constituent of the Trr H3K4 methyltransferase, nuclear receptor co-activator complex, acts as a coactivator of Ecdysone receptor by altering the chromatin structure at ecdysone-responsive promoters
Gene model reviewed during 5.53
None of the polypeptides share 100% sequence identity.
2431 (aa); 260 (kD predicted)
Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6. Interacts with nuclear receptor EcR in an ecdysone-dependent manner. Interacts with ash2; the interaction stabilizes trr.
Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motif 2 is essential for the association with nuclear receptor EcR.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\trr using the Feature Mapper tool.
trr transcripts are more abundant in 1-7hr embryos than in 7-20hr embryos on northern blots. By in situ hybridization, they are first detected during oogenesis in stage 8 nurse cells. At stage 10, they are seen at the anterior end of the oocyte and are uniformly distributed later on. In embryos, they are uniformly distributed from the preblastoderm stage until the germ band extended stage. In germ band extended embryos, they are enriched in the mesoderm. During germ band retraction, trr transcripts are strongly expressed in the anterior and posterior midguts. They become less abundant after germ band retraction and are mainly found in the ventral nerve cord and the brain. In third instar larvae, they are strongly and ubiquitously expressed in imaginal discs and at a lower level in salivary glands.
GBrowse - Visual display of RNA-Seq signalsView Dmel\trr in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
"l(1)G0355" may affect "trr".