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FB2026_01
,
released March 12, 2026
bab, bab-II, bric-a-brac, bric a brac, BTB-II
Please see the JBrowse view of Dmel\bab2 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
5.4 (northern blot)
None of the polypeptides share 100% sequence identity.
1067 (aa); 145 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bab2 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
is bab2 transcript is highly expressed in cells that form the terminal filament of the ovary. Low levels of transcript expression are observed in the apical cells, 'swarm cells' and some interstitial non-germ cells of the ovary. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs.
bab2 expression shows a gradient from high expression in tarsal segment 4, to fainter expression in the metatarsus.
At 40 hAPF (P stage 7), bab2 is expressed at high levels and in a sexually dimorphic pattern. In females, bab2 is expressed in the A2-A7 segments, though with relatively less expression in the A5 and A6 segments compared to the levels in A2-A4. In males, expression is observed in segments A2-A4, and at progressively lower levels in segment A5 and A6. At 72 hAPF (P stage 9), bab2 remains expressed at high levels in female segments A2-A7. In males, bab2 is expressed in segments A2-A4, although the levels of expression were noticeably lower than that observed in the corresponding female segments. At 90 hAPF (P stage 14), both the sexually dimorphic pattern and levels of bab2 expression persists, including a very low level in the A2-A4 segments of males. In addition to this epidermal cell expression of bab2, a monomorphic pattern of expression is observed in the oenocytes for each segment at the mid-late and late time points.
bab2 protein is expressed at early embryonic stage 12 in cardiac precursor cells that expressed eve but not lbe. At the end of stage 12, bab2 protein is detected in cardioblasts, including those expressing lbe, and is expressed in all cardiac cells by stage 13. By stage 15, bab2 protein is expressed in the heart proper.
Protein is highly expressed in cells that form the terminal filament of the ovary. Lower levels of protein expression are observed in the apical cells, 'swarm cells' and some interstitial non-germ cells of the ovary. Protein expression in the leg disc is graded with highest expression in TS3, TS4 and the proximal region of TS5 and lower expression in TS1 and TS2. Expression is also observed in the peripodial membrane and the periphery of the disc that gives rise to thorax structures.In the female genital disc strongest protein expression is observed in the vaginal plate primordium and the A8 tergite.In the male genital disc strongest protein expression is observed in a region of the male genital primordium.bab2-expressing cells are found in the central brain hemisphers and the thoracic ganglia.
JBrowse - Visual display of RNA-Seq signals
View Dmel\bab2 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2.
Source for merge of: BtbII CG13911
Annotations CG9102 and CG13911 merged as CG9102 in release 3 of the genome annotation.
