberg et al., 1997)
Reporter: P{lacW}bonS048706
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval anterior spiracle
(Salzberg et al., 1997)
embryonic/larval pharynx
(Salzberg et al., 1997)
Reporter: P{Switch2}bonGSG2451-1
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval ventral nerve cord | restricted | segmentally repeated
(Nicholson et al., 2008)
larval neuron | subset
(Nicholson et al., 2008)
larval glial cell | subset
(Nicholson et al., 2008)
DM fascicle
(Nicholson et al., 2008)
VM fascicle
(Nicholson et al., 2008)
neuron | subset of larval brain

Comment: one neuron/hemisphere

(Nicholson et al., 2008)
glial cell | subset of larval brain
(Nicholson et al., 2008)
chordotonal organ | intense
(Nicholson et al., 2008)
dendritic arborizing neuron | faint
(Nicholson et al., 2008)
abdominal intersegmental bidendritic neuron isbp
(Nicholson et al., 2008)
embryonic/larval neuromuscular junction | subset
(Nicholson et al., 2008)
larval segmental nerve branch SNa of A1-7
(Nicholson et al., 2008)
larval segmental nerve branch SNc of A1-7
(Nicholson et al., 2008)
larval transverse nerve
(Nicholson et al., 2008)
muscle cell of A1-7 lateral oblique muscle 1

Comment: muscle 5

(Nicholson et al., 2008)
A1-7 segment border muscle cell

Comment: muscle 8

(Nicholson et al., 2008)
muscle cell of A2-7 ventral transverse muscle 1

Comment: muscle 25

(Nicholson et al., 2008)
muscle cell of A1-7 ventral acute muscle 1

Comment: muscle 26

(Nicholson et al., 2008)
muscle cell of ventral acute muscle 2

Comment: muscle 27

(Nicholson et al., 2008)
muscle cell of ventral acute muscle 3

Comment: muscle 29

(Nicholson et al., 2008)
muscle cell of A1-7 lateral transverse muscle 2

Comment: muscle 22

(Nicholson et al., 2008)
muscle cell of A1-7 lateral transverse muscle 3
(Nicholson et al., 2008)
CNS surface glial cell of larval brain
(Nicholson et al., 2008)
CNS surface glial cell | subset of larval ventral nerve cord
(Nicholson et al., 2008)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\bon in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 19 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bon
Transgenic constructs containing regulatory region of bon
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | recessive | somatic clone
lethal, with Scer\GAL4Act5C.PI
lethal (with Df(3R)BSC141)
lethal (with Df(3R)BSC488)
lethal | female | first instar larval stage | recessive
lethal | first instar larval stage | male | recessive
lethal | male (with bon21B)
lethal | male (with bonS024108)
lethal | male (with bonS043420)
lethal | male (with Df(3R)H81)
lethal | recessive
lethal - all die before end of first instar larval stage | male | recessive
lethal - all die before end of first instar larval stage | male limited | recessive
lethal - all die before end of P-stage | recessive
partially lethal | female (with bon21B)
partially lethal | female (with bonS024108)
partially lethal | female (with bonS043420)
partially lethal | female (with Df(3R)H81)
partially lethal - majority die, with Scer\GAL4en.PU
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable | female limited
Sterility
Allele
fertile, with Scer\GAL4VP16.bam
fertile, with Scer\GAL4VP16.bam, Scer\GAL4VP16.mat.αTub67C
fertile, with Scer\GAL4VP16.mat.αTub67C
sterile, with Scer\GAL4VP16.bam, Scer\GAL4VP16.nanos.UTR
sterile, with Scer\GAL4VP16.nanos.UTR, Spyo\Cas9UAS.Tag:NLS(Ude)
Other Phenotypes
Allele
abnormal body color (with bonS024108)
abnormal body color (with bonS048706)
enhancer of variegation | dominant, with In(1)wm4h
enhancer of variegation | dominant, with P{SUPor-P}25-4-3
increased cell death | oogenesis, with Scer\GAL4VP16.nanos.UTR
increased cell death | somatic clone
some die during first instar larval stage | recessive
some die during pharate adult stage | recessive
suppressor of variegation, with Dp(1;f)γ878
suppressor of variegation | dominant, with Dp(1;f)γ878
suppressor of variegation | dominant, with P{SUPor-P}25-4-3
visible, with Scer\GAL4Bx-MS1096-KE
visible, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4GMR.PF
visible | adult stage, with Scer\GAL4nub.PK
visible | female limited | recessive
Phenotype manifest in
Allele
abdominal sternite bristle (with bonS024108)
abdominal sternite bristle (with bonS048706)
abdominal tergite & macrochaeta (with bonS024108)
abdominal tergite & macrochaeta (with bonS048706)
adult head & cuticle | somatic clone
embryonic/larval salivary gland (with bon21B)
embryonic/larval salivary gland (with bonS048706)
eye, with Scer\GAL4GMR.PF
eye | P-stage (with bon21B)
eye | P-stage (with bonS048706)
female germline cell | decreased number, with Scer\GAL4VP16.bam, Scer\GAL4VP16.nanos.UTR
female germline stem cell, with Scer\GAL4VP16.nanos.UTR
fusome | oogenesis, with Scer\GAL4VP16.nanos.UTR
head | P-stage (with bon21B)
head | P-stage (with bonS048706)
interommatidial bristle, with Scer\GAL4GMR.PF
larval tracheal system (with Df(3R)H-B79)
neuron | embryonic stage
ommatidium, with Scer\GAL4GMR.PF
ommatidium | female
ovary, with Scer\GAL4VP16.bam, Scer\GAL4VP16.nanos.UTR
ovary, with Scer\GAL4VP16.nanos.UTR
ovary, with Scer\GAL4VP16.nanos.UTR, Spyo\Cas9UAS.Tag:NLS(Ude)
photoreceptor neuron | somatic clone
pupal abdomen & cuticle (with bonS024108)
pupal abdomen & cuticle (with bonS048706)
wing
wing, with Scer\GAL4Bx-MS1096-KE
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4nub.PK
wing (with bonS024108)
wing (with bonS048706)
wing | P-stage (with bon21B)
wing | P-stage (with bonS048706)
wing margin bristle (with bonS024108)
wing margin bristle (with bonS048706)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (49)
Hsap\TRIM24
10 of 14
Yes
Yes
Hsap\TRIM33
10 of 14
Yes
Yes
Hsap\TRIM28
5 of 14
No
Yes
Hsap\TRIM66
4 of 14
No
Yes
Hsap\AIRE
1 of 14
No
No
Hsap\BAZ1B
1 of 14
No
No
Hsap\BAZ2A
1 of 14
No
No
Hsap\BAZ2B
1 of 14
No
No
Hsap\BPTF
1 of 14
No
No
Hsap\BRD2
1 of 14
No
No
2  
Hsap\BRD3
1 of 14
No
No
Hsap\BRD4
1 of 14
No
No
1  
Hsap\BRD8
1 of 14
No
No
Hsap\BRDT
1 of 14
No
No
Hsap\BRWD3
1 of 14
No
No
Hsap\CMYA5
1 of 14
No
No
Hsap\FSD1
1 of 14
No
No
Hsap\FSD1L
1 of 14
No
No
Hsap\FSD2
1 of 14
No
No
Hsap\MID1
1 of 14
No
No
Hsap\MID2
1 of 14
No
No
Hsap\PHIP
1 of 14
No
No
Hsap\RNF207
1 of 14
No
No
Hsap\SP110
1 of 14
No
Yes
Hsap\SP140
1 of 14
No
Yes
Hsap\SP140L
1 of 14
No
Yes
Hsap\TRIM2
1 of 14
No
No
Hsap\TRIM3
1 of 14
No
No
Hsap\TRIM6
1 of 14
No
Yes
Hsap\TRIM8
1 of 14
No
Yes
Hsap\TRIM9
1 of 14
No
No
Hsap\TRIM16
1 of 14
No
Yes
Hsap\TRIM25
1 of 14
No
Yes
Hsap\TRIM27
1 of 14
No
Yes
Hsap\TRIM29
1 of 14
No
Yes
Hsap\TRIM36
1 of 14
No
No
Hsap\TRIM38
1 of 14
No
Yes
Hsap\TRIM42
1 of 14
No
Yes
Hsap\TRIM43B
1 of 14
No
Yes
Hsap\TRIM43
1 of 14
No
Yes
Hsap\TRIM45
1 of 14
No
No
Hsap\TRIM46
1 of 14
No
No
Hsap\TRIM47
1 of 14
No
Yes
Hsap\TRIM54
1 of 14
No
Yes
Hsap\TRIM56
1 of 14
No
No
Hsap\TRIM63
1 of 14
No
Yes
Hsap\TRIM65
1 of 14
No
Yes
Hsap\TRIM67
1 of 14
No
No
Hsap\TRIM71
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (22)
Rnor\Trim33
10 of 14
Yes
Yes
Rnor\Trim28
6 of 14
No
Yes
Rnor\Trim24
5 of 14
No
Yes
Rnor\Trim66
4 of 14
No
Yes
Rnor\Aire
1 of 14
No
No
Rnor\Cmya5
1 of 14
No
No
Rnor\Fsd2
1 of 14
No
No
Rnor\Mid1
1 of 14
No
No
Rnor\Mid2
1 of 14
No
No
Rnor\Pml
1 of 14
No
No
Rnor\Sp140
1 of 14
No
Yes
Rnor\Trim2
1 of 14
No
No
Rnor\Trim3
1 of 14
No
No
Rnor\Trim9
1 of 14
No
No
Rnor\Trim36
1 of 14
No
No
Rnor\Trim42
1 of 14
No
No
Rnor\Trim45
1 of 14
No
No
Rnor\Trim46
1 of 14
No
No
Rnor\Trim54
1 of 14
No
Yes
Rnor\Trim63
1 of 14
No
Yes
Rnor\Trim67
1 of 14
No
No
Rnor\Trim71
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Trim24
10 of 14
Yes
Yes
Mmus\Trim33
9 of 14
No
Yes
Mmus\Trim28
5 of 14
No
Yes
Mmus\Trim66
3 of 14
No
Yes
Mmus\Aire
1 of 14
No
No
Mmus\Cmya5
1 of 14
No
No
Mmus\Fsd2
1 of 14
No
No
Mmus\Mid1
1 of 14
No
No
Mmus\Mid2
1 of 14
No
No
Mmus\Sp140
1 of 14
No
Yes
Mmus\Trim2
1 of 14
No
No
Mmus\Trim3
1 of 14
No
No
Mmus\Trim9
1 of 14
No
No
Mmus\Trim36
1 of 14
No
No
Mmus\Trim42
1 of 14
No
No
Mmus\Trim45
1 of 14
No
No
Mmus\Trim46
1 of 14
No
No
Mmus\Trim54
1 of 14
No
Yes
Mmus\Trim56
1 of 14
No
No
Mmus\Trim67
1 of 14
No
No
Mmus\Trim71
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\trim24
8 of 13
Yes
Yes
Xtro\trim33
8 of 13
Yes
Yes
Xtro\ppp2r3b
7 of 13
No
Yes
Xtro\trim28
5 of 13
No
Yes
Xtro\dennd2b
2 of 13
No
Yes
Xtro\baz1b
1 of 13
No
No
Xtro\baz2a
1 of 13
No
No
Xtro\baz2b
1 of 13
No
No
Xtro\brd2
1 of 13
No
No
Xtro\brdt
1 of 13
No
No
Xtro\brwd3
1 of 13
No
No
Xtro\cmya5
1 of 13
No
No
Xtro\cox15
1 of 13
No
No
Xtro\fsd2
1 of 13
No
No
Xtro\LOC100487072
1 of 13
No
Yes
Xtro\LOC100489697
1 of 13
No
No
Xtro\LOC100494464
1 of 13
No
Yes
Xtro\LOC100495443
1 of 13
No
No
Xtro\LOC100495885
1 of 13
No
Yes
Xtro\MGC79670
1 of 13
No
No
Xtro\trim2
1 of 13
No
No
Xtro\trim3
1 of 13
No
No
Xtro\trim8
1 of 13
No
No
Xtro\trim25l
1 of 13
No
Yes
Xtro\trim27
1 of 13
No
Yes
Xtro\trim63
1 of 13
No
Yes
Xtro\trim66
1 of 13
No
Yes
Xtro\XB5729271
1 of 13
No
Yes
Xtro\XB5729975
1 of 13
No
No
Xtro\XB5759442
1 of 13
No
No
Danio rerio (Zebrafish) (50)
Drer\trim33
10 of 14
Yes
Yes
Drer\trim24
9 of 14
No
Yes
Drer\trim33l
2 of 14
No
Yes
Drer\trim66
2 of 14
No
Yes
Drer\trim71
2 of 14
No
No
Drer\btr04
1 of 14
No
Yes
Drer\btr06
1 of 14
No
Yes
Drer\btr07
1 of 14
No
Yes
Drer\btr20
1 of 14
No
Yes
Drer\btr21
1 of 14
No
Yes
Drer\btr22
1 of 14
No
Yes
Drer\btr24
1 of 14
No
No
Drer\btr25
1 of 14
No
Yes
Drer\btr26
1 of 14
No
Yes
Drer\btr32
1 of 14
No
Yes
Drer\cmya5
1 of 14
No
No
Drer\fsd1
1 of 14
No
No
Drer\ftr06
1 of 14
No
No
Drer\ftr11
1 of 14
No
No
Drer\ftr26
1 of 14
No
No
Drer\ftr41
1 of 14
No
No
Drer\ftr51
1 of 14
No
Yes
Drer\ftr57
1 of 14
No
No
Drer\ftr59
1 of 14
No
No
Drer\ftr72
1 of 14
No
No
Drer\ftr79
1 of 14
No
No
Drer\ftr97
1 of 14
No
No
Drer\mid1
1 of 14
No
No
Drer\mid2
1 of 14
No
No
Drer\rnf207b
1 of 14
No
No
Drer\si:ch211-216p19.6
1 of 14
No
Yes
Drer\sp100.1
1 of 14
No
Yes
Drer\sp100.3
1 of 14
No
Yes
Drer\sp100.4
1 of 14
No
Yes
Drer\trim2a
1 of 14
No
No
Drer\trim2b
1 of 14
No
No
Drer\trim3a
1 of 14
No
No
Drer\trim3b
1 of 14
No
No
Drer\trim9
1 of 14
No
No
Drer\trim35-33
1 of 14
No
Yes
Drer\trim36
1 of 14
No
No
Drer\trim45
1 of 14
No
No
Drer\trim46a
1 of 14
No
No
Drer\trim46b
1 of 14
No
No
Drer\trim54
1 of 14
No
Yes
Drer\trim55a
1 of 14
No
Yes
Drer\trim67
1 of 14
No
No
Drer\trim101
1 of 14
No
Yes
Drer\zgc:171506
1 of 14
No
Yes
Drer\zgc:173581
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\arc-1
1 of 14
Yes
No
Cele\bet-1
1 of 14
Yes
No
Cele\bet-2
1 of 14
Yes
No
Cele\F13C5.2
1 of 14
Yes
No
Cele\lin-41
1 of 14
Yes
No
Cele\madd-2
1 of 14
Yes
No
Cele\ncl-1
1 of 14
Yes
No
Cele\nhl-1
1 of 14
Yes
No
Cele\nhl-2
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (14)
Agam\AgaP_AGAP001328
11 of 12
Yes
Yes
Agam\AgaP_AGAP001877
1 of 12
No
No
Agam\AgaP_AGAP002344
1 of 12
No
No
Agam\AgaP_AGAP002807
1 of 12
No
No
Agam\AgaP_AGAP005125
1 of 12
No
No
Agam\AgaP_AGAP005186
1 of 12
No
No
Agam\AgaP_AGAP005187
1 of 12
No
No
Agam\AgaP_AGAP006133
1 of 12
No
No
Agam\AgaP_AGAP007135
1 of 12
No
No
Agam\AgaP_AGAP007617
1 of 12
No
No
Agam\AgaP_AGAP008017
1 of 12
No
No
Agam\AgaP_AGAP008750
1 of 12
No
No
Agam\AgaP_AGAP008751
1 of 12
No
No
Agam\AgaP_AGAP010054
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (24)
Atha\AT1G05380
1 of 13
Yes
Yes
Atha\AT1G20670
1 of 13
Yes
No
Atha\AT1G58025
1 of 13
Yes
No
Atha\AT2G27980
1 of 13
Yes
Yes
Atha\AT2G36720
1 of 13
Yes
Yes
Atha\AT2G37520
1 of 13
Yes
Yes
Atha\AT3G53680
1 of 13
Yes
Yes
Atha\AT4G14920
1 of 13
Yes
Yes
Atha\AT5G36670
1 of 13
Yes
Yes
Atha\AT5G55040
1 of 13
Yes
No
Atha\AT5G58610
1 of 13
Yes
Yes
Atha\AT5G63900
1 of 13
Yes
Yes
Atha\BET9
1 of 13
Yes
No
Atha\BET10
1 of 13
Yes
No
Atha\GTE2
1 of 13
Yes
No
Atha\GTE3
1 of 13
Yes
No
Atha\GTE4
1 of 13
Yes
No
Atha\GTE6
1 of 13
Yes
No
Atha\GTE7
1 of 13
Yes
No
Atha\GTE8
1 of 13
Yes
No
Atha\HAG1
1 of 13
Yes
No
Atha\IMB1
1 of 13
Yes
No
Atha\NPX1
1 of 13
Yes
No
Atha\ROS4
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:bon. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (11)
mei-P26
2 of 13
BRWD3
1 of 13
CG8419
1 of 13
E(bx)
1 of 13
fs(1)h
1 of 13
tbrd-1
1 of 13
tbrd-3
1 of 13
tn
1 of 13
tou
1 of 13
Trim9
1 of 13
wech
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    bon21B
    ameliorates  tauopathy
    modeled by Hsap\MAPTUAS.cRa
    (Rousseaux et al., 2016)
    bonKK108237
    ameliorates  tauopathy
    modeled by Hsap\MAPTUAS.cRa
    (Rousseaux et al., 2016)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRIM24; tripartite motif containing 24
    10 of 14
    603406
        TRIM33; tripartite motif containing 33
        10 of 14
        605769
          TRIM28; tripartite motif containing 28
          5 of 14
          601742
            TRIM66; tripartite motif containing 66
            4 of 14
            612000
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                bon - ADD1
                anti tag coimmunoprecipitation, peptide massfingerprinting
                (Alekseyenko et al., 2014)
                bon - Caf1-55
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - E(z)
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - EcR
                pull down, anti tag western blot
                (Beckstead et al., 2001)
                bon - HDAC1
                anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot
                (Godneeva et al., 2023, Ito et al., 2012)
                bon - Hr3
                pull down, anti tag western blot
                (Beckstead et al., 2001)
                bon - Mi-2
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - Myb
                pull down, autoradiography
                (Nomura et al., 2004)
                bon - Su(var)2-10
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - Su(var)205
                anti bait coimmunoprecipitation, western blot
                (Ito et al., 2012)
                bon - Su(z)12
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - east
                experimental knowledge based
                (Guruharsha et al., 2011)
                bon - egg
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - esc
                anti tag coimmunoprecipitation, anti tag western blot
                (Godneeva et al., 2023)
                bon - fru
                anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
                (Ito et al., 2012)
                bon - ftz-f1
                two hybrid, pull down, anti tag western blot
                (Beckstead et al., 2001)
                bon - mof
                anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot
                (Godneeva et al., 2023)
                bon - svp
                pull down, anti tag western blot
                (Beckstead et al., 2001)
                bon - ttk
                experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
                (Rhee et al., 2014, Guruharsha et al., 2011)
                bon - usp
                pull down, anti tag western blot
                (Beckstead et al., 2001)
                bon - yki
                anti tag coimmunoprecipitation, anti tag western blot, pull down, Identification by mass spectrometry
                (Zhao et al., 2023)
                Summary of Genetic Interactions
                Interaction Browsers
                View in FlyBase Interactions Browser   View in MIST tool (external link)
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                bon
                suppressible
                p53
                (Allton et al., 2009)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                ari-1
                suppressible
                bon
                (Gradilla et al., 2011)
                Egfr
                suppressible
                bon
                (Read et al., 2005)
                fru
                suppressible
                bon
                (Goto et al., 2011)
                ftz-f1
                suppressible
                bon
                (Beckstead et al., 2001)
                Myb
                suppressible
                bon
                (Nomura et al., 2004)
                Ret
                enhanceable
                bon
                (Read et al., 2005)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                FlyBase
                External Links
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Class of Gene
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                3R
                Recombination map
                3-69
                Cytogenetic map
                92F2-92F3
                Sequence location
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                92F2-92F3
                Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                92E8-92E14
                (Prokopenko, 1999.8.3)
                92E-92E
                (determined by in situ hybridisation) 92E8--14 (determined by in situ hybridisation)
                (Szeged Stock Center, 1998-)
                92E8-92E14
                (determined by in situ hybridisation)
                (Salzberg et al., 1997)
                92E8-92E14
                (determined by in situ hybridisation) 92E (determined by in situ hybridisation) 92E8--11 (determined by in situ hybridisation)
                (Deak et al., 1997)
                Experimentally Determined Recombination Data
                Location

                3-69

                (FlyBase, 2016)

                3-72.8

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (21)
                Genomic Clones (26)
                cDNA Clones (26)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     

                    • New stable cell line derived from S2-unspecified : Stable S2-yki-SBP and S2-bon-SBP cell lines were created, which are S2 cells containing streptavidin-binding peptide (SBP)-flagged yki or bon. The S2 cells were obtained from the laboratory of Spyros Artavanis-Tsakonas.

                      (Zhao et al., 2023)
                    Other Comments

                    dsRNA has been made from templates generated with primers directed against this gene. RNAi of bon results in increased arborization of ddaD and ddaE neurons, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

                    (Parrish et al., 2006)

                    bon acts as a modifier of position-effect variegation.

                    (Beckstead et al., 2005)

                    Area matching Drosophila EST AA941568.

                    (Davies, 2001.3.15)

                    Candidate gene for quantitative trait (QTL) locus determining bristle number.

                    (Nuzhdin et al., 1999)

                    Gene identified during a P{lacW} screen shown to exhibit ectopic 22C10 expression.

                    (Salzberg et al., 1997)
                    Relationship to Other Genes
                    Source for database merge of

                    Source for merge of: bon CG5206

                    (Bayraktaroglu, 2000.8.7)

                    Source for merge of: bon l(3)S043420

                    (Beckstead et al., 2005)

                    Source for merge of: bon CG15687

                    (FlyBase, 1996-)

                    Source for merge of: bon anon-WO0118547.418

                    (FlyBase, 1996-)
                    Additional comments

                    Source for merge of bon CG15687 was sequence comparison ( date:001216 ).

                    (FlyBase, 1996-)

                    Source for merge of bon anon-WO0118547.418 was sequence comparison ( date:051113 ).

                    (FlyBase, 1996-)
                    Nomenclature History
                    Source for database identify of
                    Nomenclature comments
                    Etymology
                    Synonyms and Secondary IDs (14)
                    Reported As
                    Symbol Synonym
                    0241/08
                    (Deak et al., 1997)
                    0249/12
                    (Deak et al., 1997)
                    0434/20
                    (Deak et al., 1997)
                    0487/06
                    (Deak et al., 1997)
                    150268_at
                    (Kristensen et al., 2005)
                    150269_at
                    (Kristensen et al., 2005)
                    Bon
                    (Chang et al., 2021, Sato and Yamamoto, 2020, Slattery et al., 2014, Yamamoto and Koganezawa, 2013, Parrish et al., 2006)
                    Bonus
                    (Marin, 2012, Beckstead et al., 2000)
                    CG15687
                    (Bienz, 2006)
                    CG5206
                    (Hosono et al., 2015, Molnar et al., 2012, Ni et al., 2011.7.19, Ying et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Berger et al., 2008, Sardiello et al., 2008, Bienz, 2006, Mount, 2001.8.14)
                    anon-WO0118547.418
                    bon
                    (Godneeva et al., 2023, Zhao et al., 2023, Ostalé et al., 2021, Meyer-Nava et al., 2020, Huichalaf et al., 2019, Shimaji et al., 2019, Rousseaux et al., 2016, Dietz et al., 2015, Gene Disruption Project members, 2015-, Xie et al., 2015, Alekseyenko et al., 2014, Ashwal-Fluss et al., 2014, Boyle et al., 2014, Yamamoto et al., 2014, Ito et al., 2012, Du et al., 2011, Goto et al., 2011, Gradilla et al., 2011, Jungreis et al., 2011, Zhou et al., 2011, Mourikis et al., 2010, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Franciscovich et al., 2008, Buszczak et al., 2007, Kankel et al., 2007, Minidorff et al., 2007, Coffman et al., 2005)
                    l(3)S043420
                    Name Synonyms
                    Bonus
                    (Godneeva et al., 2023, Godneeva et al., 2023, Melnikova and Golovnin, 2023, Goodwin and Hobert, 2021, Simoes da Silva et al., 2017, Slattery et al., 2014, Ying et al., 2011, Mourikis et al., 2010, Bienz, 2006)
                    bonus
                    (Shimaji et al., 2019, Rousseaux et al., 2016, Dietz et al., 2015, Singari et al., 2014, Wisotzkey et al., 2014, Yamamoto et al., 2014, Cole et al., 2012.7.6, Tardi et al., 2012, Korcsmáros et al., 2011, Allton et al., 2009, Jain and Barton, 2009, Berger et al., 2008, Salzberg et al., 1997)
                    Secondary FlyBase IDs
                    • FBgn0038812
                    • FBgn0038813
                    • FBgn0060905
                    • FBgn0062022
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 71 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    FlyMine - An integrated database for Drosophila genomics
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Flygut - An atlas of the Drosophila adult midgut
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    References (124)