Open Close
General Information
Symbol
Hsap\APP
Species
H. sapiens
Name
amyloid beta (A4) precursor protein
Annotation Symbol
Feature Type
FlyBase ID
FBgn0025823
Gene Model Status
Stock Availability
Gene Summary
Contribute a Gene Snapshot for this gene.
Also Known As

APP, Aβ42, Aβ, AβPP, amyloid precursor protein

Key Links
Tag or Foreign Gene Data

Foreign sequence; species == Homo sapiens; gene == APP; HGNC:620.

Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Hsap\APP using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Hsap\APP in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, Transgenic Constructs, and Aberrations
      Classical and Insertion Alleles ( 0 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 165 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of Hsap\APP
      Transgenic constructs containing regulatory region of Hsap\APP
      Aberrations (Deficiencies and Duplications) ( 0 )
      Inferred from experimentation ( 0 )
      Inferred from location ( 0 )
        Alleles Representing Disease-Implicated Variants
        Phenotypes
        For more details about a specific phenotype click on the relevant allele symbol.
        Lethality
        Allele
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        Orthologs
        Human Orthologs (via DIOPT v8.0)
        Homo sapiens (Human) (0)
        No records found.
        Model Organism Orthologs (via DIOPT v8.0)
        Drosophila melanogaster (Fruit fly) (20)
        Species\Gene Symbol
        Score
        Best Score
        Best Reverse Score
        Alignment
        Complementation?
        Transgene?
        13 of 15
        Yes
        Yes
        0  
        2 of 15
        No
        No
        0  
        2 of 15
        No
        No
        0  
        2 of 15
        No
        Yes
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        1 of 15
        No
        No
        0  
        Ortholog(s) in Drosophila melanogaster (via OrthoDB v9.1) ( None identified )
        No D. melanogaster orthologies identified
        Human Disease Associations
        FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 78 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 24 )
        Allele
        Disease
        Interaction
        References
        is exacerbated by mir-282EP3041
        is ameliorated by CG2924EP1596
        is exacerbated by CG7231EP2510
        is exacerbated by svrKG02090
        is exacerbated by elB9
        is exacerbated by Nep2KG05754
        is exacerbated by SNF4AγKG10152
        is exacerbated by ATP7EY07895
        is exacerbated by cwoEP3470
        is exacerbated by Sin3A08269
        is exacerbated by SNF4AγEP3015b
        is exacerbated by elBEP965
        is exacerbated by mubEP3108
        is ameliorated by gEP514
        is exacerbated by HDAC104556
        is exacerbated by HDAC4KG09091
        is exacerbated by PrpsKG00420
        is exacerbated by TlEP1051
        is exacerbated by esgEP684
        is exacerbated by Sap130EY12079
        is ameliorated by gB166
        is exacerbated by svr126
        is exacerbated by svrEP356
        is exacerbated by Dsp1EP355
        is ameliorated by DyroEP3405
        is exacerbated by MESR4EP386
        is ameliorated by nejΔQ.UAS
        is ameliorated by nejΔHQ.UAS
        is ameliorated by nejKIX.UAS
        is ameliorated by bsk1
        is ameliorated by foxo21
        is ameliorated by foxo25
        is ameliorated by Diap1UAS.cHa
        Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser

        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (82)
        Genomic Clones (0)
         
          cDNA Clones (0)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments

                    FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

                    Other Comments

                    Expression of Hsap\APP in Drosophila induces AICD-dependent cell death and a locomotion defect.

                    Expression of Hsap\APP is able to induce cell death in non-neuronal tissues during development.

                    The ability of Xbp1 overepxression and loss-of-function alleles to modify Hsap\APP neurotoxicity in the eye suggests that Xbp1 plays a key role in Hsap\APP pathobiology.

                    Expression of Mmus\Xbp1 reduces Hsap\APP neurotoxicity without altering Aβ levels and aggregation.

                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 8 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    Synonyms and Secondary IDs (47)
                    Reported As
                    Symbol Synonym
                    APP
                    (Du et al., 2021, Jalali et al., 2021, Neuman et al., 2021, Walsh et al., 2021, Bolus et al., 2020, Jeon et al., 2020, Li et al., 2020, Vajente et al., 2020, Zhuang et al., 2020, Deshpande et al., 2019, Huichalaf et al., 2019, Mórotz et al., 2019, Sivanantharajah et al., 2019, Westfall et al., 2019, Moore et al., 2018, Dissel et al., 2017, Saburova et al., 2017, Siddique and Ali, 2017, Xu et al., 2016, Cutler et al., 2015, Fernandez-Funez et al., 2015, Lee et al., 2015, Peng et al., 2015, Xu and Elefant, 2015, Hou et al., 2014, Hu et al., 2014, Kang et al., 2014, Mhatre et al., 2014, Mhatre et al., 2014, Park et al., 2014, Sofola-Adesakin et al., 2014, Vorobyeva et al., 2014, Wang et al., 2014, Wang et al., 2014, Xu et al., 2014, Gross et al., 2013, HGNC Curators and FlyBase Curators, 2013-, Hopkins, 2013, Johnson et al., 2013, Moran et al., 2013, Lee et al., 2012, Pirooznia et al., 2012, Reis et al., 2012, Singh and Mlodzik, 2012, Wentzell et al., 2012, Zuo et al., 2012, Casas-Tinto et al., 2011, Chakraborty et al., 2011, Copenhaver et al., 2011, Goguel et al., 2011, Kim et al., 2011, Singh and Mahoney, 2011.2.17, Iijima-Ando and Iijima, 2010, Lloyd and Taylor, 2010, Merdes, 2010.2.24, Merdes, 2010.8.5, Stempfle et al., 2010, Tsuda et al., 2010, Wang et al., 2010, Iijima-Ando et al., 2009, Sarantseva et al., 2009, Gross et al., 2008, Iijima et al., 2008, Muhammad et al., 2008, Isoo et al., 2007, Li et al., 2007, Wang et al., 2007, Weaver et al., 2007, Crowther et al., 2005, Finelli et al., 2004, Greeve et al., 2004, Loewer et al., 2004, Loewer et al., 2004, Lanoue et al., 2000, Yagi et al., 2000)
                    Arctic Aβ42
                    amyloid-β
                    Name Synonyms
                    Amyloid beta A4 precursor protein
                    amyloid beta (A4) precursor protein
                    amyloid beta precursor protein
                    amyloid β
                    amyloid-beta
                    amyloid-beta (Aβ) peptide
                    amyloid-beta 42
                    amyloid-β peptide
                    amyloid-β protein
                    human Abeta
                    human amyloid precursor protein
                    β-amyloid
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (351)