FlyBase Gene Report: Hsap\SNCA

(Chen and Tully, 2018, Zhu et al., 2016, Jahromi et al., 2015, Jahromi et al., 2015, Kong et al., 2015, Chen et al., 2014, Chen et al., 2014, Riemensperger et al., 2013, Shaltiel-Karyo et al., 2012, Hernández-Vargas et al., 2011, Botella et al., 2008, Scherzer et al., 2003, Yang et al., 2003, Feany and Bender, 2000)

model of Parkinson's disease 1

CEC

(Huang et al., 2023, Golomidov et al., 2022, Liu et al., 2022, Xue et al., 2022, Cunningham et al., 2018)

CEA

(Xia et al., 2025, Dhanushkodi et al., 2023, Diaw et al., 2023, Ledahawsky et al., 2022, Rahmani et al., 2022, Dinh et al., 2021, Beaver et al., 2020, Yan et al., 2019, Abul Khair et al., 2018, Coelho et al., 2018, Fernius et al., 2017, Ito et al., 2017)

Hsap\SNCA^A53T.UAS

model of Lewy body dementia

CEA

(Imomnazarov et al., 2024)

model of Parkinson's disease

CEA

(Dinter et al., 2016, Zhu et al., 2016, Jahromi et al., 2015, Jahromi et al., 2015, Varga et al., 2014, Hernández-Vargas et al., 2011, Botella et al., 2008, Cooper et al., 2006, Yang et al., 2003, Feany and Bender, 2000)

model of synucleinopathy

CEA

(Alexopoulou et al., 2016)

model of Parkinson's disease 1

CEA

(Xia et al., 2025, Dhanushkodi et al., 2023, Diaw et al., 2023, Ledahawsky et al., 2022, Girard et al., 2021, Agerschou et al., 2019, Yan et al., 2019, Abul Khair et al., 2018, Saridaki et al., 2018)

CEC

(Nitta et al., 2023, Szinyákovics et al., 2023, Golomidov et al., 2022, Cunningham et al., 2018)

Hsap\SNCA^UAS.cFa

model of synucleinopathy

CEA

(Alexopoulou et al., 2016, Chen et al., 2009, Auluck et al., 2005)

model of bowel dysfunction

CEA

(Olsen and Feany, 2019)

model of Lewy body dementia

CEA

(Olsen and Feany, 2019)

Hsap\SNCA^UAS.cKa

model of Parkinson's disease

CEA

(Breda et al., 2015, Yin et al., 2014, Gajula Balija et al., 2011)

Hsap\SNCA^A53T.UAS.cKa

model of synucleinopathy

CEA

(Karpinar et al., 2009)

model of Parkinson's disease

CEA

(Butler et al., 2012, Gajula Balija et al., 2011)

model of Parkinson's disease 1

CEA

(Briffa et al., 2017)

Hsap\SNCA^A56P.UAS.cKa

model of synucleinopathy

CEA

(Karpinar et al., 2009)

Hsap\SNCA^A30P.UAS.cKa

model of Parkinson's disease 1

CEC

(Burr et al., 2014)

CEA

(Burr et al., 2014)

Hsap\SNCA^TP.UAS.cKa

model of synucleinopathy

CEA

(Karpinar et al., 2009)

model of Parkinson's disease

CEA

(Yin et al., 2014, Gajula Balija et al., 2011)

Hsap\SNCA^{UAS.Tag:NLS(SV40-largeT)}

model of Parkinson's disease

CEA

(Kontopoulos et al., 2006)

Hsap\SNCA^UAS.cJa

model of Parkinson's disease 1

CEA

(Moore et al., 2025, Spargo et al., 2025, Matsuoka et al., 2024, Yu et al., 2023, Dabool et al., 2020, Wu et al., 2019, Rousseaux et al., 2018, Chouhan et al., 2016)

CEC

(Ren et al., 2022)

model of Parkinson's disease

CEC

(Jansen et al., 2017)

CEA with park^HMS01651

(Narwal et al., 2023)

Hsap\SNCA^UAS.cTa

model of Parkinson's disease

CEA

(Varga et al., 2014, Trinh et al., 2008)

CEC

(Roy and Jackson, 2014, Barone et al., 2011)

model of Parkinson's disease 1

CEA

(Krzystek et al., 2021)

Hsap\SNCA^UAS.EGFP

model of neurodegenerative disease

CEA with Hsap\HTT^{UAS.103Q.mCherry}

(Poças et al., 2015)

model of Parkinson's disease 1

CEA

(Bridi et al., 2021, Krzystek et al., 2021)

Hsap\SNCA^A30P.UAS.cUa

model of Parkinson's disease

CEA

(Zhang et al., 2015)

model of Parkinson's disease 1

CEA

(Zhang et al., 2018)

Hsap\SNCA^A53T.UAS.cUa

model of Parkinson's disease

CEA

(Zhang et al., 2015)

model of Parkinson's disease 1

CEA

(Blosser et al., 2020, Shaltouki et al., 2018, Zhang et al., 2018, Qi et al., 2017, Zhao et al., 2015)

Hsap\SNCA^UAS.cUa

model of Parkinson's disease

CEA

(Liu et al., 2015, Yin et al., 2014)

model of Parkinson's disease 1

CEA

(Zhang et al., 2018, Merzetti et al., 2017, Büttner et al., 2013)

CEC

(Cunningham et al., 2018)

Hsap\SNCA^QUAS.cOa

model of synucleinopathy

CEA

(Ordonez et al., 2018)

model of Parkinson's disease 1

CEC

(Maor et al., 2023)

CEA

(Yadav et al., 2024, Olsen and Feany, 2021, Sarkar et al., 2021, Sarkar et al., 2021, Sarkar et al., 2020)

Hsap\SNCA^H50Q.UAS

model of Parkinson's disease 1

CEA

(Rai and Kumar, 2025, Mohite et al., 2018)

Hsap\SNCA^G51D.UAS

model of Parkinson's disease 1

CEA

(Mohite et al., 2018)

Hsap\SNCA^E46K.UAS

model of Parkinson's disease 1

CEA

(Mohite et al., 2018)

model of Lewy body dementia

CEA

(Mohite et al., 2018)

Hsap\SNCA^UAS.cSa

model of Parkinson's disease 1

CEA

(Sakai et al., 2019)

Hsap\SNCA^E46K.UAS.cSa

model of Parkinson's disease 1

CEA

(Sakai et al., 2019)

Hsap\SNCA^H50Q.UAS.cSa

model of Parkinson's disease 1

CEA

(Sakai et al., 2019)

Hsap\SNCA^G51D.UAS.cSa

model of Parkinson's disease 1

CEA

(Sakai et al., 2019)

Hsap\SNCA^A53T.UAS.cSa

model of Parkinson's disease 1

CEA

(Sakai et al., 2019)

Hsap\SNCA^E46K.UAS.cJa

model of Parkinson's disease 1

CEA

(Jahromi et al., 2021)

Hsap\SNCA^V15A.UAS

model of Parkinson's disease 1

CEA

(Diaw et al., 2023)

Hsap\SNCA^A53T.QUAS

model of Parkinson's disease 1

CEA

(Praschberger et al., 2023)

Hsap\SNCA^A53T.UAS.cPa

model of Parkinson's disease 1

CEA

(Kinnart et al., 2024)

Hsap\SNCA^UAS.cKb

model of Parkinson's disease 1

CEA

(Kinnart et al., 2024)

Hsap\SNCA^A30P.UAS.cKb

model of Parkinson's disease 1

CEA

(Kinnart et al., 2024)

Hsap\SNCA^E46K.UAS.cKb

model of Parkinson's disease 1

CEA

(Kinnart et al., 2024)

Hsap\SNCA^{QUAS.Tag:FLAG.T2A-GFP}

model of Parkinson's disease

CEA

(Bankapalli et al., 2024)

Hsap\SNCA^A53V.UAS

model of Parkinson's disease 1

CEA

(Xia et al., 2025)

Hsap\SNCA^E46K.UAS.cMa

model of Parkinson's disease 1

CEA

(Xia et al., 2025)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 15 )

Allele

Disease

Interaction

References

Hsap\SNCA^S129D.UAS

model of synucleinopathy

is ameliorated by Shark^UAS.cFa

(Chen et al., 2009)

Hsap\SNCA^A30P.UAS

model of synucleinopathy

is ameliorated by ple^GD1181

(Bayersdorfer et al., 2010)

model of Parkinson's disease 1

is ameliorated by Jra^Jbz.UAS

(Liu et al., 2022)

is exacerbated by bsk^UAS.cBa

(Liu et al., 2022)

is ameliorated by Sfxn1-3^EY01545

(Ledahawsky et al., 2022)

is exacerbated by Tango14^GD481

(Xue et al., 2022)

is exacerbated by Tango14^JF01144

(Xue et al., 2022)

is exacerbated by anne^KK107621

(Dhanushkodi et al., 2023)

is ameliorated by Tip60^UAS.cUa

(Beaver et al., 2020)

is ameliorated by TP53INP^FENLL.UAS

(Dinh et al., 2021)

is ameliorated by TP53INP^long.UAS

(Dinh et al., 2021)

is ameliorated by egr^HMC03963

(Huang et al., 2023)

is exacerbated by Lamp1^11B

(Rahmani et al., 2022)

is exacerbated by Lamp1^6.1

(Rahmani et al., 2022)

is ameliorated by Lamp1^Tub.PR

(Rahmani et al., 2022)

is ameliorated by st^UAS.Venus

(Cunningham et al., 2018)

is ameliorated by Atg7^GD11671

(Yan et al., 2019)

is ameliorated by Ire1^GD3071

(Yan et al., 2019)

is exacerbated by Gba1b^GD10253

(Abul Khair et al., 2018)

ameliorates Parkinson's disease

modeled by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

model of Parkinson's disease

is ameliorated by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

is ameliorated by Hsap\SOD1^UAS.cPa

(Botella et al., 2008)

exacerbates Kufor-Rakeb syndrome

modeled by anne^KK107621

(Dhanushkodi et al., 2023)

Hsap\SNCA^A53T.UAS

model of synucleinopathy

is ameliorated by Usp8^HMS01898

(Alexopoulou et al., 2016)

model of Parkinson's disease 1

is ameliorated by Sfxn1-3^EY01545

(Ledahawsky et al., 2022)

is exacerbated by anne^KK107621

(Dhanushkodi et al., 2023)

is ameliorated by Hsap\FYCO1^UAS.cSa

(Saridaki et al., 2018)

is ameliorated by st^UAS.Venus

(Cunningham et al., 2018)

is ameliorated by Zzzz\β-wrapin^UAS.AS69

(Agerschou et al., 2019)

is ameliorated by Arl8^Q75L.UAS

(Szinyákovics et al., 2023)

is ameliorated by Rab2^{Q65L.UASp.YFP}

(Szinyákovics et al., 2023)

is exacerbated by Gba1b^GD10253

(Abul Khair et al., 2018)

model of Parkinson's disease

is ameliorated by Mmus\Rab1a^UAS.cCa

(Cooper et al., 2006)

is ameliorated by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

is ameliorated by Rab7^UAS.GFP

(Dinter et al., 2016)

ameliorates Parkinson's disease

modeled by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

exacerbates Kufor-Rakeb syndrome

modeled by anne^KK107621

(Dhanushkodi et al., 2023)

Hsap\SNCA^UAS.cFa

model of Parkinson's disease 1

is ameliorated by Buffy^UAS.cQa

(M'Angale and Staveley, 2016)

is ameliorated by cn^KK101938

(Breda et al., 2016)

is exacerbated by anne^KK107621

(Dhanushkodi et al., 2023)

is exacerbated by Hsap\DNAJC13^{N855S.UAS.Tag:MYC}

(Yoshida et al., 2018)

is ameliorated by Hsap\ARSA^N352S.UAS

(Lee et al., 2019)

is ameliorated by Hsap\ARSA^UAS.cLa

(Lee et al., 2019)

is exacerbated by Hsap\GBA1^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2019)

is ameliorated by IP3K2^KK112292

(Di Leva et al., 2023)

is exacerbated by porin^JF03251

(M'Angale and Staveley, 2016)

is exacerbated by porin^KK107645

(M'Angale and Staveley, 2016)

is exacerbated by HtrA2^HM05030

(Chung et al., 2020)

is ameliorated by HtrA2^UAS.cYa

(Chung et al., 2020)

is ameliorated by Drp1^KG03815

(Krzystek et al., 2021)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Krzystek et al., 2021)

is ameliorated by Pink1^UAS.cYa

(Krzystek et al., 2021)

is ameliorated by park^UAS.cGa

(Krzystek et al., 2021)

is exacerbated by Avic\GFP^klar.LD.UASp

(Girard et al., 2021)

is exacerbated by CG7900^EY10020

(Girard et al., 2021)

is exacerbated by Lsd-1^UAS.EGFP

(Girard et al., 2021)

is exacerbated by Lsd-2^UAS.EGFP

(Girard et al., 2021)

is exacerbated by BI-1^GD1660

(M'Angale and Staveley, 2017)

is exacerbated by BI-1^KK100983

(M'Angale and Staveley, 2017)

is exacerbated by Gba1b^GD10253

(Abul Khair et al., 2018)

is exacerbated by Rop^A3

(Matsuoka et al., 2024)

is exacerbated by Rop^G27

(Matsuoka et al., 2024)

model of synucleinopathy

is ameliorated by Shark^UAS.cFa

(Chen et al., 2009)

is ameliorated by Usp8^HMS01898

(Alexopoulou et al., 2016)

exacerbates Huntington's disease

modeled by Hsap\HTT^GMR.Q120

(Winslow et al., 2010)

model of Parkinson's disease

is exacerbated by Atg6^GD11647

(M'Angale and Staveley, 2016)

is exacerbated by Pi3K59F^KK107602

(M'Angale and Staveley, 2016)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Auluck et al., 2002)

is exacerbated by Hsc70-4^K71S.UAS

(Auluck et al., 2002)

is ameliorated by Hsap\PRKN^UAS.cYa

(Yang et al., 2003)

is ameliorated by park^UAS.cHa

(Haywood and Staveley, 2004)

is ameliorated by Pink1^UAS.cTa

(Todd and Staveley, 2008)

is exacerbated by Gprk2^UAS.cCb

(Chen and Feany, 2005)

is ameliorated by Mmus\Rab1a^UAS.cCa

(Cooper et al., 2006)

is ameliorated by Rab11^UAS.EGFP

(Breda et al., 2015)

is ameliorated by Hsap\UBC^UAS.Tag:HA

(Lee et al., 2009)

is ameliorated by Hsap\UBC^{K63R.UAS.Tag:HA}

(Lee et al., 2009)

is ameliorated by Hsap\UBC^{K48.UAS.Tag:HA}

(Lee et al., 2009)

is exacerbated by HDAC6^KO

(Du et al., 2010)

is ameliorated by HDAC6^UAS.cDa

(Du et al., 2010)

is ameliorated by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Kontopoulos et al., 2006)

is exacerbated by Gba1a^GD6246

(Suzuki et al., 2015)

is exacerbated by Gal^GD936

(Suzuki et al., 2015)

is exacerbated by Vps35^GD11710

(Miura et al., 2014)

is ameliorated by chico¹

(Knight et al., 2014)

is exacerbated by Pgi^EY09730

(Knight et al., 2014)

is exacerbated by Tpi^GD10138

(Vicente Miranda et al., 2017)

is exacerbated by Glo1^KK109109

(Vicente Miranda et al., 2017)

is exacerbated by Debcl^UAS.Tag:HA

(M'Angale and Staveley, 2016)

is ameliorated by Debcl^JF02429

(M'Angale and Staveley, 2016)

is ameliorated by Hsap\HTRA2^UAS.cCa

(Chung et al., 2020)

ameliorates Parkinson's disease

modeled by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

exacerbates Parkinson's disease

modeled by Vps35^GD11710

(Miura et al., 2014)

exacerbates Kufor-Rakeb syndrome

modeled by anne^KK107621

(Dhanushkodi et al., 2023)

exacerbates developmental and epileptic encephalopathy 4

modeled by Rop^A3

(Matsuoka et al., 2024)

modeled by Rop^G27

(Matsuoka et al., 2024)

Hsap\SNCA^UAS.cKa

model of Parkinson's disease

is ameliorated by Rab8^UASp.YFP

(Yin et al., 2014)

is ameliorated by Rab11^UAS.EGFP

(Breda et al., 2015)

is NOT ameliorated by Rab11^{S25N.UASp.YFP}

(Breda et al., 2015)

Hsap\SNCA^A53T.UAS.cKa

model of Parkinson's disease

is ameliorated by Hsap\TRAP1^UAS.cBa

(Butler et al., 2012)

is exacerbated by Trap1^KG06242

(Butler et al., 2012)

Hsap\SNCA^TP.UAS.cKa

model of Parkinson's disease

is ameliorated by Rab8^UASp.YFP

(Yin et al., 2014)

Hsap\SNCA^UAS.cJa

model of Parkinson's disease 1

is ameliorated by Ca-α1D^MI08906

(Rousseaux et al., 2018)

is ameliorated by Ddc^ts2

(Rousseaux et al., 2018)

is ameliorated by Egfr^{FRT.RNAi.slbo}

(Rousseaux et al., 2018)

is ameliorated by Eip63E^{MI00413-GFSTF.1}

(Rousseaux et al., 2018)

is ameliorated by Eip63E^MI04853

(Rousseaux et al., 2018)

is ameliorated by Loxl2^MI06311

(Rousseaux et al., 2018)

is ameliorated by N^fa-swb

(Rousseaux et al., 2018)

is ameliorated by bgm^MI14249

(Rousseaux et al., 2018)

is ameliorated by cac^GD15341

(Rousseaux et al., 2018)

is exacerbated by ND-39^11-101

(Ren et al., 2022)

is ameliorated by Vhl^KK111257

(Ren et al., 2022)

is exacerbated by cpo^10-129

(Ren et al., 2022)

is exacerbated by dlt^05-188

(Ren et al., 2022)

is exacerbated by heca^06-232

(Ren et al., 2022)

is exacerbated by kto^HMS06027

(Ren et al., 2022)

is exacerbated by l(3)87Df^10-122

(Ren et al., 2022)

is exacerbated by sima^KK102226

(Ren et al., 2022)

is exacerbated by skd^06-056

(Ren et al., 2022)

is exacerbated by ABCB7^03-232

(Ren et al., 2022)

is exacerbated by skd^HMS01305

(Ren et al., 2022)

is exacerbated by CG4553^06-125

(Ren et al., 2022)

is exacerbated by skd^MI12229

(Ren et al., 2022)

is exacerbated by Cdc27^02-055

(Ren et al., 2022)

is exacerbated by skd^T606

(Ren et al., 2022)

is exacerbated by Cdk8^GL00231

(Ren et al., 2022)

is exacerbated by CycC^HMS01095

(Ren et al., 2022)

is exacerbated by Eip75B^12-111

(Ren et al., 2022)

is exacerbated by GlyRS^08-107

(Ren et al., 2022)

is ameliorated by Hph^KK100344

(Ren et al., 2022)

is exacerbated by MTA1-like^06-040

(Ren et al., 2022)

is exacerbated by Spn27A^KK109962

(Moore et al., 2025)

is exacerbated by Spn31A^GD5369

(Moore et al., 2025)

is exacerbated by Spn31A^KK106055

(Moore et al., 2025)

is exacerbated by Spn42Da^KK107708

(Moore et al., 2025)

is exacerbated by Spn42De^GD14221

(Moore et al., 2025)

is exacerbated by Spn42De^KK103216

(Moore et al., 2025)

is exacerbated by Spn47C^GD9948

(Moore et al., 2025)

is ameliorated by SkpA^UAS.ORF

(Dabool et al., 2020)

is exacerbated by Dap160^Δ1

(Spargo et al., 2025)

is ameliorated by Dap160^UAS.cKa

(Spargo et al., 2025)

is exacerbated by Csp^R1

(Yu et al., 2023)

is exacerbated by Ect3^KK102324

(Yu et al., 2023)

is exacerbated by Ect3^NIG.3132R

(Yu et al., 2023)

is exacerbated by Gba1b^GD10253

(Yu et al., 2023)

is exacerbated by Gba1b^KK107189

(Yu et al., 2023)

is exacerbated by Lip4^GD5503

(Yu et al., 2023)

is exacerbated by Lip4^KK106457

(Yu et al., 2023)

is exacerbated by Npc1a¹

(Yu et al., 2023)

is exacerbated by Npc1a²

(Yu et al., 2023)

is exacerbated by Npc1a^KK101077

(Yu et al., 2023)

is exacerbated by Snmp1^GD478

(Yu et al., 2023)

model of Parkinson's disease

is exacerbated by CG32191^KK103889

(Jansen et al., 2017)

is exacerbated by CG12025^KK107653

(Jansen et al., 2017)

is exacerbated by CG32191^GD6163

(Jansen et al., 2017)

is exacerbated by CG12025^GD2253

(Jansen et al., 2017)

is exacerbated by Ptp10D^KK101775

(Jansen et al., 2017)

is exacerbated by Ptp10D^GD115

(Jansen et al., 2017)

is exacerbated by Ptp10D^GD2611

(Jansen et al., 2017)

is exacerbated by Vps13^HMS01715

(Jansen et al., 2017)

is exacerbated by Vps13^HMS02460

(Jansen et al., 2017)

exacerbates developmental and epileptic encephalopathy 4

modeled by Rop^A3

(Matsuoka et al., 2024)

modeled by Rop^G27

(Matsuoka et al., 2024)

Hsap\SNCA^UAS.cTa

model of Parkinson's disease

is ameliorated by GstS1^UASp.cWa

(Trinh et al., 2008)

is ameliorated by Gclm^UAS.cOa

(Trinh et al., 2008)

is exacerbated by Gclm^L0580

(Trinh et al., 2008)

is exacerbated by Cth^KG02526

(Trinh et al., 2008)

is exacerbated by GstS1^M26

(Trinh et al., 2008)

is ameliorated by Hsap\MAPT^GMR.Ex.PJ

(Roy and Jackson, 2014)

is ameliorated by Hsap\MAPT^UAS.wt

(Roy and Jackson, 2014)

is ameliorated by cnc^UAS.cSa

(Barone et al., 2011)

is ameliorated by Keap1^RNAi.UAS

(Barone et al., 2011)

is ameliorated by Keap1^EY5

(Barone et al., 2011)

is ameliorated by maf-S^UAS.Tag:HA

(Barone et al., 2011)

ameliorates Parkinson's disease

modeled by Hsap\MAPT^UAS.wt

(Roy and Jackson, 2014)

modeled by Hsap\MAPT^GMR.Ex.PJ

(Roy and Jackson, 2014)

exacerbates Parkinson's disease 22

modeled by Chchd2^null

(Ikeda et al., 2019)

Hsap\SNCA^A30P.UAS.cUa

model of Parkinson's disease 1

is ameliorated by Hsap\TMEM59^UAS.cLa

(Zhang et al., 2018)

model of Parkinson's disease

is exacerbated by aux^GD7187

(Song et al., 2017)

is exacerbated by aux^KK100927

(Song et al., 2017)

Hsap\SNCA^A53T.UAS.cUa

model of Parkinson's disease 1

is ameliorated by Hsap\TMEM59^UAS.cLa

(Zhang et al., 2018)

is ameliorated by Sh^{EKO.UAS.GFP(GL)}

(Qi et al., 2017)

is ameliorated by Miro^KK102189

(Shaltouki et al., 2018)

Hsap\SNCA^UAS.cUa

model of Parkinson's disease

is ameliorated by Rab8^UASp.YFP

(Yin et al., 2014)

is exacerbated by aux^KK100927

(Song et al., 2017)

is exacerbated by aux^GD7187

(Song et al., 2017)

is exacerbated by Lk6^UAS.cUa

(Zhang et al., 2015)

model of Parkinson's disease 1

is ameliorated by EndoG^GD5747

(Büttner et al., 2013)

is ameliorated by Hsap\TMEM59^UAS.cLa

(Zhang et al., 2018)

is ameliorated by st^UAS.Venus

(Cunningham et al., 2018)

is exacerbated by PI31^GD13764

(Merzetti et al., 2017)

is ameliorated by ntc^JF01331

(Merzetti et al., 2017)

Hsap\SNCA^QUAS.cOa

model of synucleinopathy

is ameliorated by Fhos^HMJ21037

(Ordonez et al., 2018)

is exacerbated by Hsap\MAPT^UAS.cWa

(Ordonez et al., 2018)

is ameliorated by Drp1^UAS.cDb

(Ordonez et al., 2018)

is ameliorated by Act5C^G0010

(Ordonez et al., 2018)

is exacerbated by Act5C^UASp.R.GFP

(Ordonez et al., 2018)

is ameliorated by α-Spec^UAS.Tag:MYC

(Ordonez et al., 2018)

model of Parkinson's disease 1

is ameliorated by β-Spec^{ΔPH.Ubi-p63E.Tag:MYC}

(Maor et al., 2023)

is ameliorated by β-Spec^{Ubi-p63E.Tag:MYC}

(Maor et al., 2023)

is exacerbated by β-Spec^em21

(Maor et al., 2023)

is exacerbated by Lrrk^G1914S.UAS

(Sarkar et al., 2021)

is exacerbated by Lrrk^I1915T.UAS

(Sarkar et al., 2021)

is ameliorated by Lrrk^Q1003H.UAS

(Sarkar et al., 2021)

is exacerbated by Lrrk^UAS.cIa

(Sarkar et al., 2021)

is exacerbated by Lrrk^Y1383C.UAS

(Sarkar et al., 2021)

is exacerbated by Lrrk^RNAi.UAS.cIa

(Sarkar et al., 2021)

is exacerbated by Lrrk^e03680

(Sarkar et al., 2021)

is exacerbated by Pu^HMC04085

(Sarkar et al., 2020)

is exacerbated by Pu^HMS02399

(Sarkar et al., 2020)

is ameliorated by Gel^UAS.cDa

(Sarkar et al., 2021)

is ameliorated by tsr^S3A.UAS

(Sarkar et al., 2021)

is ameliorated by tsr^UAS.cNa

(Sarkar et al., 2021)

is exacerbated by Lrrk^RNAi.UAS.cUa

(Olsen and Feany, 2021)

is exacerbated by Ric^GL01247

(Olsen and Feany, 2021)

is exacerbated by Ric^JF02670

(Olsen and Feany, 2021)

is exacerbated by Vps13^HMS01715

(Olsen and Feany, 2021)

is exacerbated by Vps13^HMS02460

(Olsen and Feany, 2021)

is exacerbated by aux^GL00213

(Olsen and Feany, 2021)

is exacerbated by aux^HMS01935

(Olsen and Feany, 2021)

is exacerbated by Lrrk^GD11670

(Olsen and Feany, 2021)

is exacerbated by Lrrk^RNAi.UAS.cUa

(Olsen and Feany, 2021)

Hsap\SNCA^H50Q.UAS

model of Parkinson's disease 1

is exacerbated by InR^JF01482

(Rai and Kumar, 2025)

is ameliorated by InR^UAS.cUa

(Rai and Kumar, 2025)

is exacerbated by PEK^HMJ02063

(Rai and Kumar, 2025)

is ameliorated by PEK^UAS.cMa

(Rai and Kumar, 2025)

Hsap\SNCA^{QUAS.Tag:FLAG.T2A-GFP}

model of Parkinson's disease

is exacerbated by sgg^UAS.cBa

(Bankapalli et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hsap\SNCA - HDAC6

anti bait coimmunoprecipitation, western blot

(Du et al., 2010)

Hsap\SNCA - Lsd-2

colocalization, fluorescence microscopy, inferred by author

(Girard et al., 2021)

Hsap\SNCA - Pink1

anti bait coimmunoprecipitation, western blot

(Krzystek et al., 2021)

Hsap\SNCA - park

anti bait coimmunoprecipitation, western blot

(Krzystek et al., 2021)

Hsap\SNCA - β-Spec

pull down, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Maor et al., 2023)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

Stocks and Reagents

Stocks (16)

Bloomington

80043

w^*; P{UAS-hSNCA.E46K}2

80044

w^*; P{UAS-hSNCA.G51D}2

95241

w^*; P{UAS-SNCA.A53T.U}2

8146

w^*; P{UAS-Hsap\SNCA.F}5B

51375

w¹¹¹⁸; P{UAS-SNCA.J}1/CyO

95240

w^*; P{UAS-Hsap\SNCA.T}LP2

80045

w^*; P{UAS-hSNCA.H50Q}2/CyO

8147

w^*; P{UAS-Hsap\SNCA.A30P}40.1

607202

w^*; PBac{UAS-hSNCA.mKeima}VK00037

607205

w^*; PBac{UAS-hSNCA.mCherry}VK00037

51376

w¹¹¹⁸; P{UAS-SNCA.J}7/TM3, Sb¹

600604

w^*; P{QUAS-hSNCA.WT}3/TM3, Sb¹

More stocks available...

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

FlyBase curator comment: Name changed to reflect current HGNC name (19th Nov. 2012).

(FlyBase Curators, 1992-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (49)

Reported As

Symbol Synonym

&agr:-synuclein

(Lai et al., 2025, Roy et al., 2025, Abu-Salah et al., 2024, Murthy and Shyamala, 2024, Zhang et al., 2023, Bonini, 2022, Min et al., 2022)

Hsap\SNCA

(Fehr et al., 2025, Idowu et al., 2024, Bhattacharjee et al., 2019, Nevzglyadova et al., 2018, Ordonez et al., 2018, Kovács et al., 2017, Breda et al., 2016, Dinter et al., 2016, Yedlapudi et al., 2016, Miura et al., 2014, Siddique et al., 2014, Siddique et al., 2013)

NACP

(HGNC Curators and FlyBase Curators, 2013-, OMIM, 2013-)

PARK1

(HGNC Curators and FlyBase Curators, 2013-)

PARK4

(HGNC Curators and FlyBase Curators, 2013-)

PD1

(HGNC Curators and FlyBase Curators, 2013-)

SCNA

(Aryal and Lee, 2019)

Snca

(Ledahawsky et al., 2022)

a-syn

(Wittmann et al., 2001)

aSYN

(Todd and Staveley, 2008)

aSyn

(Vicente Miranda et al., 2017, Breda et al., 2015)

alpha syn

(Rai and Kumar Roy, 2022)

alpha-synuclein

(Perlegos et al., 2024)

h-@agr;S

(Siddique et al., 2013)

h-αS

(Rahul et al., 2020, Siddique et al., 2018, Siddique and Jyoti, 2017, Siddique et al., 2016, Siddique et al., 2013, Siddique et al., 2013)

hsyn

(Breger and Fuzzati Armentero, 2019)

hu-α-syn

(Fouillet et al., 2012)

hα-Synuclein

(Ecovoiu et al., 2022)

hαs

(Khan et al., 2012)

syn

(Botella et al., 2008, Outeiro et al., 2007, Kontopoulos et al., 2006)

synuclein

(Wang et al., 2018)

α syn

(Khan et al., 2023, Ikeda et al., 2019, Tue et al., 2012)

α-S

(Scherzer et al., 2003)

α-SYN

(Auluck et al., 2005)

α-Syn

(Agostini et al., 2023, Hegde and Srivastava, 2022, Chung et al., 2020, Dabool et al., 2019, Lin et al., 2019, Prasad et al., 2019, Coelho et al., 2018, Rousseaux et al., 2018, Collier et al., 2017, Das et al., 2017, Qi et al., 2017, Zhao et al., 2015, Roy and Jackson, 2014, Varga et al., 2014, Park et al., 2007, Park and Lee, 2006, Yang et al., 2003)

α-Synuclein

(Afsheen et al., 2024, Lenz et al., 2013)

αS

(Sugeno et al., 2016, Yin et al., 2014, Siddique et al., 2013, Siddique et al., 2013, Gajula Balija et al., 2011, Karpinar et al., 2009, Scherzer et al., 2003)

αSYN

(Miura et al., 2014)

αSyn

(Perry and More, 2025, Di Leva et al., 2023, Nitta et al., 2023, Yu et al., 2023, Suzuki et al., 2022, Lee et al., 2019, Sakai et al., 2019, Yan et al., 2019, Chouhan et al., 2016, Babcock et al., 2015, Suzuki et al., 2015, Büttner et al., 2013, Cooper et al., 2006)

αsyn

(Victor Atoki et al., 2025, Ji et al., 2019, Riemensperger et al., 2013)

Name Synonyms

& agr:-synuclein

(Bankapalli et al., 2024, Himalian et al., 2022)

-synuclein

(HGNC Curators and FlyBase Curators, 2013-)

Alpha-synuclein

(Hernández-Vargas et al., 2011, Takahashi et al., 2003)

Parkinson disease (autosomal dominant, Lewy body) 4

(HGNC Curators and FlyBase Curators, 2013-)

Synuclein

(Chiang et al., 2022)

Synuclein alpha

a-synuclein

(Lawal et al., 2007)

alpha synuclein

(Naz et al., 2020, Siddique et al., 2019, Siddique et al., 2016, Siddique et al., 2013, Hernández-Vargas et al., 2011)

alpha-synuclein

(Naz and Siddique, 2021, Rahul and Siddique, 2021, Ding et al., 2018, Zhu et al., 2016, Luan et al., 2015, HGNC Curators and FlyBase Curators, 2013-, Hillman et al., 2012, Jia et al., 2008, Bayersdorfer et al., 2007, Hrdlicka et al., 2007)

human alpha-synuclein

(Long et al., 2009)

human synuclein

(Siddique et al., 2018, Siddique et al., 2013)

human α-synuclein

(Chen et al., 2014)

non A4 component of amyloid precursor

(HGNC Curators and FlyBase Curators, 2013-)

non-A-beta component of Alzheimer disease amyeloid, precursor of

(OMIM, 2013-)

non-A4 component of amyloid, precursor of

(OMIM, 2013-)

synuclein alpha

(HGNC Curators and FlyBase Curators, 2013-)

synuclein, alpha

(OMIM, 2013-)

synuclein, alpha (non A4 component of amyloid precursor)

(HGNC Curators and FlyBase Curators, 2013-)

α-Synuclein

(Imai et al., 2019, Szabo and Tofaris, 2019, Mohite et al., 2018, Poças et al., 2015, Shaltiel-Karyo et al., 2013, Butler et al., 2012, Gajula Balija et al., 2011, Hernández-Vargas et al., 2011, Pesah et al., 2005, Bonini, 2002)

α-synuclein

(Praschberger et al., 2023, Asthana and Shravage, 2022, Lee, 2022, Kong et al., 2021, Brenman-Suttner et al., 2020, Chung et al., 2020, Denton et al., 2020, Parkhitko et al., 2020, Ikeda et al., 2019, Maor et al., 2019, Olsen and Feany, 2019, Cunningham et al., 2018, M'Angale and Staveley, 2017, M'Angale and Staveley, 2016, M'Angale and Staveley, 2016, M'Angale and Staveley, 2016, Breda et al., 2015, Jahromi et al., 2015, Kong et al., 2015, Wang et al., 2015, Zhang et al., 2015, Büttner et al., 2014, Chen et al., 2014, Davies et al., 2014, Barone and Bohmann, 2013, Büttner et al., 2013, Siddique et al., 2013, Reinhardt et al., 2012, Todd and Staveley, 2012, Tue et al., 2012, Barone et al., 2011, Chan et al., 2011, Bayersdorfer et al., 2010, Winslow et al., 2010, Iijima-Ando et al., 2009, Karpinar et al., 2009, Lee et al., 2009, Trinh et al., 2008, Hillman et al., 2007, Park et al., 2007, Kontopoulos et al., 2006, Maricich and Zoghbi, 2006, Park and Lee, 2006, Bayersdorfer, 2005, Chen and Feany, 2005, Scherzer et al., 2003, Auluck and Bonini, 2002, Pendleton et al., 2002)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 8 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

6622

Other crossreferences

Ensembl_Homo_sapiens -

ENSG00000145335

HUGO Gene Nomenclature Committee -

SNCA; synuclein alpha

MARRVEL - MARRVEL (human gene)

SNCA

OMIM_GENE - Online Mendelian Inheritance in Man (Genes)

SYNUCLEIN, ALPHA; SNCA

OMIM_PHENOTYPE - Online Mendelian Inheritance in Man (Phenotypes)

References (309)

Report Sections