Gene model reviewed during 5.47
Gene model reviewed during 5.43
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.39
Gene model reviewed during 5.55
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
1.3 (northern blot)
271 (aa); 37 (kD observed); 31 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Crk using the Feature Mapper tool.
Crk transcripts are abundant throughout embryogenesis, decline in larvae, reappear during pupal stages and are detected in adults on northern blots. Transcripts are first detected by in situ hybridization in stage 4 embryos just prior to cellularization where they are concentrated around the periphery of the embryo. As cellularization occurs, transcripts are still present at the edge of the newly forming cells but not at the termini of the embryo. During gastrulation Crk transcripts are observed in the invaginating mesoderm as well as in some lateral cells that will contribute to ectodermally derived tissue. In stage 8, expression is apparent in the anterior and posterior midgut primordia and in the cells surrounding the cephalic furrow. This expression remains strong through stages 9-12. In late stage 13, Crk transcript expression is strongest in the visceral mesoderm of the anterior and posterior midgut and in the ventral nerve cord. It is also present in the somatic mesoderm but not in the amnioserosa. By stage 16, transcript levels have declined in some tissues but are still strong in visceral musculature, ventral nerve cord, and the cephalic region. Low levels of Crk transcript are detected in mature muscle fibers.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Crk in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Crk CG1587