lipid and protein phosphatase acting in insulin pathway - PTEN, a tumour suppressor, is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating phosphatidylinositol 3,4,5-trisphosphate
Alternative translation stop created by use of multiphasic reading frames within coding region.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated (in 3' UTR).
1.872 (longest cDNA)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pten using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Pten in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Pten CG5671
dsRNA has been made from templates generated with primers directed against this gene.
dsRNA made from templates generated with primers directed against this gene results in an increase in mean cell diameter.
dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
PI3K activity is regulated through EcR signalling in a cell-autonomous manner to allow programmed autophagy in the fat body.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. Alterations of cell shape are also evident in S2R+ cells - they become round and detached. The Kc167 cell-shape change is suppressed by simultaneous treatment with dsRNA targetted against Akt1, CG31187, LIMK1, MAPk-Ak2, Pi3K92E, slpr or wee.
Pten plays an essential role in the control of, cell size, cell number, and organ size.
Both inactivation and overexpression of Pten affect cell size, and overexpression of Pten inhibits cell cycle progression at early mitosis and promotes cell death during eye development. Phenotypes caused by overexpression of Hsap\PTEN and Pten are indistinguishable.
The phosphatase activity of Pten is necessary for it to exert its functions during development. In direction of increasing cytology: Rsf1+ Pten+ CG5676+ Ror- bsk+ chico+