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General Information
Symbol
Dmel\cry
Species
D. melanogaster
Name
cryptochrome
Annotation Symbol
CG3772
Feature Type
FlyBase ID
FBgn0025680
Gene Model Status
Stock Availability
Gene Summary
Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing. (UniProt, O77059)
Contribute a Gene Snapshot for this gene.
Also Known As

dCRY, DmCry, DmCRY1

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:19,212,154..19,215,442 [+]
Recombination map
3-66
RefSeq locus
NT_033777 REGION:19212154..19215442
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (30 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by UniProt )
enables FAD binding
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
(assigned by UniProt )
inferred from physical interaction with UniProtKB:P07663
(assigned by UniProt )
inferred from physical interaction with FLYBASE:tim; FB:FBgn0014396
inferred from mutant phenotype
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000155848
(assigned by GO_Central )
enables FAD binding
inferred from biological aspect of ancestor with PANTHER:PTN000155848
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:2384
inferred from sequence or structural similarity with HGNC:2385
Biological Process (19 terms)
Terms Based on Experimental Evidence (18 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
involved_in circadian behavior
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:norpA; FB:FBgn0262738
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rh7; FB:FBgn0036260
involved_in circadian rhythm
inferred from genetic interaction with FLYBASE:per; FB:FBgn0003068
inferred from genetic interaction with FLYBASE:tim; FB:FBgn0014396
inferred from physical interaction with FLYBASE:tim; FB:FBgn0014396
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
involved_in gravitaxis
inferred from mutant phenotype
involved_in locomotor rhythm
inferred from mutant phenotype
involved_in magnetoreception
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
involved_in phototransduction
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN002479144
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN002479144
(assigned by GO_Central )
inferred from sequence or structural similarity with HGNC:2384
inferred from sequence or structural similarity with HGNC:2385
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in cytosol
inferred from direct assay
located_in nucleus
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002479144
(assigned by GO_Central )
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002479144
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the DNA photolyase class-1 family. (O77059)
Summaries
Protein Function (UniProtKB)
Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry. Necessary for light-dependent magnetosensitivity, an intact circadian system is not required for the magnetoreception mechanism to operate. Required for both the naive and trained responses to magnetic field, consistent with the notion that cry is in the input pathway of magnetic sensing.
(UniProt, O77059)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\cry for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.54

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083736
1896
542
Additional Transcript Data and Comments
Reported size (kB)

2.0 (northern blot)

1.696 (longest cDNA)

1.629 (longest cDNA)

2 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083150
62.5
542
6.29
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

542 (aa); 62.5 (kD predicted)

542 (aa); 60 (kD observed)

Comments
External Data
Subunit Structure (UniProtKB)

Interacts with tim and per; promoted by light conditions (PubMed:10417378, PubMed:11448767). Interaction with tim irreversibly commits tim to proteasomal degradation (PubMed:10417378). Interacts with l(1)G0136/CG8198 (PubMed:26569474).

(UniProt, O77059)
Domain

FAD-binding region regulates cry stability, cry-tim interaction, and circadian photosensitivity.

Photolyase/cryptochrome alpha/beta domain is sufficient for light detection and phototransduction.

(UniProt, O77059)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cry using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain

Comment: cry mRNA expression levels are lower in Z16 than in ZT4.

adult fat body

Comment: cyclical, peak ZT9-13

in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RNA-seq
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Expression is strongly enriched in the ventral midline at embryonic stage 16.

Expressed cyclically in the adult fat body.

Expression of cry is detected in up to six DN1p neurons, and sometimes in one or two DN3 neurons. Between one and three LNd neurons label positively for cry.

A doublet of ~2 kb is seen in adult head RNA preparations. The amount of cry RNA in the head oscillates during the circadian cycle, and cry is 6-11 fold more abundant at the daytime peak than at the nighttime trough. RNAse protection experiments indicate that cry is expresed in the adult brain. Expression is present in eyeless (eya) mutants, and is also detected at low levels in the adult body. No expression is detected in 0-24 hr embryos, whole third instar larvae or third instar larval brains. In situ hybridization studies indicate that cry is expressed in the adult central nervous system. Highest levels are detected in the lateral CNS, near or coincident with the position of the ventral group of Drosophila clock neurons. Expression is also detected in the gut.

cry is detected in adult heads and bodies and in pupae on Northern blots, and in larvae by RT-PCR. cry expression in the adult head shows circadian cycling. The cycling is gradually diminished in conditions of constant darkness. cry oscillations are not detected in per or tim mutant flies.

RT-PCR and Northern blot analyses indicate that cry transcript is more abundant in adult heads than in bodies. Fivefold higher expression is detected in antennae compared to mouth appendages and wings, and expression is also detected in legs.

cry mRNA from adult heads shows 5-fold amplitude cycling under standard light/dark (LD) conditions, with a peak at Zeitgeber time (ZT) 1-7, and a trough at ZT17-ZT19. Cycling persists in constant darkness (DD), but with a lower, approximately 2-fold amplitude. Cycling is also detected in the adult body, but with only a 2.5-fold amplitude. Transcriptional cycling detected under LD and DD conditions using nuclear run-on assays indicates that the mRNA oscillations are regulated largely at the transcriptional level. cry transcript levels are low in tim and per mutants, but are high in Clk and cyc mutants.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

cry protein is expressed in s-LNv neurons, l-LNv neurons, and a subset of LNd neurons and DN1 neurons, but not in DN2 and DN3 neurons. It is also detected in the pars intercerebralis and the medial protocerebrum.

Expression of cry is found in three of the six LNd neurons and in six cells of the DN1p cluster when the flies are kept in constant dark (DD) conditions. In some samples, a fourth LNd also faintly labels. Expression is detected in several cells in the anterior central brain, dorsolateral to the antennal lobes which project to the ellipsoid body. Expression of cry is detected in putative glial cells of brains from flies kept in DD conditions for 4.5 days prior to dissection. Photoreceptors R7 and R8 show a faint accumulation of cry in their distal medulla termini when flies are kept in DD for 4.5 days, but is more extensive along axons in flies maintained in constant dark conditions for 8 days. Following 35 hours of DD conditions, cry is observed in both the nucleus and cytoplasm of the s-LNv, l-LNv, DN1 and LNd neurons, but staining in the cytoplasm is stronger than in the nucleus. Expression of cry increases in the cry-expressing cells with increased time spent in dark conditions, compared to samples raised in light-dark conditions. Expression of cry shows a cycling behaviour, with levels being increasing during the dark-periods and decreasing during the light-periods, though cry was still detectable in clock neurons 1hr after lights on.

cry protein expression in light/dark entrained y w;Scer\GAL4tim.PE lines shows an 8-fold amplitude cycling, with low levels during the day and a peak at ZT23. By contrast, mRNA levels are high during the day. A far lower amplitude cycling of cry protein is seen in wild type flies, possibly due to light shielding by eye pigment in wild type flies. Unlike per, tim, and Clk proteins, the DD and LD patterns of cry protein expression differ greatly. In conditions of constant darkness (DD), cry protein levels increase continuously.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
located_in cytosol
inferred from direct assay
located_in nucleus
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{cry-GAL4.E}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{cry-GAL4.U}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{cry-GAL4.Z}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GFP-cry}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cry in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cry
Transgenic constructs containing regulatory region of cry
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
5 of 15
Yes
No
4 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
4 of 15
Yes
No
0  
4 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
3 of 13
Yes
No
3 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (6)
3 of 12
Yes
Yes
3 of 12
Yes
Yes
3 of 12
Yes
No
2 of 12
No
Yes
2 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (10)
4 of 15
Yes
No
4 of 15
Yes
No
3 of 15
No
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
3 of 15
No
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (5)
3 of 9
Yes
No
1 of 9
No
No
1 of 9
No
No
1 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
7 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905S4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502XI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W033A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Acyrthosiphon pisum
Pea aphid
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02CO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07M3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
7 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    RNA-protein
    Physical Interaction
    Assay
    References
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Interacts with tim and per; promoted by light conditions (PubMed:10417378, PubMed:11448767). Interaction with tim irreversibly commits tim to proteasomal degradation (PubMed:10417378). Interacts with l(1)G0136/CG8198 (PubMed:26569474).
    (UniProt, O77059 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-66
    Cytogenetic map
    Sequence location
    3R:19,212,154..19,215,442 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    91F11-91F11
    Limits computationally determined from genome sequence between P{EP}EP650 and P{PZ}l(3)1058510585
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    92A1-92A3
    92A1-92A2
    (determined by in situ hybridisation)
    91F6-91F13
    (determined by in situ hybridisation)
    91F8-92A3
    (determined by in situ hybridisation)
    cry maps within 91F, distal to band 91F5.
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (18)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (54)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: cry anon-WO0140519.17 anon-WO0140519.19 anon-WO0140519.20

    Additional comments

    Source for merge of cry anon-WO0140519.17 anon-WO0140519.19 anon-WO0140519.20 was sequence comparison ( date:051113 ).

    Other Comments

    cry is important for the preferential entrainment of the clock neurons and the behavioral rhythms to light.

    cry functions as a repressor of Clk/cyc-activated transcription.

    cry is required for light-induced degradation of the tim protein.

    The C-terminal is essential for maintaining cry in a stable conformation under darkness, while the photolyase-like photoreceptive part of the molecule is still light-responsive in its absence.

    cry contributes to oscillator function and physiological output rhythms in the antenna during and after entrainment to light-dark cycles and after photic input is eliminated by entraining flies to temperature cycles. cry plays a photoreceptor-independent role in the periphery.

    cry acts as a key photoreceptor for circadian rhythms and there is probably no other comparable photoreceptor in D.melanogaster.

    cry is a deep brain circadian photoreceptor.

    The cry and tim gene products physically interact in a yeast two hybrid assay in a light-dependent fashion.

    The cry gene product blocks the function of the per/tim heterodimeric complex in a light-dependent fashion. cry acts as circadian photoreceptor by directly interacting with core components of the circadian clock.

    cry mRNA abundance oscillates in a circadian manner in head RNA extracts.

    Changes in cry gene dosage are associated with alterations of the blue light resetting response for the circadian rhythm of adult locomotor activity.

    Circadian photosensitivity is increased in a cry-overexpressing strain.

    cry is an input clock gene, a major photoreceptor for behavioral circadian rhythms and a key photoreceptor for peripheral circadian rhythms. cry may act upstream of all known central pacemaker components.

    Mutant causes behavioral synchronization defects in addition to molecular cycling ones and affects molecules functioning within the circadian clock.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 50 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (26)
    Reported As
    Symbol Synonym
    CRYPTOCHROME
    anon-WO0140519.17
    anon-WO0140519.19
    anon-WO0140519.20
    anon-WO0172774.15
    cry
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    Name Synonyms
    Blue-light receptor
    Secondary FlyBase IDs
    • FBgn0044674
    • FBgn0044686
    • FBgn0044708
    • FBgn0046448
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
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    References (434)