FB2025_02 , released April 17, 2025
Gene: Dmel\Pten
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General Information
Symbol
Dmel\Pten
Species
D. melanogaster
Name
Phosphatase and tensin homolog
Annotation Symbol
CG5671
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026379
Gene Model Status
Current
Stock Availability
24 publicly available
Enzyme Name (EC)
protein-serine/threonine phosphatase (3.1.3.16)
protein-tyrosine-phosphatase (3.1.3.48)
phosphatidylinositol-3-phosphatase (3.1.3.64)
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (3.1.3.67)
Gene Summary
Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. [Date last reviewed: 2018-10-18] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dPTEN

Key Links
Genomic Location
Cytogenetic map
31B1-31B1
Sequence location
Recombination map
2-40
RefSeq locus
NT_033779 REGION:10256319..10261049
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (68 terms)
Molecular Function (10 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
(Goberdhan et al., 1999)
enables phosphoprotein phosphatase activity
inferred from mutant phenotype
(Huang et al., 1999)
enables protein serine/threonine phosphatase activity
inferred from mutant phenotype
(Gao et al., 2005)
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
inferred from electronic annotation with InterPro:IPR017361
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
enables PDZ domain binding
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
enables phosphatase activity
inferred from electronic annotation with InterPro:IPR045101
(InterPro Project Members, 2004-)
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
inferred from electronic annotation with InterPro:IPR017361
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P60484
(Goberdhan et al., 1999)
inferred from biological aspect of ancestor with PANTHER:PTN000266847
(GO Reference Genome Project, 2011-)
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
inferred from electronic annotation with InterPro:IPR017361
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
enables phosphatidylinositol-3-phosphate phosphatase activity
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
enables phosphoprotein phosphatase activity
inferred from sequence or structural similarity with UniProtKB:P60484
(Goberdhan et al., 1999)
enables protein serine/threonine phosphatase activity
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
enables protein tyrosine phosphatase activity
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
enables protein tyrosine/serine/threonine phosphatase activity
non-traceable author statement
(Hatzihristidis et al., 2015)
Biological Process (52 terms)
Terms Based on Experimental Evidence (44 terms)
CV Term
Evidence
References
involved_in actin cytoskeleton organization
inferred from mutant phenotype
(von Stein et al., 2005)
involved_in autophagy
inferred from mutant phenotype
(Rusten et al., 2004)
involved_in basement membrane organization
inferred from mutant phenotype
(Devergne et al., 2014)
involved_in cell competition in a multicellular organism
inferred from mutant phenotype
(Levayer et al., 2015)
involved_in cytoskeleton organization
inferred from mutant phenotype
(Goberdhan et al., 1999)
involved_in dendrite regeneration
inferred from mutant phenotype
(Song et al., 2012)
involved_in endosome organization
inferred from mutant phenotype
(Mondin et al., 2019)
involved_in epithelial cell fate determination, open tracheal system
inferred from mutant phenotype
(Jin et al., 2001)
involved_in follicle cell of egg chamber development
inferred from mutant phenotype
(Jia et al., 2015)
involved_in larval development
inferred from mutant phenotype
(Mirth et al., 2005)
involved_in larval midgut histolysis
inferred from genetic interaction with FLYBASE:Atg18a; FB:FBgn0035850
(Denton et al., 2012)
inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945
(Denton et al., 2012)
involved_in lipid homeostasis
inferred from mutant phenotype
(Gutierrez et al., 2007)
involved_in lymph gland development
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in melanotic encapsulation of foreign target
inferred from mutant phenotype
(Howell et al., 2012)
involved_in metamorphosis
inferred from mutant phenotype
(Mirth et al., 2005)
involved_in negative regulation of axon regeneration
inferred from mutant phenotype
(Song et al., 2012)
involved_in negative regulation of cell growth
inferred from mutant phenotype
(Parisi et al., 2011)
acts_upstream_of negative regulation of cell population proliferation
inferred from mutant phenotype
(Huang et al., 1999)
involved_in negative regulation of cell population proliferation
inferred from mutant phenotype
(Goberdhan et al., 1999)
acts_upstream_of negative regulation of cell size
inferred from mutant phenotype
(Huang et al., 1999)
involved_in negative regulation of crystal cell differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in negative regulation of epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Greenspan et al., 2022)
involved_in negative regulation of imaginal disc growth
inferred from mutant phenotype
(Gerlach et al., 2018)
involved_in negative regulation of insulin receptor signaling pathway
inferred from mutant phenotype
(Tsao et al., 2023, Kockel et al., 2010, Britton et al., 2002, Clemens et al., 2000, Gao et al., 2000)
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
(Huang et al., 1999)
inferred from genetic interaction with FLYBASE:chico; FB:FBgn0024248
(Huang et al., 1999)
inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499
(Oldham et al., 2002)
involved_in negative regulation of lamellocyte differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in negative regulation of lipid storage
inferred from mutant phenotype
(Vereshchagina and Wilson, 2006)
involved_in negative regulation of multicellular organism growth
inferred from mutant phenotype
(Oldham et al., 2002)
acts_upstream_of negative regulation of organ growth
inferred from mutant phenotype
(Scanga et al., 2000)
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from mutant phenotype
(Lizcano et al., 2003, Britton et al., 2002, Clemens et al., 2000)
inferred from mutant phenotype
(Oswald et al., 2018)
inferred from genetic interaction with FLYBASE:rictor; FB:FBgn0031006
(Hietakangas and Cohen, 2007)
involved_in negative regulation of plasmatocyte differentiation
inferred from mutant phenotype
(Benmimoun et al., 2012)
involved_in negative regulation of TORC1 signaling
inferred from mutant phenotype
(Kim et al., 2017)
acts_upstream_of positive regulation of apoptotic process
inferred from mutant phenotype
(Huang et al., 1999)
involved_in positive regulation of macroautophagy
inferred from mutant phenotype
(Pircs et al., 2012)
involved_in protein localization
inferred from mutant phenotype
(Rousso et al., 2013)
involved_in regulation of cell cycle
inferred from mutant phenotype
(Nowak et al., 2013)
involved_in regulation of cell junction assembly
inferred from mutant phenotype
(Bardet et al., 2013)
involved_in regulation of cell shape
inferred from mutant phenotype
(Bardet et al., 2013, Goberdhan et al., 1999)
involved_in regulation of cell size
inferred from mutant phenotype
(Goberdhan et al., 1999)
involved_in regulation of dendrite development
inferred from mutant phenotype
(Parrish et al., 2009)
involved_in regulation of establishment of planar polarity
inferred from mutant phenotype
(Bardet et al., 2013)
involved_in regulation of hemocyte proliferation
inferred from mutant phenotype
(Sinenko et al., 2010)
involved_in regulation of multicellular organism growth
inferred from mutant phenotype
(Mirth et al., 2005)
involved_in regulation of synaptic plasticity
inferred from mutant phenotype
(Oswald et al., 2018)
involved_in response to starvation
inferred from mutant phenotype
(Oldham et al., 2002)
involved_in rhabdomere development
inferred from mutant phenotype
(Pinal et al., 2006)
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
involved_in cell motility
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
involved_in negative regulation of cell migration
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
involved_in negative regulation of cell population proliferation
inferred from electronic annotation with InterPro:IPR017361
(InterPro Project Members, 2004-)
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
involved_in negative regulation of focal adhesion assembly
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
involved_in phosphatidylinositol dephosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR017361
(InterPro Project Members, 2004-)
involved_in protein dephosphorylation
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
involved_in regulation of protein stability
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endosome membrane
inferred from mutant phenotype
(Mondin et al., 2019)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
is_active_in cell projection
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000266847
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:P60484
(Gene Ontology Curators, 2002-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000959472
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
protein tyrosine phosphatase activity
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (3.1.3.48)
RHEA 10684: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + phosphate (3.1.3.67)
RHEA 25017: protein serine/threonine phosphatase activity
(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)
(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)
phosphatidylinositol-3-phosphate phosphatase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate (3.1.3.64)
RHEA 12316: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
RHEA 77155:
Summaries
Gene Snapshot
Phosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. [Date last reviewed: 2018-10-18]
Gene Group (FlyBase)
DUAL SPECIFICITY PROTEIN PHOSPHATASES -
Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).
PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES -
Phosphoinositide phosphate (PtdInsP) phosphatases and Inositol phosphate (InsP) phosphatases are enzymes that catalyze the hydrolysis of phosphate groups from inositol. Many of these phosphatases can act on both PtdInsP and InsP substrates. (Adapted from PMID:23681533).
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Negative Regulators of EGFR Signaling Pathway -
Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.
Summary (Interactive Fly)

lipid and protein phosphatase acting in insulin pathway - PTEN, a tumour suppressor, is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Pten for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7KMQ6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Alternative translation stop created by use of multiphasic reading frames within coding region.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated (in 3' UTR).

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pten-RA
FBtr0089905
NM_134320
2568
509
Pten-RB
FBtr0089904
NM_058075
2355
514
Pten-RC
FBtr0089902
NM_058076
1803
418
Pten-RD
FBtr0089900
NM_134322
2125
514
Pten-RE
FBtr0089901
NM_134321
2338
509
Pten-RG
FBtr0300562
NM_001169462
2617
514
Pten-RH
FBtr0301521
NM_058074
2467
514
Additional Transcript Data and Comments
Reported size (kB)

1.872 (longest cDNA)

(Huang et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pten-PA
FBpp0088844
58.4
509
7.25
Q9V3L4
NP_599147
AAF52887
Pten-PB
FBpp0088843
59.0
514
7.25
Q7KMQ6
NP_477423
AAN10731
Pten-PC
FBpp0088841
48.1
418
7.23
Q9Y0B6
NP_477424
AAN10730
Pten-PD
FBpp0088839
59.0
514
7.25
Q7KMQ6
NP_599149
AAF52888
Pten-PE
FBpp0088840
58.4
509
7.25
Q9V3L4
NP_599148
AAF52889
Pten-PG
FBpp0289789
59.0
514
7.25
Q7KMQ6
NP_001162933
ACZ94222
Pten-PH
FBpp0290736
59.0
514
7.25
Q7KMQ6
NP_477422
AAN10732
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

514 aa isoforms: Pten-PB, Pten-PD, Pten-PG, Pten-PH
509 aa isoforms: Pten-PA, Pten-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

514, 509 (aa)

(Goberdhan et al., 1999)

514 (aa)

(Huang et al., 1999)

511, 509, 418 (aa)

(Smith et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pten using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.13

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval salivary gland
(Fisher et al., 2012)
embryonic/larval salivary gland body
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
medullary zone of lymph gland primary lobe
(Dragojlovic-Munther and Martinez-Agosto, 2012)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endosome membrane
inferred from mutant phenotype
(Mondin et al., 2019)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pten in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pten
Transgenic constructs containing regulatory region of Pten
Aberrations (Deficiencies and Duplications) ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4arm.PS
lethal, with Scer\GAL4ey.PH
lethal | recessive
lethal - all die before end of first instar larval stage, with Scer\GAL4phtm.PO
lethal - all die before end of larval stage (with Df(2L)flp170B)
lethal - all die before end of larval stage | nutrition conditional (with Pten2L100)
lethal - all die before end of larval stage | nutrition conditional (with Pten117)
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage | partially, with Scer\GAL4P0206
partially lethal, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4en-e16E
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4UAS.cHa, Scer\GAL4tin.cBa
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
Other Phenotypes
Allele
abnormal cell growth, with Scer\GAL4GMR.PU
abnormal cell growth, with Scer\GAL4mirr-DE
abnormal cell shape | adult stage, with Scer\GAL4GMR.PF
abnormal cell shape | somatic clone
abnormal cell size | adult stage, with Scer\GAL4GMR.PF
abnormal developmental rate | second instar larval stage, with Scer\GAL4P0206
abnormal developmental rate | third instar larval stage, with Scer\GAL4P0206
abnormal immune response | larval stage, with Scer\GAL4Hml.PG
abnormal locomotor behavior (with Pten1)
abnormal locomotor behavior (with Pten5)
abnormal mating behavior | RU486 conditional, with Scer\GAL4αTub84B.Switch.PK
abnormal neuroanatomy | adult stage, with Scer\GAL4pnr-MD237
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4repo.PU
abnormal neuroanatomy | cell autonomous | somatic clone
abnormal neuroanatomy | larval stage, with Scer\GAL4C57
abnormal neuroanatomy | larval stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | pupal stage | somatic clone
abnormal neurophysiology | larval stage, with Ptendj189, Scer\GAL4C57
abnormal neurophysiology | larval stage, with PtenRNAi.Exel.UAS, Scer\GAL4C57
abnormal osmotic stress response (with Pten5)
abnormal osmotic stress response (with Ptendj189)
abnormal oxidative stress response (with Pten5)
abnormal oxidative stress response (with Ptendj189)
abnormal planar polarity
abnormal planar polarity | recessive | somatic clone
abnormal size, with Scer\GAL4NP0001
abnormal size, with Scer\GAL4nub-AC-62
abnormal size | adult stage, with Scer\GAL4en-e16E
abnormal size | adult stage, with Scer\GAL4ey.PH
abnormal size | adult stage, with Scer\GAL4eya.enh1+E+2
abnormal size | adult stage, with Scer\GAL4GMR.PF
abnormal size | adult stage, with Scer\GAL4nub.PU
abnormal size | adult stage, with Scer\GAL4pnr-MD237
abnormal size | dominant
abnormal size | larval stage, with Scer\GAL4ey.PH
abnormal size | somatic clone
abnormal size | third instar larval stage, with Scer\GAL4hh.PU
abnormal starvation stress response (with Pten5)
abnormal starvation stress response (with Ptendj189)
abnormal starvation stress response | adult stage, with Hsap\RELAAD.nSyb, Scer\GAL4DBD.AkhR
abnormal stress response (with Pten2L100)
abnormal stress response (with Pten117)
chemical resistant, with Scer\GAL4elav-C155
chemical resistant | adult stage | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B
decreased body size, with Scer\GAL4arm.PS
decreased cell number, with Scer\GAL4ap-md544
decreased cell number, with Scer\GAL4Bx-MS1096
decreased cell number, with Scer\GAL4dpp.blk1
decreased cell number, with Scer\GAL4en-e16E
decreased cell number | adult stage, with Scer\GAL4GMR.PF
decreased cell number | somatic clone | spermatogenesis
decreased cell number | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
decreased cell size, with Scer\GAL4ap-md544
decreased cell size, with Scer\GAL4Bx-MS1096
decreased cell size, with Scer\GAL4dpp.blk1
decreased cell size, with Scer\GAL4en-e16E
decreased cell size, with Scer\GAL4ppl.PP
decreased cell size | adult stage, with Scer\GAL4ey.PU
decreased cell size | adult stage, with Scer\GAL4nub.PU
decreased cell size | larval stage, with Scer\GAL4sns.PU
decreased cell size | somatic clone, with Scer\GAL4Act5C.PP
decreased occurrence of cell division | larval stage, with Scer\GAL4ey.PH
decreased occurrence of cell division | larval stage, with Scer\GAL4nab
decreased speed of aging, with Scer\GAL4Mhc.PW
decreased speed of aging, with Scer\GAL4UAS.cHa, Scer\GAL4tin.cBa
flightless (with Pten3)
flightless (with Pten5)
flightless (with Ptendj189)
flightless | progressive (with Pten1)
flightless | progressive (with Pten5)
hyperplasia | somatic clone
increased body size (with Pten2L100)
increased body size (with Pten117)
increased body size | adult stage (with Pten2L100)
increased body size | adult stage (with Pten117)
increased body size | larval stage (with Pten2L100)
increased body size | larval stage (with Pten117)
increased body size | larval stage | nutrition conditional (with Pten2L100)
increased body size | larval stage | nutrition conditional (with Pten117)
increased body size | male limited (with Pten1)
increased body size | male limited (with Pten5)
increased body size | pharate adult stage, with Scer\GAL4P0206
increased body size | pupal stage, with Scer\GAL4Tub.PU
increased body size | pupal stage (with Pten2L100)
increased body size | pupal stage (with Pten117)
increased body size | recessive | somatic clone
increased body size | second instar larval stage, with Scer\GAL4P0206
increased body size | somatic clone
increased body weight | adult stage (with Pten2L100)
increased body weight | adult stage (with Pten117)
increased cell death | adult stage, with Scer\GAL4byn-Gal4
increased cell death | larval stage, with Scer\GAL4GMR.PF
increased cell death | somatic clone
increased cell death | somatic clone | nutrition conditional
increased cell death | third instar larval stage, with Scer\GAL4en-e16E
increased cell growth rate
increased cell growth rate | nutrition conditional
increased cell growth rate | second instar larval stage | conditional
increased cell growth rate | somatic clone, with Scer\GAL4FRT.Rnor\Cd2.Act5C
increased cell number, with Scer\GAL4nub-AC-62
increased cell number (with Pten2L100)
increased cell number (with Pten117)
increased cell number | adult stage, with Scer\GAL4nub.PU
increased cell number | recessive | somatic clone
increased cell number | somatic clone
increased cell size (with Pten2L100)
increased cell size (with Pten117)
increased cell size | adult stage | somatic clone
increased cell size | recessive | somatic clone
increased cell size | somatic clone
increased cell size | somatic clone | third instar larval stage
increased cell size | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU
increased rate of movement | adult stage | nutrition conditional, with Hsap\RELAAD.nSyb, Scer\GAL4DBD.AkhR
increased size | spermatogenesis, with Scer\GAL4VP16.bam
increased size | third instar larval stage, with Scer\GAL4en-e16E
long lived, with Scer\GAL4Mhc.PW
long lived | RU486 conditional, with Scer\GAL4bun-Switch1.32
majority die during larval stage
neoplasia | adult stage | somatic clone, with Scer\GAL4repo.PU
short lived | RU486 conditional, with Scer\GAL4elav.Switch.PO
some die during first instar larval stage, with Scer\GAL4phtm.PO
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | partially, with Scer\GAL4P0206
some die during third instar larval stage (with Df(2L)flp170B)
visible
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4ci.PU
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4salm.PU
visible (with Df(2L)flp170B)
visible (with Pten1)
visible (with Pten5)
visible (with Ptendj189)
visible | adult stage
visible | adult stage, with Scer\GAL4en-e16E
visible | first instar larval stage, with Scer\GAL4hs.PB
visible | recessive | somatic clone
visible | somatic clone
wild-type
wild-type | RU486 conditional, with Scer\GAL4Switch1.106
Phenotype manifest in
Allele
abdominal dorsal adult muscle precursor cell | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
abdominal lateral adult muscle precursor cell | third instar larval stage, with Scer\GAL4E(spl)m6-BFM.PF
abdominal tracheal primordium 1 | germline clone | maternal effect
abdominal tracheal primordium 2 | germline clone | maternal effect
adult cuticle, with Scer\GAL4en.PU
adult head
adult head | somatic clone
adult head capsule | somatic clone
adult heart, with Scer\GAL4UAS.cHa, Scer\GAL4tin.cBa
adult hindgut | adult stage, with Scer\GAL4byn-Gal4
adult optic lobe | adult stage | somatic clone
cell cycle, with Scer\GAL4ey.PH
cell junction | pupal stage | heat sensitive, with Scer\GAL4en.PU, Scer\GAL80ts.αTub84B
chaeta | increased number, with Scer\GAL4pnr-MD237
crossvein | somatic clone
cyst cell of testis | somatic clone
cyst progenitor cell | somatic clone
dendrite | adult stage | somatic clone
dendrite | cell autonomous | somatic clone
dendrite | larval stage, with Scer\GAL4ppk.PG
distal medullary amacrine neuron Dm8 | adult stage | somatic clone
egg | germline clone | maternal effect
egg | maternal effect
embryo | blastoderm stage | germline clone | maternal effect
embryo | cleavage stage | germline clone | maternal effect
embryo | dorsal closure stage, with Scer\GAL4en.PU
embryo | dorsal closure stage, with Scer\GAL4αTub84B.PL
embryo | gastrula stage | germline clone | maternal effect
embryonic/first instar larval cuticle | first instar larval stage, with Scer\GAL4hs.PB
embryonic/larval corpus allatum, with Scer\GAL4P0206
embryonic/larval crystal cell | third instar larval stage, with Scer\GAL4kn-col85-GAL4
embryonic/larval fat body, with Scer\GAL4ppl.PP
embryonic/larval fat body | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval fat body | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PP
embryonic/larval garland cell | larval stage, with Scer\GAL4sns.PU
embryonic/larval midgut, with Scer\GAL4NP0001
embryonic/larval midgut | somatic clone, with Scer\GAL4Act5C.PP
embryonic/larval plasmatocyte | third instar larval stage, with Scer\GAL4kn-col85-GAL4
embryonic/larval salivary gland, with Scer\GAL429BD
embryonic/larval salivary gland | somatic clone, with Scer\GAL4Act5C.PP
embryonic leading edge cell, with Scer\GAL4en.PU
epithelial cell | pupal stage | heat sensitive, with Scer\GAL4en.PU, Scer\GAL80ts.αTub84B
epithelial cell | pupal stage | somatic clone
eye
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4eya.enh1+E+2
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4mirr-DE
eye (with Pten1)
eye (with Pten5)
eye (with Ptendj189)
eye | somatic clone
eye | somatic clone | nutrition conditional
eye disc, with Scer\GAL4ey.PH
eye disc, with Scer\GAL4GMR.PF
eye disc | somatic clone
eye disc | somatic clone | nutrition conditional
eye disc posterior compartment | larval stage, with Scer\GAL4ey.PH
eye photoreceptor cell, with Scer\GAL4GMR.PF
eye photoreceptor cell | somatic clone
fat body, with Scer\GAL4Lsp2.PH
fat body | nutrition conditional
glial cell | adult stage | somatic clone | increased number
glial cell | somatic clone
imaginal disc | nutrition conditional (with Pten2L100)
imaginal disc | nutrition conditional (with Pten117)
imaginal disc | somatic clone
imaginal disc | somatic clone | nutrition conditional
indirect flight muscle cell (with Pten1)
indirect flight muscle cell (with Pten5)
interommatidial bristle | P-stage
interommatidial bristle | somatic clone
interommatidial cell | adult stage
interommatidial cell | P-stage
interommatidial cell | somatic clone
larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone
larval fat cell | somatic clone | third instar larval stage
larval fat cell | somatic clone | third instar larval stage, with Scer\GAL4Tub.PU
larval neuroblast, with Scer\GAL4nab
lens, with Scer\GAL4GMR.PF
lipid droplet & larval oenocyte, with Scer\GAL4ppl.PP
lipid particle & nurse cell | somatic clone
mechanosensory neuron of posterior dorsocentral bristle, with Scer\GAL4pnr-MD237
mesonotum, with Scer\GAL4pnr-MD237
mesonotum | pupal stage | somatic clone, with Scer\GAL4FRT.Act5C
mesothoracic tracheal primordium | germline clone | maternal effect
metathoracic tracheal primordium | germline clone | maternal effect
mitochondrion (with Pten1)
mitochondrion (with Pten5)
muscle cell, with Scer\GAL4Mhc.PW
muscle cell of A1-7 dorsal acute muscle 1, with Scer\GAL4kirre.PU
neuron projection | adult stage, with Scer\GAL4pnr-MD237
NMJ bouton, with Ptendj189, Scer\GAL4C57
NMJ bouton, with PtenRNAi.Exel.UAS, Scer\GAL4C57
NMJ bouton, with Scer\GAL4C57
nurse cell & actin cytoskeleton | germ-line clone
nurse cell & nucleus | germ-line clone
nurse cell | germline clone
ommatidial precursor cluster | somatic clone
ommatidium, with Scer\GAL4ey.PH
ommatidium, with Scer\GAL4ey.PU
ommatidium, with Scer\GAL4GMR.PF
ommatidium (with Df(2L)flp170B)
ommatidium | adult stage
ommatidium | P-stage
ommatidium | somatic clone
ommatidium | somatic clone | nutrition conditional
photoreceptor neuron | adult stage, with Scer\GAL4GMR.PF
photoreceptor neuron | cell autonomous | somatic clone
photoreceptor neuron | somatic clone
pigment cell, with Scer\GAL4GMR.PF
posterior signaling center of lymph gland primary lobe | third instar larval stage, with Scer\GAL4kn-col85-GAL4
primordial germ cell | germline clone | maternal effect
prothoracic gland, with Scer\GAL4P0206
puparium cuticle, with Scer\GAL4P0206
rhabdomere, with Scer\GAL4GMR.PF
rhabdomere | cell autonomous | somatic clone
rhabdomere | somatic clone
segment border muscle cell, with Scer\GAL4kirre.PU
slit diaphragm | decreased number | larval stage, with Scer\GAL4sns.PU
spermatocyte, with Scer\GAL4VP16.bam
synapse | adult stage, with Scer\GAL4pnr-MD237
tertiary pigment cell | P-stage
tracheal primordium | ectopic | germline clone | maternal effect
tracheal primordium | germline clone | maternal effect
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4ci.PU
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4en.PU
wing, with Scer\GAL4en-e16E
wing, with Scer\GAL4nub.PU
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4P0206
wing, with Scer\GAL4salm.PU
wing (with Pten1)
wing (with Pten5)
wing & cell | somatic clone
wing | nutrition conditional
wing | pupal stage
wing | pupal stage | heat sensitive, with Scer\GAL4en.PU, Scer\GAL80ts.αTub84B
wing | pupal stage | somatic clone
wing | somatic clone
wing blade, with Scer\GAL4ap-md544
wing blade dorsal compartment, with Scer\GAL4ap-md544
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc
wing disc | third instar larval stage, with Scer\GAL4en-e16E
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en-e16E
wing disc posterior compartment | third instar larval stage, with Scer\GAL4hh.PU
wing hair, with Scer\GAL4e16A
wing hair | ectopic | somatic clone
wing margin bristle | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (25)
Hsap\PTEN
13 of 14
Yes
Yes
 
103  
Hsap\TPTE2
6 of 14
No
Yes
Hsap\TPTE
6 of 14
No
Yes
Hsap\DNAJC6
2 of 14
No
No
1  
Hsap\GAK
2 of 14
No
No
2  
Hsap\TNS1
2 of 14
No
No
Hsap\TNS2
2 of 14
No
No
Hsap\TNS3
2 of 14
No
No
Hsap\CDC14A
1 of 14
No
No
Hsap\CDC14B
1 of 14
No
No
Hsap\CDC14C
1 of 14
No
No
Hsap\CDKN3
1 of 14
No
No
Hsap\DUSP11
1 of 14
No
No
Hsap\DUSP23
1 of 14
No
No
Hsap\PTP4A1
1 of 14
No
No
3  
Hsap\PTP4A2
1 of 14
No
No
2  
Hsap\PTP4A3
1 of 14
No
No
2  
Hsap\PTPDC1
1 of 14
No
No
Hsap\PTPMT1
1 of 14
No
No
3  
Hsap\PTPN12
1 of 14
No
No
Hsap\PTPRB
1 of 14
No
No
Hsap\PTPRD
1 of 14
No
No
Hsap\PTPRF
1 of 14
No
No
2  
Hsap\PTPRS
1 of 14
No
No
Hsap\RNGTT
1 of 14
No
No
6  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Pten
13 of 14
Yes
Yes
Rnor\Tpte2
6 of 14
No
Yes
Rnor\Gak
2 of 14
No
No
Rnor\Tns1
2 of 14
No
No
Rnor\Tns3
2 of 14
No
No
Rnor\Cdc14a
1 of 14
No
No
Rnor\Cdc14b
1 of 14
No
No
Rnor\Cdkn3
1 of 14
No
No
Rnor\Dnajc6
1 of 14
No
No
Rnor\Dusp11
1 of 14
No
No
Rnor\Dusp13
1 of 14
No
No
Rnor\Dusp23
1 of 14
No
No
Rnor\Ptp4a1
1 of 14
No
No
Rnor\Ptp4a2
1 of 14
No
No
Rnor\Ptp4a3
1 of 14
No
No
Rnor\Ptpdc1
1 of 14
No
No
Rnor\Ptpmt1
1 of 14
No
No
Rnor\Ptprd
1 of 14
No
No
Rnor\Ptprs
1 of 14
No
No
Rnor\Rngtt
1 of 14
No
No
Rnor\Tns2
1 of 14
No
No
Mus musculus (laboratory mouse) (19)
Mmus\Pten
13 of 14
Yes
Yes
Mmus\Tpte
6 of 14
No
Yes
Mmus\Dnajc6
2 of 14
No
No
Mmus\Gak
2 of 14
No
No
Mmus\Tns1
2 of 14
No
No
Mmus\Tns2
2 of 14
No
No
Mmus\Tns3
2 of 14
No
No
Mmus\Cdc14a
1 of 14
No
No
Mmus\Cdc14b
1 of 14
No
No
Mmus\Dusp11
1 of 14
No
No
Mmus\Dusp23
1 of 14
No
No
Mmus\Ptp4a1
1 of 14
No
No
Mmus\Ptp4a2
1 of 14
No
No
Mmus\Ptp4a3
1 of 14
No
No
Mmus\Ptpdc1
1 of 14
No
No
Mmus\Ptpmt1
1 of 14
No
No
Mmus\Ptprd
1 of 14
No
No
Mmus\Ptprs
1 of 14
No
No
Mmus\Rngtt
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\pten
10 of 13
Yes
Yes
Xtro\tpte2
3 of 13
No
Yes
Xtro\cdc14b
1 of 13
No
No
Xtro\dusp11.2
1 of 13
No
No
Xtro\LOC108645586
1 of 13
No
No
Xtro\ptp4a1
1 of 13
No
No
Xtro\ptp4a2
1 of 13
No
No
Xtro\tns2
1 of 13
No
No
Xtro\tns3
1 of 13
No
No
Xtro\trpc3
1 of 13
No
Yes
Xtro\yeats2
1 of 13
No
No
Danio rerio (Zebrafish) (26)
Drer\ptenb
12 of 14
Yes
Yes
Drer\ptena
11 of 14
No
Yes
Drer\tpte
5 of 14
No
Yes
Drer\dnajc6
2 of 14
No
No
Drer\tns1a
2 of 14
No
No
Drer\tns1b
2 of 14
No
No
Drer\cdc14aa
1 of 14
No
No
Drer\cdc14ab
1 of 14
No
No
Drer\cdc14b
1 of 14
No
No
Drer\cdkn3
1 of 14
No
No
Drer\dusp11
1 of 14
No
No
Drer\dusp23a
1 of 14
No
No
Drer\dusp23b
1 of 14
No
No
Drer\gak
1 of 14
No
No
Drer\ptp4a1
1 of 14
No
No
Drer\ptp4a2a
1 of 14
No
No
Drer\ptp4a2b
1 of 14
No
No
Drer\ptp4a3a
1 of 14
No
No
Drer\ptp4a3b
1 of 14
No
No
Drer\ptpdc1a
1 of 14
No
No
Drer\ptpdc1b
1 of 14
No
No
Drer\ptprsa
1 of 14
No
No
Drer\rngtt
1 of 14
No
No
Drer\tns2a
1 of 14
No
No
Drer\tns2b
1 of 14
No
No
Drer\zgc:77752
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\daf-18
8 of 14
Yes
Yes
Cele\C16A3.2
1 of 14
No
No
Cele\C33H5.16
1 of 14
No
No
Cele\cdc-14
1 of 14
No
No
Cele\cel-1
1 of 14
No
No
Cele\F47B3.7
1 of 14
No
No
Cele\F54C8.4
1 of 14
No
No
Cele\F54F12.1
1 of 14
No
No
Cele\K07F5.8
1 of 14
No
No
Cele\pir-1
1 of 14
No
No
Cele\ptp-3
1 of 14
No
No
Cele\T12B3.1
1 of 14
No
No
Cele\T19D2.2
1 of 14
No
No
Cele\tns-1
1 of 14
No
No
Cele\W03F11.4
1 of 14
No
Yes
Cele\ZK484.7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (11)
Agam\AgaP_AGAP009628
6 of 12
Yes
Yes
Agam\AgaP_AGAP003715
2 of 12
No
No
Agam\AgaP_AGAP000492
1 of 12
No
No
Agam\AgaP_AGAP000617
1 of 12
No
No
Agam\AgaP_AGAP001678
1 of 12
No
No
Agam\AgaP_AGAP005142
1 of 12
No
No
Agam\AgaP_AGAP008708
1 of 12
No
No
Agam\AgaP_AGAP010090
1 of 12
No
No
Agam\AgaP_AGAP010093
1 of 12
No
No
Agam\AgaP_AGAP011155
1 of 12
No
No
Agam\AgaP_AGAP012237
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\PEN2
8 of 13
Yes
Yes
Atha\PEN3
8 of 13
Yes
Yes
Atha\PTEN1
7 of 13
No
Yes
Atha\AFH14
1 of 13
No
No
Atha\AT2G25050
1 of 13
No
No
Atha\AT3G09100
1 of 13
No
No
Atha\AT5G01290
1 of 13
No
No
Atha\AT5G07740
1 of 13
No
No
Atha\AT5G28210
1 of 13
No
No
Atha\AT5G58160
1 of 13
No
No
Atha\MKP2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\TEP1
9 of 13
Yes
Yes
Scer\CDC14
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\ptn1
8 of 12
Yes
Yes
Spom\clp1
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pten. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
aux
2 of 13
Cdc14
1 of 13
CG7378
1 of 13
CG13197
1 of 13
Lar
1 of 13
mRNA-cap
1 of 13
PRL-1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 9 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 4 )
Allele
Disease
Interaction
References
PtenUAS.cUa
ameliorates  brain glioma
modeled by btl::Egfrλ.UAS, Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS)
(Read et al., 2009)
exacerbates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.cBa
(Hwang et al., 2019)
ameliorates  Huntington's disease
modeled by Hsap\HTTN548.Q128.UAS
(Martin et al., 2021)
PtenUAS.cGb
ameliorates  Alzheimer's disease 1
modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
(Chiang et al., 2010)
PtenGD13500
exacerbates  cancer
modeled by MycUAS.cZa, p53RNAi.UAS.RasG12D
(Diaz et al., 2024)
PtenKK109278
ameliorates  chromosome 16p11.2 deletion syndrome, 593-kb
modeled by Pp4-19CGD9561
(Iyer et al., 2018)
model of  cancer
is ameliorated by CG10565KK102428
(Parniewska and Stocker, 2020)
is ameliorated by GirdinKK101725
(Parniewska and Stocker, 2020)
is exacerbated by B52KK108253
(Parniewska and Stocker, 2020)
is ameliorated by Mo25GD11213
(Parniewska and Stocker, 2020)
is ameliorated by OsbpKK107784
(Parniewska and Stocker, 2020)
is ameliorated by S6kKK107986
(Parniewska and Stocker, 2020)
is ameliorated by SF2GD12097
(Parniewska and Stocker, 2020)
is ameliorated by SF2HM05199
(Parniewska and Stocker, 2020)
is ameliorated by SF2HMS00358
(Parniewska and Stocker, 2020)
is exacerbated by Srp54GD10663
(Parniewska and Stocker, 2020)
is ameliorated by SlikGD11338
(Parniewska and Stocker, 2020)
is ameliorated by SRPKKK100641
(Parniewska and Stocker, 2020)
is ameliorated by Vha100-1KK105748
(Parniewska and Stocker, 2020)
is ameliorated by brpKK108677
(Parniewska and Stocker, 2020)
is ameliorated by chicoKK107581
(Parniewska and Stocker, 2020)
is ameliorated by mib1GD11786
(Parniewska and Stocker, 2020)
is ameliorated by cicKK112641
(Parniewska and Stocker, 2020)
is ameliorated by maskKK100529
(Parniewska and Stocker, 2020)
is ameliorated by tra2KK108747
(Parniewska and Stocker, 2020)
is ameliorated by ttvGD1993
(Parniewska and Stocker, 2020)
is ameliorated by zfh1KK109931
(Parniewska and Stocker, 2020)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PTEN; phosphatase and tensin homolog
13 of 14
601728
 
TPTE2; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
6 of 14
606791
      TPTE; transmembrane phosphatase with tensin homology
      6 of 14
      604336
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Dmel gene
          Ortholog showing functional complementation
          Supporting References
          Pten
          Hsap\PTEN
          (Ganguly et al., 2021)
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please see the Physical Interaction reports below for full details
          protein-protein
          Physical Interaction
          Assay
          References
          Pten - 14-3-3ζ
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - AGO2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Acc
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - AspRS-m
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Bap111
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Brr2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CCT1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG10333
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG13185
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG15099
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG15784
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG2691
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG30122
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CG8939
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - CaMKII
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Caf1-55
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Cand1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Cpsf6
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Gnf1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Gp150
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - HDAC1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - HUWE1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - His3:CG31613
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - HnRNP-K
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Hsc70-3
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - MEP-1
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Nup107
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Nup358
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Nup98-96
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Prp8
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - RanGAP
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Rm62
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - RpS14a
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - RpS7
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Rpt2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - ScsβA
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Syp
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Tep4
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - Uggt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - alt
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - ana2
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - baz
          anti tag coimmunoprecipitation, anti tag western blot, two hybrid
          (von Stein et al., 2005)
          Pten - eIF3a
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - eIF3c
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - eIF3e
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - eIF3m
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - faf
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - gw
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - kst
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - larp
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - lva
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - mRpL12
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - msk
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - ncd
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - ncm
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - poe
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - puf
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - sta
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - wal
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Pten - α-Spec
          anti tag coimmunoprecipitation, Identification by mass spectrometry
          (Vinayagam et al., 2016)
          Summary of Genetic Interactions
          Interaction Browsers
          View in FlyBase Interactions Browser   View in MIST tool (external link)
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Pten
          suppressible
          Acn
          (Haberman et al., 2010)
          Pten
          suppressible
          Akt
          (Mensah et al., 2015, Nowak et al., 2013, Vereshchagina et al., 2008, Pinal et al., 2006, Stocker et al., 2002, Gao et al., 2000)
          Ras85D|Pten
          enhanceable
          Apc
          (Bangi et al., 2016)
          Pten
          suppressible
          Atg1
          (Denton et al., 2012)
          Pten
          suppressible
          Atg18a
          (Denton et al., 2012)
          Pten
          suppressible
          babo
          (Luo et al., 2020)
          Pten
          suppressible
          bsk
          (Nowak et al., 2013)
          Pten
          enhanceable
          btl::Egfr
          (Read et al., 2009)
          Pten
          suppressible
          Buffy
          (Mensah et al., 2015)
          Pten
          enhanceable
          chico
          (Huang et al., 1999)
          Pten
          suppressible
          chico
          (Huang et al., 1999)
          Pten
          enhanceable
          DJ-1α
          (Kim et al., 2005)
          Pten
          suppressible
          DJ-1α
          (Aron et al., 2010)
          Pten
          suppressible
          dj-1β
          (Aron et al., 2010)
          Pten
          suppressible
          dx
          (Aradhya et al., 2015)
          Pten
          enhanceable
          Egfr
          (Read et al., 2009)
          Pten
          suppressible
          eIF4A
          (Gao et al., 2000)
          Pten
          suppressible
          FASN1
          (Devilliers et al., 2021)
          Pten
          suppressible
          foxo
          (Junger et al., 2003)
          Ras85D|Apc|p53|Pten
          enhanceable
          gig
          (Bangi et al., 2016)
          Pten
          suppressible
          hppy
          (Resnik-Docampo and de Celis, 2011)
          Pten
          suppressible
          Hr3
          (Montagne et al., 2010)
          Pten
          suppressible
          Ilp2
          (Nowak et al., 2013)
          Pten|mTor
          enhanceable
          ImpL2
          (Nowak et al., 2013)
          Pten
          enhanceable
          ImpL2
          (Nowak et al., 2013)
          Pten
          suppressible
          InR
          (Nowak et al., 2013)
          Pten
          suppressible
          Ldh
          (Devilliers et al., 2021)
          Pten
          suppressible
          lilli
          (Wittwer et al., 2001)
          Pten
          suppressible
          mTor
          (Mensah et al., 2015, Nowak et al., 2013, Oldham et al., 2000)
          Pten|Ras85D
          suppressible
          p53
          (Bangi et al., 2016)
          Pten
          suppressible
          Pdha1
          (Devilliers et al., 2021)
          Pten
          suppressible
          Pfk
          (Devilliers et al., 2021)
          Pten
          suppressible
          Pi3K92E
          (Malin et al., 2024, Yuen et al., 2021, Sun et al., 2020, Gao et al., 2000, Goberdhan et al., 1999, Huang et al., 1999)
          Pten
          enhanceable
          Pi3K92E
          (Gao et al., 2000, Huang et al., 1999)
          Pten
          suppressible
          PRL-1
          (Urwyler et al., 2019)
          Pten
          suppressible
          Pyk
          (Devilliers et al., 2021)
          Pten
          suppressible
          Rac1
          (Pickering et al., 2013)
          Pten
          enhanceable
          Ras85D
          (Read et al., 2009)
          Pten
          suppressible
          Ret
          (Aron et al., 2010)
          Pten
          enhanceable
          Rheb
          (Devilliers et al., 2021)
          Pten
          suppressible
          Rheb
          (Mensah et al., 2015)
          Pten
          suppressible
          rictor
          (Hietakangas and Cohen, 2007)
          Pten
          suppressible
          Rok
          (Bardet et al., 2013)
          Pten
          suppressible
          Rtca
          (Song et al., 2015)
          Pten
          suppressible
          S6k
          (Montagne et al., 2010)
          Apc|p53|Ras85D|Pten
          suppressible
          sc
          (Quintero and Bangi, 2023)
          Pten
          enhanceable
          Sesn
          (Lee et al., 2010)
          Pten
          enhanceable
          sev
          (Luo et al., 2020)
          Pten
          suppressible
          slif
          (Nowak et al., 2013)
          Pten
          enhanceable
          slif
          (Nowak et al., 2013)
          Pten
          suppressible
          Smox
          (Hevia et al., 2017)
          Pten|Ras85D
          suppressible
          Tep1
          (Gangwani et al., 2020)
          Pten|Ras85D
          suppressible
          Tep1|yki
          (Gangwani et al., 2020)
          Apc|p53|Ras85D|Pten
          suppressible
          Tk
          (Quintero and Bangi, 2023)
          Apc|p53|Ras85D|Pten
          suppressible
          TkR99D
          (Quintero and Bangi, 2023)
          Pten
          suppressible
          trbl
          (Das et al., 2014)
          Pten
          suppressible
          Tsc1
          (Nowak et al., 2013)
          Ras85D|Apc|p53|Pten
          enhanceable
          Tsc1
          (Bangi et al., 2016)
          Pten
          suppressible
          Tsc1|gig
          (Nowak et al., 2013, Vereshchagina et al., 2008)
          Pten
          suppressible
          wdb
          (Vereshchagina et al., 2008)
          Pten|Ras85D
          suppressible
          yki
          (Gangwani et al., 2020)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Apc|p53|Ras85D
          suppressible
          Pten
          (Quintero and Bangi, 2023)
          Atg1
          suppressible
          Pten
          (Denton et al., 2012)
          Atg18a
          suppressible
          Pten
          (Denton et al., 2012)
          btl::Egfr
          enhanceable
          Pten
          (Read et al., 2009)
          Cul1
          suppressible
          Pten
          (Wong et al., 2013)
          DJ-1α
          enhanceable
          Pten
          (Yang et al., 2005)
          EcR
          suppressible
          Pten
          (Rusten et al., 2004)
          Egfr
          enhanceable
          Pten
          (Read et al., 2009)
          egh
          suppressible
          Pten
          (Dahlgaard et al., 2012)
          egr
          enhanceable
          Pten
          (Tsuda et al., 2010)
          foxo
          suppressible
          Pten
          (Nowak et al., 2013)
          Ide
          suppressible
          Pten
          (Galagovsky et al., 2014)
          InR
          suppressible
          Pten
          (Oldham et al., 2002, Huang et al., 1999)
          lilli
          suppressible
          Pten
          (Wittwer et al., 2001)
          mTor
          suppressible
          Pten
          (Devilliers et al., 2021)
          parvin
          suppressible
          Pten
          (Chountala et al., 2012)
          Pi3K21B
          suppressible
          Pten
          (Oldham et al., 2002)
          Pi3K92E
          enhanceable
          Pten
          (Gao et al., 2000)
          Pi3K92E
          suppressible
          Pten
          (Goberdhan et al., 1999)
          Pi3K92E|Arf1
          suppressible
          Pten
          (Khadilkar et al., 2014)
          Pi3K92E|btl::Egfr
          suppressible
          Pten
          (Read et al., 2009)
          POSH|egr
          suppressible
          Pten
          (Tsuda et al., 2010)
          Rac1
          suppressible
          Pten
          (Malin et al., 2024)
          Ras85D
          enhanceable
          Pten|Apc|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Pten|Apc|Med|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Pten|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Pten|Med|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Pten|Apc|Med
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Pten
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Pten
          (Bangi et al., 2016, Read et al., 2009)
          Ras85D
          suppressible
          Pten|p53
          (Bangi et al., 2016)
          Ras85D
          enhanceable
          Pten|Apc
          (Bangi et al., 2016)
          Ras85D
          suppressible
          Pten|Apc|p53
          (Bangi et al., 2016)
          Ras85D|dlg1
          suppressible
          Pten
          (Willecke et al., 2011)
          Ras85D|Apc
          suppressible
          Pten|p53
          (Bangi et al., 2016)
          Ras85D|Apc
          enhanceable
          Pten
          (Bangi et al., 2016)
          Rheb
          suppressible
          Pten
          (Stocker et al., 2003)
          Rheb
          enhanceable
          Pten
          (Devilliers et al., 2021)
          Rtca
          suppressible
          Pten
          (Song et al., 2015)
          Smox
          suppressible
          Pten
          (Hevia et al., 2017)
          Tsc1|gig
          enhanceable
          Pten
          (Tapon et al., 2001)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2L
          Recombination map
          2-40
          Cytogenetic map
          31B1-31B1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          31B1-31B1
          Limits computationally determined from genome sequence between P{lacW}me31Bk06607 and P{PZ}nmd08774
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          31B-31C
          (Goberdhan, 1999.11.4)
          31C-31D
          (Tao, 1999.4.19)
          31A1-31D6
          (Smith, 1999.6.23)
          31B-31C
          (determined by in situ hybridisation)
          (Wilson, 1999.3.4)
          Experimentally Determined Recombination Data
          Location

          2-40

          (FlyBase, 2016)

          2-34.8

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (24)
          Genomic Clones (26)
          cDNA Clones (27)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Ramachandran et al., 2009)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
          Other Stable Cell Lines
           
            Other Comments

            dsRNA has been made from templates generated with primers directed against this gene.

            (Frias et al., 2006)

            dsRNA made from templates generated with primers directed against this gene results in an increase in mean cell diameter.

            (Guertin et al., 2006)

            dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.

            (Yang et al., 2006)

            dsRNA made from templates generated with primers directed against this gene increase the levels of phosphorylation of boh Akt1 and S6k in S2 cells.

            (Yang et al., 2006)

            One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

            (Inlow and Restifo, 2004)

            PI3K activity is regulated through EcR signalling in a cell-autonomous manner to allow programmed autophagy in the fat body.

            (Rusten et al., 2004)

            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

            (Kiger et al., 2003)

            RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells - they become round and detached. The Kc167 cell-shape change is suppressed by simultaneous treatment with dsRNA targetted against Akt1, CG31187, LIMK1, MAPk-Ak2, Pi3K92E, slpr or wee.

            (Kiger et al., 2003)

            Pten plays an essential role in the control of, cell size, cell number, and organ size.

            (Gao et al., 2000)

            Pten acts antagonistically to Pi3K92E and chico. In direction of increasing cytology: chico- bsk- Ror+ Pten-

            (Goberdhan et al., 1999)

            Pten has a complex role in regulating tissue and body size. Pten regulates the subcellular organization of the actin cytoskeleton in multiple cell types.

            (Goberdhan et al., 1999)

            Both inactivation and overexpression of Pten affect cell size, and overexpression of Pten inhibits cell cycle progression at early mitosis and promotes cell death during eye development. Phenotypes caused by overexpression of Hsap\PTEN and Pten are indistinguishable.

            (Huang et al., 1999)

            The phosphatase activity of Pten is necessary for it to exert its functions during development. In direction of increasing cytology: Rsf1+ Pten+ CG5676+ Ror- bsk+ chico+

            (Huang et al., 1999)

            Pten acts in the insulin signalling pathway. All signals from the InR protein can be antagonized by Pten.

            (Huang et al., 1999)

            Pten regulates cell size and cell proliferation via the actin cytoskeleton.

            (Wilson et al., 1999)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Pten CG5671

            (Bayraktaroglu, 2000.4.13)
            Additional comments
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (18)
            Reported As
            Symbol Synonym
            CG5671
            (National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Caizzi et al., 2016, Balakrishnan et al., 2015, Hosono et al., 2015, Schertel et al., 2013, Howell et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Goldstein and Gunawardena, 2000, Morrison et al., 2000)
            D.PTEN
            (Jones and Srivastava, 2014)
            DPTEN
            (Partridge et al., 2005, Claeys et al., 2002, Goberdhan and Wilson, 2002, Goberdhan and Wilson, 2002, Towers and Sattelle, 2002, Clemens et al., 2000, Coelho and Leevers, 2000, Potter et al., 2000, Scanga et al., 2000, Goberdhan et al., 1999, Smith et al., 1999, Wilson et al., 1999)
            PTEN
            (Reimels et al., 2024, Banach-Latapy et al., 2023, Frappaolo and Giansanti, 2023, Ikawa et al., 2023, Koehler and Huber, 2023, Krejčová et al., 2023, Buckley and St Johnston, 2022, Jarabo et al., 2022, Noguchi et al., 2022, Nogueira Alves et al., 2022, Alvarez-Ochoa et al., 2021, Gautam et al., 2021, Lam Wong and Verheyen, 2021, Yu and Hyun, 2021, Barretto et al., 2020, Coelho, 2020, Jossin, 2020, Luo et al., 2020, Rambur et al., 2020, Sudhakar et al., 2020, Yuan et al., 2020, Borreguero-Muñoz et al., 2019, Galenza and Foley, 2019, Hwang et al., 2019, Lang et al., 2019, Mondin et al., 2019, Rosen et al., 2019, Shadkhoo and Mani, 2019, Ahmad et al., 2018, Ghiglione et al., 2018, Gruntenko and Rauschenbach, 2018, Inoue et al., 2018, Muñoz-Soriano et al., 2018, Parvy et al., 2018, Pichaud, 2018, Poon et al., 2018, Richardson and Portela, 2018, Spéder and Brand, 2018, Swevers et al., 2018, Brace and DiAntonio, 2017, Misra et al., 2017, Moeller et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Paglia et al., 2017, Romero-Pozuelo et al., 2017, Chang et al., 2016, Cheng et al., 2016, Hemalatha et al., 2016, Kaynar et al., 2016, Marmor-Kollet and Schuldiner, 2016, Yadav et al., 2016, Aradhya et al., 2015, Bennett et al., 2015, Nässel et al., 2015, Devergne et al., 2014, Oliveira et al., 2014, Pichaud, 2014, Radermacher et al., 2014, Wang et al., 2014, Andersen et al., 2013, Chen and Zhang, 2013, Hwang et al., 2013, Koyama et al., 2013, Nowak et al., 2013, Okamoto et al., 2013, Oortveld et al., 2013, Shim et al., 2013, Sim and Denlinger, 2013, Tran et al., 2013, Wong et al., 2013, Yin et al., 2013, Chountala et al., 2012, Dahlgaard et al., 2012, Denton et al., 2012, Eleftherianos and Castillo, 2012, Gault et al., 2012, Lv et al., 2012, Ogmundsdóttir et al., 2012, Tepass, 2012, Bangi et al., 2011, Friedman et al., 2011, Laprise and Tepass, 2011, Miles et al., 2011, Nakajima et al., 2011, Oldham, 2011, Park et al., 2011, Partridge et al., 2011, Poon et al., 2011, Read, 2011, Resnik-Docampo and de Celis, 2011, Tang et al., 2011, Yang and Xu, 2011, Delanoue et al., 2010, Lee et al., 2010, Mesquita et al., 2010, Montagne et al., 2010, Tsuda et al., 2010, Tsuda et al., 2010, Géminard et al., 2009, Ikeya et al., 2009, Ninov et al., 2009, Nuzhdin et al., 2009, Read et al., 2009, Shelly et al., 2009, Werz et al., 2009, Bakal et al., 2008, Honegger et al., 2008, Howlett et al., 2008, Lee et al., 2008, Mattila et al., 2008, Rafel and Milán, 2008, Seisenbacher et al., 2008, Vereshchagina et al., 2008, Basu and Krek, 2007, Bergman et al., 2007, Cortina-Andrada et al., 2007, Gutierrez et al., 2007, Hall et al., 2007, Hietakangas and Cohen, 2007, Hoshizaki and Gibbs, 2007, Jovceva et al., 2007, Juhász et al., 2007, Libert, 2007, Palmer and Pichaud, 2007, Tyler et al., 2007, Wilson et al., 2007, Betschinger et al., 2006, Edgar, 2006, Edgar, 2006, Fehon, 2006, Frias et al., 2006, Frias et al., 2006, Guertin et al., 2006, Lindmo et al., 2006, Pinal et al., 2006, Shiojima and Walsh, 2006, Vereshchagina and Wilson, 2006, Cygnar et al., 2005, McNeill and Bateman, 2005, Mikeladze-Dvali et al., 2005, Mirth et al., 2005, Shingleton, 2005, Bilder, 2004, Clague et al., 2004, Pan et al., 2004, Scott et al., 2004, Scott et al., 2004, von Stein et al., 2004, Hardie, 2003, von Stein et al., 2003, Gao et al., 2002, Neufeld, 2001.1.11, Oldham et al., 2001, Potter et al., 2000, Scanga et al., 2000, Weinkove and Leevers, 2000, Wilson et al., 2000, Smith, 1999.6.23, Smith, 1999.6.23, Smith, 1999.6.23)
            PTEN3
            (Goldstein and Gunawardena, 2000)
            Pten
            (Sánchez-Sánchez et al., 2025, Barbaste et al., 2023, Hou et al., 2023, Dalton et al., 2022, Ecovoiu et al., 2022, Li et al., 2022, Lu et al., 2022, Raghu, 2022.1.6, Zhou et al., 2022, Zipper et al., 2022, Anqueira-González et al., 2021, Aromolaran et al., 2021, Azuma et al., 2021, Bilder et al., 2021, García-López et al., 2021, Gong et al., 2021, Han et al., 2021, Kim and O'Connor, 2021, Liguori et al., 2021, Ostalé et al., 2021, Parkhitko et al., 2021, Salim et al., 2021, Yuen et al., 2021, Zhou et al., 2021, Allen et al., 2020, Cui et al., 2020, Gangwani et al., 2020, Gupta and Stocker, 2020, Luo et al., 2020, Morata and Calleja, 2020, Parniewska and Stocker, 2020, Singh et al., 2020, Strilbytska et al., 2020, Sun et al., 2020, Vega-Cuesta et al., 2020, Yusuff et al., 2020, Zeng et al., 2020, Birnbaum et al., 2019, Brodskiy et al., 2019, Chen and Read, 2019, Fahey-Lozano et al., 2019, Hall et al., 2019, Hunt et al., 2019, Hwang et al., 2019, Lattner et al., 2019, Luhur et al., 2019, Pfeifle et al., 2019, Zheng, 2019.3.1, Ayala et al., 2018, Kang et al., 2018, Nowak et al., 2018, Tang et al., 2018, Villegas et al., 2018, Viswanatha et al., 2018, Wang et al., 2018, Fedina et al., 2017, Hevia et al., 2017, Mensah et al., 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Di Cara and King-Jones, 2016, Padash Barmchi et al., 2016, Pan et al., 2016, Schmid et al., 2016, Vinayagam et al., 2016, Xu et al., 2016, Grotewiel and Bettinger, 2015, Hatzihristidis et al., 2015, Jia et al., 2015, Kwon et al., 2015, Mensah et al., 2015, Park et al., 2015, Song et al., 2015, Sopko et al., 2015, Tokusumi et al., 2015, Das et al., 2014, Khadilkar et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Wang et al., 2014, Carter, 2013, Dobens and Dobens, 2013, Heigwer et al., 2013, Pickering et al., 2013, Pomerantz and Blau, 2013, Rousso et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Howell et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Justiniano et al., 2012, Kuo et al., 2012, Marinari et al., 2012, Papatheodorou et al., 2012, Pircs et al., 2012, Song et al., 2012, Tokusumi et al., 2012, Zhai et al., 2012, Djiane et al., 2011, Eddison et al., 2011, Lindquist et al., 2011, Sousa-Nunes et al., 2011, Willecke et al., 2011, Demontis and Perrimon, 2010, Haberman et al., 2010, Kim et al., 2010, Lee et al., 2010, Nedelsky et al., 2010, Sinenko et al., 2010, Zheng and Sehgal, 2010, Alvarez-Ponce et al., 2009, Demontis and Perrimon, 2009, Doumanis et al., 2009, Mirth et al., 2009, Mummery-Widmer et al., 2009, Parrish et al., 2009, Qian and Bodmer, 2009, Rhiner et al., 2009, Sims et al., 2009, Hou et al., 2008, Yin et al., 2008, Zhou et al., 2008, Chen et al., 2007, Ford et al., 2007, Knox et al., 2007, Friedman and Perrimon, 2006, Wiggin et al., 2005, Bruckner et al., 2004, Wheeler et al., 2004)
            dPTEN
            (Antonica et al., 2022, Weina et al., 2022, Biglou et al., 2021, Millet-Boureima et al., 2021, Miller et al., 2020, Álvarez-Rendón et al., 2018, Otsuki and Brand, 2018, Jouette et al., 2017, Mathew et al., 2017, Zhu et al., 2017, Altintas et al., 2016, Balakrishnan et al., 2015, Chen et al., 2015, Kannan and Fridell, 2013, Neckameyer and Argue, 2013, Montagne et al., 2010, Read et al., 2009, Honegger et al., 2008, Kim et al., 2008, Porstmann et al., 2008, DiAngelo and Birnbaum, 2007, Song et al., 2007, DiAngelo and Birnbaum, 2006, Yang et al., 2006, Yang et al., 2006, Cavaliere et al., 2005, Dekanty et al., 2005, Findlay et al., 2005, Gao et al., 2005, Kim et al., 2005, Sarbassov et al., 2005, Trotta et al., 2005, Wu et al., 2005, Kim et al., 2004, Maehama et al., 2004, Wessells et al., 2004, Junger et al., 2003, Lizcano et al., 2003, Miron et al., 2003, Oldham and Hafen, 2003, Raisin et al., 2003, Szuplewski et al., 2003, Britton et al., 2002, Burgering and Kops, 2002, Kozma and Thomas, 2002, Marygold and Leevers, 2002, Oldham et al., 2002, Prober and Edgar, 2002, Radimerski et al., 2002, Stocker et al., 2002, Downward and Leevers, 2001, Gingras et al., 2001, Jin et al., 2001, Potter et al., 2001, Rintelen et al., 2001, Gao et al., 2000, Stocker and Hafen, 2000, Zhang et al., 2000, Huang et al., 1999)
            dPten
            (Hong et al., 2016, Wittwer et al., 2005)
            dpten
            (Constantinou et al., 2016, Chiang et al., 2010, Ma et al., 2008)
            pTEN
            (Canales Coutiño et al., 2020)
            pten
            (Datta and Bangi, 2024, Datta et al., 2023, Li et al., 2023, Quintero and Bangi, 2023, Hu et al., 2022, Jiang et al., 2022, Yamamura et al., 2021, Denton et al., 2020, Sun et al., 2020, Kim and Choi, 2019, Enomoto et al., 2018, Bangi et al., 2016, Hirabayashi, 2016, Iyer et al., 2016, Levayer et al., 2015, Parker and Struhl, 2015, Zaessinger et al., 2015, Claret et al., 2014, Claret et al., 2014, Bardet et al., 2013, Newquist et al., 2013, Hafezi et al., 2012, Killip and Grewal, 2012, Murray et al., 2012, Wang et al., 2012, Portela et al., 2010, Ramachandran et al., 2009, Wang et al., 2009, McNeill et al., 2008, Menut et al., 2007, Bateman and McNeill, 2004, Lee and Orr-Weaver, 2003)
            Name Synonyms
            Drosophila phosphatase and tensin homologue deleted on chromosome 10
            (Lizcano et al., 2003)
            PI 3-phosphatase
            (Hardie, 2003)
            PTEN
            (Hall et al., 2007)
            Phosphatase and tensin homolog
            Phosphatase and tensin homologue
            (Lee et al., 2008)
            PtdIns(3,4,5)P3 phosphatase
            (Jovceva et al., 2007)
            Pten
            (Justiniano et al., 2012, Mummery-Widmer et al., 2009, Zhou et al., 2008)
            phosphatase and tensin homolog
            (Koyama et al., 2013, Chiang et al., 2010, Lee et al., 2010)
            phosphatidylinositol (3,4,5)-trisphosphate phosphatase
            (Jovceva et al., 2007)
            Secondary FlyBase IDs
            • FBgn0032201
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 103 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            References (563)