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General Information
Symbol
Dmel\TotA
Species
D. melanogaster
Name
Turandot A
Annotation Symbol
CG31509
Feature Type
FlyBase ID
FBgn0028396
Gene Model Status
Stock Availability
Gene Summary
Turandot A (TotA) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

Tot-A, Tot, Turandot, Tot A, Turt

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:20,871,036..20,871,700 [+]
Recombination map
3-69
RefSeq locus
NT_033777 REGION:20871036..20871700
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from expression pattern
inferred from expression pattern
inferred from expression pattern
inferred from expression pattern
inferred from high throughput expression pattern
inferred from direct assay
(assigned by UniProt )
involved_in response to cold
inferred from direct assay
(assigned by UniProt )
involved_in response to heat
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
involved_in response to UV
inferred from direct assay
(assigned by UniProt )
inferred from expression pattern
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR010825
(assigned by InterPro )
involved_in response to heat
traceable author statement
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the Turandot family. (Q8IN44)
Summaries
Gene Snapshot
Turandot A (TotA) encodes a protein that belongs to a class of poorly characterized secreted peptides. Some Turandot genes are expressed in response to stress in the fat body by the JAK-STAT pathway. [Date last reviewed: 2019-03-14]
Protein Function (UniProtKB)
A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response.
(UniProt, Q8IN44)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\TotA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083971
579
129
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083378
14.2
129
4.50
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TotA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\TotA in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of TotA
Transgenic constructs containing regulatory region of TotA
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190ILV )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila simulans
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila yakuba
Drosophila pseudoobscura pseudoobscura
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-69
    Cytogenetic map
    Sequence location
    3R:20,871,036..20,871,700 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    93A2-93A2
    Limits computationally determined from genome sequence between P{EP}SyndEP409 and P{lacW}l(3)j5C7j5C7
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    93A1-93A2
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (6)
    Genomic Clones (20)
    cDNA Clones (18)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: TotA CG31509

      Additional comments

      Source for merge of TotA CG31509 was sequence comparison ( date:021112 ).

      Other Comments

      New annotation (CG31509) in release 3 of the genome annotation.

      TotA is strongly induced upon bacterial challenge and other types of stress.

      Identification: in a screen for genes activated upon an immune challenge.

      TotA encodes a peptide that is expressed in response to microbial challenge, heat shock dehydration and internal wounding. The TotA protein does not seem to have any direct antimicrobial effect.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 27 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      EMBL-EBI Single Cell Expression Atlas
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Synonyms and Secondary IDs (14)
      Reported As
      Symbol Synonym
      TotA
      (Higareda Alvear et al., 2021, Hsu et al., 2021, Schneider and Imler, 2021, Ågren et al., 2020, Benoit et al., 2020, Deng et al., 2020, Garrido-Maraver et al., 2020, Huang et al., 2020, Kwon et al., 2020, Nonaka et al., 2020, Ramond et al., 2020, Stoffel et al., 2020, Swanson et al., 2020, Yurkevych et al., 2020, Belmonte et al., 2019, Fowler et al., 2019, Leech et al., 2019, Maitra et al., 2019, Merkling et al., 2019, Moskalev et al., 2019, Sinha et al., 2019, Stobdan et al., 2019, Troha and Buchon, 2019, Troha et al., 2019, Wang et al., 2019, Sherri et al., 2018, Wei et al., 2018, Aw et al., 2017, Daisley et al., 2017, Duneau et al., 2017, Kuintzle et al., 2017, Mohorianu et al., 2017, Seong et al., 2017, Hosamani et al., 2016, Katzenberger et al., 2016, Kubrak et al., 2016, Kubrak et al., 2016, Kučerová et al., 2016, Shen et al., 2016, Bartok et al., 2015, Hamilton et al., 2015, Kavi et al., 2015, Merkling et al., 2015, Terhzaz et al., 2015, Xia et al., 2015, Faisal et al., 2014, Lai et al., 2014, Salazar-Jaramillo et al., 2014, Taylor et al., 2014, Wang et al., 2014, Garcia et al., 2013, Gendrin et al., 2013, Morin-Poulard et al., 2013, Radyuk et al., 2013, Short and Lazzaro, 2013, Wang et al., 2013, Catalán et al., 2012, Chakrabarti et al., 2012, Grönholm et al., 2012, Mahapatra and Rand, 2012, Rynes et al., 2012, Cherbas et al., 2011, Gerbasi et al., 2011, Karpac et al., 2011, Marcu et al., 2011, Zhang et al., 2011, Bina et al., 2010, Chen et al., 2010, Kallio et al., 2010, Kim et al., 2010, Mahapatra et al., 2010, Graze et al., 2009, Reumer et al., 2009, Seugnet et al., 2009, Arbouzova and Zeidler, 2006, Brun et al., 2006, King-Jones et al., 2006, Ekengren, 2001.4.10)
      Secondary FlyBase IDs
      • FBgn0051509
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (146)