FlyBase Gene Report: Dmel\Idgf4

General Information

Symbol

Dmel\Idgf4

Species

D. melanogaster

Name

Imaginal disc growth factor 4

Annotation Symbol

CG1780

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026415

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex. (UniProt, Q9W303)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DmIDGF4, IDGF

Key Links

Genomic Location

Cytogenetic map

9A3-9A3

Sequence location

X:9,927,973..9,930,948 [-]

Recombination map

1-30

RefSeq locus

NC_004354 REGION:9927973..9930948

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables imaginal disc growth factor receptor binding

inferred from direct assay

(Kawamura et al., 1999)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables chitin binding

inferred from electronic annotation with InterPro:IPR011583

(InterPro Project Members, 2004-)

NOT enables chitinase activity

inferred from key residues

(Varela et al., 2002)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in chitin-based cuticle development

inferred from mutant phenotype

(Pesch et al., 2016)

involved_in ecdysis, chitin-based cuticle

inferred from mutant phenotype

(Pesch et al., 2016)

involved_in imaginal disc development

inferred from direct assay

(Kawamura et al., 1999)

involved_in wound healing

inferred from mutant phenotype

(Pesch et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in carbohydrate metabolic process

inferred from electronic annotation with InterPro:IPR001223

(InterPro Project Members, 2004-)

involved_in chitin catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular region

inferred from biological aspect of ancestor with PANTHER:PTN000126545

(GO Reference Genome Project, 2011-)

located_in extracellular region

non-traceable author statement

(Kawamura et al., 1999)

Gene Group (FlyBase)

IMAGINAL DISC GROWTH FACTORS

Protein Family (UniProt)

Belongs to the glycosyl hydrolase 18 family. IDGF subfamily. (Q9W303)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

IMAGINAL DISC GROWTH FACTORS -: The Imaginal Disc Growth Factors (IDGF) belong to the 18-glycosylhydrolase family. IDGFs possess a single glyco18 domain which is catalytically inactive and may act as a chitin binding module. (Adapted from FBrf0231276 and FBrf0230884).

Protein Function (UniProtKB)

(UniProt, Q9W303)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Idgf4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W303)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.51

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Idgf4-RA

FBtr0071393

NM_078546

1514

442

Idgf4-RB

FBtr0071394

NM_167207

1541

442

Idgf4-RC

FBtr0343030

NM_001298139

1807

442

Additional Transcript Data and Comments

Reported size (kB)

1.500 (longest cDNA)

(Kawamura et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Idgf4-PA

FBpp0071328

48.6

442

7.98

FBpp0071329

48.6

442

7.98

FBpp0309782

48.6

442

7.98

Q9W303

NP_001285068

AHN59538

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

442 aa isoforms: Idgf4-PA, Idgf4-PB, Idgf4-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

442 (aa)

(Kawamura et al., 1999)

Comments

External Data

Post Translational Modification

Glycosylated.

(UniProt, Q9W303)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idgf4 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.84

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

ventral furrow | vicinity of

(Kawamura et al., 1999)

yolk

(Kawamura et al., 1999)

amnioproctodeal invagination | vicinity of

(Kawamura et al., 1999)

cephalic furrow | vicinity of

(Kawamura et al., 1999)

larval tracheal system

(Kawamura et al., 1999)

embryonic stage & larval stage

embryonic/larval salivary gland

(Kawamura et al., 1999)

embryonic/larval fat body

(Kawamura et al., 1999)

third instar larval stage

larval brain

(Kawamura et al., 1999)

embryonic/larval lymph gland

(Kawamura et al., 1999)

ring gland

(Kawamura et al., 1999)

embryonic/larval optic lobe

(Kawamura et al., 1999)

imaginal disc

(Kawamura et al., 1999)

adult stage & oogenesis

nurse cell

(Kawamura et al., 1999)

oocyte

(Kawamura et al., 1999)

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

seminal receptacle

(Prokupek et al., 2009)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

• cytoplasm | basal

Comment: apically cleared

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | intense | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

primordial germ cell

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

germline cell

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 13 -- 16

amnioserosa

(Fisher et al., 2012)

embryonic anal pad

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic stomatogastric nervous system

(Fisher et al., 2012)

embryonic/larval fat body

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

Additional Descriptive Data

Idgf4 transcripts are expressed at all stages tested on northern blots but most heavily in mid-larval stages. Idgf4 transcripts are present in the yolk cytoplasm in the early embryo but are excluded from the blastoderm as it cellularizes. During gastrulation, transcripts are observed in rows parallel to the major invaginations including the ventral furrow, the cephalic furrow, and the anterior and posterior midgut invaginations. In late embryos, Idgf4 transcripts are observed in yolk cells, fat body, salivary glands, and in the tracheal system. In third instar larvae, Idgf4 transcripts are strongly expressed in fat body, the ring gland, and in lymph glands. Expression is also observed in the optic lobes, the central brain, and in imaginal discs. Duing oogenesis, Idgf4 transcripts are present in nurse cells and in the oocyte. While the patterns of expression of the four Idgf genes are in general very similar, they are differentially expressed in the larval salivary glands. Levels of Idgf2 and Idgf4 are generally higher than Idgf1 and Idgf3.

(Kawamura et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

adult stage | female

adult hemolymph

(Zeng et al., 2016)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Idgf4 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Idgf4

View exonic expression by tissue for Dmel\Idgf4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026415

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31926/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026415

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026415

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026415

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1780

Flygut - An atlas of the Drosophila adult midgut

FBgn0026415

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Idgf4

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Idgf4

Transgenic constructs containing regulatory region of Idgf4

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(1)ED6989

(Sustar et al., 2023)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^69B

Idgf4^KK112601

viable

Idgf4^d00895

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Idgf4^GD6462

viable, with Scer\GAL4^Mef2.PR

Idgf4^GD6462

viable, with Scer\GAL4^pnr-MD237

Idgf4^GD6462

Sterility

Allele

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

Idgf4^GL01142

fertile

Idgf4^d00895

male fertile, with Scer\GAL4^bam.PU

Idgf4^GL01142

Other Phenotypes

Allele

abnormal meiotic cell cycle | female, with Scer\GAL4^{VP16.nanos.UTR}

Idgf4^GL01142

abnormal wound healing, with Scer\GAL4^69B

Idgf4^KK112601

some die during larval stage, with Scer\GAL4^69B

Idgf4^KK112601

Phenotype manifest in

Allele

embryonic/larval cuticle, with Scer\GAL4^69B

Idgf4^KK112601

pronucleus | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}

Idgf4^GL01142

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (7)

Hsap\CHI3L1

5 of 14

Yes

Hsap\CHIT1

5 of 14

Yes

Hsap\OVGP1

5 of 14

Yes

4 of 14

4 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Chi3l1

4 of 14

Yes

Rnor\Chit1

4 of 14

Yes

Rnor\RGD1309110

4 of 14

Yes

3 of 14

3 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (10)

Mmus\Chil1

5 of 14

Yes

Mmus\Chit1

5 of 14

Yes

Mmus\Ovgp1

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (6)

Xtro\chit1

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (9)

Drer\chia.3

5 of 14

Yes

Drer\chia.6

5 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

Drer\si:ch211-226m16.2

1 of 14

Drer\usp49

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\chil-7

4 of 14

Yes

Cele\chil-15

4 of 14

Yes

Cele\chil-16

4 of 14

Yes

Cele\chil-17

4 of 14

Yes

Cele\chil-18

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Cele\cht-4

2 of 14

Cele\T01C4.8

2 of 14

Cele\btb-16

1 of 14

Yes

Cele\btb-17

1 of 14

Yes

Cele\btb-18

1 of 14

Yes

Cele\C45E5.3

1 of 14

Yes

Cele\K08F9.3

1 of 14

Anopheles gambiae (African malaria mosquito) (29)

Agam\AgaP_AGAP008060

12 of 12

Yes

Agam\AgaP_AGAP008061

11 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT4G19720

4 of 13

Yes

Atha\AT4G19730

4 of 13

Yes

Atha\AT4G19750

4 of 13

Yes

Atha\AT4G19760

4 of 13

Yes

Atha\AT4G19800

4 of 13

Yes

Atha\AT4G19820

4 of 13

Yes

Atha\ChiC

4 of 13

Yes

Atha\AT4G19770

3 of 13

Atha\AT4G19740

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CTS2

4 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Idgf4. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

11 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

4 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CHI3L1; chitinase 3 like 1

model of schizophrenia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CHI3L1; chitinase 3 like 1

5 of 14

601525

schizophrenia

CHIT1; chitinase 1

5 of 14

600031

CHITOTRIOSIDASE DEFICIENCY; CHITD

OVGP1; oviductal glycoprotein 1

5 of 14

603578

CHI3L2; chitinase 3 like 2

4 of 14

601526

CHIA; chitinase acidic

4 of 14

606080

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Idgf4 - Nplp2

experimental knowledge based

(Guruharsha et al., 2011)

Idgf4 - Nrd1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Yoon et al., 2017)

Idgf4 - Obp44a

experimental knowledge based

(Guruharsha et al., 2011)

Idgf4 - apolpp

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58363

DroID - A comprehensive database of gene and protein interactions.

FBgn0026415

MIST (protein-protein) - An integrated Molecular Interaction Database

31926

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-30

Cytogenetic map

9A3-9A3

Sequence location

X:9,927,973..9,930,948 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

9A3-9A3

Limits computationally determined from genome sequence between P{EP}nej^EP1149&P{EP}nej^EP1179 and P{EP}α-Man-I^EP1628&P{EP}α-Man-I^EP1307

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

9A-9A

(Kawamura et al., 1999, Kawamura, 1998.10.28)

Experimentally Determined Recombination Data

Location

1-30

(FlyBase, 2016)

1-31.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41602

y¹ v¹; P{TRiP.GL01142}attP2

55381

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04069}attP40

19153

w¹¹¹⁸ P{XP}Idgf4^d00895; l(3)*^*/TM6B, Tb¹

1780R-1

v104968

v14624

w¹¹¹⁸; P{GD6462}v14624

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (188)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026415

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026415

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG1780

(Rabadiya and Behr, 2024, Ibrahim et al., 2013, Lombard et al., 2013, Cammarato et al., 2011, Mosallanejad et al., 2010, Ni et al., 2010.12.1, Shibata et al., 2010, Keleman et al., 2009.8.5, Reumer et al., 2009, Karlsson et al., 2004, Zhu et al., 2004)

DmIDGF4

(Zhang et al., 2011, Zhu et al., 2008)

IDGF

(Edgar, 2006, Britton et al., 1999)

IDGF-4

(Varela et al., 2002)

IDGF4

(Rabadiya and Behr, 2024, Shippy et al., 2022, Lee et al., 2015, Kucerova and Zurovec, 2007, Monserrate et al., 2003, Monserrate et al., 2003, Hipfner and Cohen, 1999, Kawamura, 1998.10.28)

IGDF4

(Prudêncio et al., 2018)

Idgf

(Zimmerman and Berg, 2024)

idgf4

(Behr and Riedel, 2020, Pesch et al., 2016, Lai et al., 2007)

Name Synonyms

Imaginal disc growth factor 4

(Rice et al., 2020, Ibrahim et al., 2013, Cammarato et al., 2011, Shibata et al., 2010, Reumer et al., 2009, Lai et al., 2007)

Secondary FlyBase IDs

FBgn0026066

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 73 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31926

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W303

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W303

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JEB6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W303

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026415

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31926/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026415

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026415

FlyMine - An integrated database for Drosophila genomics

FBgn0026415

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1780

MARRVEL_MODEL - MARRVEL (model organism gene)

31926

Linkouts

BioGRID - A database of protein and genetic interactions.

58363

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026415

DroID - A comprehensive database of gene and protein interactions.

FBgn0026415

DRSC - Results frm RNAi screens

FBgn0026415

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026415

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026415

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1780

Flygut - An atlas of the Drosophila adult midgut

FBgn0026415

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0026415

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

31926

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Neutrophil degranulation

References (92)

The following external sites may use different assemblies or annotations than FlyBase.

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