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FB2021_04, released August 17, 2021

Gene: Dmel\Mnt

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General Information
Symbol
Dmel\Mnt
Species
D. melanogaster
Name
Mnt
Annotation Symbol
CG13316
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023215
Gene Model Status
Current
Stock Availability
27 publicly available
Gene Summary
Mnt (Mnt) encodes a protein that belongs to the basic-helic-loop-helix-zipper class of transcription factors, which form heterodimers with the protein encoded by Max. Mnt product acts as a repressor of transcription by recruiting a co-repressor complex to its genomic binding sites. It antagonizes cell growth promoting functions of the product encoded by Myc and its depletion produces flies with larger cells, increased weight, and decreased lifespan. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dMnt, dMad, Mad, Mad-3E, EG:114E2.2

Key Links
Genomic Location
Cytogenetic map
3E2-3E5
Sequence location
X:3,671,801..3,701,672 [+]
Recombination map
1-4
RefSeq locus
NC_004354 REGION:3671801..3701672
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein heterodimerization activity
inferred from physical interaction with FLYBASE:Max; FB:FBgn0017578
(Loo et al., 2005)
inferred from physical interaction with FLYBASE:Sin3A; FB:FBgn0022764
(Loo et al., 2005)
enables sequence-specific DNA binding
inferred from direct assay
(Loo et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000239511
(assigned by GO_Central )
(Gaudet et al., 2011)
enables DNA-binding transcription factor activity
inferred from sequence or structural similarity with FLYBASE:Myc; FB:FBgn0262656
(Peyrefitte et al., 2001)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000239511
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in negative regulation of cell growth
inferred from mutant phenotype
(Loo et al., 2005)
involved_in negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Loo et al., 2005)
involved_in regulation of cell cycle
inferred from mutant phenotype
(Loo et al., 2005)
involved_in regulation of transcription, DNA-templated
inferred from mutant phenotype
(Hulf et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000239511
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of transcription, DNA-templated
inferred from sequence or structural similarity with FLYBASE:Myc; FB:FBgn0262656
(Peyrefitte et al., 2001)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred by curator from GO:0003700
(Peyrefitte et al., 2001)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Mnt (Mnt) encodes a protein that belongs to the basic-helic-loop-helix-zipper class of transcription factors, which form heterodimers with the protein encoded by Max. Mnt product acts as a repressor of transcription by recruiting a co-repressor complex to its genomic binding sites. It antagonizes cell growth promoting functions of the product encoded by Myc and its depletion produces flies with larger cells, increased weight, and decreased lifespan. [Date last reviewed: 2018-09-20]
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Summary (Interactive Fly)

bHLH-zipper transcription factor - Max-interacting transcriptional repressor - associates with the Sin3 corepressor - Larval growth and endoreplication are coupled processes that, although linked to cell cycle control mechanisms, are regulated by dMyc and dMnt

Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
7

Please see the JBrowse view of Dmel\Mnt for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mnt-RA
FBtr0070579
NM_166983
2440
582
Mnt-RC
FBtr0070578
NM_166984
2581
582
Mnt-RD
FBtr0301821
NM_001169180
3280
790
Mnt-RE
FBtr0301822
NM_001169181
3242
582
Mnt-RF
FBtr0301823
NM_001169182
4094
789
Mnt-RG
FBtr0301824
NM_001169183
2578
581
Mnt-RH
FBtr0301825
NM_130715
3064
790
Mnt-RI
FBtr0307277
NM_001258583
4097
790
Mnt-RJ
FBtr0307278
NM_001258584
3335
583
Mnt-RK
FBtr0343578
NM_001297913
3734
716
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Mnt-PA
FBpp0070554
59.1
582
9.86
NP_726879
AAF45887
Mnt-PC
FBpp0070553
59.1
582
9.86
NP_726880
AAN09101
Mnt-PD
FBpp0291035
80.9
790
10.16
NP_001162651
ACZ95188
Mnt-PE
FBpp0291036
59.1
582
9.86
NP_001162652
ACZ95189
Mnt-PF
FBpp0291037
80.8
789
10.16
NP_001162653
ACZ95190
Mnt-PG
FBpp0291038
59.0
581
9.86
NP_001162654
ACZ95191
Mnt-PH
FBpp0291039
80.9
790
10.16
NP_570071
AAF45888
Mnt-PI
FBpp0298278
80.9
790
10.16
NP_001245512
AFH07226
Mnt-PJ
FBpp0298279
59.2
583
9.86
NP_001245513
AFH07227
Mnt-PK
FBpp0310175
73.2
716
10.17
NP_001284842
AHN59313
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

582 aa isoforms: Mnt-PA, Mnt-PC, Mnt-PE
790 aa isoforms: Mnt-PD, Mnt-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mnt using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
organism

Comment: maternally contributed

(Peyrefitte et al., 2001)
embryonic stage 4 -- 6
pole plasm
(Fisher et al., 2012)
embryonic stage 5 -- 11
germline stem cell
(Peyrefitte et al., 2001)
embryonic stage 7
early stomodeal invagination | posterior to | precursor
(Peyrefitte et al., 2001)
embryonic stage 7 -- 8
primordial germ cell
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
amnioserosa
(Peyrefitte et al., 2001)
embryonic stage 10 -- 17
presumptive embryonic/larval central nervous system
(Peyrefitte et al., 2001)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
salivary gland duct primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
embryonic/larval salivary gland
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 13 -- 17
embryonic/larval salivary gland
(Peyrefitte et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 16
embryonic epidermis
(Loo et al., 2005)
presumptive embryonic salivary gland
(Loo et al., 2005)
presumptive embryonic/larval central nervous system
(Loo et al., 2005)
presumptive embryonic/larval peripheral nervous system
(Loo et al., 2005)
third instar larval stage
eye-antennal disc
(Loo et al., 2005)
eye disc posterior to the morphogenetic furrow
(Loo et al., 2005)
morphogenetic furrow
(Loo et al., 2005)
wing disc
(Loo et al., 2005)
embryonic/larval fat body
(Loo et al., 2005)
embryonic/larval salivary gland
(Loo et al., 2005)
Additional Descriptive Data

Mnt protein is detected in the epidermis in embryos from stage 11 as well as in the cental and peripheral nervous systems. It is also detected in the salivary gland primordium. In third instar larvare, Mnt protein is detected predominantly in differentiated cells posterior to the morphogenetic furrow but also in the furrow. It is also detected in actively dividing peripodial membrane cells of the wing and eye-antennal imaginal discs as well as in salivary gland and fat body.

(Loo et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleus
inferred from high throughput direct assay
(Sarov et al., 2016)
Expression Deduced from Reporters
Reporter: PBac{681.P.FSVS-1}MntCPTI001879
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mnt in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mnt
Transgenic constructs containing regulatory region of Mnt
Aberrations (Deficiencies and Duplications) ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal | recessive
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal heat stress response | third instar larval stage, with Scer\GAL4ppk.1.9
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4ppk.1.9
abnormal starvation stress response | somatic clone, with Scer\GAL4unspecified
decreased cell size | larval stage | somatic clone, with Scer\GAL4Act5C.PP
decreased cell size | somatic clone, with Scer\GAL4Act5C.PP
increased body size
increased cell size
short lived
visible
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult head, with Scer\GAL4ey.PH
dendrite | third instar larval stage, with Scer\GAL4ppk.1.9
embryonic/larval fat body | somatic clone, with Scer\GAL4unspecified
eye, with Scer\GAL4ey.PH
larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4ppk.1.9
mesothoracic tergum, with Scer\GAL4pnr-MD237
ommatidium
wing, with Scer\GAL4Bx-MS1096
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc | somatic clone, with Scer\GAL4Act5C.PP
wing hair
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MNT
6 of 15
Yes
Yes
Hsap\MXD3
2 of 15
No
Yes
Hsap\MXI1
2 of 15
No
Yes
Hsap\MAX
1 of 15
No
No
Hsap\MXD1
1 of 15
No
Yes
Hsap\MXD4
1 of 15
No
Yes
Hsap\MYC
1 of 15
No
No
5  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mnt
6 of 15
Yes
Yes
Mmus\Mxd3
2 of 15
No
Yes
Mmus\Mxi1
2 of 15
No
Yes
Mmus\Bmyc
1 of 15
No
Yes
Mmus\Max
1 of 15
No
No
Mmus\Mxd1
1 of 15
No
Yes
Mmus\Mxd4
1 of 15
No
Yes
Mmus\Myc
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
Rnor\Mnt
5 of 13
Yes
Yes
Rnor\Bmyc
1 of 13
No
Yes
Rnor\Mxd1
1 of 13
No
Yes
Rnor\Mxd3
1 of 13
No
Yes
Rnor\Mxd4
1 of 13
No
Yes
Rnor\Mxi1
1 of 13
No
Yes
Rnor\Myc
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\mnt
4 of 12
Yes
Yes
Xtro\mxd3
2 of 12
No
Yes
Xtro\max
1 of 12
No
No
Xtro\mxd4
1 of 12
No
Yes
Xtro\mxi1
1 of 12
No
Yes
Xtro\myc
1 of 12
No
No
Danio rerio (Zebrafish) (10)
Drer\mntb
6 of 15
Yes
Yes
Drer\mnta
3 of 15
No
Yes
Drer\mxd3
2 of 15
No
Yes
Drer\mxi1
2 of 15
No
Yes
Drer\max
1 of 15
No
No
Drer\mxd1
1 of 15
No
Yes
Drer\mxd4
1 of 15
No
Yes
Drer\myca
1 of 15
No
No
Drer\mycb
1 of 15
No
No
Drer\mych
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\mdl-1
3 of 15
Yes
Yes
Cele\mxl-1
1 of 15
No
No
Cele\mxl-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\AT1G22490
1 of 9
Yes
Yes
Atha\AT1G72210
1 of 9
Yes
Yes
Atha\AT2G46810
1 of 9
Yes
Yes
Atha\AT3G61950
1 of 9
Yes
Yes
Atha\AT4G01460
1 of 9
Yes
Yes
Atha\AT5G65320
1 of 9
Yes
Yes
Atha\bHLH071
1 of 9
Yes
Yes
Atha\BHLH101
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190HHR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD24741
Drosophila sechellia
Dsec\GM12301
Drosophila erecta
Dere\GG18664
Drosophila yakuba
Dyak\GE16308
Drosophila ananassae
Dana\GF22645
Drosophila pseudoobscura pseudoobscura
Dpse\GA12197
Drosophila persimilis
Dper\GL15949
Drosophila willistoni
Dwil\GK10211
Drosophila virilis
Dvir\GJ19328
Drosophila mojavensis
Dmoj\GI15838
Drosophila grimshawi
Dgri\GH24213
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DBG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025912
Musca domestica
House fly
Mdoa\17025788
Musca domestica
House fly
Mdoa\17026503
Musca domestica
House fly
Mdoa\17026490
Musca domestica
House fly
Mdoa\17026449
Glossina morsitans
Tsetse fly
Gmor\GMOY004886
Mayetiola destructor
Hessian fly
Mdes\Mdes019093
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006567
Anopheles darlingi
American malaria mosquito
Adar\ADAC004994
Anopheles gambiae
Malaria mosquito
Agam\AGAP013301
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015473
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0G3G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA013173
Danaus plexippus
Monarch butterfly
Dple\DPOGS212725-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL003564
Apis florea
Little honeybee
Aflo\2268280788
Apis mellifera
Western honey bee
Amel\GB51809
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20592
Bombus terrestris
Buff-tailed bumblebee
Bter\15210586
Linepithema humile
Argentine ant
Lhum\LH12596
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001f09
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0002e7
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011761
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11244
Tribolium castaneum
Red flour beetle
Tcas\TC033299
Pediculus humanus
Human body louse
Phum\PHUM607610
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085637
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008703
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007295
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI36294
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI35638
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01279
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0G3W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003191
Ixodes scapularis
Black-legged tick
Isca\ISCW007968
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61194.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g06060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g06310
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_115557
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_333219
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_115558
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_264736
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_261850
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0PW2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Mnt
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023058
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000005830
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Max
1 of 10
Myc
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    MNT; MAX network transcriptional repressor
    6 of 15
    603039
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Myc
        suppressible
        Mnt
        (Steiger et al., 2008, Steiger et al., 2008)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-4
        Cytogenetic map
        3E2-3E5
        Sequence location
        X:3,671,801..3,701,672 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        3E2-3E5
        Limits computationally determined from genome sequence between P{EP}EP1623 and P{EP}EP911&P{EP}EP1094
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        3E-3E
        (determined by in situ hybridisation)
        (Loo, 1998.3.23)
        Experimentally Determined Recombination Data
        Location

        1-4

        (FlyBase, 2016)

        1-4.3

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (27)
        Genomic Clones (21)
        cDNA Clones (39)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        monoclonal

        (Loo et al., 2005)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: Mnt Mad-3E

        (Orian, 2003.2.10)

        Source for merge of: EG:114E2.2 CG13316

        (FlyBase, 1996-)
        Additional comments

        Source for merge of EG:114E2.2 CG13316 was a shared cDNA ( date:010720 ).

        (FlyBase, 1996-)
        Other Comments

        DNA-protein interactions: genome-wide binding profile assayed for Mnt protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

        (Filion et al., 2010)

        S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

        (Stroschein-Stevenson et al., 2006)

        S2 cells have been transfected with dsRNA made from templates generated with primers directed against this gene.

        (Hulf et al., 2005)

        Phylogenetic analyses indicate that Mnt is the ortholog of vertebrate MNT.

        (Robertson, 2002.4.16)

        Identification: Two hybrid screen using Max as bait.

        (Loo et al., 1998)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 84 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB
        EMBL-EBI Single Cell Expression Atlas
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (13)
        Reported As
        Symbol Synonym
        CG13316
        (Kolkhof et al., 2017, Neuert et al., 2017, Honjo et al., 2016, Hosono et al., 2015, Schertel et al., 2013, Wang et al., 2013, Prabhakaran and Kelley, 2012, Ni et al., 2010.12.1, Gelbart et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Sepp et al., 2008, Stevens et al., 2008, Stevens et al., 2008, Gandhi et al., 2007, Larschan et al., 2007, Larschan et al., 2007, Quinones-Coello, 2007)
        CG2856
        (Bourbon et al., 2002, Peyrefitte et al., 2001)
        DmMnt
        (Peyrefitte et al., 2001)
        EG:114E2.2
        (Huntley and Golding, 2004)
        MNT
        (Filion et al., 2010, van Steensel et al., 2010)
        Mad
        (Nagy et al., 2015, Nagy et al., 2013, Orian et al., 2003)
        Mad-3E
        (Loo, 1998.3.23)
        Mnt
        (Destefanis et al., 2020, Lepesant et al., 2020, Robles-Murguia et al., 2020, Samuels et al., 2020, Shokri et al., 2019, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Honjo et al., 2016, Sarov et al., 2016, Schertel et al., 2015, Steele et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Chen et al., 2014, Luck et al., 2014, Lundberg et al., 2013, Nagy et al., 2013, Schertel et al., 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Spokony and White, 2012.11.14, Abruzzi et al., 2011, Luo et al., 2011, Shevelyov et al., 2009, de Wit et al., 2008, Erives et al., 2008, Sepp et al., 2008, Steiger et al., 2008, Steiger et al., 2008, Quinones-Coello, 2007, Stroschein-Stevenson et al., 2006, Tsuda et al., 2006)
        bHLHe43
        (Stevens et al., 2008)
        dMad
        (Loo et al., 2002, Yost et al., 2002, Loo et al., 2001, Yost et al., 2001, Loo et al., 2000, Loo et al., 1999, Loo et al., 1998)
        dMnt
        (Abed et al., 2011, Pierce et al., 2008, Orian et al., 2007, Orian et al., 2007, Orian, 2006, Loo et al., 2005, Loo et al., 2005, Pierce et al., 2004, Pile et al., 2003, Secombe et al., 2003)
        dmnt
        (Hsieh et al., 2019, Demontis and Perrimon, 2009, Steiger and Gallant, 2007, Steiger et al., 2006, Hulf et al., 2005)
        mnt
        (Grifoni and Bellosta, 2015, Spratford and Kumar, 2015, Abruzzi et al., 2011, Schwinkendorf and Gallant, 2009, Smith-Bolton et al., 2009)
        Name Synonyms
        Mnt
        Secondary FlyBase IDs
        • FBgn0024333
        • FBgn0029674
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • transgene_used
        FBGSE22069
        Protein profiling reveals five principal chromatin types in Drosophila cells.
        References (123)