AMPK, SNF1A, AMP-activated protein kinase, EG:132E8.2 , dAMPKα
adenosine 5'monophosphate-activated kinase - cellular energy sensor - coordinates epithelial polarity and proliferation with cellular energy status
Please see the JBrowse view of Dmel\AMPKα for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AMPKα using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\AMPKα in GBrowse 21-0.2
1-0.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: AMPKα SNF1A
Source for merge of: SNF1A CG3051
Source for merge of: SNF1A Gprk4
Changed symbol from 'SNF1A' to 'AMPKα' to reflect overwhelming usage in the published literature, including all research papers to characterize the gene.
Reduced SNF1A signaling leads to hypersensitivity to starvation conditions as measured by lifespan and locomotor activity.
Reduced SNF1A function results in hyperphagia.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of S phase cells, an increase in the proportion of G2/M phase cells, a whole range of mitotic abnormalities, and centrosome abnormalities are seen.
