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FB2026_01
,
released March 12, 2026
Sir2, dSir2
histone deacetylase required for euchromatic and heterochromatic silencing - interacts genetically and physically with members of the Hairy/Deadpan/E(Spl) family of bHLH euchromatic repressors
Please see the JBrowse view of Dmel\Sirt1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.50
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with the transcriptional repressors hairy (hry) and deadpan (dpn); via basic domains. Associates with the Esc/E(z) histone methyltransferase complex. Interacts directly with E(z) and HDAC1/Rpd3.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sirt1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: all stages
Sirt1 protein is detected during syncitial and cellular blastoderm stages. It is observed at high levels in nuclei surrounding the morphogenetic furrows during gastrulation and in the germ band.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Sirt1 in JBrowse2-47
2-43.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Overexpression of Sir2 between approximately 2-5 fold above normal results in a dose-dependent increase in lifespan. Expression below this range or slightly above it (5-10 fold above normal) inconsistently extends lifespan, while higher levels of expression are detrimental to lifespan.
DNA-protein interactions: genome-wide binding profile assayed for Sir2 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
Sir2 plays a role in silencing mediated by the Polycomb group proteins.
Homozygosity for a Sir2 mutation has no apparent deleterious effect on viability, developmental rate or sex ratio.
Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex.
Sir2 is not essential for viability.
Sir2 is similar to S.cerevisiae SIR2 in the core domain but also has a unique 40kD C-terminal extension. Sir2 transcript is expressed maternally and throughout embryogenesis, especially within the nervous system.
Source for merge of: Sir2 l(2)05327
Source for merge of: Sir2 BEST:LD38188
Source for identity of: Sir2 CG5216
Source for identity of: Sirt1 Sir2
Renamed from 'Sir2' to 'Sirt1' to match the naming convention of the other D. melanogaster Sirtuin genes (i.e. nomenclature follows that of the mammalian orthologs).
