FB2026_02 , released June 18, 2026
Gene: Mmus\Nkx2-5
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General Information
Symbol
Mmus\Nkx2-5
Species
M. musculus
Name
NK2 homeobox 5
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0025363
Gene Model Status
Not Applicable
Stock Availability
1 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

Nkx2.5

Key Links
Foreign Gene Data

Foreign sequence; species == Mus musculus; gene == Nkx2-5; MGI:97350.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mmus\Nkx2-5
Transgenic constructs containing regulatory region of Mmus\Nkx2-5
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4how-24B
Phenotype manifest in
Allele
embryonic/larval heart & mesoderm, with Scer\GAL4Mef2.PR, Scer\GAL4twi.PB
eye, with Scer\GAL4GMR.PU
wing, with Scer\GAL4vg.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (49)
tin
4 of 14
Yes
No
 
0  
scro
3 of 14
No
No
0  
bap
2 of 14
No
No
0  
NK7.1
2 of 14
No
Yes
0  
vnd
2 of 14
No
No
0  
al
1 of 14
No
No
0  
Antp
1 of 14
No
No
0  
B-H1
1 of 14
No
No
0  
B-H2
1 of 14
No
No
0  
bsh
1 of 14
No
No
0  
btn
1 of 14
No
No
0  
C15
1 of 14
No
No
0  
cad
1 of 14
No
No
0  
CG9876
1 of 14
No
No
0  
CG15696
1 of 14
No
No
0  
CG18599
1 of 14
No
No
0  
CG34031
1 of 14
No
No
0  
CG34367
1 of 14
No
No
0  
Dbx
1 of 14
No
No
0  
Dfd
1 of 14
No
No
0  
Dll
1 of 14
No
No
0  
Dr
1 of 14
No
No
0  
Drgx
1 of 14
No
No
0  
ems
1 of 14
No
No
0  
en
1 of 14
No
No
0  
eve
1 of 14
No
No
0  
gsb
1 of 14
No
No
0  
gsb-n
1 of 14
No
No
0  
hbn
1 of 14
No
No
0  
HGTX
1 of 14
No
No
0  
Hmx
1 of 14
No
No
0  
lbe
1 of 14
No
No
0  
lbl
1 of 14
No
No
0  
Lim1
1 of 14
No
No
0  
lms
1 of 14
No
No
0  
pb
1 of 14
No
No
0  
PHDP
1 of 14
No
No
0  
Pph13
1 of 14
No
No
0  
prd
1 of 14
No
No
0  
repo
1 of 14
No
No
0  
Rx
1 of 14
No
No
0  
Scr
1 of 14
No
No
0  
slou
1 of 14
No
No
0  
toe
1 of 14
No
No
0  
toy
1 of 14
No
No
0  
unpg
1 of 14
No
No
0  
vvl
1 of 14
No
No
0  
zen2
1 of 14
No
No
0  
zen
1 of 14
No
No
0  
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Dmel gene
    Ortholog showing functional complementation
    Supporting References
    tin
    Mmus\Nkx2-5
    (Ranganayakulu et al., 1998)
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Other Comments

    While tin and Mmus\Nkx2-5 show close functional kinship, their mode of deployment in cardiogenesis has diverged possibly because of differences in their interactions with accessory factors. The distinct cardiogenic programs in vertebrates and flies may be built upon a common and perhaps more ancient program for the specification of visceral muscle.

    (Ranganayakulu et al., 1998)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (5)
    Reported As
    Symbol Synonym
    MNkx2-5
    (Park et al., 1998)
    Mmus\Nkx2-5
    Nkx2-5
    Nkx2.5
    (Amodio et al., 2012, Zaffran et al., 2006)
    Name Synonyms
    NK2 homeobox 5
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 3 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      Other crossreferences
      MARRVEL_MODEL - MARRVEL (model organism gene)
      Mouse Genome Database - The international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
      References (5)