FlyBase Gene Report: Dmel\Stam

General Information

Symbol

Dmel\Stam

Species

D. melanogaster

Name

Signal transducing adaptor molecule

Annotation Symbol

CG6521

Feature Type

protein_coding_gene

FlyBase ID

FBgn0027363

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Signal transducing adaptor molecule (Stam) encodes a component of the ESCRT-0 complex, which mediates multivesicular body formation. It is involved in RTK signaling regulation, tracheal cell migration and endosomal trafficking. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Dstam

Key Links

Genomic Location

Cytogenetic map

32B2-32B3

Sequence location

2L:10,858,536..10,862,006 [+]

Recombination map

2-43

RefSeq locus

NT_033779 REGION:10858536..10862006

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables phosphatidylinositol binding

inferred from electronic annotation with InterPro:IPR002014

(InterPro Project Members, 2004-)

enables ubiquitin binding

inferred from sequence or structural similarity with SGD:S000000994

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR002014

(InterPro Project Members, 2004-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in endosomal transport

inferred from mutant phenotype

(Sheng et al., 2016, Chanut-Delalande et al., 2010)

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Chanut-Delalande et al., 2007)

involved_in neuron remodeling

inferred from genetic interaction with FLYBASE:Hrs; FB:FBgn0031450

(Issman-Zecharya and Schuldiner, 2014)

involved_in regulation of cell cycle

inferred from genetic interaction with FLYBASE:Hrs; FB:FBgn0031450

(Tognon et al., 2014)

involved_in regulation of epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Chanut-Delalande et al., 2010)

involved_in wound healing

inferred from high throughput mutant phenotype

(Campos et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in endosomal transport

inferred from sequence or structural similarity with SGD:S000000994

(Gene Ontology Curators, 2002-)

involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

inferred from biological aspect of ancestor with PANTHER:PTN000354756

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of ESCRT-0 complex

inferred from biological aspect of ancestor with PANTHER:PTN000354756

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with SGD:S000000994

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

ESCRT-0 COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ESCRT-0 COMPLEX -: The ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is made up of five complexes, ESCRT-0 to -III and the Vps4-Vta1 ATPase complex, which are sequentially recruited to the cytosolic face of the membrane, and mediate cargo recognition, membrane budding and fission. ESCRT-0 initiates mediates multivesicular body (MVB) formation, binding ubiquitinated membrane proteins destined for degradation and concentrating them in early endosome membranes. ESCRT-0 recruits ESCRT-I. (Adapted from PMID:22361144 and FBrf0209668).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Stam for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9XTL2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Stam-RA

FBtr0080143

NM_058100

2854

689

Additional Transcript Data and Comments

Reported size (kB)

2.85 (longest cDNA)

(Mesilaty-Gross et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Stam-PA

FBpp0079732

74.6

689

5.31

Q9XTL2

NP_477448

AAF53027

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

689 (aa)

(Mesilaty-Gross et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9XTL2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Stam using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Stam_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.80

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4

organism | ubiquitous | uniform

(Mesilaty-Gross et al., 1999)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 11 -- 12

midline primordium

(Fisher et al., 2012)

larval ventral midline glial cell

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic ventral midline neuroblast

(Fisher et al., 2012)

embryonic stage 11 -- 13

larval ventral nerve cord | segmentally repeated

(Mesilaty-Gross et al., 1999)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

adult stage | female oogenesis stage S9 -- S14

nurse cell

• cytoplasm

(Mesilaty-Gross et al., 1999)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Mesilaty-Gross et al., 1999)

embryonic stage 4

(Mesilaty-Gross et al., 1999)

embryonic stage 7 -- 17

organism | segmentally repeated

(Mesilaty-Gross et al., 1999)

embryonic stage 14 -- 17

larval ventral nerve cord | restricted

(Mesilaty-Gross et al., 1999)

adult stage & oogenesis

oocyte

(Mesilaty-Gross et al., 1999)

adult stage oogenesis stage S9 -- S10

nurse cell

(Mesilaty-Gross et al., 1999)

adult stage oogenesis stage S9 -- S14

(Mesilaty-Gross et al., 1999)

Additional Descriptive Data

Stam and aurB transcripts are detected in all developmental stages, but are at highest levels in embryos and adults. Stam and aurB transcripts are detected at very high levels in syncytial blastoderm embryos. From stage 7 onwards, a segmentally repeated pattern is visible for both transcripts. Expression is detected in the developing ventral nerve cord; later, a limited number of cells in the condensed nerve cord continue to express Stam and aurB transcripts. Stam and aurB transcript expression is also detected during oogenesis, starting at stage S9. In stages S9-S10, expression is high in the nurse cell cytoplasm. Transcript is detected in deposited eggs.

(Mesilaty-Gross et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S2 -- S9

female germline cell

(Galasso et al., 2007)

oogenesis stage S5 -- S9

oocyte | posterior

(Galasso et al., 2007)

oogenesis stage S7 -- S9

polar follicle cell

(Galasso et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Stam in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Stam

View exonic expression by tissue for Dmel\Stam

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027363

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34505/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027363

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027363

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027363

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6521

Flygut - An atlas of the Drosophila adult midgut

FBgn0027363

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Stam

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Stam

Transgenic constructs containing regulatory region of Stam

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(2L)BSC213

(Kahsai et al., 2016)

Df(2L)Exel7038

(Chanut-Delalande et al., 2007)

Df(2L)Exel7049

(Chanut-Delalande et al., 2007, Ryder, 2004.4.26)

Df(2L)Exel8026

(Chanut-Delalande et al., 2007)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2L)BSC213)

Stam^2L2896

lethal | recessive

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Stam^GD11948

viable

Stam^e00677

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Stam^GD11948

viable, with Scer\GAL4^tin.CΔ4

Stam^GD11948

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Stam^HMS01429

fertile

Stam^e00677

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Mef2.PR

Stam^GD11948

increased cell death | somatic clone | third instar larval stage

increased cell number | larval stage, with Scer\GAL4^MESO.dome

Stam^GD11948

some die during pupal stage, with Scer\GAL4^pnr-MD237

Stam^GD11948

visible, with Scer\GAL4^pnr-MD237

Stam^GD11948

visible | adult stage | somatic clone, with Scer\GAL4^Act.PU

Stam^HMS01429

Phenotype manifest in

Allele

dorsal air sac primordium | somatic clone

embryonic/larval crystal cell | increased number | larval stage, with Scer\GAL4^MESO.dome

Stam^GD11948

endosome | somatic clone | third instar larval stage

Stam¹⁹

eye | somatic clone

Stam^2L2896

eye | somatic clone, with Scer\GAL4^Act.PU

Stam^HMS01429

eye disc | somatic clone | third instar larval stage

imaginal disc epithelial cell | somatic clone

Stam^2L2896

major mitochondrial derivative, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Stam^HMS01429

nucleus | increased number | larval stage, with Scer\GAL4^MESO.dome

Stam^GD11948

photoreceptor neuron | somatic clone

Stam^2L2896

photoreceptor neuron | somatic clone | third instar larval stage

Stam¹⁹

primary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^MESO.dome

Stam^GD11948

secondary lobe of embryonic/larval lymph gland | larval stage, with Scer\GAL4^MESO.dome

Stam^GD11948

trichogen cell, with Scer\GAL4^pnr-MD237

Stam^GD11948

wing disc | somatic clone | third instar larval stage

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (17)

Hsap\STAM2

13 of 14

Yes

Hsap\STAM

12 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\WDFY1

1 of 14

Hsap\WDFY2

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Stam2

13 of 14

Yes

Rnor\Stam

11 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (14)

Mmus\Stam2

13 of 14

Yes

Mmus\Stam

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\stam

9 of 13

Yes

Xtro\stam2

6 of 13

Yes

Xtro\arhgef6

1 of 13

Xtro\limch1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (18)

Drer\stam

12 of 14

Yes

Drer\stam2

11 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\stam-1

11 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP008494

9 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\AT1G06210

2 of 13

Yes

Atha\AT5G16880

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\HSE1

11 of 13

Yes

Scer\GGA1

2 of 13

Scer\GGA2

2 of 13

Scer\BEM1

1 of 13

Yes

Scer\LSB1

1 of 13

Scer\LSB5

1 of 13

Yes

Scer\VPS27

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\hse1

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Stam. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

CG3529

3 of 13

Gga

2 of 13

Hrs

2 of 13

Crk

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Stam^JF02637

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^UAS.cUa

(Zhuang et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

STAM2; signal transducing adaptor molecule 2

13 of 14

606244

STAM; signal transducing adaptor molecule

12 of 14

601899

TOM1L2; target of myb1 like 2 membrane trafficking protein

3 of 14

615519

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Stam - ct

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rbf|Stam

suppressible

E2f1

(Sheng et al., 2016)

Rbf|Stam

suppressible

Egfr

(Sheng et al., 2016)

Rbf|Stam

suppressible

hid

(Sheng et al., 2016)

Rbf|Stam

suppressible

Ras85D

(Sheng et al., 2016)

Stam

enhanceable

Rbf

(Sheng et al., 2016)

Rbf|Stam

suppressible

spi

(Sheng et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rbf

enhanceable

Stam

(Sheng et al., 2016)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60577

DroID - A comprehensive database of gene and protein interactions.

FBgn0027363

MIST (protein-protein) - An integrated Molecular Interaction Database

34505

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9XTL2

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-43

Cytogenetic map

32B2-32B3

Sequence location

2L:10,858,536..10,862,006 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

32B2-32B3

Limits computationally determined from genome sequence between P{PZ}dbf¹ and P{lacW}SCAR^k03107

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

32A-32A

(Lloyd et al., 2000)

32B-32B

(Reich, 1999.1.21)

32C-32C

(Mesilaty-Gross, 1999.1.20)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

2-43

(FlyBase, 2016)

2-36.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

95220

w^*; P{UAS-Stam.FLAG.HA}attP2

17879

w¹¹¹⁸; PBac{RB}Stam^e00677

27487

y¹ v¹; P{TRiP.JF02637}attP2

41804

Stam^2L2896 P{neoFRT}40A/CyO, P{ftz-lacB}E3

41805

Stam^2L3297 P{neoFRT}40A/CyO, P{ftz-lacB}E3

35016

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01429}attP2

NIG-Fly

M2L-1847

y¹ w¹¹¹⁸; Stam^SK1 P{neoFRT}40A/CyO-Tb

M2L-1848

y¹ w¹¹¹⁸; Stam^SK6 P{neoFRT}40A/CyO-Tb

VDRC

v330248

P{VSH330248}attP40

v22497

w¹¹¹⁸; P{GD11948}v22497

v342883

P{hsFLP}1, y1 w1118; P{HD_CFD02426}attP40/CyO-GFP

v342545

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02158}attP40/CyO-GFP

More stocks available...

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (60)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD02639

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0027363

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0027363

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Galasso et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Stam is required for the normal clearance of the paternal mitochondrial derivatives in developing embryos.

(Politi et al., 2014)

Stam is involved in tracheal cell migration during the morphogenesis of the dorsal air sac primordium.

(Chanut-Delalande et al., 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG6521

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.1.11, Hosono et al., 2015, Ni et al., 2011.7.19, Perkins et al., 2009, Gandhi et al., 2007, Verstreken and Bellen, 2000.9.4)

Dstam

(Hou et al., 2002, Lohi and Lehto, 2001)

STAM

(Hunt et al., 2019, Du et al., 2011, Castelli-Gair Hombria and Brown, 2002, Lohi et al., 2002, Lloyd et al., 2000, Bischoff and Plowman, 1999, Mesilaty-Gross, 1999.1.20)

Stam1

(Michelet et al., 2010)

dstam

(Galasso et al., 2007)

stam

(Sheng et al., 2016, Di Cara et al., 2015, Issman-Zecharya and Schuldiner, 2014, Politi et al., 2014, Chanut-Delalande et al., 2010, Chanut-Delalande et al., 2007, Galasso et al., 2007, Zeidler et al., 2000)

Name Synonyms

Signal Transducing Adaptor Molecule

(Chanut-Delalande et al., 2010)

Signal transducer adaptor molecule

(Du et al., 2011)

Signal transducing adaptor molecule

(Mesilaty-Gross et al., 1999)

signal transducing adaptor molecule

(Chanut-Delalande et al., 2007)

signal-transducing adaptor molecule

(Galasso et al., 2007)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34505

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9XTL2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9XTL2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9XTL2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0027363

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34505/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0027363

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0027363

FlyMine - An integrated database for Drosophila genomics

FBgn0027363

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6521

MARRVEL_MODEL - MARRVEL (model organism gene)

34505

Linkouts

BioGRID - A database of protein and genetic interactions.

60577

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0027363

DroID - A comprehensive database of gene and protein interactions.

FBgn0027363

DRSC - Results frm RNAi screens

FBgn0027363

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Stam_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027363

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0027363

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6521

Flygut - An atlas of the Drosophila adult midgut

FBgn0027363

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0027363

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014037

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

MIST (protein-protein) - An integrated Molecular Interaction Database

34505

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9XTL2

References (99)

The following external sites may use different assemblies or annotations than FlyBase.

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